EP0977595A4 - Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers - Google Patents

Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers

Info

Publication number
EP0977595A4
EP0977595A4 EP97925747A EP97925747A EP0977595A4 EP 0977595 A4 EP0977595 A4 EP 0977595A4 EP 97925747 A EP97925747 A EP 97925747A EP 97925747 A EP97925747 A EP 97925747A EP 0977595 A4 EP0977595 A4 EP 0977595A4
Authority
EP
European Patent Office
Prior art keywords
graft
versus
prevention
polynucleotides encoding
host disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97925747A
Other languages
German (de)
French (fr)
Other versions
EP0977595A1 (en
Inventor
Nikhil Munshi
David L Ennist
William F Jacob
Yawen L Chiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Therapy Inc
Original Assignee
Genetic Therapy Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Therapy Inc filed Critical Genetic Therapy Inc
Publication of EP0977595A1 publication Critical patent/EP0977595A1/en
Publication of EP0977595A4 publication Critical patent/EP0977595A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97925747A 1996-05-31 1997-05-28 Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers Withdrawn EP0977595A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65645196A 1996-05-31 1996-05-31
US656451 1996-05-31
PCT/US1997/009040 WO1997045142A1 (en) 1996-05-31 1997-05-28 Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers

Publications (2)

Publication Number Publication Date
EP0977595A1 EP0977595A1 (en) 2000-02-09
EP0977595A4 true EP0977595A4 (en) 2001-05-16

Family

ID=24633085

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97925747A Withdrawn EP0977595A4 (en) 1996-05-31 1997-05-28 Prevention of graft-versus-host disease with t-cells including polynucleotides encoding negative selective markers

Country Status (8)

Country Link
EP (1) EP0977595A4 (en)
JP (1) JP2000511539A (en)
AU (1) AU719930B2 (en)
CA (1) CA2255941A1 (en)
IL (1) IL127211A0 (en)
NO (1) NO985522L (en)
NZ (1) NZ333053A (en)
WO (1) WO1997045142A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705744D0 (en) * 1997-03-20 1997-05-07 Davies Alison M Methods for selecting cells and their uses
US6565831B1 (en) 1999-02-24 2003-05-20 Oncolytics Biotech Inc. Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
FR2780891A1 (en) * 1998-07-10 2000-01-14 Univ Paris Curie EXCHANGE OF T LYMPHOCYTES
AU777970C (en) 1999-05-07 2006-08-17 F. Hoffman-La Roche Ag Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
ITMI991299A1 (en) * 1999-06-11 2000-12-11 Consiglio Nazionale Ricerche USE OF ANTIBODIES AGAINST SURFACE ANTIGENS FOR THE TREATMENT OF DISEASE TRANSPLANT AGAINST GUESTS
CA2388807C (en) 1999-11-12 2013-08-06 Matthew C. Coffey Viruses for the treatment of cellular proliferative disorders
CA2633768A1 (en) * 2005-11-10 2007-05-18 Bayer Schering Pharma Aktiengesellschaft Reduction of restenosis
US8465733B2 (en) * 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
RU2456924C1 (en) * 2010-12-14 2012-07-27 Федеральное государственное учреждение "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" Method of predicting overall survival of patients with multiple myeloma

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MULLEN C A: "Metabolic suicide genes in gene therapy.", PHARMACOLOGY AND THERAPEUTICS, (1994 AUG) 63 (2) 199-207. REF: 35, XP000566391 *
See also references of WO9745142A1 *
TIBERGIEN P ET AL: "GANCICLOVIR TREATMENT OF HERPES SIMPLEX THYMIDINE KINASE-TRANSDUCEDPRIMARY T LYMPHOCYTES: AN APPROACH FOR SPECIFIC IN VIVO DONOR T-CELL DEPLETION AFTER BONE MARROW TRANSPLANTATION?", BLOOD,US,W.B. SAUNDERS, PHILADELPHIA, VA, vol. 84, no. 4, 15 August 1994 (1994-08-15), pages 1333 - 1341, XP000566470, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
NO985522L (en) 1999-01-25
IL127211A0 (en) 1999-09-22
WO1997045142A1 (en) 1997-12-04
CA2255941A1 (en) 1997-12-04
AU719930B2 (en) 2000-05-18
EP0977595A1 (en) 2000-02-09
NZ333053A (en) 2000-06-23
AU3079697A (en) 1998-01-05
NO985522D0 (en) 1998-11-26
JP2000511539A (en) 2000-09-05

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