EP1012334A4 - Compositions et procedes permettant de determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux, et criblage de medicaments antiviraux - Google Patents

Compositions et procedes permettant de determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux, et criblage de medicaments antiviraux

Info

Publication number
EP1012334A4
EP1012334A4 EP98940779A EP98940779A EP1012334A4 EP 1012334 A4 EP1012334 A4 EP 1012334A4 EP 98940779 A EP98940779 A EP 98940779A EP 98940779 A EP98940779 A EP 98940779A EP 1012334 A4 EP1012334 A4 EP 1012334A4
Authority
EP
European Patent Office
Prior art keywords
viral drug
compositions
resistance
methods
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98940779A
Other languages
German (de)
English (en)
Other versions
EP1012334A1 (fr
Inventor
Daniel J Capon
Jeannette M Whitcomb
Neil T Parkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Virologic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virologic Inc filed Critical Virologic Inc
Publication of EP1012334A1 publication Critical patent/EP1012334A1/fr
Publication of EP1012334A4 publication Critical patent/EP1012334A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP98940779A 1997-07-30 1998-07-30 Compositions et procedes permettant de determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux, et criblage de medicaments antiviraux Withdrawn EP1012334A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90350797A 1997-07-30 1997-07-30
US903507 1997-07-30
PCT/US1998/015967 WO1999006597A1 (fr) 1997-07-30 1998-07-30 Compositions et procedes permettant de determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux, et criblage de medicaments antiviraux

Publications (2)

Publication Number Publication Date
EP1012334A1 EP1012334A1 (fr) 2000-06-28
EP1012334A4 true EP1012334A4 (fr) 2004-12-29

Family

ID=25417619

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98940779A Withdrawn EP1012334A4 (fr) 1997-07-30 1998-07-30 Compositions et procedes permettant de determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux, et criblage de medicaments antiviraux

Country Status (6)

Country Link
EP (1) EP1012334A4 (fr)
JP (1) JP2001512036A (fr)
KR (1) KR20010022420A (fr)
AU (1) AU8897698A (fr)
CA (1) CA2298102A1 (fr)
WO (1) WO1999006597A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
KR100537153B1 (ko) * 1996-01-29 2006-12-15 바이럴러직, 인코퍼레이티드 항바이러스약품감수성및내성그리고항바이러스약물의스크리닝을결정하는방법및조성물
US20030028011A1 (en) * 1997-07-30 2003-02-06 Parkin Neil T. Compositions and methods for determining susceptibility of hepatitis C virus to anti-viral drugs
WO2001007646A2 (fr) * 1999-07-21 2001-02-01 Martin Heinkelein Procede de quantification de l'effet antiviral de principes actifs antiviraux
DE60140211D1 (de) * 2000-06-08 2009-11-26 Virco Bvba Verfahren um die resistenz gegen ein therapeutisches agenz vorherzusagen unter verwendung neuronaler netze
AU2003218111B8 (en) * 2002-03-11 2008-11-20 Lab 21 Limited Methods and compositions for identifying and characterizing hepatitis C
EP1454988A1 (fr) * 2003-03-03 2004-09-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Pseudo-particules du flavivirus infectieuses contenant des protéines prM-E d'enveloppe
EP2527474A1 (fr) 2006-10-20 2012-11-28 Innogenetics N.V. Méthodologie d'analyse des variations de séquence dans la zone génomique HCV NS3/4A
US20090325145A1 (en) 2006-10-20 2009-12-31 Erwin Sablon Methodology for analysis of sequence variations within the hcv ns5b genomic region
CN104039984A (zh) * 2011-12-02 2014-09-10 美国控股实验室公司 用于hcv抑制剂抗性亚群表型检测的方法
CN113299340B (zh) * 2021-06-09 2023-06-30 四川大学华西医院 靶标试验药物的筛选方法、靶标试验药物筛选器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (fr) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Lignes de cellules humaines stables exprimant un produit de gène indicateur sous des contrôles génétiques specifiques à un virus
WO1994008002A2 (fr) * 1992-09-28 1994-04-14 Chiron Corporation Procedes et compositions de regulation de la translation de proteines hcv
WO1995022622A1 (fr) * 1994-02-18 1995-08-24 University Of Washington Procedes et compositions de criblage de medicaments anti-sida
WO1997027480A1 (fr) * 1996-01-26 1997-07-31 Virco N.V. Procede pour gerer la chimiotherapie de patients seropositifs vih sur la base de la sensibilite medicamenteuse phenotypique de souches humaines du vih
WO1997027319A1 (fr) * 1996-01-29 1997-07-31 Virologic, Inc. Compositions et procedes pour determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux et criblage de medicaments antiviraux

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (fr) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Lignes de cellules humaines stables exprimant un produit de gène indicateur sous des contrôles génétiques specifiques à un virus
WO1994008002A2 (fr) * 1992-09-28 1994-04-14 Chiron Corporation Procedes et compositions de regulation de la translation de proteines hcv
WO1995022622A1 (fr) * 1994-02-18 1995-08-24 University Of Washington Procedes et compositions de criblage de medicaments anti-sida
WO1997027480A1 (fr) * 1996-01-26 1997-07-31 Virco N.V. Procede pour gerer la chimiotherapie de patients seropositifs vih sur la base de la sensibilite medicamenteuse phenotypique de souches humaines du vih
WO1997027319A1 (fr) * 1996-01-29 1997-07-31 Virologic, Inc. Compositions et procedes pour determiner la sensibilite et la resistance vis-a-vis de medicaments antiviraux et criblage de medicaments antiviraux

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ENOMOTO N ET AL: "Hepatitis C virus quasispecies populations during chronic hepatitis C infection", TRENDS IN MICROBIOLOGY 1995 UNITED KINGDOM, vol. 3, no. 11, 1995, pages 445 - 447, XP002284841, ISSN: 0966-842X *
HAHM BUMSUK ET AL: "Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity", VIROLOGY, vol. 226, no. 2, 1996, pages 318 - 326, XP002284878, ISSN: 0042-6822 *
See also references of WO9906597A1 *
STRAIR R K ET AL: "RECOMBINANT RETROVIRAL SYSTEMS FOR THE ANALYSIS OF DRUG RESISTANT HIV", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 20, 1993, pages 4836 - 4842, XP002924448, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
KR20010022420A (ko) 2001-03-15
CA2298102A1 (fr) 1999-02-11
AU8897698A (en) 1999-02-22
EP1012334A1 (fr) 2000-06-28
WO1999006597A1 (fr) 1999-02-11
JP2001512036A (ja) 2001-08-21

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