EP1119549A4 - Verfahren zur herstellung von in 4-stellung substituierten 1h-indol-3-glyoxamiden - Google Patents

Verfahren zur herstellung von in 4-stellung substituierten 1h-indol-3-glyoxamiden

Info

Publication number
EP1119549A4
EP1119549A4 EP99917552A EP99917552A EP1119549A4 EP 1119549 A4 EP1119549 A4 EP 1119549A4 EP 99917552 A EP99917552 A EP 99917552A EP 99917552 A EP99917552 A EP 99917552A EP 1119549 A4 EP1119549 A4 EP 1119549A4
Authority
EP
European Patent Office
Prior art keywords
glyoxamides
indole
substituted
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99917552A
Other languages
English (en)
French (fr)
Other versions
EP1119549A1 (de
Inventor
Benjamin Alan Anderson
Nancy Kay Harn
Richard Duane Miller
Edward Francis Plocharczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP1119549A1 publication Critical patent/EP1119549A1/de
Publication of EP1119549A4 publication Critical patent/EP1119549A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP99917552A 1998-10-09 1999-04-15 Verfahren zur herstellung von in 4-stellung substituierten 1h-indol-3-glyoxamiden Withdrawn EP1119549A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10360498P 1998-10-09 1998-10-09
US103604P 1998-10-09
PCT/US1999/008325 WO2000021929A1 (en) 1998-10-09 1999-04-15 Process for preparing 4-substituted-1h-indole-3-glyoxamides

Publications (2)

Publication Number Publication Date
EP1119549A1 EP1119549A1 (de) 2001-08-01
EP1119549A4 true EP1119549A4 (de) 2003-01-29

Family

ID=22296053

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99917552A Withdrawn EP1119549A4 (de) 1998-10-09 1999-04-15 Verfahren zur herstellung von in 4-stellung substituierten 1h-indol-3-glyoxamiden

Country Status (11)

Country Link
EP (1) EP1119549A4 (de)
JP (1) JP2002527421A (de)
AR (1) AR015766A1 (de)
AU (1) AU3564499A (de)
CA (1) CA2347718A1 (de)
CO (1) CO5021230A1 (de)
DZ (1) DZ2771A1 (de)
PE (1) PE20000429A1 (de)
SV (1) SV1999000042A (de)
TW (1) TW472041B (de)
WO (1) WO2000021929A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ876400A0 (en) * 2000-07-14 2000-08-03 University Of Queensland, The Compositions and method of using them

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6032769A (ja) * 1983-08-02 1985-02-19 Sagami Chem Res Center ４−ヒドロキシインド−ル誘導体の製造方法
EP0675110A1 (de) * 1994-04-01 1995-10-04 Eli Lilly And Company 1H-Indol-3-Glyoxylamid sPLA2 Inhibitoren

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6229298A (en) * 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6032769A (ja) * 1983-08-02 1985-02-19 Sagami Chem Res Center ４−ヒドロキシインド−ル誘導体の製造方法
EP0675110A1 (de) * 1994-04-01 1995-10-04 Eli Lilly And Company 1H-Indol-3-Glyoxylamid sPLA2 Inhibitoren

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0021929A1 *
W. A. REEMERS ET AL.: "Synthesis of Indoles from 4-Oxo-4,5,6,7-tetrahydroindoles. II. Introduction of Substituents into the 4 and 5 Positions", JOURNAL OF ORGANIC CHEMISTRY., vol. 36, no. 9, 1971, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 1232 - 1240, XP002221421, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
CA2347718A1 (en) 2000-04-20
TW472041B (en) 2002-01-11
AR015766A1 (es) 2001-05-16
SV1999000042A (es) 2000-04-11
PE20000429A1 (es) 2000-05-23
JP2002527421A (ja) 2002-08-27
AU3564499A (en) 2000-05-01
EP1119549A1 (de) 2001-08-01
DZ2771A1 (fr) 2003-12-01
CO5021230A1 (es) 2001-03-27
WO2000021929A1 (en) 2000-04-20

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Legal Events

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Effective date: 20010326

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 20021216

STAA Information on the status of an ep patent application or granted ep patent

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R18D Application deemed to be withdrawn (corrected)

Effective date: 20021101