EP1056762A4 - Genetic immunization with nonstructural proteins of hepatitis c virus - Google Patents
Genetic immunization with nonstructural proteins of hepatitis c virusInfo
- Publication number
- EP1056762A4 EP1056762A4 EP99904381A EP99904381A EP1056762A4 EP 1056762 A4 EP1056762 A4 EP 1056762A4 EP 99904381 A EP99904381 A EP 99904381A EP 99904381 A EP99904381 A EP 99904381A EP 1056762 A4 EP1056762 A4 EP 1056762A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hepatitis
- virus
- nonstructural proteins
- genetic immunization
- immunization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7315698P | 1998-01-30 | 1998-01-30 | |
US73156P | 1998-01-30 | ||
PCT/US1999/001823 WO1999038880A1 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis c virus |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1056762A1 EP1056762A1 (en) | 2000-12-06 |
EP1056762A4 true EP1056762A4 (en) | 2003-07-23 |
Family
ID=22112053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99904381A Withdrawn EP1056762A4 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis c virus |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1056762A4 (en) |
JP (1) | JP2002501737A (en) |
KR (2) | KR20060057653A (en) |
CN (3) | CN101126095A (en) |
AU (1) | AU746258B2 (en) |
BR (1) | BR9908540A (en) |
CA (1) | CA2318744A1 (en) |
IL (1) | IL137458A0 (en) |
WO (1) | WO1999038880A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562346B1 (en) * | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
AU2574601A (en) * | 1999-11-24 | 2001-06-04 | Chiron Corporation | Novel hcv non-structural polypeptide |
JP4475561B2 (en) | 2001-10-11 | 2010-06-09 | メルク・シャープ・エンド・ドーム・コーポレイション | Hepatitis C virus vaccine |
FR2855758B1 (en) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | COMPOSITION COMPRISING NS3 / NS4 POLYPROTEIN AND HCV NS5B POLYPEPTIDE, EXPRESSION VECTORS INCLUDING THE CORRESPONDING NUCLEIC SEQUENCES AND THEIR USE IN THERAPEUTICS |
CA2851336C (en) * | 2011-10-24 | 2021-01-12 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996037606A1 (en) * | 1995-05-22 | 1996-11-28 | Bionova Corporation | Compositions and methods for the diagnosis of, and vaccination against, hepatitis c virus (hcv) |
US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
WO1997047358A1 (en) * | 1996-06-11 | 1997-12-18 | Merck & Co., Inc. | Synthetic hepatitis c genes |
WO1999029843A1 (en) * | 1997-12-11 | 1999-06-17 | Smithkline Beecham Corporation | Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2079105C (en) * | 1990-04-04 | 2000-06-13 | Michael Houghton | Hepatitis c virus protease |
ATE302854T1 (en) * | 1993-01-26 | 2005-09-15 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR ADMINISTRATION OF GENETIC MATERIAL |
CA2250723C (en) * | 1996-05-24 | 2012-07-17 | Chiron Corporation | Multiple epitope fusion protein |
-
1999
- 1999-01-28 AU AU24786/99A patent/AU746258B2/en not_active Ceased
- 1999-01-28 CN CNA2007101398938A patent/CN101126095A/en active Pending
- 1999-01-28 IL IL13745899A patent/IL137458A0/en unknown
- 1999-01-28 JP JP2000529347A patent/JP2002501737A/en not_active Withdrawn
- 1999-01-28 EP EP99904381A patent/EP1056762A4/en not_active Withdrawn
- 1999-01-28 CN CNA2007101384653A patent/CN101126094A/en active Pending
- 1999-01-28 KR KR1020067008960A patent/KR20060057653A/en not_active IP Right Cessation
- 1999-01-28 CA CA002318744A patent/CA2318744A1/en not_active Abandoned
- 1999-01-28 KR KR1020007008307A patent/KR100628411B1/en not_active IP Right Cessation
- 1999-01-28 BR BR9908540-2A patent/BR9908540A/en not_active Application Discontinuation
- 1999-01-28 WO PCT/US1999/001823 patent/WO1999038880A1/en not_active Application Discontinuation
- 1999-01-28 CN CNB998024813A patent/CN100335637C/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
WO1996037606A1 (en) * | 1995-05-22 | 1996-11-28 | Bionova Corporation | Compositions and methods for the diagnosis of, and vaccination against, hepatitis c virus (hcv) |
WO1997047358A1 (en) * | 1996-06-11 | 1997-12-18 | Merck & Co., Inc. | Synthetic hepatitis c genes |
WO1999029843A1 (en) * | 1997-12-11 | 1999-06-17 | Smithkline Beecham Corporation | Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds |
Non-Patent Citations (8)
Title |
---|
CHOO Q-L ET AL: "GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, 1 March 1991 (1991-03-01), pages 2451 - 2455, XP000652139, ISSN: 0027-8424 * |
ENCKE J. ET AL.: "Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model", JOURNAL OF IMMUNOLOGY, vol. 161, no. 9, 1 November 1998 (1998-11-01), pages 4917 - 4923, XP002233910 * |
INCHAUSPE G.: "Gene vaccination for hepatitis C", SPRINGER SEMINARS IN IMMUNOPATHOLOGY, vol. 19, no. 2, 1997, pages 211 - 221, XP008014824 * |
INCHAUSPE G.: "Mechanism of protection in hepatitis C virus infection", MEDECINE ET MALADIES INFECTIEUSES, vol. 25, October 1995 (1995-10-01), pages 1067 - 1073, XP008017646 * |
PAPA S. ET AL.: "Development of a multigenic plasmid vector for HCV DNA immunization", RESEARCH IN VIROLOGY, vol. 149, no. 5, September 1998 (1998-09-01), pages 315 - 319, XP002233911 * |
SAITO T ET AL: "PLASMID DNA-BASED IMMUNIZATON FOR HEPATITIS C VIRUS STRUCTURAL PROTEINS: IMMUNE RESPONSES IN MICE", GASTROENTEROLOGY, vol. 112, no. 4, April 1997 (1997-04-01), pages 1321 - 1330, XP001013414, ISSN: 0016-5085 * |
See also references of WO9938880A1 * |
STUYVER L ET AL: "CLONING AND PHYLOGENETIC ANALYSIS OF THE CORE, E2, AND NS3/NS4 REGIONS OF THE HEPATITIS C VIRUS TYPE 5A+", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 202, no. 3, 1994, pages 1308 - 1314, XP002057873, ISSN: 0006-291X * |
Also Published As
Publication number | Publication date |
---|---|
AU746258B2 (en) | 2002-04-18 |
CN101126094A (en) | 2008-02-20 |
KR20010086226A (en) | 2001-09-10 |
KR100628411B1 (en) | 2006-09-28 |
EP1056762A1 (en) | 2000-12-06 |
AU2478699A (en) | 1999-08-16 |
KR20060057653A (en) | 2006-05-26 |
JP2002501737A (en) | 2002-01-22 |
BR9908540A (en) | 2000-11-28 |
CA2318744A1 (en) | 1999-08-05 |
IL137458A0 (en) | 2001-07-24 |
CN1289339A (en) | 2001-03-28 |
WO1999038880A1 (en) | 1999-08-05 |
CN100335637C (en) | 2007-09-05 |
CN101126095A (en) | 2008-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL131688A0 (en) | Functional dna clone for hepatitis c virus (hcv) and uses thereof | |
DE60014345D1 (en) | Makrozyklische peptide als hepatitis c virus ns3 protease inhibitore | |
AU2055301A (en) | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease | |
DK1001801T3 (en) | Product comprising at least one double-chain RNA combined with at least one interferon for the treatment of viral hepatitis | |
AP2001002301A0 (en) | Inhibition of viral infection using monovalentantigen-binding proteins | |
AU5285899A (en) | Anti hepatitis c virus antibody and uses thereof | |
AU6371900A (en) | Lactam inhibitors of hepatitis c virus ns3 protease | |
ZA9811316B (en) | Novel hepatitis C virus NS5B protein | |
AU2003284689A8 (en) | Nucleic acid construct containing hepatitis c virus (hcv) of genocype 2a genome-origin nucleic acid and cell having the nucleic acid construct transferred thereinto | |
AU3714499A (en) | Hepatitis c virus mimotopes | |
AU7602800A (en) | Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof | |
EP1141255A4 (en) | Modified forms of hepatitis c virus ns3 protease | |
AU2001246331A1 (en) | Hepatitis b virus (hbv) antigenic polypeptide-heat shock protein complex and use thereof | |
EP0747482A3 (en) | Hepatitis GB virus recombinant proteins and uses thereof | |
IL137458A0 (en) | Genetic immunization with nonstructural proteins of hepatitis c virus | |
EP1100545A4 (en) | Regulated expression of recombinant proteins using rna viruses | |
EP1591524A4 (en) | Oligoribonucleotide or peptidic nucleic acid inhibiting function of hepatitis c virus | |
IL138804A0 (en) | Hepatitis c virus ns5b nucleic acids and proteins | |
EP1113777A4 (en) | Novel hepatitis c virus peptides and uses thereof | |
AU9494998A (en) | (in vivo), animal model for expression of hepatitis c virus | |
ZA964094B (en) | Compositions and methods for the diagnosis of and vaccination against hepatitis c virus (hcv) | |
EP1521849A4 (en) | Hepatitis a virus nucleotide sequences, recombinant proteins and uses thereof | |
AU5681598A (en) | Liposomes comprising peptide antigens derived from x protein of hepatitis b virus | |
EP1421222A4 (en) | Cell culture system for synthesis of infectious hepatitis c virus | |
IL151033A0 (en) | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000830 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07K 14/18 B Ipc: 7A 61K 39/29 B Ipc: 7A 61K 39/12 B Ipc: 7C 12N 15/85 B Ipc: 7C 12N 5/10 B Ipc: 7C 12N 15/51 B Ipc: 7C 07H 21/04 B Ipc: 7C 07H 21/02 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030604 |
|
17Q | First examination report despatched |
Effective date: 20040824 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20080602 |