EP1100878B8 - Process for producing genetically modified cd34-negative adherently growing haematopoietic stem cells - Google Patents
Process for producing genetically modified cd34-negative adherently growing haematopoietic stem cells Download PDFInfo
- Publication number
- EP1100878B8 EP1100878B8 EP99948706A EP99948706A EP1100878B8 EP 1100878 B8 EP1100878 B8 EP 1100878B8 EP 99948706 A EP99948706 A EP 99948706A EP 99948706 A EP99948706 A EP 99948706A EP 1100878 B8 EP1100878 B8 EP 1100878B8
- Authority
- EP
- European Patent Office
- Prior art keywords
- stem cells
- genetically modified
- negative
- therapy
- adherently growing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833476A DE19833476B4 (en) | 1998-07-24 | 1998-07-24 | Genetically modified CD34 negatives, adherently growing hematopoietic stem cells and their use in gene therapy |
DE19833476 | 1998-07-24 | ||
PCT/DE1999/002309 WO2000006705A2 (en) | 1998-07-24 | 1999-07-22 | Genetically modified cd34-negative adherently growing stem cells and their use in gene therapy |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1100878A2 EP1100878A2 (en) | 2001-05-23 |
EP1100878B1 EP1100878B1 (en) | 2005-06-01 |
EP1100878B8 true EP1100878B8 (en) | 2005-08-17 |
Family
ID=7875274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99948706A Expired - Lifetime EP1100878B8 (en) | 1998-07-24 | 1999-07-22 | Process for producing genetically modified cd34-negative adherently growing haematopoietic stem cells |
Country Status (9)
Country | Link |
---|---|
US (1) | US6361997B1 (en) |
EP (1) | EP1100878B8 (en) |
JP (1) | JP4012688B2 (en) |
AT (1) | ATE296875T1 (en) |
AU (1) | AU741168B2 (en) |
CA (1) | CA2338541C (en) |
DE (2) | DE19833476B4 (en) |
ES (1) | ES2242422T3 (en) |
WO (1) | WO2000006705A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL147722A0 (en) * | 1999-07-20 | 2002-08-14 | Univ Southern California | Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
JP2004529621A (en) * | 2001-02-14 | 2004-09-30 | ティー ファークト,レオ | Pluripotent adult stem cells, their origin, methods of obtaining and maintaining them, methods of differentiating them, methods of their use, and cells derived therefrom |
US20070111201A1 (en) * | 2001-04-30 | 2007-05-17 | Benjamin Doranz | Reverse transfection of cell arrays for structural and functional analyses of proteins |
DE10144326B4 (en) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Method and system for monitoring a tire air pressure |
ITRM20030376A1 (en) | 2003-07-31 | 2005-02-01 | Univ Roma | PROCEDURE FOR THE ISOLATION AND EXPANSION OF CARDIOC STAMIN CELLS FROM BIOPSIA. |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
EP2087098A4 (en) * | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells |
WO2008063675A2 (en) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
WO2008150368A1 (en) * | 2007-05-24 | 2008-12-11 | Apceth Gmbh & Co. Kg | Cd34 stem cell-related methods and compositions |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9677042B2 (en) | 2010-10-08 | 2017-06-13 | Terumo Bct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
JP6433896B2 (en) | 2012-08-13 | 2018-12-05 | シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center | Exosomes and microribonucleic acids for tissue regeneration |
US9617506B2 (en) | 2013-11-16 | 2017-04-11 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP3613841B1 (en) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passive replacement of media |
EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
JP6878274B2 (en) | 2014-10-03 | 2021-05-26 | シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center | Myocardial cell-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
EP3656842A1 (en) | 2017-03-31 | 2020-05-27 | Terumo BCT, Inc. | Cell expansion |
CA3059634A1 (en) | 2017-04-13 | 2018-10-18 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
EP3612191A4 (en) | 2017-04-19 | 2020-12-30 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
EP3727351A4 (en) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
CA3116138A1 (en) | 2018-10-17 | 2020-04-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744347A (en) * | 1987-01-16 | 1998-04-28 | Ohio University Edison Biotechnology Institute | Yolk sac stem cells and their uses |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5921856A (en) | 1997-07-10 | 1999-07-13 | Sp3, Inc. | CVD diamond coated substrate for polishing pad conditioning head and method for making same |
-
1998
- 1998-07-24 DE DE19833476A patent/DE19833476B4/en not_active Expired - Fee Related
-
1999
- 1999-07-22 ES ES99948706T patent/ES2242422T3/en not_active Expired - Lifetime
- 1999-07-22 AT AT99948706T patent/ATE296875T1/en active
- 1999-07-22 US US09/743,904 patent/US6361997B1/en not_active Expired - Lifetime
- 1999-07-22 WO PCT/DE1999/002309 patent/WO2000006705A2/en active IP Right Grant
- 1999-07-22 DE DE59912118T patent/DE59912118D1/en not_active Expired - Lifetime
- 1999-07-22 AU AU61872/99A patent/AU741168B2/en not_active Ceased
- 1999-07-22 CA CA002338541A patent/CA2338541C/en not_active Expired - Fee Related
- 1999-07-22 JP JP2000562487A patent/JP4012688B2/en not_active Expired - Fee Related
- 1999-07-22 EP EP99948706A patent/EP1100878B8/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2242422T3 (en) | 2005-11-01 |
DE19833476A1 (en) | 2000-01-27 |
WO2000006705A2 (en) | 2000-02-10 |
ATE296875T1 (en) | 2005-06-15 |
US6361997B1 (en) | 2002-03-26 |
EP1100878A2 (en) | 2001-05-23 |
JP2003527817A (en) | 2003-09-24 |
WO2000006705A3 (en) | 2000-05-04 |
DE59912118D1 (en) | 2005-07-07 |
JP4012688B2 (en) | 2007-11-21 |
CA2338541C (en) | 2007-04-03 |
EP1100878B1 (en) | 2005-06-01 |
AU741168B2 (en) | 2001-11-22 |
AU6187299A (en) | 2000-02-21 |
CA2338541A1 (en) | 2000-02-10 |
DE19833476B4 (en) | 2005-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1100878B8 (en) | Process for producing genetically modified cd34-negative adherently growing haematopoietic stem cells | |
Zhu et al. | Periodontal ligament stem cells: current status, concerns, and future prospects | |
CN102282252B (en) | Amnion-derived attached cell | |
Suchánek et al. | Human dental pulp stem cells-isolation and long term cultivation | |
Terai et al. | Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway | |
Yang et al. | Regulation of the secretion of immunoregulatory factors of mesenchymal stem cells (MSCs) by collagen-based scaffolds during chondrogenesis | |
AU4336499A (en) | Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells | |
Dai et al. | Non-genetic direct reprogramming and biomimetic platforms in a preliminary study for adipose-derived stem cells into corneal endothelia-like cells | |
HUP0500477A2 (en) | Methods and compositions for the use of stromal cells to support embryonic and adult stem cells | |
JPH1189587A (en) | Genetically modified cell and its use in preventing and treating disease | |
Narang et al. | Stem cells: A potential regenerative future in dentistry | |
Pantic et al. | Reliable and versatile immortal muscle cell models from healthy and myotonic dystrophy type 1 primary human myoblasts | |
CN110305839A (en) | Mesenchymal stem cell serum-free culture medium | |
Olmedo-Moreno et al. | Heterogeneity of in vitro expanded mesenchymal stromal cells and strategies to improve their therapeutic actions | |
KR20170036105A (en) | Stem cell compositions and methods of producing stem cells for therapeutic applications | |
Silini et al. | CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine | |
KR920004570A (en) | Gene encoding human MK protein, expression vector and host cell comprising same, method for producing and using MK protein | |
ATE400654T1 (en) | NEW MAMMAL GENE BC1-W, WHICH BELONGS TO THE BC1-2 FAMILY OF APOPTOSIS-CONTROLING GENES | |
Saini et al. | Therapeutics of stem cells in periodontal regeneration | |
Murakami et al. | Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers | |
DE50009932D1 (en) | Gene transfer into human lymphocytes using retroviral SCFV cell culture vectors | |
CN1536076A (en) | Method for making adult bone marrow mesenchymal stem cells implement in vito amplification and directionally inducing them to be differentiated into myocardium-like cells | |
Zhou et al. | Treating congenital megacolon by transplanting GDNF and GFRα-1 double genetically modified rat bone marrow mesenchymal stem cells | |
Radfar et al. | Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival | |
Zhu et al. | Differentiation of Human umbilical cord-derived mesenchymal stem cells to melanocyte, Osteogenic and Neural cells in vitro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010206 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
17Q | First examination report despatched |
Effective date: 20011019 |
|
RTI1 | Title (correction) |
Free format text: GENETICALLY MODIFIED CD34-NEGATIVE ADHERENTLY GROWING HAEMATOPOIETIC STEM CELLS AND THEIR USE IN GENE THERAPY |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RTI1 | Title (correction) |
Free format text: PROCESS FOR PRODUCING GENETICALLY MODIFIED CD34-NEGATIVE ADHERENTLY GROWING HAEMATOPOIETIC STEM CELLS |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050601 Ref country code: IE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050601 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050601 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REF | Corresponds to: |
Ref document number: 59912118 Country of ref document: DE Date of ref document: 20050707 Kind code of ref document: P |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050722 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050722 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050731 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050731 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050901 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050901 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050901 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: SERVOPATENT GMBH |
|
GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 20050922 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2242422 Country of ref document: ES Kind code of ref document: T3 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051103 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FD4D |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
ET | Fr: translation filed | ||
26N | No opposition filed |
Effective date: 20060302 |
|
BERE | Be: lapsed |
Owner name: HUSS, RALF Effective date: 20050731 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFA Owner name: HUSS, RALF Free format text: HUSS, RALF#TEGERNSEER STRASSE 78#83666 WAAKIRCHEN (DE) -TRANSFER TO- HUSS, RALF#TEGERNSEER STRASSE 78#83666 WAAKIRCHEN (DE) |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PUE Owner name: APCETH GMBH & CO. KG Free format text: HUSS, RALF#TEGERNSEER STRASSE 78#83666 WAAKIRCHEN (DE) -TRANSFER TO- APCETH GMBH & CO. KG#ROSENHEIMER PLATZ 6#81669 MUENCHEN (DE) |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20090514 AND 20090520 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: PC2A |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: TP |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: AT Payment date: 20140620 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20140725 Year of fee payment: 16 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 17 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20150723 Year of fee payment: 17 Ref country code: DE Payment date: 20150729 Year of fee payment: 17 Ref country code: GB Payment date: 20150724 Year of fee payment: 17 Ref country code: ES Payment date: 20150723 Year of fee payment: 17 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 59912118 Country of ref document: DE Representative=s name: HERTIN & PARTNER RECHTS- UND PATENTANWAELTE PA, DE Ref country code: DE Ref legal event code: R082 Ref document number: 59912118 Country of ref document: DE |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20150730 Year of fee payment: 17 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 296875 Country of ref document: AT Kind code of ref document: T Effective date: 20150722 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20150722 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20150722 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 59912118 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20160722 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160731 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160731 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170201 Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160801 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20170331 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160722 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20180507 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160723 |