EP1012172A4 - Acylierte peptide als inhibitoren für cytolytische peptide - Google Patents

Acylierte peptide als inhibitoren für cytolytische peptide

Info

Publication number
EP1012172A4
EP1012172A4 EP97934376A EP97934376A EP1012172A4 EP 1012172 A4 EP1012172 A4 EP 1012172A4 EP 97934376 A EP97934376 A EP 97934376A EP 97934376 A EP97934376 A EP 97934376A EP 1012172 A4 EP1012172 A4 EP 1012172A4
Authority
EP
European Patent Office
Prior art keywords
peptide
cytolytic
acylated
inhibitors
peptide inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97934376A
Other languages
English (en)
French (fr)
Other versions
EP1012172A1 (de
Inventor
Cyril Curtis Curtain
Barry Ross Matthews
Jonathan Bayldon Baell
Donald Edward Rivett
Dean Raymond Hewish
Jerome Werkmeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commonwealth Scientific and Industrial Research Organization CSIRO
Biomolecular Research Institute Ltd
Original Assignee
Commonwealth Scientific and Industrial Research Organization CSIRO
Biomolecular Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commonwealth Scientific and Industrial Research Organization CSIRO, Biomolecular Research Institute Ltd filed Critical Commonwealth Scientific and Industrial Research Organization CSIRO
Publication of EP1012172A4 publication Critical patent/EP1012172A4/de
Publication of EP1012172A1 publication Critical patent/EP1012172A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97934376A 1996-08-13 1997-08-13 Acylierte peptide als inhibitoren für cytolytische peptide Withdrawn EP1012172A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPO1611A AUPO161196A0 (en) 1996-08-13 1996-08-13 Novel compounds
AUPO161196 1996-08-13
PCT/AU1997/000511 WO1998006743A1 (en) 1996-08-13 1997-08-13 Acylated peptide cytolytic peptide inhibitors

Publications (2)

Publication Number Publication Date
EP1012172A4 true EP1012172A4 (de) 2000-06-28
EP1012172A1 EP1012172A1 (de) 2000-06-28

Family

ID=3795925

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97934376A Withdrawn EP1012172A1 (de) 1996-08-13 1997-08-13 Acylierte peptide als inhibitoren für cytolytische peptide

Country Status (5)

Country Link
EP (1) EP1012172A1 (de)
JP (1) JP2001505541A (de)
AU (1) AUPO161196A0 (de)
CA (1) CA2263789A1 (de)
WO (1) WO1998006743A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2959992A1 (fr) * 2010-05-11 2011-11-18 Univ Claude Bernard Lyon Peptides a activite antiproteasique

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2659114A1 (de) * 1976-12-28 1978-07-06 Troponwerke Gmbh & Co Kg Neue dehydrooligopeptide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CA1141374A (en) * 1978-07-03 1983-02-15 Charles H. Stammer Preparation of dehydropeptides
FR2482961A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
FR2482958A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux tripeptides, leur preparation et les medicaments qui les contiennent
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
DK156252C (da) * 1979-07-31 1989-12-18 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af di-, tri- eller tetrapeptidderivater eller salte deraf
US4283328A (en) * 1979-10-01 1981-08-11 Research Corporation Preparation of dehydropeptides
FR2496654A1 (fr) * 1980-12-19 1982-06-25 Rhone Poulenc Sante Nouveaux tri-, tetra- et pentapeptides, leur preparation et les medicaments qui les contiennent
JPS5821645A (ja) * 1981-07-29 1983-02-08 Komatsu Seiren Kk テレフタル酸の回収方法
JPS59172445A (ja) * 1983-03-19 1984-09-29 Fujisawa Pharmaceut Co Ltd グルタミン酸含有ペプタイド
US4584284A (en) * 1985-01-31 1986-04-22 Ortho Pharmaceutical Corporation Bursopoietin
ES8702436A1 (es) * 1986-02-11 1986-12-16 Consejo Superior Investigacion Procedimiento para la sintesis de dipeptidos de n elevado a alfa-acil arginina de cadena grasa e hidrolizados de proteina como tensioactivos ionicos de accion antimicrobiana
ES2020148A6 (es) * 1990-06-07 1991-07-16 Consejo Superior Investigacion Procedimiento para la sintesis de dipeptidos de n-alfa-acil arginina de cadena grasa y amino-acidos puros como tensioactivos ionicos de accion antimicrobiana.
DE59106648D1 (de) * 1990-07-12 1995-11-16 Degussa Neue N-Acyldipeptide und deren Verwendung.
YU183090A (sh) * 1990-09-27 1992-12-21 Lek Novi n-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, kojih vsebujejo
JP3523252B2 (ja) * 1990-11-21 2004-04-26 ホウテン ファーマシューティカルズ インコーポレイテッド 等モル多種オリゴマー混合物、特にオリゴペプチド混合物の合成
EP0500332B1 (de) * 1991-02-19 1998-05-27 National Food Research Institute Ministry Of Agriculture, Forestry And Fisheries Acylaminosäure-Verbindungen und Verfahren zu ihrer Herstellung
ES2151888T3 (es) * 1991-05-16 2001-01-16 Warner Lambert Co Antagonistas de la endotelina.
JPH05208914A (ja) * 1991-09-03 1993-08-20 Fujisawa Pharmaceut Co Ltd ペプチド化合物を含有する医薬組成物
AU671850B2 (en) * 1992-07-29 1996-09-12 Merrell Dow Pharmaceuticals Inc. Peptide lung surfactants and therapeutic combinations
EP0604945A1 (de) * 1992-12-28 1994-07-06 Takeda Chemical Industries, Ltd. TAN-1511, Derivate, Herstellung und Verwendung

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J., vol. 316, no. 2, 1996, pages 525 - 529 *
CHEMICAL ABSTRACTS, vol. 125, no. 11, 9 September 1996, Columbus, Ohio, US; abstract no. 135159, D HEWISH ET AL.: "Peptide inhibitors of melittin action" XP002129820 *
CHEMICAL ABSTRACTS, vol. 125, no. 5, 29 July 1996, Columbus, Ohio, US; abstract no. 51227, D E RIVETT ET AL.: "Dimerization of truncated melittin analogs results in cytolytic peptides" XP002129821 *
J. PROT. CHEM., vol. 15, no. 4, 1996, pages 395 - 403 *
See also references of WO9806743A1 *

Also Published As

Publication number Publication date
WO1998006743A1 (en) 1998-02-19
CA2263789A1 (en) 1998-02-19
AUPO161196A0 (en) 1996-09-05
JP2001505541A (ja) 2001-04-24
EP1012172A1 (de) 2000-06-28

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