EP1012172A4 - Acylated peptide cytolytic peptide inhibitors - Google Patents

Acylated peptide cytolytic peptide inhibitors

Info

Publication number
EP1012172A4
EP1012172A4 EP97934376A EP97934376A EP1012172A4 EP 1012172 A4 EP1012172 A4 EP 1012172A4 EP 97934376 A EP97934376 A EP 97934376A EP 97934376 A EP97934376 A EP 97934376A EP 1012172 A4 EP1012172 A4 EP 1012172A4
Authority
EP
European Patent Office
Prior art keywords
peptide
cytolytic
acylated
inhibitors
peptide inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97934376A
Other languages
German (de)
French (fr)
Other versions
EP1012172A1 (en
Inventor
Cyril Curtis Curtain
Barry Ross Matthews
Jonathan Bayldon Baell
Donald Edward Rivett
Dean Raymond Hewish
Jerome Werkmeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commonwealth Scientific and Industrial Research Organization CSIRO
Biomolecular Research Institute Ltd
Original Assignee
Commonwealth Scientific and Industrial Research Organization CSIRO
Biomolecular Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commonwealth Scientific and Industrial Research Organization CSIRO, Biomolecular Research Institute Ltd filed Critical Commonwealth Scientific and Industrial Research Organization CSIRO
Publication of EP1012172A4 publication Critical patent/EP1012172A4/en
Publication of EP1012172A1 publication Critical patent/EP1012172A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97934376A 1996-08-13 1997-08-13 Acylated peptide cytolytic peptide inhibitors Withdrawn EP1012172A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPO1611A AUPO161196A0 (en) 1996-08-13 1996-08-13 Novel compounds
AUPO161196 1996-08-13
PCT/AU1997/000511 WO1998006743A1 (en) 1996-08-13 1997-08-13 Acylated peptide cytolytic peptide inhibitors

Publications (2)

Publication Number Publication Date
EP1012172A4 true EP1012172A4 (en) 2000-06-28
EP1012172A1 EP1012172A1 (en) 2000-06-28

Family

ID=3795925

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97934376A Withdrawn EP1012172A1 (en) 1996-08-13 1997-08-13 Acylated peptide cytolytic peptide inhibitors

Country Status (5)

Country Link
EP (1) EP1012172A1 (en)
JP (1) JP2001505541A (en)
AU (1) AUPO161196A0 (en)
CA (1) CA2263789A1 (en)
WO (1) WO1998006743A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2959992A1 (en) * 2010-05-11 2011-11-18 Univ Claude Bernard Lyon PEPTIDES WITH ANTIPROTEASE ACTIVITY

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2659114A1 (en) * 1976-12-28 1978-07-06 Troponwerke Gmbh & Co Kg Dehydro-oligopeptide cpds. - useful for treatment of tumours
CA1141374A (en) * 1978-07-03 1983-02-15 Charles H. Stammer Preparation of dehydropeptides
FR2482961A2 (en) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Merrifield synthesis of immunostimulant tetra- and penta-peptide(s) - acylated with fatty acid gps. e.g. N-alpha N,N-hexanoyl-L-alanyl gamma-D-glutamyl N-epsilon-glycyl-L-lysine
FR2460290A1 (en) * 1979-06-29 1981-01-23 Rhone Poulenc Ind NOVEL TETRA- OR PENTAPEPTIDES, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM
FR2482958A2 (en) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Immunostimulant and adjuvant L-alanyl-D-glutamyl tri:peptide derivs. - in which the C-terminal aminoacid is l-lysine or di:amino-pimelic acid and which has a fatty acid n-acyl gp.
DK156252C (en) * 1979-07-31 1989-12-18 Fujisawa Pharmaceutical Co METHOD OF ANALOGUE FOR THE PREPARATION OF DI, TRIAL OR TETRAPEPTIDE DERIVATIVES OR SALTS THEREOF
US4283328A (en) * 1979-10-01 1981-08-11 Research Corporation Preparation of dehydropeptides
FR2496654A1 (en) * 1980-12-19 1982-06-25 Rhone Poulenc Sante NOVEL TRI-, TETRA- AND PENTAPEPTIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING SAME
JPS5821645A (en) * 1981-07-29 1983-02-08 Komatsu Seiren Kk Recovery of terephthalic acid
JPS59172445A (en) * 1983-03-19 1984-09-29 Fujisawa Pharmaceut Co Ltd Glutamic acid-containing peptide
US4584284A (en) * 1985-01-31 1986-04-22 Ortho Pharmaceutical Corporation Bursopoietin
ES8702436A1 (en) * 1986-02-11 1986-12-16 Consejo Superior Investigacion Ionic surfactant prepn.
ES2020148A6 (en) * 1990-06-07 1991-07-16 Consejo Superior Investigacion Procedure for the synthesis of dipeptides from fatty chain N-[alpha]-acyl arginine and pure amino acids as ionic surfactants with antimicrobial action
ATE128984T1 (en) * 1990-07-12 1995-10-15 Degussa NEW N-ACYLDIPEPTIDES AND THEIR USE.
YU183090A (en) * 1990-09-27 1992-12-21 Lek NEW N-ACYLDIPEPTIDES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE69130831T2 (en) * 1990-11-21 1999-09-16 Iterex Pharmaceuticals Ltd. Partnership, San Diego SYNTHESIS OF EQUIMOLAR MIXTURES OF VARIOUS OLIGOMERS, SPECIALLY OLIGOPEPTIDE MIXTURES
EP0500332B1 (en) * 1991-02-19 1998-05-27 National Food Research Institute Ministry Of Agriculture, Forestry And Fisheries Novel acylamino acid compounds and a method for their production
CA2108754A1 (en) * 1991-05-16 1992-11-17 Wayne L. Cody Endothelin antagonists
JPH05208914A (en) * 1991-09-03 1993-08-20 Fujisawa Pharmaceut Co Ltd Medicinal composition containing peptide compound
WO1994003485A1 (en) * 1992-07-29 1994-02-17 Merrell Dow Pharmaceuticals Inc. Peptide lung surfactants and therapeutic combinations
EP0604945A1 (en) * 1992-12-28 1994-07-06 Takeda Chemical Industries, Ltd. TAN-1511, its derivatives, production and use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J., vol. 316, no. 2, 1996, pages 525 - 529 *
CHEMICAL ABSTRACTS, vol. 125, no. 11, 9 September 1996, Columbus, Ohio, US; abstract no. 135159, D HEWISH ET AL.: "Peptide inhibitors of melittin action" XP002129820 *
CHEMICAL ABSTRACTS, vol. 125, no. 5, 29 July 1996, Columbus, Ohio, US; abstract no. 51227, D E RIVETT ET AL.: "Dimerization of truncated melittin analogs results in cytolytic peptides" XP002129821 *
J. PROT. CHEM., vol. 15, no. 4, 1996, pages 395 - 403 *
See also references of WO9806743A1 *

Also Published As

Publication number Publication date
CA2263789A1 (en) 1998-02-19
WO1998006743A1 (en) 1998-02-19
AUPO161196A0 (en) 1996-09-05
JP2001505541A (en) 2001-04-24
EP1012172A1 (en) 2000-06-28

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Legal Events

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