EP1039915A4 - Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method - Google Patents

Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method

Info

Publication number
EP1039915A4
EP1039915A4 EP98953531A EP98953531A EP1039915A4 EP 1039915 A4 EP1039915 A4 EP 1039915A4 EP 98953531 A EP98953531 A EP 98953531A EP 98953531 A EP98953531 A EP 98953531A EP 1039915 A4 EP1039915 A4 EP 1039915A4
Authority
EP
European Patent Office
Prior art keywords
transfer protein
phosphonate ester
microsomal triglyceride
triglyceride transfer
cyclic phosphonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98953531A
Other languages
German (de)
French (fr)
Other versions
EP1039915A1 (en
Inventor
Richard B Sulsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1039915A1 publication Critical patent/EP1039915A1/en
Publication of EP1039915A4 publication Critical patent/EP1039915A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
EP98953531A 1997-10-28 1998-10-14 Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method Withdrawn EP1039915A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6334797P 1997-10-28 1997-10-28
US63347P 1997-10-28
PCT/US1998/021750 WO1999021564A1 (en) 1997-10-28 1998-10-14 Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method

Publications (2)

Publication Number Publication Date
EP1039915A1 EP1039915A1 (en) 2000-10-04
EP1039915A4 true EP1039915A4 (en) 2001-02-14

Family

ID=22048585

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98953531A Withdrawn EP1039915A4 (en) 1997-10-28 1998-10-14 Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method

Country Status (5)

Country Link
EP (1) EP1039915A4 (en)
JP (1) JP2001521001A (en)
AU (1) AU753520B2 (en)
CA (1) CA2307889A1 (en)
WO (1) WO1999021564A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026240A1 (en) * 1996-01-16 1997-07-24 Bristol-Myers Squibb Company Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562543B1 (en) * 1984-04-10 1987-09-25 Elf Aquitaine NOVEL CYCLIC PHOSPHONITES, THEIR PREPARATION AND APPLICATIONS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026240A1 (en) * 1996-01-16 1997-07-24 Bristol-Myers Squibb Company Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9921564A1 *

Also Published As

Publication number Publication date
JP2001521001A (en) 2001-11-06
WO1999021564A1 (en) 1999-05-06
CA2307889A1 (en) 1999-05-06
EP1039915A1 (en) 2000-10-04
AU753520B2 (en) 2002-10-17
AU1087699A (en) 1999-05-17

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