EP1003516A4 - Verfahren zur verabreichung von camptothecin verbindungen zur krebsbehandlung mit verringerten nebenwirkungen - Google Patents
Verfahren zur verabreichung von camptothecin verbindungen zur krebsbehandlung mit verringerten nebenwirkungenInfo
- Publication number
- EP1003516A4 EP1003516A4 EP99935334A EP99935334A EP1003516A4 EP 1003516 A4 EP1003516 A4 EP 1003516A4 EP 99935334 A EP99935334 A EP 99935334A EP 99935334 A EP99935334 A EP 99935334A EP 1003516 A4 EP1003516 A4 EP 1003516A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cancer
- treatment
- methods
- side effects
- reduced side
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8978198P | 1998-06-18 | 1998-06-18 | |
US89781P | 1998-06-18 | ||
PCT/US1999/013906 WO1999065493A1 (en) | 1998-06-18 | 1999-06-18 | Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1003516A1 EP1003516A1 (de) | 2000-05-31 |
EP1003516A4 true EP1003516A4 (de) | 2006-07-12 |
Family
ID=22219554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99935334A Withdrawn EP1003516A4 (de) | 1998-06-18 | 1999-06-18 | Verfahren zur verabreichung von camptothecin verbindungen zur krebsbehandlung mit verringerten nebenwirkungen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003516A4 (de) |
JP (1) | JP2002518332A (de) |
CN (1) | CN1325305A (de) |
AU (1) | AU764370B2 (de) |
CA (1) | CA2300892A1 (de) |
IL (1) | IL134592A0 (de) |
WO (1) | WO1999065493A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999065493A1 (en) * | 1998-06-18 | 1999-12-23 | The George Washington University | Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects |
WO2000069390A2 (en) | 1999-05-17 | 2000-11-23 | Cancer Research Ventures Limited | Compositions for improving bioavailability of orally administered drugs |
CA2295429A1 (en) * | 2000-01-06 | 2001-07-06 | Michael Michael | Treatment or prevention of diarrhea |
EP1372571A4 (de) * | 2001-03-20 | 2006-06-07 | New Century Pharmaceuticals | Methode und zubereitungen zur optimierung von blut- und gewebe-stabilität von camptothecin und anderen albumin-bindenden wirkstoffen |
WO2007113687A2 (en) | 2006-03-30 | 2007-10-11 | Diatos S.A. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
CA2683109A1 (en) * | 2006-10-11 | 2008-04-17 | Fusion Antibodies Limited | Combination therapy |
US20170246190A1 (en) * | 2014-10-21 | 2017-08-31 | Johnpro Biotech Inc. | Methods and formulation for improving oral availability of cpt-11 while reducing cpt-11 induced gastrointestinal toxicity in cancer therapy |
KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
CN107281462A (zh) * | 2017-08-21 | 2017-10-24 | 滨州医学院 | 沙奎拉韦减轻伊立替康毒性的医药新用途 |
US11000540B1 (en) * | 2019-11-22 | 2021-05-11 | Al Siamon | Treatment for reducing adverse events including chemotherapy discomfort and other conditions |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4294819A (en) * | 1980-08-18 | 1981-10-13 | Bristol-Myers Company | Alkaline analgesic capsule |
JPH02270822A (ja) * | 1989-02-07 | 1990-11-05 | Duphar Internatl Res Bv | 経口再水和溶液調製用の発泡製品 |
EP0524579A1 (de) * | 1991-07-22 | 1993-01-27 | Bristol-Myers Squibb Company | Verbesserte und dosierte orale Formulierungen von Dideoxypurinenukleosiden |
WO1994028911A1 (en) * | 1993-06-08 | 1994-12-22 | Farmaceutisk Laboratorium Ferring A/S | COMPOSITIONS FOR USE IN THE REGULATION OF SUBNORMAL pH VALUES IN THE INTESTINAL TRACT AND FOR TREATMENT OF BOWEL DISEASES |
WO1996006635A1 (en) * | 1994-08-31 | 1996-03-07 | Cortecs Limited | Pharmaceutical compositions containing a bile salt and a buffer for increased bioavailability of an active compound |
WO1996011005A2 (en) * | 1994-10-06 | 1996-04-18 | Atlas Leon T | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
JPH10201821A (ja) * | 1997-01-23 | 1998-08-04 | Material Eng Tech Lab Inc | 医療用容器 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3894029A (en) * | 1971-08-26 | 1975-07-08 | Basf Ag | Production of camptothecin and camptothecin-like compounds |
US5552156A (en) * | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
WO1999065493A1 (en) * | 1998-06-18 | 1999-12-23 | The George Washington University | Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects |
-
1999
- 1999-06-18 WO PCT/US1999/013906 patent/WO1999065493A1/en not_active Application Discontinuation
- 1999-06-18 EP EP99935334A patent/EP1003516A4/de not_active Withdrawn
- 1999-06-18 JP JP2000554373A patent/JP2002518332A/ja active Pending
- 1999-06-18 CA CA002300892A patent/CA2300892A1/en not_active Abandoned
- 1999-06-18 IL IL13459299A patent/IL134592A0/xx not_active IP Right Cessation
- 1999-06-18 AU AU50833/99A patent/AU764370B2/en not_active Ceased
- 1999-06-18 CN CN99801114A patent/CN1325305A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4294819A (en) * | 1980-08-18 | 1981-10-13 | Bristol-Myers Company | Alkaline analgesic capsule |
JPH02270822A (ja) * | 1989-02-07 | 1990-11-05 | Duphar Internatl Res Bv | 経口再水和溶液調製用の発泡製品 |
EP0524579A1 (de) * | 1991-07-22 | 1993-01-27 | Bristol-Myers Squibb Company | Verbesserte und dosierte orale Formulierungen von Dideoxypurinenukleosiden |
WO1994028911A1 (en) * | 1993-06-08 | 1994-12-22 | Farmaceutisk Laboratorium Ferring A/S | COMPOSITIONS FOR USE IN THE REGULATION OF SUBNORMAL pH VALUES IN THE INTESTINAL TRACT AND FOR TREATMENT OF BOWEL DISEASES |
WO1996006635A1 (en) * | 1994-08-31 | 1996-03-07 | Cortecs Limited | Pharmaceutical compositions containing a bile salt and a buffer for increased bioavailability of an active compound |
WO1996011005A2 (en) * | 1994-10-06 | 1996-04-18 | Atlas Leon T | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
JPH10201821A (ja) * | 1997-01-23 | 1998-08-04 | Material Eng Tech Lab Inc | 医療用容器 |
Non-Patent Citations (11)
Title |
---|
ARAKI E ET AL: "RELATIONSHIP BETWEEN DEVELOPMENT OF DIARRHEA AND THE CONCENTRATION OF SN-38, AN ACTIVE METABOLITE OF CPT-11, IN THE INTESTINE AND THE BLOOD PLASMA OF ATHYMIC MICE FOLLOWING INTRAPERITONEAL ADMINISTRATION OF CPT-11", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 84, no. 6, June 1993 (1993-06-01), pages 697 - 702, XP008059720, ISSN: 0910-5050 * |
ATSUMI R ET AL: "METABOLISM OF IRINOTECAN TO SN-38 IN A TISSUE-ISOLATED TUMOR MODEL", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 18, no. 7, July 1995 (1995-07-01), pages 1024 - 1026, XP008059867, ISSN: 0918-6158 * |
HERBEN V M M ET AL: "CLINICAL PHARMACOKINETICS OF TOPOTECAN", CLINICAL PHARMACOKINETICS, LEA & FEBIGER, PHILADELPHIA, PA, US, vol. 31, no. 2, 1996, pages 85 - 102, XP000874360 * |
KOBAYASGI K. ET AL.: "Reduced Irinotecan-induced side-effects by the oral Alkalinization", PROC. AM. SOC. CLIN. ONCOL., vol. 18, no. 35, 15 May 1999 (1999-05-15), 35th annual meeting of ASCO, pages 492A, XP002370825 * |
KOBAYASHI K ET AL: "UPTAKE MECHANISM OF IRINOTECAN (CPT-11) AND ITS METABOLITE (SN-38) BY HAMSTER INTESTINAL CELLS", GASTROENTEROLOGY, SAUNDERS, PHILADELPHIA, PA,, US, vol. 114, no. 4, 15 April 1998 (1998-04-15), pages A626 - A627, XP008059718, ISSN: 0016-5085 * |
MATSUZAKI Y ET AL: "CELLULAR UPTAKE AND TOXICITY OF IRINOTECAN AND ITS ACTIVE METABOLITE, SN-38 IN HAMSTER INTESTINE AND HUMAN COLON CANCER CELLS", GASTROENTEROLOGY, SAUNDERS, PHILADELPHIA, PA,, US, vol. 116, no. 4, PART 2, April 1999 (1999-04-01), pages A906,ABSTRNOG3940, XP008059942, ISSN: 0016-5085 * |
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 13 30 November 1998 (1998-11-30) * |
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 06 31 March 1999 (1999-03-31) * |
SCHELLENS J H M ET AL: "PHARMACOKINETICS (PK), CLINICAL PHARMACODYNAMICS (PD), AND SAFETY OF CHRONIC ORAL TOPOTECAN (T), IN A PHASE STUDY", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 31, no. 6, 1 November 1995 (1995-11-01), pages S192,ABSTRNO926, XP008059770, ISSN: 0959-8049 * |
SCOTT D O ET AL: "URINARY AND BILIARY DISPOSITION OF THE LACTONE AND CARBOXYLATE FORMS OF 20(S)-CAMPTOTHECIN IN RATS", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS., BALTIMORE, MD, US, vol. 22, no. 3, May 1994 (1994-05-01), pages 438 - 442, XP008059680, ISSN: 0090-9556 * |
See also references of WO9965493A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999065493A1 (en) | 1999-12-23 |
AU764370B2 (en) | 2003-08-14 |
IL134592A0 (en) | 2001-04-30 |
CA2300892A1 (en) | 1999-12-23 |
JP2002518332A (ja) | 2002-06-25 |
WO1999065493A9 (en) | 2000-03-23 |
AU5083399A (en) | 2000-01-05 |
CN1325305A (zh) | 2001-12-05 |
EP1003516A1 (de) | 2000-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE FR GB NL |
|
17P | Request for examination filed |
Effective date: 20000320 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060612 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20060912 |