EP0989852A4 - Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs - Google Patents

Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs

Info

Publication number
EP0989852A4
EP0989852A4 EP98904548A EP98904548A EP0989852A4 EP 0989852 A4 EP0989852 A4 EP 0989852A4 EP 98904548 A EP98904548 A EP 98904548A EP 98904548 A EP98904548 A EP 98904548A EP 0989852 A4 EP0989852 A4 EP 0989852A4
Authority
EP
European Patent Office
Prior art keywords
cholesterol lowering
treating atherosclerosis
lowering drugs
mpt
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98904548A
Other languages
German (de)
French (fr)
Other versions
EP0989852A1 (en
Inventor
Bruce D Behounek
Mark E Mcgovern
Rene Belder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP0989852A1 publication Critical patent/EP0989852A1/en
Publication of EP0989852A4 publication Critical patent/EP0989852A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
EP98904548A 1997-01-17 1998-01-12 Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs Withdrawn EP0989852A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3559297P 1997-01-17 1997-01-17
US35592P 1997-01-17
PCT/US1998/000524 WO1998031366A1 (en) 1997-01-17 1998-01-12 Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs

Publications (2)

Publication Number Publication Date
EP0989852A1 EP0989852A1 (en) 2000-04-05
EP0989852A4 true EP0989852A4 (en) 2002-11-13

Family

ID=21883624

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98904548A Withdrawn EP0989852A4 (en) 1997-01-17 1998-01-12 Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs

Country Status (5)

Country Link
EP (1) EP0989852A4 (en)
JP (1) JP2001508795A (en)
AU (1) AU727895B2 (en)
CA (1) CA2276467A1 (en)
WO (1) WO1998031366A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001517617A (en) * 1997-09-24 2001-10-09 ノヴァ モレキュラー インク． Methods for increasing APOE levels for the treatment of neurodegenerative diseases
WO1999063929A2 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
SE9902987D0 (en) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
DE10030375A1 (en) * 2000-06-21 2002-01-03 Bayer Ag Use of MTP inhibitors to lower ppTRL
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (en) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
SE0301369D0 (en) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
DK1725234T4 (en) 2004-03-05 2016-05-09 Univ Pennsylvania METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
WO2007047724A2 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Compositions for lowering serum cholesterol and/or triglycerides
CN111187200A (en) * 2020-04-09 2020-05-22 南京昊绿生物科技有限公司 Synthesis method of lomitapide-D8

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0584446A2 (en) * 1992-03-06 1994-03-02 E.R. SQUIBB & SONS, INC. Microsomal triglyceride transfer protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
MX7065E (en) * 1980-06-06 1987-04-10 Sankyo Co A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0584446A2 (en) * 1992-03-06 1994-03-02 E.R. SQUIBB & SONS, INC. Microsomal triglyceride transfer protein

Also Published As

Publication number Publication date
JP2001508795A (en) 2001-07-03
AU727895B2 (en) 2001-01-04
EP0989852A1 (en) 2000-04-05
AU6239798A (en) 1998-08-07
WO1998031366A1 (en) 1998-07-23
CA2276467A1 (en) 1998-07-23

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