EP1014979A4 - Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use - Google Patents

Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use

Info

Publication number
EP1014979A4
EP1014979A4 EP98926517A EP98926517A EP1014979A4 EP 1014979 A4 EP1014979 A4 EP 1014979A4 EP 98926517 A EP98926517 A EP 98926517A EP 98926517 A EP98926517 A EP 98926517A EP 1014979 A4 EP1014979 A4 EP 1014979A4
Authority
EP
European Patent Office
Prior art keywords
antihistaminic
compounds
combined
intended
mast cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98926517A
Other languages
German (de)
French (fr)
Other versions
EP1014979A1 (en
Inventor
A K Gunnar Aberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bridge Pharma Inc
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Publication of EP1014979A1 publication Critical patent/EP1014979A1/en
Publication of EP1014979A4 publication Critical patent/EP1014979A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP98926517A 1997-06-09 1998-06-09 Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use Withdrawn EP1014979A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4910397P 1997-06-09 1997-06-09
US49103P 1997-06-09
PCT/US1998/012031 WO1998056381A1 (en) 1997-06-09 1998-06-09 Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use

Publications (2)

Publication Number Publication Date
EP1014979A1 EP1014979A1 (en) 2000-07-05
EP1014979A4 true EP1014979A4 (en) 2003-08-20

Family

ID=21958068

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98926517A Withdrawn EP1014979A4 (en) 1997-06-09 1998-06-09 Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use

Country Status (4)

Country Link
US (1) US6207684B1 (en)
EP (1) EP1014979A4 (en)
AU (1) AU7833698A (en)
WO (1) WO1998056381A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4851035B2 (en) * 1999-06-18 2012-01-11 アルコン ラボラトリーズ，インコーポレイティド Topical eye mast cell stabilizer for treating allergic eye diseases
BR0013935A (en) * 1999-09-13 2002-05-14 Bridge Pharma Inc Optically active isomers of ketotifen and therapeutically active metabolites thereof
US6395756B2 (en) * 1999-12-23 2002-05-28 Novartis Ag Use of ophthalmic agent
TWI231759B (en) * 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US7977376B2 (en) 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
US8445437B2 (en) * 2006-07-27 2013-05-21 The Brigham And Women's Hospital, Inc. Treatment and prevention of cardiovascular disease using mast cell stabilizers
TWI611047B (en) * 2006-12-21 2018-01-11 恩特葛瑞斯股份有限公司 Liquid cleaner for the removal of post-etch residues
WO2008153761A1 (en) * 2007-05-23 2008-12-18 Mastcell Pharmaceuticals, Inc. Methods
JP5460600B2 (en) 2007-09-28 2014-04-02 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Mast cell stabilizer in the treatment of obesity
WO2009142772A2 (en) * 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
US8741930B2 (en) * 2008-10-24 2014-06-03 Bridge Pharma, Inc. Treating xerophthalmia with norketotifen
WO2010059894A1 (en) 2008-11-21 2010-05-27 Bridge Pharma, Inc. Ocular formulations of norketotifen
US8778971B2 (en) 2012-10-23 2014-07-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in companion animals
US20150272941A1 (en) 2012-10-30 2015-10-01 Bridge Pharma, Inc. Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US20140120121A1 (en) 2012-10-30 2014-05-01 Bridge Pharma, Inc. Medicinal treatment of atopic inflammatory diseases
US9345697B2 (en) 2013-08-06 2016-05-24 Bridge Pharma, Inc. Methods of treatment of non-histaminic pruritus
US9138431B2 (en) 2013-08-06 2015-09-22 Bridge Pharma, Inc. Methods of treatment of histamine H-4 receptor-related pruritus
US9439895B2 (en) 2013-08-06 2016-09-13 Bridge Pharma, Inc. Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients
PT3104853T (en) 2014-02-10 2020-01-14 Respivant Sciences Gmbh Mast cell stabilizers treatment for systemic disorders
ES2792682T3 (en) 2014-02-10 2020-11-11 Respivant Sciences Gmbh Methods for the treatment of lung diseases with mast cell stabilizers
EP3331522A1 (en) 2015-08-07 2018-06-13 Patara Pharma LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
CA3035528A1 (en) 2016-08-31 2018-03-08 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
CA3036230A1 (en) * 2016-09-08 2018-03-15 Emergo Therapeutics, Inc. Mast cell stabilizers for treatment of hypercytokinemia and viral infection
CN109803724A (en) 2016-10-07 2019-05-24 瑞思皮万特科学有限责任公司 For treating the Cromoglycic acid composition of pulmonary fibrosis
WO2018075574A1 (en) * 2016-10-18 2018-04-26 Emergo Therapeutics, Inc. Mast cell stabilizers for treatment of chronic inflammatory conditions
JP7173870B2 (en) * 2016-12-28 2022-11-16 中外製薬株式会社 Self-emulsifying formulations to improve membrane permeability of compounds
PE20211202A1 (en) 2017-08-24 2021-07-05 Novo Nordisk As COMPOSITIONS OF GLP-1 AND ITS USES
US20220387408A1 (en) 2019-11-12 2022-12-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mast cell stabilizer for the treatment of heart failure with preserved ejection fraction
WO2021144476A1 (en) 2020-02-18 2021-07-22 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH531000A (en) * 1970-03-11 1972-11-30 Sandoz Ag Process for the preparation of new benzocycloheptathiophenes
US4073915A (en) * 1975-05-20 1978-02-14 Sandoz Ltd. Treating asthma
NL8701335A (en) 1986-06-21 1988-01-18 Sandoz Ag ORAL PHARMACEUTICAL PREPARATIONS.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
AU7833698A (en) 1998-12-30
EP1014979A1 (en) 2000-07-05
US6207684B1 (en) 2001-03-27
WO1998056381A1 (en) 1998-12-17

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000315

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20030707

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31/4535 B

Ipc: 7A 61K 31/445 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040201