EP1008354A4 - Immediately disintegrable medicinal compositions - Google Patents

Immediately disintegrable medicinal compositions

Info

Publication number
EP1008354A4
EP1008354A4 EP97950375A EP97950375A EP1008354A4 EP 1008354 A4 EP1008354 A4 EP 1008354A4 EP 97950375 A EP97950375 A EP 97950375A EP 97950375 A EP97950375 A EP 97950375A EP 1008354 A4 EP1008354 A4 EP 1008354A4
Authority
EP
European Patent Office
Prior art keywords
medicinal compositions
immediately disintegrable
disintegrable
immediately
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97950375A
Other languages
German (de)
French (fr)
Other versions
EP1008354A1 (en
EP1008354B1 (en
Inventor
Hirokazu Takagi
Atsushi Kajiyama
Masahiro Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Priority to EP06023230A priority Critical patent/EP1759712A2/en
Publication of EP1008354A1 publication Critical patent/EP1008354A1/en
Publication of EP1008354A4 publication Critical patent/EP1008354A4/en
Application granted granted Critical
Publication of EP1008354B1 publication Critical patent/EP1008354B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97950375A 1996-12-25 1997-12-24 Immediately disintegrable medicinal compositions Expired - Lifetime EP1008354B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06023230A EP1759712A2 (en) 1996-12-25 1997-12-24 Rapidly disintegrable pharmaceutical composition

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34476896 1996-12-25
JP34476896 1996-12-25
PCT/JP1997/004788 WO1998029137A1 (en) 1996-12-25 1997-12-24 Immediately disintegrable medicinal compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP06023230A Division EP1759712A2 (en) 1996-12-25 1997-12-24 Rapidly disintegrable pharmaceutical composition

Publications (3)

Publication Number Publication Date
EP1008354A1 EP1008354A1 (en) 2000-06-14
EP1008354A4 true EP1008354A4 (en) 2006-02-01
EP1008354B1 EP1008354B1 (en) 2008-06-04

Family

ID=18371833

Family Applications (2)

Application Number Title Priority Date Filing Date
EP97950375A Expired - Lifetime EP1008354B1 (en) 1996-12-25 1997-12-24 Immediately disintegrable medicinal compositions
EP06023230A Withdrawn EP1759712A2 (en) 1996-12-25 1997-12-24 Rapidly disintegrable pharmaceutical composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP06023230A Withdrawn EP1759712A2 (en) 1996-12-25 1997-12-24 Rapidly disintegrable pharmaceutical composition

Country Status (14)

Country Link
US (4) US20020031547A1 (en)
EP (2) EP1008354B1 (en)
JP (1) JP3988193B2 (en)
KR (1) KR100534504B1 (en)
CN (1) CN1132635C (en)
AR (1) AR009438A1 (en)
AT (1) ATE397459T1 (en)
AU (1) AU5339798A (en)
CA (1) CA2272586C (en)
DE (1) DE69738755D1 (en)
ES (1) ES2307303T3 (en)
TW (1) TW486370B (en)
WO (1) WO1998029137A1 (en)
ZA (1) ZA9711508B (en)

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TW486370B (en) * 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
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DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
EP1334720B1 (en) * 2000-10-24 2008-09-03 Ajinomoto Co., Inc. Nateglinide-containing preparations
EP1275377B1 (en) * 2001-07-11 2003-06-18 Apr Applied Pharma Research S.A. Granulates containing liposoluble substances and process of preparation thereof
JP2005517690A (en) 2002-02-01 2005-06-16 ファイザー・プロダクツ・インク Immediate release dosage form containing solid drug dispersion
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
DK1683524T3 (en) * 2003-11-14 2011-03-14 Ajinomoto Kk Solid-form dispersion or phenyalanine derivative solid form medical preparation
AU2005247048B2 (en) * 2004-05-28 2007-12-13 Imaginot Pty Ltd Oral therapeutic compound delivery system
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
US20080031825A1 (en) * 2004-08-20 2008-02-07 Yisheng Chen Pharmaceutical Compositions Comprising Effervescent Agents And Fenofibrate
DE102005026755A1 (en) * 2005-06-09 2006-12-14 Basf Ag Production of solid solutions of sparingly soluble active ingredients by short-term overheating and rapid drying
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WO2007026864A1 (en) * 2005-09-01 2007-03-08 Eisai R & D Management Co., Ltd. Method for preparation of pharmaceutical composition having improved disintegradability
AU2006317530B2 (en) * 2005-11-28 2011-09-01 Imaginot Pty Ltd Oral therapeutic compound delivery system
WO2007115305A2 (en) 2006-04-04 2007-10-11 Cogentus Pharmaceuticals, Inc. Oral dosage forms including an antiplatelet agent and an acid inhibitor
JP2007308479A (en) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd Solid-dispersed substance preparation
US20080132560A1 (en) * 2006-11-21 2008-06-05 San-Laung Chow Solid dispersion composition
WO2009123169A1 (en) * 2008-04-02 2009-10-08 アステラス製薬株式会社 Amide derivative-containing pharmaceutical composition
DE102009013611A1 (en) * 2009-03-17 2010-09-23 Ratiopharm Gmbh Solid retigabine in non-crystalline form
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
WO2010113324A1 (en) * 2009-04-03 2010-10-07 日医工ファーマ株式会社 Pectin-containing jelly preparation
CN101810563B (en) * 2009-09-25 2012-04-25 宋洪涛 Tacrolimus ophthalmic in-situ gel preparation and preparation method thereof
WO2011062202A1 (en) * 2009-11-19 2011-05-26 日本曹達株式会社 Reduction treatment method for ballast water
TWI564008B (en) 2010-09-30 2017-01-01 鹽野義製藥股份有限公司 Formulation for solubility enhancement of poorly soluble drugs
CN103313703A (en) * 2010-12-27 2013-09-18 富田制药株式会社 Decay-type nuclear particle for pharmaceutical formulation
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US20140024723A1 (en) * 2012-07-17 2014-01-23 Dow Global Technologies Llc Composition comprising an organic liquid diluent and a specific hydroxypropyl methylcellulose
HUE057701T2 (en) 2012-09-11 2022-05-28 Medivation Prostate Therapeutics Llc Formulations of enzalutamide
MX2015004979A (en) 2012-12-21 2015-07-17 Eisai R&D Man Co Ltd Amorphous form of quinoline derivative, and method for producing same.
ES2687968T3 (en) 2013-05-14 2018-10-30 Eisai R&D Management Co., Ltd. Biomarkers to predict and evaluate the reactivity of subjects with endometrial cancer to compounds with lenvatinib
US20160346198A1 (en) * 2014-02-05 2016-12-01 Merck Sharp & Dohme Corp. Novel disintegration systems for pharmaceutical dosage forms
RU2696578C1 (en) 2014-02-05 2019-08-05 Мерк Шарп И Доум Корп. Tablets preparation technology for cgrp-active compounds
TW201613579A (en) 2014-06-24 2016-04-16 Astellas Pharma Inc Pharmaceutical composition for oral administration
BR112017002827B1 (en) 2014-08-28 2023-04-18 Eisai R&D Management Co., Ltd HIGHLY PURE QUINOLINE DERIVATIVE AND METHOD FOR PRODUCING THE SAME
JP6650933B2 (en) 2014-10-31 2020-02-19 ベンド リサーチ， インコーポレイテッド Process for forming active drug domains dispersed in a matrix
MX2017010474A (en) 2015-02-25 2017-11-28 Eisai R&D Man Co Ltd Method for suppressing bitterness of quinoline derivative.
KR20240064733A (en) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
JP6680297B2 (en) * 2015-04-28 2020-04-15 アステラス製薬株式会社 Pharmaceutical composition for oral administration
SG11201710198YA (en) 2015-06-16 2018-01-30 Eisai R&D Man Co Ltd Anticancer agent
CA3036011A1 (en) 2016-08-20 2018-03-01 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
EP3705118B1 (en) 2017-10-31 2024-02-14 Samyang Holdings Corporation Oral solid dosage form composition having improved disintegration and preparation method therefor
WO2019172420A1 (en) * 2018-03-09 2019-09-12 協和発酵キリン株式会社 Pharmaceutical composition
WO2020027011A1 (en) * 2018-07-30 2020-02-06 中外製薬株式会社 Solid dispersion of hydantoin derivative
US12049584B2 (en) * 2019-03-18 2024-07-30 Sabine Zureikat Composition and method for producing the sensory stimulant
WO2020234448A1 (en) 2019-05-23 2020-11-26 Helm Ag Nanoparticles comprising enzalutamide
IL295007A (en) 2020-01-31 2022-09-01 Nanocopoeia Llc Amorphous nilotinib microparticles and uses thereof
EP4142699A1 (en) 2020-04-30 2023-03-08 Nanocopoeia LLC Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib

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US4673564A (en) * 1979-07-05 1987-06-16 Yamanouchi Pharmaceutical Co., Ltd. Sustained release pharmaceutical composition of solid medical material
US5091191A (en) * 1988-02-03 1992-02-25 Yoshitomi Pharmaceutical Industries, Ltd. Pharmaceutical composition with improved dissolution property
JPH08231403A (en) * 1995-02-27 1996-09-10 Yamanouchi Pharmaceut Co Ltd Stable aqueous solution containing arginine vasopressin antagonist

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US5091191A (en) * 1988-02-03 1992-02-25 Yoshitomi Pharmaceutical Industries, Ltd. Pharmaceutical composition with improved dissolution property
JPH08231403A (en) * 1995-02-27 1996-09-10 Yamanouchi Pharmaceut Co Ltd Stable aqueous solution containing arginine vasopressin antagonist

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Also Published As

Publication number Publication date
EP1008354A1 (en) 2000-06-14
WO1998029137A1 (en) 1998-07-09
KR20000062327A (en) 2000-10-25
TW486370B (en) 2002-05-11
EP1008354B1 (en) 2008-06-04
CA2272586C (en) 2005-11-22
US20070014856A1 (en) 2007-01-18
US20050095289A1 (en) 2005-05-05
CN1132635C (en) 2003-12-31
ATE397459T1 (en) 2008-06-15
EP1759712A2 (en) 2007-03-07
CN1241946A (en) 2000-01-19
US20020031547A1 (en) 2002-03-14
DE69738755D1 (en) 2008-07-17
JP3988193B2 (en) 2007-10-10
ES2307303T3 (en) 2008-11-16
ZA9711508B (en) 1998-06-24
US6899899B2 (en) 2005-05-31
AU5339798A (en) 1998-07-31
US20030003146A1 (en) 2003-01-02
KR100534504B1 (en) 2005-12-08
US7189415B2 (en) 2007-03-13
AR009438A1 (en) 2000-04-12
CA2272586A1 (en) 1998-07-09

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