EP1051169A4 - Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases - Google Patents

Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases

Info

Publication number
EP1051169A4
EP1051169A4 EP99905546A EP99905546A EP1051169A4 EP 1051169 A4 EP1051169 A4 EP 1051169A4 EP 99905546 A EP99905546 A EP 99905546A EP 99905546 A EP99905546 A EP 99905546A EP 1051169 A4 EP1051169 A4 EP 1051169A4
Authority
EP
European Patent Office
Prior art keywords
compositions
treating
compounds
methods
associated diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99905546A
Other languages
German (de)
French (fr)
Other versions
EP1051169A1 (en
Inventor
Theodore J Nitz
Daniel C Pevear
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viropharma Biologics LLC
Original Assignee
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc filed Critical Viropharma Inc
Publication of EP1051169A1 publication Critical patent/EP1051169A1/en
Publication of EP1051169A4 publication Critical patent/EP1051169A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP99905546A 1998-01-29 1999-01-29 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases Withdrawn EP1051169A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7303898P 1998-01-29 1998-01-29
US73038P 1998-01-29
US7307898P 1998-01-30 1998-01-30
US73078P 1998-01-30
PCT/US1999/001985 WO1999038508A1 (en) 1998-01-29 1999-01-29 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases

Publications (2)

Publication Number Publication Date
EP1051169A1 EP1051169A1 (en) 2000-11-15
EP1051169A4 true EP1051169A4 (en) 2002-05-29

Family

ID=26754055

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99905546A Withdrawn EP1051169A4 (en) 1998-01-29 1999-01-29 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases

Country Status (9)

Country Link
EP (1) EP1051169A4 (en)
JP (1) JP2002501894A (en)
CN (1) CN1289248A (en)
AU (1) AU759772B2 (en)
BR (1) BR9908522A (en)
CA (1) CA2319465C (en)
MX (1) MXPA00007394A (en)
NZ (1) NZ505894A (en)
WO (1) WO1999038508A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
KR20040058229A (en) 2001-10-22 2004-07-03 더 스크립스 리서치 인스티튜트 Antibody targeting compounds
CA2495266A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US8119672B2 (en) * 2002-08-09 2012-02-21 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2005042530A1 (en) 2003-10-30 2005-05-12 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
PL1706385T3 (en) 2003-12-23 2011-03-31 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators
JP2008546751A (en) 2005-06-22 2008-12-25 アステックス・セラピューティクス・リミテッド Pharmaceutical composition
JP5345842B2 (en) 2005-06-23 2013-11-20 アステックス・セラピューティクス・リミテッド Pharmaceutical combinations containing pyrazole derivatives as protein kinase modulators
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
JP2012517447A (en) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート Chemically programmed vaccination methods
NZ628880A (en) 2012-06-29 2016-08-26 Microdose Therapeutx Inc Compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2015085844A1 (en) 2013-12-10 2015-06-18 南京明德新药研发股份有限公司 Imidazole derivative used as antiviral agent and use thereof in preparation of medicament
PT3305790T (en) 2015-06-08 2020-10-19 Shangdong Danhong Pharmaceutical Co Ltd Method for preparing imidazole derivative and intermediate thereof and crystal form
EP3982994A4 (en) * 2019-06-13 2023-10-04 Cidara Therapeutics, Inc. Compositions and methods for the treatment of respiratory syncytial virus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508391A (en) * 1975-01-20 1978-04-26 Sterling Drug Inc Phenylalkylamines
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US5098920A (en) * 1990-05-04 1992-03-24 G. D. Searle & Co. 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof
EP0795549A1 (en) * 1996-02-13 1997-09-17 American Cyanamid Company Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivatives, their preparation and their use as antiviral agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124280A (en) * 1995-07-27 2000-09-26 Warner-Lambert Company Substituted phenols as novel calcium channel blockers
DE69706407T2 (en) * 1996-03-29 2002-05-29 G.D. Searle & Co., Chicago META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTERGRIN ANTAGONISTS OR INHIBITORS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508391A (en) * 1975-01-20 1978-04-26 Sterling Drug Inc Phenylalkylamines
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US5098920A (en) * 1990-05-04 1992-03-24 G. D. Searle & Co. 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof
EP0795549A1 (en) * 1996-02-13 1997-09-17 American Cyanamid Company Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivatives, their preparation and their use as antiviral agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAKER, B.R. ET AL: "Irreversible Enzyme Inhibitors. 181. Inhibition of Brain Choline Acetyltransferase by Derivatives of 4-Stilbazole", J. MED. CHEM., 1984, pages 315 - 322, XP000938518 *
DE CLERCQ, ERIK: "Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 7, 1996, pages 193 - 202, XP002193685 *
SCHLEGEL, DONALD C. ET AL: "Bulky amine analogs of ketoprofen: potent antiinflammatory agents", J. MED. CHEM. (1984), 27(12), 1682-90, XP000973055 *
See also references of WO9938508A1 *

Also Published As

Publication number Publication date
WO1999038508A1 (en) 1999-08-05
AU759772B2 (en) 2003-05-01
CA2319465C (en) 2013-03-19
CN1289248A (en) 2001-03-28
MXPA00007394A (en) 2003-08-01
BR9908522A (en) 2001-10-02
CA2319465A1 (en) 1999-08-05
JP2002501894A (en) 2002-01-22
NZ505894A (en) 2002-12-20
EP1051169A1 (en) 2000-11-15

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