EP1057750B1 - Child-resistant package for tablets - Google Patents

Child-resistant package for tablets Download PDF

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Publication number
EP1057750B1
EP1057750B1 EP99810480A EP99810480A EP1057750B1 EP 1057750 B1 EP1057750 B1 EP 1057750B1 EP 99810480 A EP99810480 A EP 99810480A EP 99810480 A EP99810480 A EP 99810480A EP 1057750 B1 EP1057750 B1 EP 1057750B1
Authority
EP
European Patent Office
Prior art keywords
cup
blister pack
pack
package according
strip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99810480A
Other languages
German (de)
French (fr)
Other versions
EP1057750A1 (en
Inventor
Peter Kancsar
Laurenz Zellweger
Michael Krohn
Claudia Schmauder
Susanne Marti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3A Composites International AG
Original Assignee
Alcan Technology and Management Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99810480A priority Critical patent/EP1057750B1/en
Application filed by Alcan Technology and Management Ltd filed Critical Alcan Technology and Management Ltd
Priority to DE59904731T priority patent/DE59904731D1/en
Priority to AU49216/00A priority patent/AU4921600A/en
Priority to MXPA01011937A priority patent/MXPA01011937A/en
Priority to US09/926,580 priority patent/US6997320B1/en
Priority to PCT/EP2000/004330 priority patent/WO2000075044A1/en
Priority to CA002375279A priority patent/CA2375279A1/en
Priority to JP2001501533A priority patent/JP3479525B2/en
Publication of EP1057750A1 publication Critical patent/EP1057750A1/en
Application granted granted Critical
Publication of EP1057750B1 publication Critical patent/EP1057750B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
    • B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
    • B65D83/0463—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments formed in a band or a blisterweb, inserted in a dispensing device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2215/00—Child-proof means
    • B65D2215/04—Child-proof means requiring the combination of different actions in succession
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3218—Details with special means for gaining access to the contents
    • B65D2575/3227—Cuts or weakening lines

Definitions

  • the invention relates to a childproof packaging according to the preamble of claim 1.
  • Blister packs in particular have been used to package tablets and capsules enforced.
  • the so-called blister packs are widespread, where the tablet from a bowl in the bottom part of the packaging is pressed through a cover film.
  • a cover film is removed by peeling it off.
  • Yet other blister packs have a notch as a tear-open aid.
  • blister packs for tablets and capsules mentioned consist of the difficult to open by measures that require increased power, such as. stronger push-through foils, increased adhesive strength of peel-off foils or high tear resistance with tear notches.
  • Packaging that can only be opened with increased effort, are childproof, but can also be a problem for seniors.
  • a childproof packaging according to the preamble of claim 1 is disclosed in US-A-5,150,793.
  • the invention is therefore based on the object of child-resistant packaging of the type mentioned at the outset by seniors without difficulty can be opened. Basically it's about packaging to be designed so that it can be combined to open them is required or that simultaneous or complex movements are carried out Need to become.
  • a packaging with the features of claim 1 leads to the achievement of the object according to the invention.
  • Opening the packaging according to the invention requires a combination ability in the sense that it has to be recognized that to push through the tablet the bowl must be guided over the removal opening.
  • the opening slit is preferably at least partially covered Tear strips connected to the cover part via a perforation line.
  • packaging according to the invention protrude from the edge of the opening slot the free displacement of the bowl inhibiting projections inwards.
  • the blister pack is advantageously with one of the displacement movements counteracting spring element connected. This spring element is preferred Part of the blister pack.
  • the outer packaging is used from a single blank.
  • At least two packs can be combined into multi-portion packs be, the individual packages to a strip pack lined up and preferably from the strip pack along one Line of weakness, preferably a line of perforations, can be separated.
  • foil-like materials are metal foils such as for example aluminum foils.
  • film-shaped materials are paper, semi-cardboard and cardboard.
  • Plastic-containing ones are also particularly important Foils, e.g. based on polyolefins, such as polyethylene or Polypropylenes, polyamides, polyvinyl chloride, polyesters, such as polyalkylene terephthalates and especially polyethylene terephthalate.
  • the plastic ones Films can be monofilms made of plastics, laminates made of two or more Plastic films, laminates of metal and plastic films, laminates of Papers and plastic films or laminates made of paper and metal and Be plastic films.
  • the individual layers of the sheet-like materials can by means of adhesives, laminating adhesives, adhesion promoters and / or through Extrusion coating, coextrusion or lamination etc. fixed to each other become.
  • Suitable plastic films are, for example, non-oriented or axially or biaxially oriented monofilms or laminates of two or several non-oriented or axially or biaxially oriented films
  • Plastics based on polyolefins such as polyethylenes or polypropylenes, Polyamides, polyvinyl chloride, polyesters such as polyalkylene terephthalates and especially polyethylene terephthalate, cyclo-olefin copolymers (COC) and polychlorotrifluorethylene (PCTFE, brand name ACLAR).
  • Transparent parts are particularly suitable for the bottom parts of blister packs Plastics with good forming properties such as polyethylene, polypropylene, Cyclo-olefin copolymers, polyvinyl chloride, polyethylene terephthalate, polyamide as well as laminates made from the materials mentioned, e.g. made of PVC and polychlorotrifluoroethylene (PCTFE) or PVC and PVDC (polyvinyl dichloride).
  • Laminates for example, are used for non-transparent blister packs from an aluminum foil planked on both sides with a plastic foil with the for example construction polyamide / aluminum / PVC or pigmented Plastic films used.
  • the cover film is usually an aluminum film an example thickness of 20 microns, which is painted and / or with a Heat seal lacquer can be coated.
  • All of the above-mentioned sheet-like materials such as paper, semi-cardboard, cardboard and plastic films in the form of monofilms, laminates, etc. can have at least one further continuous layer of sputtered or vacuum-deposited ceramic materials with a thickness of about 5 to 500 nm (nanometers) , for example Al 2 O 3 or SiO x , where x is a number between 1.5 and 2. These layers of ceramic materials have barrier properties and prevent the diffusion of gases and water vapor through the packaging.
  • An outer packaging 10 shown in FIGS. 1 to 4, for example Cardboard for a blister pack 12 of substantially strip shape is equipped with a bottom part 14 and a cover part 16.
  • the blister pack 12 - in the example shown a one-portion pack for one Tablet 18 - has a bottom part 20 made of, for example, polyvinyl chloride (PVC) with a cup 22 molded out of it for receiving the tablet 18 and a cover film sealed or glued to the base part 20 24 made of aluminum, for example.
  • the bottom part 20 of the blister pack 12 forms in the area of the cup 22 a shoulder 26 running around the latter with a diameter s and is integrally connected to a spring strip 28.
  • PVC polyvinyl chloride
  • the cover part 16 of the outer packaging 10 is in one piece with the bottom part 14 connected and forms a loop with this, cover part 16 and Bottom part 14 are approximately parallel to form an intermediate space 17.
  • the cover part 16 has an opening slot 30, the width t is smaller than the diameter s of the shoulder 26 of the cup 22, but wider than the diameter u of the cup 22 in the region of the base part 20.
  • the opening slot 30 is 10 except for the area when the outer packaging is closed of the cup 22 with a tear strip integrally arranged in the cover part 16 32 connected to tear tab 34 and over a line of weakness or perforations 36 arranged in a line form detachable from the cover part 16.
  • the blister pack 12 is arranged in the outer packaging 10 so that the Shoulder 26 of the bottom part 20 in the edge region of the opening slot 30 in the Gap 17 protrudes laterally between base part 14 and cover part 16, the cup 22 protrudes outwards from the plane of the cover part 16.
  • the bottom part 14 of the outer packaging 10 is a top view inside the opening slot 30 and removal opening covered by tear strip 32 38 provided.
  • the tear strip 32 on the tear tab 34 gripped and by means of an opening movement carried out in the direction of arrow A. separated from the cover part 16, whereby the opening slot 30 is formed.
  • the tear-open tab arranged in the area of the cup 22 in the example shown 34 can of course also on the more distant from the bowl 22 Side of the tear strip may be provided, in which case the opening movement against the bowl 22 out.
  • the from the cover part 16th protruding cup 22 can now - for example by moving with the thumb - moved along the opening slot in the direction of arrow B. until the cup 22 over the removal opening 38 in the bottom part 14 of the Outer packaging 10 is located.
  • the removal opening 38 is in this position - only separated by the cover film 24 - the tablet 18 in the bowl 22 freely opposite.
  • the tablet 18 can be opened by finger pressure pushed the bowl 22 in the direction of arrow C through the cover film 24 and be ejected through the removal opening 38.
  • the removal opening 38 can also be covered by a push-through opening closure his. This additional closure is, for example, from a line of weakness, e.g. a perforation line, limited and is simultaneously with the Pushing through the cover film 24 separated.
  • substantially strip-shaped blank for the Outer packaging 10 shows the weakened and therefore easily separable connection between the tear strip 32 with tear tab 34 as a perforation line 36 in the cover part 16.
  • the blister packaging is already on the base part 12 with the spring strip 28.
  • the outer packaging is closed by folding the cover part 16 in the direction of the arrow D by a fold line d, to the cover part 16 rests on the base part 14 or on the blister pack 12. With this step, at least partial gluing of Edge parts 44 of the cover part 16 with edge parts 46 of the bottom part 14 for Formation of the intermediate space serving as a guide for the shoulder 26 of the cup 22 17th
  • the spring strip 28 is so here provided with cuts 48 arranged alternately from both sides, that the spring strip 28 forms a restoring force
  • Spring straps 50 stretch in the direction of the strip.
  • the spring strips 28 with incisions 48 can be made directly from the material of the base part 20 and / or Cover film 24 of the blister pack 12 to be made.
  • a spring strip 28 can of course also another spring material such as a rubber band is provided his.
  • An outer packaging 60 shown in FIG. 8 for a blister pack 52 - in An example of a two-portion pack for two tablets 18a, b - is essentially from outer packaging 10 standing in mirror image to one another according to Fig. 1 constructed. The same parts are therefore also with the same reference numerals provided, the double configuration each by an addition a or b is expressed.
  • the bottom parts 14a, b are in one piece with one another connected and each form a loop with the cover parts 16a, b.
  • the two partial packaging 10a, b are on both sides a mirror plane S.
  • the two partial packaging 10a, b can in the same Opened in this way and the tablets 18a, b removed in the same way are like the outer packaging 10 shown in FIGS. 1 to 5.
  • Fig. 9 shows a strip-shaped package 70 with six strings lined up Individual packs according to FIG. 1. These are arranged in a line Perforations 72 separable from each other. The individual outer packaging 10 can also be opened without removing them from the packaging strip 70 must be separated. Such a strip arrangement is suitable also for outer packaging 60 with a two-portion blister pack 62 according to FIG. 8.
  • Another advantage of the packaging according to the invention is seen in that the printable area for attaching information to the consumer can be increased significantly.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

Die Erfindung betrifft eine kindersichere Verpackung nach dem Oberbegriff von Anspruch 1.The invention relates to a childproof packaging according to the preamble of claim 1.

Die Gefährlichkeit einer unkontrollierten Medikamenteneinnahme ist unbestritten, wobei vor allem Kleinkinder insbesondere beim Herumliegenlassen von Medikamenten dieser potentiellen Gefahr verstärkt ausgesetzt sind.The danger of an uncontrolled drug intake is undisputed especially small children, especially when lying around Medicines are increasingly exposed to this potential danger.

Zur Verpackung von Tabletten und Kapseln haben sich vor allem Blisterverpackungen durchgesetzt. Weit verbreitet sind die sogenannten Durchdrückpackungen, bei der die Tablette aus einem Napf im Bodenteil der Verpackung durch eine Deckelfolie hindurchgedrückt wird. Bei anderen bekannten Blisterverpackungen wird eine Deckelfolie durch Abziehen (Peelen) entfernt. Noch andere Blisterverpackungen weisen eine Kerbe als Aufreisshilfe auf.Blister packs in particular have been used to package tablets and capsules enforced. The so-called blister packs are widespread, where the tablet from a bowl in the bottom part of the packaging is pressed through a cover film. In other known blister packs a cover film is removed by peeling it off. Yet other blister packs have a notch as a tear-open aid.

Heute bereits genutzte Möglichkeiten zur Erhöhung der Kindersicherheit der genannten Blisterverpackungen für Tabletten und Kapseln bestehen darin, das öffnen durch Massnahmen zu erschweren, die einen erhöhten Kraftbedarf erfordern, wie z.B. stärkere Durchdrückfolien, erhöhte Klebkraft von Abziehfolien oder hoher Reisswiderstand bei Aufreisskerben.Ways already used today to increase child safety The blister packs for tablets and capsules mentioned consist of the difficult to open by measures that require increased power, such as. stronger push-through foils, increased adhesive strength of peel-off foils or high tear resistance with tear notches.

Verpackungen, die nur mit erhöhtem Kraftaufwand geöffnet werden können, sind zwar kindersicher, können jedoch auch für Senioren ein Problem darstellen.Packaging that can only be opened with increased effort, are childproof, but can also be a problem for seniors.

Ein kindersichere Verpackung nach dem Oberbegriff von Anspruch 1 ist in der US-A-5 150 793 offenbart.A childproof packaging according to the preamble of claim 1 is disclosed in US-A-5,150,793.

Der Erfindung liegt deshalb die Aufgabe zugrunde, eine kindersichere Verpakkung der eingangs genannten Art zu schaffen, die von Senioren ohne Schwierigkeiten geöffnet werden kann. Im wesentlichen geht es darum, eine Verpakkung so auszugestalten, dass zu deren Öffnung eine Kombinationsfähigkeit erforderlich ist oder dass simultane oder komplexe Bewegungsabläufe durchgeführt werden müssen.The invention is therefore based on the object of child-resistant packaging of the type mentioned at the outset by seniors without difficulty can be opened. Basically it's about packaging to be designed so that it can be combined to open them is required or that simultaneous or complex movements are carried out Need to become.

Zur erfindungsgemässen Lösung der Aufgabe führt eine Verpackung mit den Merkmalen von Anspruch 1.A packaging with the features of claim 1 leads to the achievement of the object according to the invention.

Das Öffnen der erfindungsgemässen Verpackung erfordert eine Kombinationsfähigkeit in dem Sinne, dass erkannt werden muss, dass zum Durchdrücken der Tablette der Napf über die Entnahmeöffnung geführt werden muss.Opening the packaging according to the invention requires a combination ability in the sense that it has to be recognized that to push through the tablet the bowl must be guided over the removal opening.

Bevorzugt ist der den Öffnungsschlitz zumindest teilweise abdeckende Aufreissstreifen über eine Perforationslinie mit dem Abdeckteil verbunden.The opening slit is preferably at least partially covered Tear strips connected to the cover part via a perforation line.

Bei einer zweckmässigen Ausgestaltung der erfindungsgemässen Verpackung ragen vom Rand des Öffnungsschlitzes die freie Verschiebbarkeit des Napfes hemmende Vorsprünge nach innen ab.In an expedient embodiment of the packaging according to the invention protrude from the edge of the opening slot the free displacement of the bowl inhibiting projections inwards.

Vorteilhafterweise ist die Blisterverpackung mit einem der Verschiebebewegung entgegenwirkenden Federelement verbunden. Bevorzugt ist dieses Federelement Teil der Blisterverpackung.The blister pack is advantageously with one of the displacement movements counteracting spring element connected. This spring element is preferred Part of the blister pack.

Bei einer besonders kostengünstigen Herstellungsvariante besteht die Umverpackung aus einem einzigen Zuschnitt. In a particularly inexpensive manufacturing variant, the outer packaging is used from a single blank.

Aus zwei spiegelsymmetrisch angeordneten Teilverpackungen kann auf einfache Weise eine Doppelpackung gefertigt werden.From two mirror-symmetrically arranged partial packaging can easily Way a double pack can be made.

Wenigstens zwei Verpackungen können zu Mehrportionenpackungen zusammengefasst sein, wobei die einzelnen Verpackungen zu einer Streifenpackung aneinandergereiht und vorzugsweise von der Streifenpackung entlang einer Schwächungslinie, vorzugsweise einer Perforationslinie, abtrennbar sind.At least two packs can be combined into multi-portion packs be, the individual packages to a strip pack lined up and preferably from the strip pack along one Line of weakness, preferably a line of perforations, can be separated.

Zur Herstellung der erfindungsgemässen Verpackung können die heute zur Herstellung von Verpackungen bekannten starren, halbstarren und flexiblen Werkstoffe in Form von Blättern, Folien, Laminaten oder anderen Schichtstoffen einer Dicke von wenigen µm bis wenige mm, beispielsweise 8 µm bis 3 mm, verwendet werden. Beispiele für folienförmige Materialien sind Metallfolien wie beispielsweise Aluminiumfolien. Weitere Beispiele für folienförmige Materialien sind Papier, Halbkarton und Karton. Bedeutsam sind insbesondere auch kunststoffhaltige Folien, z.B. auf der Basis von Polyolefinen, wie Polyethylenen oder Polypropylenen, Polyamiden, Polyvinylchlorid, Polyestem, wie Polyalkylenterephthalaten und insbesondere Polyethylenterephthalat. Die kunststoffhaltigen Folien können Monofolien aus Kunststoffen, Laminate aus zwei oder mehreren Kunststofffolien, Laminate aus Metall- und Kunststofffolien, Laminate aus Papieren und Kunststofffolien oder Laminate aus Papieren und Metall- und Kunststofffolien sein. Die einzelnen Schichten der folienförmigen Materialien können mittels Klebstoffen, Kaschierklebern, Haftvermittlern und/oder durch Extrusionsbeschichten, Coextrusion oder Kaschieren usw. aneinander festgelegt werden. Geeignete Kunststofffolien sind beispielsweise nicht orientierte oder axial oder biaxial orientierte Monofolien oder Laminate aus zwei oder mehreren nicht orientierten oder axial oder biaxial orientierten Folien aus Kunststoffen auf der Basis von Polyolefinen, wie Polyethylenen oder Polypropylenen, Polyamiden, Polyvinylchlorid, Polyestern, wie Polyalkylenterephthalaten und insbesondere Polyethylenterephthalat, Cyclo-Olfin-Copolymere (COC) und Polychlortrifluorethylene (PCTFE, Markenname ACLAR).For the production of the packaging according to the invention can be used today Production of packaging known rigid, semi-rigid and flexible Materials in the form of sheets, foils, laminates or other laminates a thickness of a few µm to a few mm, for example 8 µm to 3 mm, be used. Examples of foil-like materials are metal foils such as for example aluminum foils. More examples of film-shaped materials are paper, semi-cardboard and cardboard. Plastic-containing ones are also particularly important Foils, e.g. based on polyolefins, such as polyethylene or Polypropylenes, polyamides, polyvinyl chloride, polyesters, such as polyalkylene terephthalates and especially polyethylene terephthalate. The plastic ones Films can be monofilms made of plastics, laminates made of two or more Plastic films, laminates of metal and plastic films, laminates of Papers and plastic films or laminates made of paper and metal and Be plastic films. The individual layers of the sheet-like materials can by means of adhesives, laminating adhesives, adhesion promoters and / or through Extrusion coating, coextrusion or lamination etc. fixed to each other become. Suitable plastic films are, for example, non-oriented or axially or biaxially oriented monofilms or laminates of two or several non-oriented or axially or biaxially oriented films Plastics based on polyolefins, such as polyethylenes or polypropylenes, Polyamides, polyvinyl chloride, polyesters such as polyalkylene terephthalates and especially polyethylene terephthalate, cyclo-olefin copolymers (COC) and polychlorotrifluorethylene (PCTFE, brand name ACLAR).

Für die Bodenteile von Blisterverpackungen eignen sich vor allem transparente Kunststoffe mit guten Umformeigenschaften wie Polyethylen, Polypropylen, Cyclo-Olefin-Copolymere, Polyvinylchlorid, Polyethylenterephthalat, Polyamid sowie aus den genannten Werkstoffen hergestellte Laminate, z.B. aus PVC und Polychlortrifluorethylen (PCTFE) oder PVC und PVDC (Polyvinyldichlorid). Für nicht transparente Blisterverpackungen werden beispielsweise Laminate aus einer beidseitig mit einer Kunststofffolie beplankten Aluminiumfolie mit dem beispielsweisen Aufbau Polyamid/Aluminium/PVC oder auch pigmentierte Kunststofffolien eingesetzt. Die Deckelfolie ist üblicherweise eine Aluminiumfolie einer beispielsweisen Dicke von 20µm, die lackiert und/oder mit einem Heisssiegellack beschichtet sein kann.Transparent parts are particularly suitable for the bottom parts of blister packs Plastics with good forming properties such as polyethylene, polypropylene, Cyclo-olefin copolymers, polyvinyl chloride, polyethylene terephthalate, polyamide as well as laminates made from the materials mentioned, e.g. made of PVC and polychlorotrifluoroethylene (PCTFE) or PVC and PVDC (polyvinyl dichloride). Laminates, for example, are used for non-transparent blister packs from an aluminum foil planked on both sides with a plastic foil with the for example construction polyamide / aluminum / PVC or pigmented Plastic films used. The cover film is usually an aluminum film an example thickness of 20 microns, which is painted and / or with a Heat seal lacquer can be coated.

Alle vorstehend genannten folienförmigen Materialien wie Papier, Halbkarton, Karton und Kunststofffolien in der Form von Monofolien, Laminaten usw. können zumindest eine weitere kontinuierliche Schicht aus gesputterten oder aus dem Vakuum abgeschiedenen keramischen Materialien in einer Dicke von etwa 5 bis 500 nm (Nanometer) aufweisen, beispielsweise Al2O3 oder SiOx, wobei x eine Zahl zwischen 1.5 und 2 ist. Diese Schichten aus keramischen Materialien haben Barriereeigenschaften und verhindern die Diffusion von Gasen und Wasserdampf durch die Verpackung.All of the above-mentioned sheet-like materials such as paper, semi-cardboard, cardboard and plastic films in the form of monofilms, laminates, etc. can have at least one further continuous layer of sputtered or vacuum-deposited ceramic materials with a thickness of about 5 to 500 nm (nanometers) , for example Al 2 O 3 or SiO x , where x is a number between 1.5 and 2. These layers of ceramic materials have barrier properties and prevent the diffusion of gases and water vapor through the packaging.

Weitere Vorteile, Merkmale und Einzelheiten der Erfindung ergeben sich aus der nachfolgenden Beschreibung bevorzugter Ausführungsbeispiele sowie anhand der Zeichnung; diese zeigt schematisch in

  • Fig. 1 einen Längsschnitt durch eine Blisterverpackung mit Umverpakkung;
  • Fig. 2 eine Draufsicht auf die Umverpackung von Fig. 1 in Blickrichtung y;
  • Fig. 3 eine Draufsicht auf die geöffnete Umverpackung von Fig. 1 in Blickrichtung y;
  • Fig. 4 einen Längsschnitt durch die Blisterverpackung mit geöffneter Umverpackung von Fig. 3 in Entnahmestellung;
  • Fig. 5 eine Draufsicht auf einen Zuschnitt zur Herstellung der Umverpackung von Fig. 1;
  • Fig. 6 eine Draufsicht auf eine Blisterverpackung mit integriertem Federelement;
  • Fig. 7 eine Draufsicht auf die Blisterverpackung von Fig. 6 mit unter Zug stehendem Federelement;
  • Fig. 8 einen Längsschnitt durch eine analog zu Fig. 1 ausgestaltete Blisterverpackung mit Umverpackung als Doppelpackung;
  • Fig. 9 eine Draufsicht auf eine als Mehrportionenpackung ausgestaltete Blisterverpackung mit Umverpackung von Fig. 1.
Further advantages, features and details of the invention result from the following description of preferred exemplary embodiments and from the drawing; this shows schematically in
  • 1 shows a longitudinal section through a blister pack with outer packaging.
  • FIG. 2 shows a plan view of the outer packaging of FIG. 1 in the viewing direction y;
  • 3 shows a plan view of the opened outer packaging from FIG. 1 in the direction of view y;
  • 4 shows a longitudinal section through the blister pack with the outer packaging of FIG. 3 open in the removal position;
  • 5 shows a plan view of a blank for producing the outer packaging of FIG. 1;
  • 6 shows a plan view of a blister pack with an integrated spring element;
  • FIG. 7 is a top view of the blister pack of FIG. 6 with the spring element under tension;
  • FIG. 8 shows a longitudinal section through a blister pack with an outer packaging as a double pack, configured analogously to FIG. 1;
  • 9 is a plan view of a blister pack with outer packaging of FIG. 1, which is designed as a multi-portion pack.

Eine in den Fig. 1 bis 4 dargestellte Umverpackung 10 aus beispielsweise Karton für eine Blisterverpackung 12 von im wesentlichen streifenförmiger Gestalt ist mit einem Bodenteil 14 und einem Abdeckteil 16 ausgestattet. Die Blisterverpackung 12 - im gezeigten Beispiel eine Einportionenpackung für eine Tablette 18 - weist einen Bodenteil 20 aus beispielsweise Polyvinylchlorid (PVC) mit einem aus diesem herausgeformten Napf 22 zur Aufnahme der Tablette 18 und eine mit dem Bodenteil 20 versiegelte bzw. verklebte Deckelfolie 24 aus beispielsweise Aluminium auf. Der Bodenteil 20 der Blisterverpackung 12 bildet im Bereich des Napfes 22 eine um diesen herumlaufende Schulter 26 mit einem Durchmesser s und ist einstückig mit einem Federstreifen 28 verbunden.An outer packaging 10 shown in FIGS. 1 to 4, for example Cardboard for a blister pack 12 of substantially strip shape is equipped with a bottom part 14 and a cover part 16. The blister pack 12 - in the example shown a one-portion pack for one Tablet 18 - has a bottom part 20 made of, for example, polyvinyl chloride (PVC) with a cup 22 molded out of it for receiving the tablet 18 and a cover film sealed or glued to the base part 20 24 made of aluminum, for example. The bottom part 20 of the blister pack 12 forms in the area of the cup 22 a shoulder 26 running around the latter with a diameter s and is integrally connected to a spring strip 28.

Der Abdeckteil 16 der Umverpackung 10 ist mit dem Bodenteil 14 einstückig verbunden und bildet mit diesem eine Schlaufe, wobei sich Abdeckteil 16 und Bodenteil 14 unter Bildung eines Zwischenraumes 17 etwa parallel gegenüberliegen. Der Abdeckteil 16 weist einen Öffnungsschlitz 30 auf, dessen Breite t kleiner ist als der Durchmesser s der Schulter 26 des Napfes 22, jedoch breiter als der Durchmesser u des Napfes 22 im Bereich des Bodenteils 20. Der Öffnungsschlitz 30 ist bei geschlossener Umverpackung 10 bis auf den Bereich des Napfes 22 mit einem integral im Abdeckteil 16 angeordneten Aufreissstreifen 32 mit Aufreisslasche 34 verbunden und über eine Schwächungslinie oder linienförmig angeordnete Perforationen 36 vom Abdeckteil 16 lösbar.The cover part 16 of the outer packaging 10 is in one piece with the bottom part 14 connected and forms a loop with this, cover part 16 and Bottom part 14 are approximately parallel to form an intermediate space 17. The cover part 16 has an opening slot 30, the width t is smaller than the diameter s of the shoulder 26 of the cup 22, but wider than the diameter u of the cup 22 in the region of the base part 20. The opening slot 30 is 10 except for the area when the outer packaging is closed of the cup 22 with a tear strip integrally arranged in the cover part 16 32 connected to tear tab 34 and over a line of weakness or perforations 36 arranged in a line form detachable from the cover part 16.

Die Blisterverpackung 12 ist in der Umverpackung 10 so angeordnet, dass die Schulter 26 des Bodenteils 20 im Randbereich des Öffnungsschlitzes 30 in den Zwischenraum 17 zwischen Bodenteil 14 und Abdeckteil 16 seitlich einragt, wobei der Napf 22 aus der Ebene des Abdeckteils 16 nach aussen hin abragt. Im Bodenteil 14 der Umverpackung 10 ist eine in Draufsicht innerhalb des Öffnungsschlitzes 30 und vom Aufreissstreifen 32 überdeckte Entnahmeöffnung 38 vorgesehen.The blister pack 12 is arranged in the outer packaging 10 so that the Shoulder 26 of the bottom part 20 in the edge region of the opening slot 30 in the Gap 17 protrudes laterally between base part 14 and cover part 16, the cup 22 protrudes outwards from the plane of the cover part 16. In the bottom part 14 of the outer packaging 10 is a top view inside the opening slot 30 and removal opening covered by tear strip 32 38 provided.

Zur Entnahme der Tablette 18 wird der Aufreissstreifen 32 an der Aufreisslasche 34 ergriffen und mittels einer in Pfeilrichtung A durchgeführten Öffnungsbewegung vom Abdeckteil 16 getrennt, wodurch der Öffnungsschlitz 30 entsteht. Die im gezeigten Beispiel im Bereich des Napfes 22 angeordnete Aufreisslasche 34 kann selbstverständlich auch auf der dem Napf 22 entfernteren Seite des Aufreissstreifens vorgesehen sein, wobei in diesem Fall die Öffnungsbewegung gegen den Napf 22 hin erfolgt. Der aus dem Abdeckteil 16 hervorstehende Napf 22 kann nun - beispielsweise durch eine Bewegung mit dem Daumen - entlang des Öffnungsschlitzes in Pfeilrichtung B verschoben werden, bis sich der Napf 22 über der Entnahmeöffnung 38 im Bodenteil 14 der Umverpackung 10 befindet. Die Entnahmeöffnung 38 liegt in dieser Position - einzig getrennt durch die Deckelfolie 24 - der Tablette 18 im Napf 22 frei gegenüber. In dieser Offenstellung kann die Tablette 18 durch Fingerdruck auf den Napf 22 in Pfeilrichtung C durch die Deckelfolie 24 hindurchgestossen und durch die Entnahmeöffnung 38 ausgeworfen werden. Die Entnahmeöffnung 38 kann zusätzlich noch von einem durchdrückbaren Öffnungsverschluss abgedeckt sein. Dieser zusätzliche Verschluss ist beispielsweise von einer Schwächungslinie, z.B. einer Perforationslinie, begrenzt und wird gleichzeitig mit dem Durchdrücken der Deckelfolie 24 herausgetrennt.To remove the tablet 18, the tear strip 32 on the tear tab 34 gripped and by means of an opening movement carried out in the direction of arrow A. separated from the cover part 16, whereby the opening slot 30 is formed. The tear-open tab arranged in the area of the cup 22 in the example shown 34 can of course also on the more distant from the bowl 22 Side of the tear strip may be provided, in which case the opening movement against the bowl 22 out. The from the cover part 16th protruding cup 22 can now - for example by moving with the thumb - moved along the opening slot in the direction of arrow B. until the cup 22 over the removal opening 38 in the bottom part 14 of the Outer packaging 10 is located. The removal opening 38 is in this position - only separated by the cover film 24 - the tablet 18 in the bowl 22 freely opposite. In this open position, the tablet 18 can be opened by finger pressure pushed the bowl 22 in the direction of arrow C through the cover film 24 and be ejected through the removal opening 38. The removal opening 38 can also be covered by a push-through opening closure his. This additional closure is, for example, from a line of weakness, e.g. a perforation line, limited and is simultaneously with the Pushing through the cover film 24 separated.

Die oben beschriebene Verschiebung des Napfes 22 innerhalb des Öffnungsschlitzes 30 erfolgt gegen die Rückstellkraft des Federstreifens 28, der sich gemäss Fig. 4 zu einer elastisch gespannten Schlaufe 40 verformt, so dass der Napf 22 nach dem Loslassen selbsttätig in die Ausgangsstellung zurückgeführt wird. Im Bereich des Napfes 22 ragen beidseits des hier auch bei verschlossener Umverpackung 10 offenen Öffnungsschlitzes 30 vom Abdeckteil 16 Vorsprünge 42 nach innen hin ab. Diese Vorsprünge 42 hemmen nach dem Wegziehen des Aufreissstreifens 32 die freie Bewegung des Napfes 22 in Richtung der Entnahmeöffnung 38, d.h. die Verschiebung des Napfes 22 in die Entnahmestellung erfordert zunächst einen gewissen Kraftaufwand zur Verdrängung der in den Öffnungsschlitz 32 einragenden Vorsprünge 42.The above described displacement of the cup 22 within the opening slot 30 takes place against the restoring force of the spring strip 28, which is 4 deformed into an elastically tensioned loop 40 so that the Cup 22 automatically returns to the starting position after releasing it becomes. In the area of the cup 22 protrude on both sides of the here also when closed Outer packaging 10 open opening slot 30 from the cover part 16 projections 42 towards the inside. These projections 42 inhibit after pulling away the tear strip 32, the free movement of the cup 22 in the direction the removal opening 38, i.e. the displacement of the bowl 22 into the removal position first requires a certain amount of force to displace the projections 42 protruding into the opening slot 32.

Der in Fig. 5 dargestellte, im wesentlichen streifenförmige Zuschnitt für die Umverpackung 10 zeigt die geschwächte und daher leicht trennbare Verbindung zwischen dem Aufreissstreifen 32 mit Aufreisslasche 34 als Perforationslinie 36 im Abdeckteil 16. Auf dem Bodenteil liegt bereits die Blisterverpackung 12 mit dem Federstreifen 28. Das Verschliessen der Umverpackung erfolgt durch Umlegen des Abdeckteils 16 in Pfeilrichtung D um eine Falzlinie d, bis der Abdeckteil 16 auf dem Bodenteil 14 bzw. auf der Blisterverpackung 12 aufliegt. Mit diesem Schritt erfolgt auch ein zumindest teilweises Verkleben von Randpartien 44 des Abdeckteils 16 mit Randpartien 46 des Bodenteils 14 zur Bildung des als Führung für die Schulter 26 des Napfes 22 dienenden Zwischenraumes 17.5, substantially strip-shaped blank for the Outer packaging 10 shows the weakened and therefore easily separable connection between the tear strip 32 with tear tab 34 as a perforation line 36 in the cover part 16. The blister packaging is already on the base part 12 with the spring strip 28. The outer packaging is closed by folding the cover part 16 in the direction of the arrow D by a fold line d, to the cover part 16 rests on the base part 14 or on the blister pack 12. With this step, at least partial gluing of Edge parts 44 of the cover part 16 with edge parts 46 of the bottom part 14 for Formation of the intermediate space serving as a guide for the shoulder 26 of the cup 22 17th

Die Fig. 6 und 7 zeigen eine andere Möglichkeit zur Erzeugung einer Rückstellkraft für den Napf 22 im Öffnungsschlitz 30. Der Federstreifen 28 ist hier so mit abwechselnd von beiden Seiten angeordneten Einschnitten 48 versehen, dass sich der Federstreifen 28 unter Ausbildung von eine Rückstellkraft erzeugenden Federbändem 50 in Streifenrichtung strecken lässt. Bei dieser Variante wird der Federstreifen 28 an dem dem Kopf 31 des Öffnungsschlitzes 30 naheliegenden Ende der Umverpackung 10 festgelegt. Die Federstreifen 28 mit Einschnitten 48 können direkt aus dem Material des Bodenteils 20 und/oder der Deckelfolie 24 der Blisterverpackung 12 gefertigt sein. Es ist jedoch auch möglich, den Federstreifen 28 separat herzustellen und mit der Blisterverpackung 12 zu verbinden. Anstelle eines Federstreifens 28 kann selbstverständlich auch ein anderes Federmaterial wie beispielsweise ein Gummiband vorgesehen sein.6 and 7 show another possibility for generating a restoring force for the cup 22 in the opening slot 30. The spring strip 28 is so here provided with cuts 48 arranged alternately from both sides, that the spring strip 28 forms a restoring force Spring straps 50 stretch in the direction of the strip. In this variant becomes the spring strip 28 on the head 31 of the opening slot 30 End of the outer packaging 10 set. The spring strips 28 with incisions 48 can be made directly from the material of the base part 20 and / or Cover film 24 of the blister pack 12 to be made. However, it is also possible to produce the spring strip 28 separately and with the blister pack 12 to connect. Instead of a spring strip 28 can of course also another spring material such as a rubber band is provided his.

Eine in Fig. 8 dargestellte Umverpackung 60 für eine Blisterverpackung 52 - im Beispiel eine Zweiportionenpackung für zwei Tabletten 18a, b - ist im wesentlichen aus spiegelbildlich zueinander stehenden Umverpackungen 10 gemäss Fig. 1 aufgebaut. Gleiche Teile sind deshalb auch mit gleichen Bezugszeichen versehen, wobei die doppelte Ausgestaltung jeweils durch einen Zusatz a bzw. b zum Ausdruck gebracht ist. Die Bodenteile 14a, b sind einstückig miteinander verbunden und bilden mit den Abdeckteilen 16a, b jeweils eine Schlaufe. In der verschlossenen Position liegen die zwei Teilumverpackungen 10a, b beidseits einer Spiegelebene S. Die beiden Teilumverpackungen 10a, b können in gleicher Weise geöffnet und die Tabletten 18a, b in gleicher Weise entnommen werden wie bei der in den Fig. 1 bis 5 gezeigten Umverpackung 10.An outer packaging 60 shown in FIG. 8 for a blister pack 52 - in An example of a two-portion pack for two tablets 18a, b - is essentially from outer packaging 10 standing in mirror image to one another according to Fig. 1 constructed. The same parts are therefore also with the same reference numerals provided, the double configuration each by an addition a or b is expressed. The bottom parts 14a, b are in one piece with one another connected and each form a loop with the cover parts 16a, b. In the closed position, the two partial packaging 10a, b are on both sides a mirror plane S. The two partial packaging 10a, b can in the same Opened in this way and the tablets 18a, b removed in the same way are like the outer packaging 10 shown in FIGS. 1 to 5.

Fig. 9 zeigt eine streifenförmige Packung 70 mit sechs aneinandergereihten Einzelpackungen gemäss Fig. 1. Diese sind durch linienförmig angeordnete Perforationen 72 voneinander abtrennbar. Die einzelnen Umverpackungen 10 können jedoch auch geöffnet werden, ohne dass diese vom Verpackungsstreifen 70 abgetrennt werden müssen. Eine derartige Streifenanordnung eignet sich auch für Umverpackungen 60 mit einer Zweiportionen-Blisterverpackung 62 gemäss Fig. 8. Fig. 9 shows a strip-shaped package 70 with six strings lined up Individual packs according to FIG. 1. These are arranged in a line Perforations 72 separable from each other. The individual outer packaging 10 can also be opened without removing them from the packaging strip 70 must be separated. Such a strip arrangement is suitable also for outer packaging 60 with a two-portion blister pack 62 according to FIG. 8.

Ein weiterer Vorteil der erfindungsgemässen Verpackung wird darin gesehen, dass die bedruckbare Fläche zum Anbringen von Informationen für den Konsumenten wesentlich vergrössert werden kann.Another advantage of the packaging according to the invention is seen in that the printable area for attaching information to the consumer can be increased significantly.

Claims (9)

  1. Child-resistant package for tablets, capsules and similar pharmaceutical products, comprising a blister pack (12) with at least one cup (22) for receiving the tablets (18) closed by means of a press-through covering film (24), in which package the blister pack (12) is arranged between a bottom part (14) and a cover part (16) of an outer packaging (10), the covering film (24) of the blister pack (12) is directed towards the bottom part (14), the bottom part (14) has a removal opening (38) and the cup (22) in the blister pack (12) is displaceably guided in an opening slot (30) in the cover part (16) and can be brought over the removal opening (38) in the bottom part (14) in order to press through the covering film (24) and remove the tablet (18), characterised in that the opening slot (30) has a width (t) smaller than the diameter (s) of a shoulder (26) of the cup (22), but greater than the diameter (u) of the cup (22) and that a tear strip (32) at least partially covering the opening slot (30) and separable by means of a weakening line (36) is joined to the cover part (16), wherein the cup (22) in the blister pack (12) can only be moved over the removal opening (38) once the tear strip (32) has been separated from the cover part (16).
  2. Package according to claim 1, characterised in that the weakening line (36) is a perforated line.
  3. Package according to claim 1 or claim 2, characterised in that the removal opening (38) is covered by a press-through closure.
  4. Package according to one of claims 1 to 3, characterised in that projections (42) obstructing the free displaceability of the cup (22) project inwardly from the edge of the opening slot (30).
  5. Package according to one of claims 1 to 4, characterised in that the blister pack (12) is joined to a spring element (28) opposing the displacement movement.
  6. Package according to claim 5, characterised in that the spring element (28) is part of the blister pack (12).
  7. Package according to one of claims 1 to 6, characterised in that the outer packaging (10) consists of one single blank.
  8. Double pack, characterised in that it consists of two partial packages according to one of claims 1 to 7 arranged in mirror symmetry.
  9. Multi-pack consisting of at least two packages according to one of claims 1 to 8, characterised in that the individual packages are arranged in a row to form a strip pack (70) and can preferably be separated from the strip pack (70) along a weakening line, in particular a perforated line (72).
EP99810480A 1999-06-02 1999-06-02 Child-resistant package for tablets Expired - Lifetime EP1057750B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE59904731T DE59904731D1 (en) 1999-06-02 1999-06-02 Childproof packaging for tablets
EP99810480A EP1057750B1 (en) 1999-06-02 1999-06-02 Child-resistant package for tablets
MXPA01011937A MXPA01011937A (en) 1999-06-02 2000-05-13 Child-resistant packaging for tablets.
US09/926,580 US6997320B1 (en) 1999-06-02 2000-05-13 Child-resistant packaging for tablets
AU49216/00A AU4921600A (en) 1999-06-02 2000-05-13 Child-resistant packaging for tablets
PCT/EP2000/004330 WO2000075044A1 (en) 1999-06-02 2000-05-13 Child-resistant packaging for tablets
CA002375279A CA2375279A1 (en) 1999-06-02 2000-05-13 Child-resistant packaging for tablets
JP2001501533A JP3479525B2 (en) 1999-06-02 2000-05-13 Packaging for children safe tablets

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99810480A EP1057750B1 (en) 1999-06-02 1999-06-02 Child-resistant package for tablets

Publications (2)

Publication Number Publication Date
EP1057750A1 EP1057750A1 (en) 2000-12-06
EP1057750B1 true EP1057750B1 (en) 2003-03-26

Family

ID=8242859

Family Applications (1)

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EP99810480A Expired - Lifetime EP1057750B1 (en) 1999-06-02 1999-06-02 Child-resistant package for tablets

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US (1) US6997320B1 (en)
EP (1) EP1057750B1 (en)
JP (1) JP3479525B2 (en)
AU (1) AU4921600A (en)
CA (1) CA2375279A1 (en)
DE (1) DE59904731D1 (en)
MX (1) MXPA01011937A (en)
WO (1) WO2000075044A1 (en)

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US6997320B1 (en) 2006-02-14
EP1057750A1 (en) 2000-12-06
JP2003501326A (en) 2003-01-14
CA2375279A1 (en) 2000-12-14
AU4921600A (en) 2000-12-28
JP3479525B2 (en) 2003-12-15
DE59904731D1 (en) 2003-04-30
MXPA01011937A (en) 2004-03-19
WO2000075044A1 (en) 2000-12-14

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