EP1019435A4 - Amplification de la reponse d'une proteine de recombinaison exprimee - Google Patents

Amplification de la reponse d'une proteine de recombinaison exprimee

Info

Publication number
EP1019435A4
EP1019435A4 EP97906880A EP97906880A EP1019435A4 EP 1019435 A4 EP1019435 A4 EP 1019435A4 EP 97906880 A EP97906880 A EP 97906880A EP 97906880 A EP97906880 A EP 97906880A EP 1019435 A4 EP1019435 A4 EP 1019435A4
Authority
EP
European Patent Office
Prior art keywords
amplification
response
recombinant protein
expressed recombinant
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97906880A
Other languages
German (de)
English (en)
Other versions
EP1019435A1 (fr
Inventor
Eugene A Davidson
Shutong Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of EP1019435A1 publication Critical patent/EP1019435A1/fr
Publication of EP1019435A4 publication Critical patent/EP1019435A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
EP97906880A 1996-01-29 1997-01-29 Amplification de la reponse d'une proteine de recombinaison exprimee Withdrawn EP1019435A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59356096A 1996-01-29 1996-01-29
US593560 1996-01-29
PCT/US1997/001394 WO1997027216A1 (fr) 1996-01-29 1997-01-29 Amplification de la reponse d'une proteine de recombinaison exprimee

Publications (2)

Publication Number Publication Date
EP1019435A1 EP1019435A1 (fr) 2000-07-19
EP1019435A4 true EP1019435A4 (fr) 2001-12-12

Family

ID=24375210

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97906880A Withdrawn EP1019435A4 (fr) 1996-01-29 1997-01-29 Amplification de la reponse d'une proteine de recombinaison exprimee

Country Status (5)

Country Link
EP (1) EP1019435A4 (fr)
JP (1) JP2000504330A (fr)
KR (1) KR19990082085A (fr)
AU (1) AU724621B2 (fr)
WO (1) WO1997027216A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766091A1 (fr) * 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001041A1 (fr) * 1987-08-06 1989-02-09 Genentech, Inc. Acide nucleique et procedes de synthese de nouveaux polypeptides de fusion ayant un domaine d'ancrage phospholipidique
WO1989007140A1 (fr) * 1988-02-05 1989-08-10 Commonwealth Scientific And Industrial Research Or Systeme d'expression par genes (en particulier pour la proteine de rotavirus vp7) employant un peptide de signal etranger et eventuellement une sequence d'ancrage transmembrane
WO1994018330A1 (fr) * 1993-02-10 1994-08-18 Unilever N.V. Proteines immobilisees a capacites de fixation specifique et leur utilisation dans divers procedes et produits

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE105334T1 (de) * 1988-04-22 1994-05-15 Upjohn Co Schimaerische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3.
US5223394A (en) * 1989-04-10 1993-06-29 Biogen, Inc. Recombinant dna molecule comprising lymphocyte function-associated antigen 3 phosphatidylinositol linkage signal sequence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001041A1 (fr) * 1987-08-06 1989-02-09 Genentech, Inc. Acide nucleique et procedes de synthese de nouveaux polypeptides de fusion ayant un domaine d'ancrage phospholipidique
WO1989007140A1 (fr) * 1988-02-05 1989-08-10 Commonwealth Scientific And Industrial Research Or Systeme d'expression par genes (en particulier pour la proteine de rotavirus vp7) employant un peptide de signal etranger et eventuellement une sequence d'ancrage transmembrane
WO1994018330A1 (fr) * 1993-02-10 1994-08-18 Unilever N.V. Proteines immobilisees a capacites de fixation specifique et leur utilisation dans divers procedes et produits

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LEE S W ET AL: "EXPRESSION OF AN ANCHORED UROKINASE IN THE APICAL ENDOTHELIAL-CELL MEMBRANE - PRESERVATION OF ENZYMATIC-ACTIVITY AND ENHANCEMENT OF CELL-SURFACE PLASMINOGEN ACTIVATION", JOURNAL OF BIOLOGICAL CHEMISTRY, (25 JUN 1992) VOL. 267, NO. 18, PP. 13020-13027. ISSN: 0021-9258., - 25 June 1992 (1992-06-25), NHLBI, MOLEC HEMATOL BRANCH, BLDG 10, RM 7D-18, BETHESDA, MD, 20892, XP002172674 *
See also references of WO9727216A1 *
SRINIVASAN J ET AL: "Targeting vaccinia virus-expressed secretory beta subunit of human chorionic gonadotropin to the cell surface induces antibodies.", INFECTION AND IMMUNITY, vol. 63, no. 12, 1995, pages 4907 - 4911, XP002172672, ISSN: 0019-9567 *
TAUER THOMAS J ET AL: "Expression of the insulin receptor with a recombinant vaccinia virus: Biochemical evidence that the insulin receptor has intrinsic serine kinase activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 1, 1996, pages 331 - 336, XP002172673, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2000504330A (ja) 2000-04-11
AU2248997A (en) 1997-08-20
AU724621B2 (en) 2000-09-28
WO1997027216A1 (fr) 1997-07-31
KR19990082085A (ko) 1999-11-15
EP1019435A1 (fr) 2000-07-19

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