EP1067954A4 - Utilisation d'anticorps anti-gp39 pour traiter et/ou faire regresser un lupus et une maladie renale associee - Google Patents
Utilisation d'anticorps anti-gp39 pour traiter et/ou faire regresser un lupus et une maladie renale associeeInfo
- Publication number
- EP1067954A4 EP1067954A4 EP99915237A EP99915237A EP1067954A4 EP 1067954 A4 EP1067954 A4 EP 1067954A4 EP 99915237 A EP99915237 A EP 99915237A EP 99915237 A EP99915237 A EP 99915237A EP 1067954 A4 EP1067954 A4 EP 1067954A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- lupus
- reversal
- antibodies
- treatment
- kidney disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5448898A | 1998-04-03 | 1998-04-03 | |
US54488 | 1998-04-03 | ||
PCT/US1999/007321 WO1999051258A1 (fr) | 1998-04-03 | 1999-04-02 | Utilisation d'anticorps anti-gp39 pour traiter et/ou faire regresser un lupus et une maladie renale associee |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1067954A1 EP1067954A1 (fr) | 2001-01-17 |
EP1067954A4 true EP1067954A4 (fr) | 2004-08-18 |
Family
ID=21991433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99915237A Withdrawn EP1067954A4 (fr) | 1998-04-03 | 1999-04-02 | Utilisation d'anticorps anti-gp39 pour traiter et/ou faire regresser un lupus et une maladie renale associee |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1067954A4 (fr) |
JP (1) | JP2002510643A (fr) |
KR (1) | KR20010072564A (fr) |
CN (2) | CN100352497C (fr) |
AU (1) | AU743824B2 (fr) |
HU (1) | HUP0101689A3 (fr) |
NO (1) | NO20004966L (fr) |
TW (1) | TWI224969B (fr) |
WO (1) | WO1999051258A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
CN107921128B (zh) | 2015-08-05 | 2022-04-26 | 詹森生物科技公司 | 抗cd154抗体及其使用方法 |
KR20200010294A (ko) | 2017-05-24 | 2020-01-30 | 에이엘에스 테라피 디벨럽먼트 인스티튜트 | 치료용 항-cd40 리간드 항체 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0555880A2 (fr) * | 1992-02-14 | 1993-08-18 | Bristol-Myers Squibb Company | Récepteur CD40CR et ses ligands |
WO1997017446A2 (fr) * | 1995-11-07 | 1997-05-15 | Idec Pharmaceutical Corporation | ANTICORPS HUMANISES DIRIGES CONTRE LA gp39 D'ORIGINE HUMAINE, COMPOSITIONS CONTENANT CES ANTICORPS ET LEUR UTILISATION THERAPEUTIQUE |
WO1998030240A1 (fr) * | 1997-01-10 | 1998-07-16 | Biogen, Inc. | Traitement de la nephropathie lupique a l'aide des composes anti-cd40l |
WO1998039026A2 (fr) * | 1997-03-07 | 1998-09-11 | Biogen, Inc. | Procedes d'administration therapeutiques de composes anti-cd40l |
US5833987A (en) * | 1995-06-07 | 1998-11-10 | Trustees Of Dartmouth College | Treatment of T cell mediated autoimmune disorders |
WO1999000143A1 (fr) * | 1997-06-27 | 1999-01-07 | Biogen, Inc. | Therapie de blocage par cd154 pour maladies auto-immunes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
-
1999
- 1999-04-02 WO PCT/US1999/007321 patent/WO1999051258A1/fr not_active Application Discontinuation
- 1999-04-02 CN CNB200410078988XA patent/CN100352497C/zh not_active Expired - Fee Related
- 1999-04-02 KR KR1020007011045A patent/KR20010072564A/ko active Search and Examination
- 1999-04-02 JP JP2000542029A patent/JP2002510643A/ja not_active Withdrawn
- 1999-04-02 EP EP99915237A patent/EP1067954A4/fr not_active Withdrawn
- 1999-04-02 AU AU33796/99A patent/AU743824B2/en not_active Withdrawn - After Issue
- 1999-04-02 CN CNB998067563A patent/CN1173735C/zh not_active Expired - Fee Related
- 1999-04-02 HU HU0101689A patent/HUP0101689A3/hu unknown
- 1999-06-28 TW TW088105322A patent/TWI224969B/zh not_active IP Right Cessation
-
2000
- 2000-10-02 NO NO20004966A patent/NO20004966L/no not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0555880A2 (fr) * | 1992-02-14 | 1993-08-18 | Bristol-Myers Squibb Company | Récepteur CD40CR et ses ligands |
US5833987A (en) * | 1995-06-07 | 1998-11-10 | Trustees Of Dartmouth College | Treatment of T cell mediated autoimmune disorders |
WO1997017446A2 (fr) * | 1995-11-07 | 1997-05-15 | Idec Pharmaceutical Corporation | ANTICORPS HUMANISES DIRIGES CONTRE LA gp39 D'ORIGINE HUMAINE, COMPOSITIONS CONTENANT CES ANTICORPS ET LEUR UTILISATION THERAPEUTIQUE |
WO1998030240A1 (fr) * | 1997-01-10 | 1998-07-16 | Biogen, Inc. | Traitement de la nephropathie lupique a l'aide des composes anti-cd40l |
WO1998039026A2 (fr) * | 1997-03-07 | 1998-09-11 | Biogen, Inc. | Procedes d'administration therapeutiques de composes anti-cd40l |
WO1999000143A1 (fr) * | 1997-06-27 | 1999-01-07 | Biogen, Inc. | Therapie de blocage par cd154 pour maladies auto-immunes |
Non-Patent Citations (7)
Title |
---|
DESAI-MEHTA A ET AL: "Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 9, no. 97, 1 May 1996 (1996-05-01), pages 2063 - 2073, XP002080040, ISSN: 0021-9738 * |
EARLY G ET AL: "Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand White mice", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 157, no. 7, 1 October 1996 (1996-10-01), pages 3159 - 3164, XP002080042, ISSN: 0022-1767 * |
GRAY DAVID ET AL: "Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, no. 1, 1994, pages 141 - 155, XP002283910, ISSN: 0022-1007 * |
KOOTEN C V ET AL: "Functions of CD40 on B cells, dendritic cells and other cells", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 9, no. 3, June 1997 (1997-06-01), pages 330 - 337, XP004313522, ISSN: 0952-7915 * |
MOHAN C ET AL: "INTERACTION BETWEEN CD40 AND ITS LIGAND GP39 IN THE DEVELOPMENT OF MURINE LUPUS NEPHRITIS", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 154, no. 3, 1995, pages 1470 - 1480, XP002062342, ISSN: 0022-1767 * |
NOELLE R J ET AL: "A 39-KDA PROTEIN ON ACTIVATED HELPER T CELLS BINDS CD40 AND TRANSDUCES THE SIGNAL FOR COGNATE ACTIVATION OF B CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, July 1992 (1992-07-01), pages 6550 - 6554, XP002941549, ISSN: 0027-8424 * |
See also references of WO9951258A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2002510643A (ja) | 2002-04-09 |
CN1303301A (zh) | 2001-07-11 |
CN1757413A (zh) | 2006-04-12 |
TWI224969B (en) | 2004-12-11 |
WO1999051258A1 (fr) | 1999-10-14 |
NO20004966D0 (no) | 2000-10-02 |
AU3379699A (en) | 1999-10-25 |
CN1173735C (zh) | 2004-11-03 |
HUP0101689A3 (en) | 2004-08-30 |
HUP0101689A2 (hu) | 2001-08-28 |
CN100352497C (zh) | 2007-12-05 |
KR20010072564A (ko) | 2001-07-31 |
NO20004966L (no) | 2000-12-04 |
AU743824B2 (en) | 2002-02-07 |
EP1067954A1 (fr) | 2001-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001102 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07K 16/18 B Ipc: 7C 07K 14/525 B Ipc: 7C 07K 14/52 B Ipc: 7A 61K 39/395 B Ipc: 7C 07K 16/28 B Ipc: 7A 61K 38/17 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040630 |
|
17Q | First examination report despatched |
Effective date: 20050127 |
|
17Q | First examination report despatched |
Effective date: 20050127 |
|
17Q | First examination report despatched |
Effective date: 20050127 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090415 |