EP1039915A4 - Inhibiteurs phosphonate ester cyclique de proteine microsomale de transfert des triglycerides et procede associe - Google Patents
Inhibiteurs phosphonate ester cyclique de proteine microsomale de transfert des triglycerides et procede associeInfo
- Publication number
- EP1039915A4 EP1039915A4 EP98953531A EP98953531A EP1039915A4 EP 1039915 A4 EP1039915 A4 EP 1039915A4 EP 98953531 A EP98953531 A EP 98953531A EP 98953531 A EP98953531 A EP 98953531A EP 1039915 A4 EP1039915 A4 EP 1039915A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- transfer protein
- phosphonate ester
- microsomal triglyceride
- triglyceride transfer
- cyclic phosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 Cyclic phosphonate ester Chemical class 0.000 title 1
- 102100031545 Microsomal triglyceride transfer protein large subunit Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108010038232 microsomal triglyceride transfer protein Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6334797P | 1997-10-28 | 1997-10-28 | |
US63347P | 1997-10-28 | ||
PCT/US1998/021750 WO1999021564A1 (fr) | 1997-10-28 | 1998-10-14 | Inhibiteurs phosphonate ester cyclique de proteine microsomale de transfert des triglycerides et procede associe |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1039915A1 EP1039915A1 (fr) | 2000-10-04 |
EP1039915A4 true EP1039915A4 (fr) | 2001-02-14 |
Family
ID=22048585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98953531A Withdrawn EP1039915A4 (fr) | 1997-10-28 | 1998-10-14 | Inhibiteurs phosphonate ester cyclique de proteine microsomale de transfert des triglycerides et procede associe |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1039915A4 (fr) |
JP (1) | JP2001521001A (fr) |
AU (1) | AU753520B2 (fr) |
CA (1) | CA2307889A1 (fr) |
WO (1) | WO1999021564A1 (fr) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026240A1 (fr) * | 1996-01-16 | 1997-07-24 | Bristol-Myers Squibb Company | Composes aromatiques a conformation restreinte servant d'inhibiteurs de la proteine de transfert de triglyceride microsomique et procede associe |
US5760246A (en) * | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2562543B1 (fr) * | 1984-04-10 | 1987-09-25 | Elf Aquitaine | Nouveaux phosphonites cycliques, leur preparation et applications |
-
1998
- 1998-10-14 CA CA002307889A patent/CA2307889A1/fr not_active Abandoned
- 1998-10-14 WO PCT/US1998/021750 patent/WO1999021564A1/fr not_active Application Discontinuation
- 1998-10-14 EP EP98953531A patent/EP1039915A4/fr not_active Withdrawn
- 1998-10-14 AU AU10876/99A patent/AU753520B2/en not_active Ceased
- 1998-10-14 JP JP2000517722A patent/JP2001521001A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026240A1 (fr) * | 1996-01-16 | 1997-07-24 | Bristol-Myers Squibb Company | Composes aromatiques a conformation restreinte servant d'inhibiteurs de la proteine de transfert de triglyceride microsomique et procede associe |
US5760246A (en) * | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
Non-Patent Citations (1)
Title |
---|
See also references of WO9921564A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999021564A1 (fr) | 1999-05-06 |
AU753520B2 (en) | 2002-10-17 |
JP2001521001A (ja) | 2001-11-06 |
CA2307889A1 (fr) | 1999-05-06 |
EP1039915A1 (fr) | 2000-10-04 |
AU1087699A (en) | 1999-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000524 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20010104 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 31/675 A, 7A 61K 31/66 B, 7C 07F 9/6574 B, 7C 07F 9/6541 B, 7C 07F 9/6533 B, 7C 07F 9/653 B, 7C 07F 9/59 B, 7C 07F 9/58 B, 7C 07F 9/6571 B, 7C 07F 9/40 B |
|
17Q | First examination report despatched |
Effective date: 20020103 |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20030417 |