EP1086104A4 - Fused phenoxymethyl carbapenem antibacterials - Google Patents

Fused phenoxymethyl carbapenem antibacterials

Info

Publication number
EP1086104A4
EP1086104A4 EP99926080A EP99926080A EP1086104A4 EP 1086104 A4 EP1086104 A4 EP 1086104A4 EP 99926080 A EP99926080 A EP 99926080A EP 99926080 A EP99926080 A EP 99926080A EP 1086104 A4 EP1086104 A4 EP 1086104A4
Authority
EP
European Patent Office
Prior art keywords
phenoxymethyl
fused
carbapenem antibacterials
carbapenem
antibacterials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99926080A
Other languages
German (de)
French (fr)
Other versions
EP1086104A1 (en
Inventor
Frank P Dininno
Kevin D Dykstra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1086104A1 publication Critical patent/EP1086104A1/en
Publication of EP1086104A4 publication Critical patent/EP1086104A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
EP99926080A 1998-06-02 1999-05-28 Fused phenoxymethyl carbapenem antibacterials Withdrawn EP1086104A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8777298P 1998-06-02 1998-06-02
US87772P 1998-06-02
PCT/US1999/012042 WO1999062907A1 (en) 1998-06-02 1999-05-28 Fused phenoxymethyl carbapenem antibacterials

Publications (2)

Publication Number Publication Date
EP1086104A1 EP1086104A1 (en) 2001-03-28
EP1086104A4 true EP1086104A4 (en) 2002-02-06

Family

ID=22207159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99926080A Withdrawn EP1086104A4 (en) 1998-06-02 1999-05-28 Fused phenoxymethyl carbapenem antibacterials

Country Status (6)

Country Link
US (1) US6284753B2 (en)
EP (1) EP1086104A4 (en)
JP (1) JP2002517395A (en)
AU (1) AU4224099A (en)
CA (1) CA2333658A1 (en)
WO (1) WO1999062907A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020027553A1 (en) * 2018-08-03 2020-02-06 한양대학교 에리카산학협력단 Probe for detecting carbapenem-resistant bacteria and use thereof
KR102288736B1 (en) * 2018-08-03 2021-08-12 한양대학교 에리카산학협력단 Probes for Detecting Carbapenem-Resistance Bacteria in a Sample and Uses Thereof
CN109942527A (en) * 2019-04-26 2019-06-28 新乡市润宇新材料科技有限公司 A kind of synthetic method of 3- bromine dibenzofurans
KR102365852B1 (en) * 2019-12-27 2022-02-22 주식회사 노블바이오 Kit for detecting carbapenemase-producing enterobacteriaceae comprising fluorescent probe and method for detecting carbapenemase-producing enterobacteriaceae using the same
JP2024503753A (en) 2021-01-27 2024-01-26 ヴァンドリア エスアー Urolithin derivatives and their usage

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
EP0405774A1 (en) * 1989-06-08 1991-01-02 Merck & Co. Inc. 2-(substituted-dibenzofuranyl and dibenzothienyl)carbapenem antibacterial agents
EP0444889A1 (en) * 1990-02-26 1991-09-04 Merck & Co. Inc. Novel synthesis of carbapenem intermediates
WO1999014217A1 (en) * 1997-09-17 1999-03-25 Merck & Co., Inc. Aryloxymethyl carbapenem antibacterials
WO1999062878A1 (en) * 1998-06-02 1999-12-09 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6277843B1 (en) * 1997-09-17 2001-08-21 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR244550A1 (en) 1978-07-24 1993-11-30 Merck & Co Inc An antibacterial composition of thienamycin-type compound and a dipeptidase inhibitor
NZ201471A (en) 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
US5192758A (en) 1992-02-28 1993-03-09 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
US5756725A (en) * 1996-04-24 1998-05-26 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
EP0405774A1 (en) * 1989-06-08 1991-01-02 Merck & Co. Inc. 2-(substituted-dibenzofuranyl and dibenzothienyl)carbapenem antibacterial agents
EP0444889A1 (en) * 1990-02-26 1991-09-04 Merck & Co. Inc. Novel synthesis of carbapenem intermediates
WO1999014217A1 (en) * 1997-09-17 1999-03-25 Merck & Co., Inc. Aryloxymethyl carbapenem antibacterials
US6277843B1 (en) * 1997-09-17 2001-08-21 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
WO1999062878A1 (en) * 1998-06-02 1999-12-09 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9962907A1 *
YAMADA A ET AL: "Synthesis and Biological Evaluation of Novel 2-Vinyl Carbapenems. Remarkable DHP-1 Stability of 1'-Substituted Analogs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 22, 19 November 1996 (1996-11-19), pages 2705 - 2708, XP004135879, ISSN: 0960-894X *

Also Published As

Publication number Publication date
US6284753B2 (en) 2001-09-04
EP1086104A1 (en) 2001-03-28
JP2002517395A (en) 2002-06-18
CA2333658A1 (en) 1999-12-09
AU4224099A (en) 1999-12-20
WO1999062907A1 (en) 1999-12-09
US20010011086A1 (en) 2001-08-02

Similar Documents

Publication Publication Date Title
AU136238S (en) Eyewear
IL142420A0 (en) Heterocyclyl amino methyloxa zolidinones as antibacterials
GB2338672B (en) Toolholder
GB9903275D0 (en) Earphone-microphone adaptor
EP1086104A4 (en) Fused phenoxymethyl carbapenem antibacterials
AU5818398A (en) Replaceable sleeve
EP1015453A4 (en) 3-(iodophenoxymethyl) carbapenem antibacterials
HUP0101830A3 (en) Purification carboxaldehyde
GB2343263B (en) Eyewear
EP1023293A4 (en) Aryloxymethyl carbapenem antibacterials
EP1084124A4 (en) Benzothiazolythiomethyl carbapenem antibacterial
EP1082325A4 (en) Naphthosulfamylmethyl penem antibacterials
HUP0002131A3 (en) Scarf joint for windows
GB9816777D0 (en) Spectacles
GB2334993B (en) Glazing bead
EP1090000A4 (en) Naphtho 1,8-de]thiasin-2-yl methyl carbapenem antibacterials
TW420357U (en) Object lens driver
EP1089999A4 (en) (heterocyclic) methyl substituted carbapenem antibacterials
EP1090001A4 (en) (heterocyclic)methyl substituted carbapenem antibacterials
GB0022760D0 (en) Cutter for road surfaces
TW347874U (en) Spectacles
AU2807701A (en) Cardiomyocyte regeneration
CA84646S (en) Eyewear
CA84645S (en) Eyewear
CA83851S (en) Eyewear

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010102

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20010102;LT PAYMENT 20010102;LV PAYMENT 20010102;MK PAYMENT 20010102;RO PAYMENT 20010102;SI PAYMENT 20010102

A4 Supplementary search report drawn up and despatched

Effective date: 20011221

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07D 477/14 A, 7A 61K 31/40 B, 7C 07D 519/00 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020320