EP1048654A3 - Process for the preparation of chloropyridine sulfonyl chloride - Google Patents

Process for the preparation of chloropyridine sulfonyl chloride Download PDF

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Publication number
EP1048654A3
EP1048654A3 EP00104753A EP00104753A EP1048654A3 EP 1048654 A3 EP1048654 A3 EP 1048654A3 EP 00104753 A EP00104753 A EP 00104753A EP 00104753 A EP00104753 A EP 00104753A EP 1048654 A3 EP1048654 A3 EP 1048654A3
Authority
EP
European Patent Office
Prior art keywords
hydroxypyridine
mixture
general formula
chloropyridine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00104753A
Other languages
German (de)
French (fr)
Other versions
EP1048654B1 (en
EP1048654A2 (en
Inventor
Bruno Biedenbach
Hans-Peter Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ruetgers Organics GmbH
Original Assignee
Ruetgers Organics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ruetgers Organics GmbH filed Critical Ruetgers Organics GmbH
Priority to HU0200795A priority Critical patent/HUP0200795A3/en
Priority to PCT/EP2000/002795 priority patent/WO2000063177A1/en
Priority to CZ20013406A priority patent/CZ20013406A3/en
Publication of EP1048654A2 publication Critical patent/EP1048654A2/en
Publication of EP1048654A3 publication Critical patent/EP1048654A3/en
Application granted granted Critical
Publication of EP1048654B1 publication Critical patent/EP1048654B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached

Abstract

A process is disclosed for preparing chlorinated pyridinesulphonic acid chlorides of the general formula Ifrom hydroxypyridine-sulphonic acids of the general formula IIThe process generally entails a) passing chlorine gas into a mixture of a hydroxypyridine-sulphonic acid and of phosphorus trichloride; b) heating the mixture of a) to temperatures of about 100 to about 120° C.; c) removing any phosphorus oxychloride formed and any excess phosphorus trichloride by distillation; d) taking up the residue with an organic solvent; and e) distilling the liquid phase in a vacuum, thereby obtaining the chlorinated pyridine-sulphonic acid chloride.
EP00104753A 1999-04-21 2000-03-04 Process for the preparation of chloropyridine sulfonyl chloride Expired - Lifetime EP1048654B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU0200795A HUP0200795A3 (en) 1999-04-21 2000-03-30 Method of producing chloropyridine sulfonic acid chlorides
PCT/EP2000/002795 WO2000063177A1 (en) 1999-04-21 2000-03-30 Method of producing chloropyridine sulfonic acid chlorides
CZ20013406A CZ20013406A3 (en) 1999-04-21 2000-03-30 Process for preparing chlorides of chlorinated pyridine sulfonic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918021 1999-04-21
DE19918021A DE19918021C1 (en) 1999-04-21 1999-04-21 Preparation of chlorinated pyridine sulfonic acid chloride derivatives from hydroxypyridine sulfonic acids and phosphorus trichloride/chlorine gas; useful as intermediates for drugs, e.g. torasemide

Publications (3)

Publication Number Publication Date
EP1048654A2 EP1048654A2 (en) 2000-11-02
EP1048654A3 true EP1048654A3 (en) 2000-11-08
EP1048654B1 EP1048654B1 (en) 2003-07-30

Family

ID=7905316

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00104753A Expired - Lifetime EP1048654B1 (en) 1999-04-21 2000-03-04 Process for the preparation of chloropyridine sulfonyl chloride

Country Status (8)

Country Link
US (1) US6310214B1 (en)
EP (1) EP1048654B1 (en)
JP (1) JP4695742B2 (en)
AT (1) ATE246176T1 (en)
DE (2) DE19918021C1 (en)
ES (1) ES2203361T3 (en)
IL (1) IL134984A (en)
PT (1) PT1048654E (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6165374B1 (en) * 2017-02-24 2017-07-19 タマ化学工業株式会社 Method for producing pyridine-3-sulfonyl chloride
CN112194618B (en) * 2020-12-03 2021-04-02 苏州开元民生科技股份有限公司 Preparation method of 2, 3-dichloropyridine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795361A1 (en) * 1967-09-20 1972-03-16 Ciba Geigy Ag Process for the preparation of 2,4-dichloropyrimidine-5-carboxylic acid chloride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR88352E (en) * 1964-08-08 1967-01-27 Kuhlmann Ets New reactive dyes, their applications and intermediates for their preparation
NL128672C (en) 1964-08-08
ES436109A1 (en) * 1974-04-04 1977-01-01 Christiaens Sa A Procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)
JPS585897B2 (en) 1977-07-20 1983-02-02 住友化学工業株式会社 Method for producing aromatic carboxylic acid chloride
FR2703051B1 (en) 1993-03-26 1995-04-28 Adir New pyridothiadiazines, processes for their preparation, and pharmaceutical compositions containing them.
DE19713506A1 (en) * 1997-04-01 1998-10-08 Bayer Ag Process for the preparation of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyrid-6-one monosodium salt and its tautomers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795361A1 (en) * 1967-09-20 1972-03-16 Ciba Geigy Ag Process for the preparation of 2,4-dichloropyrimidine-5-carboxylic acid chloride

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DELARGE, J.: "Chemistry and Pharmacological Properties of the Pyridine-3-sulfonylurea Derivative Torasemide", ARZNEIM.-FORSCHUNG/DRUG RES., vol. 38, no. 1, 1988, pages 144 - 150, XP002146357 *
DELARGE, J.: "Synthèse de nouvelles substance antiinflammatoires non stéroïdiques", MEM. ACAD. R. MED. BELG., vol. 47, no. 3, 1974, pages 131 - 210, XP002146356 *
HOUBEN-WEYL, BD 9, 4.AUFL.: "Methoden der Organischen Chemie: Schwefel-, Selen-, Tellurverbindungen", 1955, GEORG THIEME VERLAG, STUTTGART, XP002146358 *
HOUBEN-WEYL, BD. 5 (3), 4. AUFL.: "Methoden der Organischen Chemie: Herstellung von Chlorverbindungen", 1955, GEORG THIEME VERLAG, STUTTGART, XP002146359 *

Also Published As

Publication number Publication date
EP1048654B1 (en) 2003-07-30
ES2203361T3 (en) 2004-04-16
JP2000327661A (en) 2000-11-28
ATE246176T1 (en) 2003-08-15
PT1048654E (en) 2003-12-31
DE50003063D1 (en) 2003-09-04
EP1048654A2 (en) 2000-11-02
DE19918021C1 (en) 2000-06-29
IL134984A (en) 2006-06-11
IL134984A0 (en) 2001-05-20
JP4695742B2 (en) 2011-06-08
US6310214B1 (en) 2001-10-30

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