EP1068295A4 - CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF - Google Patents

CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF

Info

Publication number
EP1068295A4
EP1068295A4 EP99914359A EP99914359A EP1068295A4 EP 1068295 A4 EP1068295 A4 EP 1068295A4 EP 99914359 A EP99914359 A EP 99914359A EP 99914359 A EP99914359 A EP 99914359A EP 1068295 A4 EP1068295 A4 EP 1068295A4
Authority
EP
European Patent Office
Prior art keywords
proliferation
cell differentiation
maintenance factor
maintenance
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99914359A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1068295A1 (en
Inventor
Michael David Bettess
Peter David Rathjen
Joy Rathjen
Julie-Anne Lake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viacyte Georgia Inc
Original Assignee
Bresagen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP2912A external-priority patent/AUPP291298A0/en
Priority claimed from AUPP6097A external-priority patent/AUPP609798A0/en
Application filed by Bresagen Ltd filed Critical Bresagen Ltd
Publication of EP1068295A1 publication Critical patent/EP1068295A1/en
Publication of EP1068295A4 publication Critical patent/EP1068295A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8775—Murine embryos
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones
    • C12N2501/83—Tachykinins, e.g. substance P
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP99914359A 1998-04-09 1999-04-09 CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF Withdrawn EP1068295A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPP2912A AUPP291298A0 (en) 1998-04-09 1998-04-09 Biologically active factor, uses thereof and cells derived from use thereof
AUPP291298 1998-04-09
AUPP6097A AUPP609798A0 (en) 1998-09-23 1998-09-23 Biologically active factor, uses thereof and cells derived from use thereof
AUPP609798 1998-09-23
PCT/AU1999/000265 WO1999053021A1 (en) 1998-04-09 1999-04-09 Cell differentiation/proliferation and maintenance factor and uses thereof

Publications (2)

Publication Number Publication Date
EP1068295A1 EP1068295A1 (en) 2001-01-17
EP1068295A4 true EP1068295A4 (en) 2002-08-21

Family

ID=25645753

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99914359A Withdrawn EP1068295A4 (en) 1998-04-09 1999-04-09 CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF

Country Status (6)

Country Link
EP (1) EP1068295A4 (ja)
JP (1) JP2002517982A (ja)
CA (1) CA2324591A1 (ja)
IL (1) IL138502A0 (ja)
NZ (1) NZ507103A (ja)
WO (1) WO1999053021A1 (ja)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
AU2399601A (en) 1999-12-21 2001-07-03 Takeda Chemical Industries Ltd. Novel tachykinin-like polypeptides and use thereof
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
WO2001051610A1 (en) * 2000-01-14 2001-07-19 Bresagen Limited Ectoderm cell production
US20030134413A1 (en) * 2000-01-14 2003-07-17 Rathjen Peter David Cell production
CN1311228A (zh) * 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽——人精子特异蛋白em1,em6－48和编码这种多肽的多核苷酸
AU2000266138A1 (en) 2000-05-11 2001-11-20 The Dow Chemical Company Method of making elastic articles having improved heat-resistance
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
KR100903755B1 (ko) 2000-05-17 2009-06-18 제론 코포레이션 신경 선조세포 집단
EP1491093B1 (en) 2001-02-14 2013-07-31 ABT Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
CA2453438C (en) * 2001-07-12 2016-04-05 Geron Corporation Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
EP1421182A4 (en) * 2001-07-24 2005-03-23 Es Cell Int Pte Ltd PROCESS FOR INDUCING DIFFERENTIATION OF STEM CELLS
US7432104B2 (en) 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
AU2003276924A1 (en) 2002-09-25 2004-04-19 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
WO2005121319A1 (en) * 2004-06-14 2005-12-22 Novathera Ltd Methods for production of mesodermal lineage cells
WO2006020919A2 (en) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
ES2800973T3 (es) * 2004-09-28 2021-01-07 Wisconsin Alumni Res Found Cultivo de células madre embrionarias de primates
CN101228264B (zh) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 使灵长类多能干细胞分化成心肌细胞系细胞
CN105802904B (zh) 2006-02-23 2021-04-20 维亚赛特公司 用于培养可分化细胞的组合物和方法
CA2670497A1 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US9329169B2 (en) * 2007-10-29 2016-05-03 University Of Georgia Research Foundation, Inc Vivo isotopic labeling method for quantitative glycomics
WO2009072990A1 (en) 2007-12-06 2009-06-11 Agency For Science, Technology And Research Method for extracellular matrix mediated differentiation and proliferation of stem cells
JPWO2009148170A1 (ja) 2008-06-06 2011-11-04 独立行政法人理化学研究所 幹細胞の培養方法
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
AU2008363829B2 (en) 2008-11-04 2014-11-20 Viacyte, Inc. Stem cell aggregate suspension compositions and methods for differentiation thereof
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
CN102282254B (zh) 2008-11-14 2015-12-16 维赛特公司 源于人多能干细胞的胰腺细胞的包封
JP5115530B2 (ja) * 2009-09-18 2013-01-09 ユーハ味覚糖株式会社 神経新生促進剤を含有する飴、グミまたは飲料
ES2619564T3 (es) 2009-11-05 2017-06-26 Riken Un método de inducción de diferenciación de células madre cultivadas
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
JP6234485B2 (ja) 2013-03-07 2017-11-22 ヴィアサイト インコーポレイテッド ３次元大収容力細胞封入デバイスアセンブリー
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
EP3290510A1 (en) * 2016-08-31 2018-03-07 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Model kit for suspension cell lines
EP3537986A4 (en) 2016-11-10 2020-06-03 ViaCyte, Inc. PANCREATIC ENDODERM CELLS PDX1 IN CELL DELIVERY DEVICES AND RELATED METHODS
WO2018128586A1 (en) 2017-01-05 2018-07-12 Agency For Science, Technology And Research Methods of generating hepatic macrophages and uses thereof
WO2018185260A1 (en) * 2017-04-06 2018-10-11 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Novel human hepatocyte-derived matrix for stem-cell differentiation and tissue repair
US20190167724A1 (en) * 2017-12-04 2019-06-06 Caire Medical-Biotechnology International Co. Neuroprotective composition, preparation process thereof and medical uses thereof
CN114807005B (zh) * 2022-04-09 2023-11-21 翌圣生物科技(上海)股份有限公司 使用动物尸体制备基质胶的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOBAYASHI M ET AL: "Rat hepatoma Reuber H-35 cells produce factors that promote the hatching of mouse embryos cultured in vitro.", BIOLOGY OF REPRODUCTION, vol. 56, no. 4, 1997, pages 1041 - 1049, XP008005166, ISSN: 0006-3363 *

Also Published As

Publication number Publication date
WO1999053021A9 (en) 2000-05-04
NZ507103A (en) 2002-10-25
IL138502A0 (en) 2001-10-31
CA2324591A1 (en) 1999-10-21
JP2002517982A (ja) 2002-06-25
EP1068295A1 (en) 2001-01-17
WO1999053021A1 (en) 1999-10-21

Similar Documents

Publication Publication Date Title
EP1068295A4 (en) CELL DIFFERENTIATION / PROLIFERATION AND CONSERVATION FACTOR AND METHODS OF USE THEREOF
IL143529A0 (en) An electrolysis cell and methods utilizing the same
HUP0102535A3 (en) Cd19xcd3 specific polypeptides and uses thereof
GB2339344B (en) Power distribution block
GB2293453B (en) Load cell unit
AU2731497A (en) Electrolytic system and cell
HU9600507D0 (en) Thin load cell with uniform structure
GB2332507B (en) Pivotal and removable cooling system
HUP0003012A3 (en) Composition and method for regulating cell proliferation and cell death
EP0929804A4 (en) ANALYSIS CELL
EP1015474A4 (en) DON-1 GENE, POLYPEPTIDES AND USES THEREOF
IL130335A0 (en) Serum-derived factor inducing cell differentiation and medical uses thereof
GB9821193D0 (en) Mammalian artificial chromosomes and uses thereof
EP0717271A3 (de) Wägezellenanordnung
AU5875799A (en) Mip-1alpha isoform ld78beta and uses thereof
EP1197554A4 (en) PROLIFERATION DIFFERENTIATION FACTOR
EP1009047A4 (en) BATTERY PLATE AND BATTERY
GB9605453D0 (en) Cultured cells
EP0889953A4 (en) MATRIX OF HUMAN EPITHELIAL CELLS AND USE THEREOF
HK1111295A1 (en) Cell load control method and system
GB9705744D0 (en) Methods for selecting cells and their uses
EP1099755A4 (en) NEW AND TRANSFORMING GENE BEARING THIS GENE
EP0706034A3 (en) Mounting of load cell
AU6160598A (en) Differentiation enhancing factors and uses therefor
GB2378458B (en) Space dividing system with centralized power and communication distribution

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000914

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LAKE, JULIE-ANNE

Inventor name: RATHJEN, JOY

Inventor name: RATHJEN, PETER, DAVID

Inventor name: BETTESS, MICHAEL, DAVID

A4 Supplementary search report drawn up and despatched

Effective date: 20020710

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 12N 1/38 A, 7C 12N 5/06 B, 7C 12N 5/16 B, 7C 12N 5/22 B, 7C 07K 14/78 B, 7A 01K 67/027 B

17Q First examination report despatched

Effective date: 20041122

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BRESAGEN INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061101

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1034741

Country of ref document: HK