EP1113841A1 - Kombinierte reizung von ventralen und dorsalen sakralen wurzeln zur kontrolle der blasenfunktion - Google Patents

Kombinierte reizung von ventralen und dorsalen sakralen wurzeln zur kontrolle der blasenfunktion

Info

Publication number
EP1113841A1
EP1113841A1 EP99951446A EP99951446A EP1113841A1 EP 1113841 A1 EP1113841 A1 EP 1113841A1 EP 99951446 A EP99951446 A EP 99951446A EP 99951446 A EP99951446 A EP 99951446A EP 1113841 A1 EP1113841 A1 EP 1113841A1
Authority
EP
European Patent Office
Prior art keywords
electrode
bladder
ventral
sacral
dorsal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99951446A
Other languages
English (en)
French (fr)
Inventor
Narendra Bhadra
J. Thomas Mortimer
Volker Grunewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axon Engineering Inc
Original Assignee
Axon Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axon Engineering Inc filed Critical Axon Engineering Inc
Publication of EP1113841A1 publication Critical patent/EP1113841A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control

Definitions

  • This invention relates generally to selective nerve stimulation for bladder
  • urinary calculi remains a major factor leading to morbidity in spinal cord injured
  • urethral or anal sphincter allows the development of techniques to selectively
  • the motor impulse is
  • sacral nerves are separated to isolate the ventral and dorsal roots thereof, and the
  • inferior somatic nerve SI is sectioned to isolate the external sphincter on one side.
  • the dorsal root of S2 is then sectioned unilaterally to isolate the sensory function
  • An electrode is positioned on the S3 sacral nerve to stimulate the detrusor
  • sphincter response may be
  • the present invention contemplates a new technique for bladder function
  • sacral motor roots and also the sacral sensory roots.
  • FIG. 1 schematically illustrates the placement of electrodes for controlling the
  • FIG. 2 is a graphic representation showing average voided volume from
  • FIG. 3 is a graphic representation showing average voided volume when
  • FIG. 4 illustrates a stimulation scheme which may be used for combined
  • FIG. 1 there is shown an illustrative embodiment of the
  • Kidney 10 is
  • Urine is expelled from the body through bladder neck 16 and
  • urethra 18 and out from urethral sphincter 20.
  • Bladder 12 and sphincter 20 function
  • Dorsal roots 23 are primarily sensory (afferent) to transmit sensation to spinal cord 19, while ventral roots 22
  • Ventral roots 22 include nerve bundles 22a which include larger diameter
  • nerve fibers and nerve bundles 22b which include smaller diameter fibers. Larger
  • fibers 22a connect between spinal cord 19 and sphincter 20, while smaller fibers 22b
  • Smaller fibers 22b usually carry no action potentials until the person desires
  • a cuff electrode 30 can be
  • Cuff electrode 30 which is preferably a self-curling spiral electrode that is biased to curl around the selected root and is described in U.S. Patent No. 4,602,624, is configured to accommodate nerves of
  • the present invention also includes an additional cuff electrode 32 which is
  • roots can result in the voiding of bladder contents without increasing sphincter
  • a controller 34 is electrically coupled to electrodes 30 and 32 to provide
  • nerve cuff electrode implanted on S2 motor roots. Either a quasitrapezoidal, balanced biphasic, 20 Hz pulse, with current amplitude set at a volume determined
  • the efferent sensory stimulus was applied to the S2 dermatome
  • the surface stimulus was varied to be continuous or intermittent (1 second
  • FIG. 2 shows the average volume of fluid voided during a 10 second pulse
  • halothane inhalation anesthesia The motor stimulus was applied by a spiral nerve
  • the sensory stimulus was applied to SI, S2, or
  • the intermittent surface stimulation was varied to be either 1
  • Table 1 shows the average results from three trials for each stimulus pattern.
  • FIG. 3 shows the
  • V(ml) Average voided volume in ml
  • FIG. 4 illustrates the stimulus pattern for the combined dorsal and ventral
  • An intermittent pulse train 100 is applied
  • pressure bladder activation can be achieved by modulating the reflexes associated
  • Pulse train 100 preferably consists of pulses delivered at a frequency of 10 to
  • each pulse having a nominal amplitude of less than 1 ma and a pulse
  • Pulse train 100 is generated intermittently, with a
  • Pulse train 102 preferably

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
EP99951446A 1998-09-16 1999-09-14 Kombinierte reizung von ventralen und dorsalen sakralen wurzeln zur kontrolle der blasenfunktion Withdrawn EP1113841A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10054298P 1998-09-16 1998-09-16
US100542P 1998-09-16
PCT/US1999/021049 WO2000015293A1 (en) 1998-09-16 1999-09-14 Combined stimulation of ventral and dorsal sacral roots for control of bladder function

Publications (1)

Publication Number Publication Date
EP1113841A1 true EP1113841A1 (de) 2001-07-11

Family

ID=22280289

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99951446A Withdrawn EP1113841A1 (de) 1998-09-16 1999-09-14 Kombinierte reizung von ventralen und dorsalen sakralen wurzeln zur kontrolle der blasenfunktion

Country Status (4)

Country Link
EP (1) EP1113841A1 (de)
AU (1) AU758611B2 (de)
CA (1) CA2343928A1 (de)
WO (1) WO2000015293A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7890176B2 (en) 1998-07-06 2011-02-15 Boston Scientific Neuromodulation Corporation Methods and systems for treating chronic pelvic pain
AU3361901A (en) 2000-02-17 2001-08-27 Neurodan A/S Methods and implantable systems for neural sensing and nerve stimulation
ES2164017B1 (es) * 2000-05-26 2004-06-01 Consejo Superior De Investigaciones Cientificas Sistema de estimulacion de raices sacras mediante implante alimentado por radio frecuencia.
US7813803B2 (en) 2005-06-09 2010-10-12 Medtronic, Inc. Regional therapies for treatment of pain
WO2010069317A1 (en) * 2008-12-19 2010-06-24 Neurodan A/S Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation
CN105142714B (zh) 2013-01-21 2018-02-16 卡拉健康公司 用于控制震颤的设备和方法
EP4360697A1 (de) 2014-06-02 2024-05-01 Cala Health, Inc. Systeme und verfahren zur peripheren nervenstimulation zur behandlung von tremor
JP2018516702A (ja) 2015-06-10 2018-06-28 カラ ヘルス, インコーポレイテッドCala Health, Inc. 取り外し可能な治療装置および監視装置で振戦を治療するための末梢神経刺激用のシステムおよび方法
CN108348746B (zh) 2015-09-23 2021-10-12 卡拉健康公司 用于手指或手中的周围神经刺激以治疗手震颤的系统和方法
EP3405251A4 (de) 2016-01-21 2019-08-28 Cala Health, Inc. Systeme, verfahren und vorrichtungen zur peripheren neuromodulation zur behandlung von erkrankungen im zusammenhang mit blasenhyperaktivität
CA3030029A1 (en) 2016-07-08 2018-01-11 Cala Health, Inc. Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes
CN110809486B (zh) 2017-04-03 2024-10-11 卡拉健康公司 用于治疗与膀胱过度活动症相关的疾病的周围神经调节系统、方法和装置
US11857778B2 (en) 2018-01-17 2024-01-02 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608985A (en) * 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1434524A (en) * 1972-04-27 1976-05-05 Nat Res Dev Urinary control apparatus
US4607639A (en) 1984-05-18 1986-08-26 Regents Of The University Of California Method and system for controlling bladder evacuation
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4569351A (en) * 1984-12-20 1986-02-11 University Of Health Sciences/The Chicago Medical School Apparatus and method for stimulating micturition and certain muscles in paraplegic mammals
ATE55697T1 (de) * 1986-05-12 1990-09-15 Univ California Elektronisches system zur nervenstimulation von beckenorganen.
US5199430A (en) * 1991-03-11 1993-04-06 Case Western Reserve University Micturitional assist device
US5370670A (en) * 1993-12-13 1994-12-06 Thomas Jefferson University Detrusor myoplasty and neuromuscular electrical stimulation of the urinary bladder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608985A (en) * 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking

Also Published As

Publication number Publication date
CA2343928A1 (en) 2000-03-23
WO2000015293A1 (en) 2000-03-23
AU758611B2 (en) 2003-03-27
AU6388599A (en) 2000-04-03

Similar Documents

Publication Publication Date Title
US7142925B1 (en) Combined stimulation of ventral and dorsal sacral roots for control of bladder function
US9393411B2 (en) System and method of bladder and sphincter control
US5199430A (en) Micturitional assist device
US7571000B2 (en) Apparatus for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses
ES2233822T3 (es) Aparato de estimulacion.
US9623243B2 (en) Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade
AU758611B2 (en) Combined stimulation of ventral and dorsal sacral roots for control of bladder function
US6061596A (en) Method for conditioning pelvic musculature using an implanted microstimulator
US20140309708A1 (en) System and Method for Electrical Stimulation of Anorectal Structures to Treat Anal Dysfunction
JP2003520653A (ja) 電子刺激インプラント
WO1997018857A9 (en) System and method for conditioning pelvic musculature using an implanted microstimulator
US20050209651A1 (en) System and method for treatment of sexual dysfunction
Shafik Magnetic stimulation: a novel method for inducing evacuation of the neuropathic rectum and urinary bladder in a canine model
Kerrebroeck Neuromodulation and other electrostimulatory techniques
Fall et al. Peripheral electrical stimulation
Bodner et al. Neuroprosthetic control of bladder and bowel in spinal cord injury patients

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010417

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17Q First examination report despatched

Effective date: 20040209

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061012