EP1102784A4 - A CONNECTION WITH A LABILES DISULFIDE TIE - Google Patents

A CONNECTION WITH A LABILES DISULFIDE TIE

Info

Publication number
EP1102784A4
EP1102784A4 EP00939635A EP00939635A EP1102784A4 EP 1102784 A4 EP1102784 A4 EP 1102784A4 EP 00939635 A EP00939635 A EP 00939635A EP 00939635 A EP00939635 A EP 00939635A EP 1102784 A4 EP1102784 A4 EP 1102784A4
Authority
EP
European Patent Office
Prior art keywords
compound containing
disulfide bond
labile disulfide
labile
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00939635A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1102784A1 (en
Inventor
Jon A Wolff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arrowhead Madison Inc
Original Assignee
Mirus Bio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Bio Corp filed Critical Mirus Bio Corp
Publication of EP1102784A1 publication Critical patent/EP1102784A1/en
Publication of EP1102784A4 publication Critical patent/EP1102784A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP00939635A 1999-06-07 2000-06-07 A CONNECTION WITH A LABILES DISULFIDE TIE Withdrawn EP1102784A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13785999P 1999-06-07 1999-06-07
US137859P 1999-06-07
PCT/US2000/015652 WO2000075162A1 (en) 1999-06-07 2000-06-07 A compound containing a labile disulfide bond

Publications (2)

Publication Number Publication Date
EP1102784A1 EP1102784A1 (en) 2001-05-30
EP1102784A4 true EP1102784A4 (en) 2009-12-30

Family

ID=22479359

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00939635A Withdrawn EP1102784A4 (en) 1999-06-07 2000-06-07 A CONNECTION WITH A LABILES DISULFIDE TIE

Country Status (3)

Country Link
EP (1) EP1102784A4 (ja)
JP (1) JP2003501440A (ja)
WO (1) WO2000075162A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091192B1 (en) 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
US7375096B1 (en) 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
PT2277551E (pt) 2002-09-06 2013-08-22 Cerulean Pharma Inc Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente
WO2004032862A2 (en) 2002-10-09 2004-04-22 Insert Therapeutics, Inc. Cyclodextrin-based materials, compositions and uses related thereto
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
GB0908963D0 (en) * 2009-05-22 2009-07-01 Imuthes Ltd Compositions
BR112014004585A2 (pt) * 2011-08-26 2017-06-13 Arrowhead Res Corp polímeros de poli(éster vinílico) para liberação de ácido nucleico in vivo
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
WO2015052155A1 (en) 2013-10-08 2015-04-16 Ascendis Pharma A/S Protecting group comprising a purification tag

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0736297A2 (en) * 1995-04-04 1996-10-09 CRODA INTERNATIONAL plc Cystine-silicone copolymers and their use for treating keratin substrates
WO1996041606A2 (en) * 1995-06-08 1996-12-27 Therexsys Limited Improved pharmaceutical compositions for gene therapy
WO1998019710A2 (en) * 1996-11-06 1998-05-14 Etienne Honore Schacht Delivery of nucleic acid material to target cells in biological systems
WO2000050617A1 (en) * 1999-02-26 2000-08-31 Mirus Corporation Intravascular delivery of non-viral nucleic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983727A (en) * 1988-04-11 1991-01-08 University Of North Dakota School Of Engineering & Mines Foundation Palladium mediated reaction of organic disulfides with mercurated nucleic acid components
US5157123A (en) * 1989-03-13 1992-10-20 Georgetown University S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent
WO1994018954A1 (en) * 1993-02-22 1994-09-01 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of biologics and compositions useful therefor
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
US5700921A (en) * 1995-11-27 1997-12-23 Vector Laboratories Labeling nucleic acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0736297A2 (en) * 1995-04-04 1996-10-09 CRODA INTERNATIONAL plc Cystine-silicone copolymers and their use for treating keratin substrates
WO1996041606A2 (en) * 1995-06-08 1996-12-27 Therexsys Limited Improved pharmaceutical compositions for gene therapy
WO1998019710A2 (en) * 1996-11-06 1998-05-14 Etienne Honore Schacht Delivery of nucleic acid material to target cells in biological systems
WO2000050617A1 (en) * 1999-02-26 2000-08-31 Mirus Corporation Intravascular delivery of non-viral nucleic acid

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANNIS, IOANA ET AL: "Novel Solid-Phase Reagents for Facile Formation of Intramolecular Disulfide Bridges in Peptides under Mild Conditions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120(29), 7226-7238 CODEN: JACSAT; ISSN: 0002-7863, 1998, XP002555112 *
GROTE, JAMES R. ET AL: "Effect of products from heated amino acids on conductance in lipid bilayer membranes and non-aqueous solvents", BIOSYSTEMS , 10(4), 287-92 CODEN: BSYMBO; ISSN: 0303-2647, 1978, XP002555111 *
See also references of WO0075162A1 *

Also Published As

Publication number Publication date
JP2003501440A (ja) 2003-01-14
EP1102784A1 (en) 2001-05-30
WO2000075162A1 (en) 2000-12-14

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010228

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MIRUS BIO CORPORATION

A4 Supplementary search report drawn up and despatched

Effective date: 20091130

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 323/52 20060101ALI20091120BHEP

Ipc: C07K 7/06 20060101ALI20091120BHEP

Ipc: C07C 323/62 20060101ALI20091120BHEP

Ipc: A61K 48/00 20060101AFI20091120BHEP

Ipc: C12N 15/87 20060101ALI20091120BHEP

Ipc: C07H 21/00 20060101ALI20091120BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100101