EP1090651A1 - Nadellose Spritze mit Reibungstriggerung - Google Patents

Nadellose Spritze mit Reibungstriggerung Download PDF

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Publication number
EP1090651A1
EP1090651A1 EP00402594A EP00402594A EP1090651A1 EP 1090651 A1 EP1090651 A1 EP 1090651A1 EP 00402594 A EP00402594 A EP 00402594A EP 00402594 A EP00402594 A EP 00402594A EP 1090651 A1 EP1090651 A1 EP 1090651A1
Authority
EP
European Patent Office
Prior art keywords
syringe
trigger
needle
friction
rough
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00402594A
Other languages
English (en)
French (fr)
Other versions
EP1090651B1 (de
Inventor
Patrick Alexandre
Bernard Brouquieres
Philippe Gautier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crossject Co
Original Assignee
Societe Nationale des Poudres et Explosifs
Cross Site Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Nationale des Poudres et Explosifs , Cross Site Technologies SA filed Critical Societe Nationale des Poudres et Explosifs
Publication of EP1090651A1 publication Critical patent/EP1090651A1/de
Application granted granted Critical
Publication of EP1090651B1 publication Critical patent/EP1090651B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F42—AMMUNITION; BLASTING
    • F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
    • F42B3/00—Blasting cartridges, i.e. case and explosive
    • F42B3/10—Initiators therefor
    • F42B3/117—Initiators therefor activated by friction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge

Definitions

  • the technical field of the invention is that of syringes without needle intended to inject, through the skin, solid, liquid or mixed particles of active ingredient for therapeutic use.
  • the invention relates to a syringe without needle operating from a device initiation involving a tripping associated with a pyrotechnic charge. More specially, this triggering device must be suitable for igniting a housed pyrotechnic charge in a light, small object that should be manually operated.
  • the solution proposed by the invention advocates the use of a rough as the main piece of the syringe trigger device without needle.
  • French patent FR 2 487 968 describes an igniter plug particularly suitable for setting grenade fire and containing in particular a chain ignition pyrotechnics of which the first element is a pyrotechnic charge that can be initiated by friction.
  • Needle-free syringes must have an actuatable trigger device manually and allowing to get rid of a source too energetic or too bulky activation all while remaining reliable and efficient.
  • the commonly used trip devices involve primers whose composition primary is particularly sensitive. In a situation of storage, these syringes can then have a risk of inadvertent operation, due to high sensitivity of the primer to stresses conditions such as high temperatures or falls.
  • primers require, to be initiated, a device relatively bulky percussion. So that solve this congestion problem and this risk of untimely operation it was discovered the possibility of miniaturizing an initiation by friction, performed with good safety, and triggering with excellent reliability.
  • the syringe without needle according to the invention having a triggering device by friction has a double safety, one, under the shape of a retractable piece preventing everything depression of the trigger, the other, in the form a roughness zone requiring effort particular to press the shutter button once the retractable part has been removed.
  • the syringe without needle according to the invention has all these technical characteristics particularly suitable for injection without a needle.
  • the object of the present invention relates to a syringe without needle fitted with a device initiation including a trigger device and a pyrotechnic charge characterized in that the trigger device includes a trigger connected to a means of friction of the load pyrotechnic.
  • the friction means consists of a room whose main function is to come rub against a pyrotechnic charge in order to cause its direct initiation.
  • Such a device requires a pyrotechnic composition sensitive to friction such as for example compositions based on Zirconium.
  • the friction means is a rough.
  • the rough is consisting of an elongated part, one end of which has rough edges.
  • the piece is rigid and has a substantially cylindrical shape.
  • the part is integral with the member trigger so that its movement is dictated by the movement imprinted on the said organ.
  • the trigger member is a button pusher intended to be actuated manually and slidable along a hollow central body lying in which is housed the pyrotechnic charge.
  • the rough In "storage" configuration for which the syringe without needle has not yet worked, the rough is distant from the pyrotechnic charge. The ignition of this will happen when the rough comes to its contact by causing direct mechanical friction.
  • the push button is placed at one end of the central body to facilitate its actuation, and more particularly at the end opposite to that by which the active ingredient is injected.
  • the rough and the load pyrotechnics are aligned along the axis of the body hollow.
  • the rough and the filler pyrotechnics have a substantially cylindrical shape and their axis coincides with the axis of the hollow body.
  • a roughness zone located between the push button and the central body allows to increase the friction forces between these two elements, in case of sliding one over the other. More concrete, this area allows to introduce a resistance, preventing any initiation as long as a sufficient effort is not applied sufficiently long to drive the rough in contact with the pyrotechnic charge.
  • the roughness zone is constituted by the mutual nesting of asperities of one of the two elements in grooves of the other element planned to receive them, so to induce a minimum pressure level to start to press the push button. This avoids a nuisance triggering from a request harmless or unintentional when the syringe without needle is made operational by removing the retractable stopper which protects the end through which the active ingredient is injected.
  • the push button has a safety in the form of a stop retractable preventing any movement of said button.
  • the other function of this security is to protect the end of the syringe through which to eject the active ingredient.
  • the retractable stop is constituted by a stopper provided with a collar blocking the push button.
  • a line of weakness circular dissociates the flange from the plug.
  • the collar is rigid and has a zipper to tear it.
  • the annular roughness constituting the roughness zone have the characteristic of preferentially deforming along the thrust axis and therefore have a anti-return effect. In this way, the user does not no risk of experiencing a sudden button retreat pusher.
  • the rough is in stainless steel.
  • the needleless syringes according to the invention have the advantage of producing a reaction less violent pyrotechnic than that which is perceived during the operation of a percussion primer. In indeed, they allow a gentle initiation of the gas-generating composition via a friction and no longer via a wave of choc.
  • Figure 1 is an axial sectional view longitudinal of a syringe without needle according to the invention has not yet worked.
  • Figure 2 is an axial sectional view longitudinal of the syringe of Figure 1 having worked.
  • the syringe without needle 1 has an upstream part comprising a trigger device and a downstream part comprising a pyrotechnic charge 2, the principle active in solid or liquid form, an ejection nozzle and an application guide on the skin.
  • the device trigger includes a push button 3 and a means friction in the form of a rough 12.
  • the push button 3 has a substantially shaped cylindrical and consists of a solid part 4 extended by a hollow cylindrical part 5 of identical outside diameter.
  • This cylindrical part hollow 5 of constant outside diameter has a internal shoulder to distinguish a cylinder thick rear hollow in continuity with a thinner hollow front cylinder, the rear cylinder being between the solid part 4 and the front cylinder.
  • the rear cylinder has on its internal side wall an area with a series of annular roughness.
  • the hollow cylindrical part 5 encloses, over part of its length, a body hollow cylindrical 6 having on its side wall external an area also showing a series of annular roughness, said body 6 being extended by an enlarged cylindrical base 7.
  • the hollow cylindrical body 6 has a internal shoulder to distinguish a channel upstream of small diameter in continuity with a channel larger downstream in which the pyrotechnic charge 2.
  • This pyrotechnic charge 2 is divided into two distinct parts, one relating to a composition based on zirconium sensitive to friction, and the other, to a composition generating gas which will be used to expel the particles.
  • the rough 12 is constituted by an elongated piece 11, of form cylindrical, having a free end 8 provided roughness, and is located in the solid part 4 of the push button 3 so it ends up in the hollow cylindrical part 5 of said button 3, in a central position for which their two axes are confused.
  • Push button 3 encloses the cylindrical body hollow 6 so that their respective zones with annular asperities correspond in overlapping one another and that a free space 9 remains between the solid part 4 of the push button 3 and the end of the hollow cylindrical body 6 making it face.
  • the interlocking of these two areas creates a roughness zone 10 made up of hard spots, so as to increase the friction forces in the event of sliding of the push button 3 along the body cylindrical hollow 6.
  • These annular asperities constituting the roughness zone 10 have the particularity to deform preferentially along the axis of push and therefore have a non-return effect.
  • the external side wall of the enlarged base 7 of the hollow cylindrical body 6 finds itself in contact with the inner side wall of the front cylinder of the hollow cylindrical part 5 of the push button 3, and the end of the front cylinder is in contact with the base 7 so as to avoid the push button 3 to be easily removed from syringe 1.
  • Syringe 1 has a safety in the form a retractable stop constituted by a plug 13 provided with a detachable rigid collar 14, having the same diameter as the outside diameter of the button push button 3.
  • the button 13 of cylindrical shape comes fit around the sensitive end of the syringe 1 through which the active ingredient is expelled.
  • the active ingredient, or at least its location in the syringe, is not shown in the figures, but whatever configuration is chosen, it is located downstream of the pyrotechnic charge 2, either in the gas path, either on the side.
  • the collar 14 which is cylindrical in shape is integral with the plug 13, and is blocked between said plug 13 and the free end of the part hollow cylindrical 5 of the push button 3.
  • the user takes hold of the pull tab 15 and acts so as to cause the separation of the collar 14 and of plug 13 along the circular line of precut. Once the flange 14 has been removed, the protective cap 13 is in turn removed and the syringe 1 is thus found unlocked.
  • the downstream part of the syringe 1 is brought to skin contact of the patient to be treated.
  • the user then exerts manual pressure on the button pusher 3 at the level of its solid part 4, so as to push it down. To do this, he must make an effort to overcome the friction forces induced by the roughness zone 10.
  • the push button 3 begins to slide along the hollow cylindrical body 6, it causes a linear displacement of the rough 12 in the hollow cylindrical body 6 until its free end 8 with rough edges reaches the load pyrotechnic 2 at the level of its part constituted by the composition based on Zirconium sensitive to friction. This end 8, which plays the role of a friction, induces friction within said load 2 which reacts by igniting.
  • the gases generated by this combustion will cause initiation of the gas-generating composition.
  • the gases resulting from this second combustion are going allow the active ingredient to be ejected through the skin of the patient, either by moving, for example, a plunger to eject active ingredient in liquid form at through a nozzle, either by creating, for example, a wave shock to accelerate particles of active ingredient in solid form.
  • Maximum movement of the button push-button 3 corresponds to the abutment of the internal shoulder of the hollow cylindrical part 5 against the enlarged base 7 of the hollow cylindrical body 6.
  • the roughness of the roughness zone 10 being able to deform along the thrust axis, have a non-return effect to allow in particular the button push-button 3 to stay pressed, keeping its position relative to the hollow cylindrical body 6.
  • the seal circular 16 also avoids a rise nuisance gas towards push button 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP00402594A 1999-10-08 2000-09-20 Nadellose Spritze mit Reibungstriggerung Expired - Lifetime EP1090651B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9912559 1999-10-08
FR9912559A FR2799374B1 (fr) 1999-10-08 1999-10-08 Seringue sans aiguille munie d'un systeme de declenchement par friction

Publications (2)

Publication Number Publication Date
EP1090651A1 true EP1090651A1 (de) 2001-04-11
EP1090651B1 EP1090651B1 (de) 2004-06-09

Family

ID=9550704

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00402594A Expired - Lifetime EP1090651B1 (de) 1999-10-08 2000-09-20 Nadellose Spritze mit Reibungstriggerung

Country Status (6)

Country Link
US (1) US6537245B1 (de)
EP (1) EP1090651B1 (de)
AT (1) ATE268614T1 (de)
DE (1) DE60011361T2 (de)
ES (1) ES2222166T3 (de)
FR (1) FR2799374B1 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039633A2 (en) * 2001-11-02 2003-05-15 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
DE19820172A1 (de) * 1997-09-30 2005-01-27 Wolfgang Wagner Einrichtung und einrichtungsbezogenes Verfahren zur Einbringung eines Diagnostikträgers oder einer Arznei unter die Haut eines Lebewesens
EP1637174A2 (de) * 2001-07-26 2006-03-22 PowderJect Research Limited Schalldämpfereinrichtung und verfahren zum betreiben einer nadellose spritze
CN101987218B (zh) * 2009-07-30 2013-07-10 陈建龙 传输装置

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807946B1 (fr) * 2000-04-19 2002-06-07 Poudres & Explosifs Ste Nale Seringue sans aiguille fonctionnant avec un chargement pyrotechnique bicomposition
EP1339442A4 (de) 2000-11-30 2006-12-27 Biovalve Technologies Inc Injektionssysteme
DK2532378T3 (en) * 2004-12-01 2016-07-25 Acushot Inc needleless injector
US20080234626A1 (en) * 2006-04-26 2008-09-25 Chelak Todd M Multi-stage microporation device
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
WO2008103997A2 (en) * 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
JP6396825B2 (ja) * 2015-02-25 2018-09-26 株式会社ダイセル 点火器
FR3123139B1 (fr) * 2021-05-18 2023-04-28 Synchrotron Soleil Electro-aimant multipolaire

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145712A (en) * 1963-03-13 1964-08-25 Jr Charles J Litz Percutaneous medication device
US3308818A (en) * 1964-07-24 1967-03-14 Eugene V Rutkowski Injection cartridge
US3335722A (en) * 1963-11-01 1967-08-15 Olin Mathieson Hypodermic device
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
FR2487968A1 (fr) * 1980-07-30 1982-02-05 Poudres & Explosifs Ste Nale Bouchon allumeur initiable par frottement ou par gaz chauds
CH681175A5 (en) * 1990-07-19 1993-01-29 Samuel Eglin Pyrotechnic based warning signal device - has friction-actuated ignition which is activated by removal of cap

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2322244A (en) 1940-03-18 1943-06-22 Marshall L Lockhart Hypodermic injector
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
FR2393261A1 (fr) 1977-06-01 1978-12-29 Ruggieri Ets Mine indetectable pour chenille

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145712A (en) * 1963-03-13 1964-08-25 Jr Charles J Litz Percutaneous medication device
US3335722A (en) * 1963-11-01 1967-08-15 Olin Mathieson Hypodermic device
US3308818A (en) * 1964-07-24 1967-03-14 Eugene V Rutkowski Injection cartridge
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
FR2487968A1 (fr) * 1980-07-30 1982-02-05 Poudres & Explosifs Ste Nale Bouchon allumeur initiable par frottement ou par gaz chauds
CH681175A5 (en) * 1990-07-19 1993-01-29 Samuel Eglin Pyrotechnic based warning signal device - has friction-actuated ignition which is activated by removal of cap

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19820172A1 (de) * 1997-09-30 2005-01-27 Wolfgang Wagner Einrichtung und einrichtungsbezogenes Verfahren zur Einbringung eines Diagnostikträgers oder einer Arznei unter die Haut eines Lebewesens
EP1637174A2 (de) * 2001-07-26 2006-03-22 PowderJect Research Limited Schalldämpfereinrichtung und verfahren zum betreiben einer nadellose spritze
EP1637174A3 (de) * 2001-07-26 2006-05-03 PowderJect Research Limited Schalldämpfereinrichtung und verfahren zum betreiben einer nadellose spritze
WO2003039633A2 (en) * 2001-11-02 2003-05-15 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
WO2003039633A3 (en) * 2001-11-02 2004-01-15 Meridian Medical Technologies Automatic injector with anti-coring needle
US7569035B1 (en) 2001-11-02 2009-08-04 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
CN101987218B (zh) * 2009-07-30 2013-07-10 陈建龙 传输装置

Also Published As

Publication number Publication date
DE60011361T2 (de) 2005-06-09
US6537245B1 (en) 2003-03-25
EP1090651B1 (de) 2004-06-09
FR2799374B1 (fr) 2001-12-07
FR2799374A1 (fr) 2001-04-13
ATE268614T1 (de) 2004-06-15
DE60011361D1 (de) 2004-07-15
ES2222166T3 (es) 2005-02-01

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