EP1100826A4 - Isoformes de recepteur de calcium humain - Google Patents

Isoformes de recepteur de calcium humain

Info

Publication number
EP1100826A4
EP1100826A4 EP99937584A EP99937584A EP1100826A4 EP 1100826 A4 EP1100826 A4 EP 1100826A4 EP 99937584 A EP99937584 A EP 99937584A EP 99937584 A EP99937584 A EP 99937584A EP 1100826 A4 EP1100826 A4 EP 1100826A4
Authority
EP
European Patent Office
Prior art keywords
isoforms
sensing receptor
human calcium
calcium sensing
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99937584A
Other languages
German (de)
English (en)
Other versions
EP1100826A1 (fr
Inventor
Kin T Yu
Richard F Labaudiniere
Larry W Thrower
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of EP1100826A1 publication Critical patent/EP1100826A1/fr
Publication of EP1100826A4 publication Critical patent/EP1100826A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99937584A 1998-07-30 1999-07-28 Isoformes de recepteur de calcium humain Withdrawn EP1100826A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9470298P 1998-07-30 1998-07-30
US94702P 1998-07-30
PCT/US1999/017116 WO2000006601A1 (fr) 1998-07-30 1999-07-28 Isoformes de recepteur de calcium humain

Publications (2)

Publication Number Publication Date
EP1100826A1 EP1100826A1 (fr) 2001-05-23
EP1100826A4 true EP1100826A4 (fr) 2002-08-07

Family

ID=22246675

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99937584A Withdrawn EP1100826A4 (fr) 1998-07-30 1999-07-28 Isoformes de recepteur de calcium humain

Country Status (5)

Country Link
EP (1) EP1100826A4 (fr)
JP (1) JP2002521052A (fr)
AU (1) AU767010B2 (fr)
CA (1) CA2336543A1 (fr)
WO (1) WO2000006601A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020053091A1 (en) * 2000-09-19 2002-05-02 Ishwar Chandramouliswaran Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
US7867168B2 (en) 2004-08-24 2011-01-11 Sonosite, Inc. Ultrasonic transducer having distributed weight properties
US7754873B2 (en) * 2005-07-16 2010-07-13 Zymo Research Corporation Isolation of nucleic acid using colored buffers
CA2762130A1 (fr) 2009-05-27 2010-12-02 Leo Pharma A/S Composes inedits modulant les recepteurs du calcium et leur utilisation pharmaceutique
EP2435404A1 (fr) 2009-05-27 2012-04-04 Leo Pharma A/S Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique
US20130244995A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
EP2643298A1 (fr) 2010-11-26 2013-10-02 Leo Pharma A/S Cyclopentylazines substituées en tant que composés casr-actifs
EP2643292A1 (fr) 2010-11-26 2013-10-02 Leo Pharma A/S Composés actifs sur les récepteurs du calcium
CN103270018A (zh) 2010-11-26 2013-08-28 利奥制药有限公司 钙敏感受体激活化合物
EP3204772B2 (fr) 2014-10-10 2023-12-20 Mars, Incorporated Procédés permettant d'identifier des modulateurs de récepteurs de détection du calcium
CN115873113B (zh) * 2021-09-28 2024-06-18 中国科学院上海药物研究所 靶向CaSR的纳米抗体及其制备方法和应用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FREICHEL M ET AL: "EXPRESSION OF A CALCIUM-SENSING RECEPTOR IN A HUMAN MEDULLARY THYROID CARCINOMA CELL LINE AND ITS CONTRIBUTION TO CALCITONIN SECRETION", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 137, no. 9, September 1996 (1996-09-01), pages 3842 - 3848, XP002925084, ISSN: 0013-7227 *
JOURNOT L ET AL: "THE PACAP RECEPTOR: GENERATION BY ALTERNATIVE SPLICING OF FUNCTIONAL DIVERSITY AMONG G PROTEIN- COUPLED RECEPTORS IN NERVE CELLS", SEMINARS IN CELL BIOLOGY, SAUNDERS SCIENTIFIC PUBLICATIONS, PHILADELPHIA,, US, vol. 5, no. 4, August 1994 (1994-08-01), pages 263 - 272, XP001008535, ISSN: 1043-4675 *
ODA Y. ET AL: "A novel alternative splicing of the calcium receptor correlates with keratinocyte differentiation", FASEB JOURNAL, vol. 11, no. 9, 1997, pages A925, XP001080428 *
PEARCE S.H.S. ET AL: "Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism", JOURNAL FOR CLINICAL INVESTIGATION, vol. 96, 1995, pages 2683 - 2692, XP001079436 *
See also references of WO0006601A1 *

Also Published As

Publication number Publication date
AU767010B2 (en) 2003-10-30
JP2002521052A (ja) 2002-07-16
AU5238999A (en) 2000-02-21
CA2336543A1 (fr) 2000-02-10
EP1100826A1 (fr) 2001-05-23
WO2000006601A1 (fr) 2000-02-10

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