EP0971944A4 - Antivirale, guanosin-reiche oligonukleotide, die eine tetrade bilden - Google Patents

Antivirale, guanosin-reiche oligonukleotide, die eine tetrade bilden

Info

Publication number
EP0971944A4
EP0971944A4 EP98904843A EP98904843A EP0971944A4 EP 0971944 A4 EP0971944 A4 EP 0971944A4 EP 98904843 A EP98904843 A EP 98904843A EP 98904843 A EP98904843 A EP 98904843A EP 0971944 A4 EP0971944 A4 EP 0971944A4
Authority
EP
European Patent Office
Prior art keywords
rich
forming oligonucleotides
tetrad forming
guanosine
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98904843A
Other languages
English (en)
French (fr)
Other versions
EP0971944A1 (de
Inventor
Robert F Rando
Joshua O Ojwang
Michael E Hogan
Thomas L Wallace
Paul A Cossum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Aronex Pharmaceuticals Inc
Original Assignee
Baylor College of Medicine
Aronex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/987,574 external-priority patent/US6150339A/en
Application filed by Baylor College of Medicine, Aronex Pharmaceuticals Inc filed Critical Baylor College of Medicine
Publication of EP0971944A1 publication Critical patent/EP0971944A1/de
Publication of EP0971944A4 publication Critical patent/EP0971944A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
EP98904843A 1997-02-04 1998-02-03 Antivirale, guanosin-reiche oligonukleotide, die eine tetrade bilden Withdrawn EP0971944A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3737497P 1997-02-04 1997-02-04
US37374P 1997-02-04
US08/987,574 US6150339A (en) 1993-04-23 1997-12-09 Anti-viral guanosine-rich oligonucleotides
US987574 1997-12-09
PCT/US1998/001974 WO1998033807A1 (en) 1997-02-04 1998-02-03 Anti-viral guanosine-rich tetrad forming oligonucleotides

Publications (2)

Publication Number Publication Date
EP0971944A1 EP0971944A1 (de) 2000-01-19
EP0971944A4 true EP0971944A4 (de) 2005-01-26

Family

ID=26714074

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98904843A Withdrawn EP0971944A4 (de) 1997-02-04 1998-02-03 Antivirale, guanosin-reiche oligonukleotide, die eine tetrade bilden

Country Status (4)

Country Link
EP (1) EP0971944A4 (de)
AU (1) AU6262598A (de)
CA (1) CA2279488A1 (de)
WO (1) WO1998033807A1 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1994025037A1 (en) * 1993-04-23 1994-11-10 Triplex Pharmaceutical Corporation Anti-viral guanosine-rich oligonucleotides
WO1997003997A1 (en) * 1995-07-19 1997-02-06 Aronex Pharmaceuticals, Inc. Anti-viral guanosine-rich oligonucleotides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4388306A (en) * 1980-06-04 1983-06-14 Merck & Co., Inc. Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
GB8717430D0 (en) * 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5176996A (en) * 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5397702A (en) * 1989-03-06 1995-03-14 The Regents Of The University Of California Assay for and treatment of autoimmune diseases
US5075217A (en) * 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
DE4216134A1 (de) * 1991-06-20 1992-12-24 Europ Lab Molekularbiolog Synthetische katalytische oligonukleotidstrukturen
US5591721A (en) * 1994-10-25 1997-01-07 Hybridon, Inc. Method of down-regulating gene expression

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1994025037A1 (en) * 1993-04-23 1994-11-10 Triplex Pharmaceutical Corporation Anti-viral guanosine-rich oligonucleotides
WO1997003997A1 (en) * 1995-07-19 1997-02-06 Aronex Pharmaceuticals, Inc. Anti-viral guanosine-rich oligonucleotides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BISHOP JEFFREY S ET AL: "Intramolecular G-quartet motifs confer nuclease resistance to a potent anti-HIV oligonucleotide", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 10, 8 March 1996 (1996-03-08), pages 5698 - 5703, XP002148821, ISSN: 0021-9258 *
OJWANG J O ET AL: "T30177, AN OLIGONUCLEOTIDE STABILIZED BY AN INTRAMOLECULAR GUANOSINE OCTET, IS A POTENT INHIBITOR OF LABORATORY STRAINS AND CLINICAL ISOLATES OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 39, no. 11, November 1995 (1995-11-01), pages 2426 - 2435, XP000946679, ISSN: 0066-4804 *
RANDO R F ET AL: "SUPPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 ACTIVITY IN VITRO BY OLIGONUCLEOTIDES WHICH FORM INTRAMOLECULAR TETRADS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 4, 27 January 1995 (1995-01-27), pages 1754 - 1760, XP002068457, ISSN: 0021-9258 *
See also references of WO9833807A1 *
WOLFE J L ET AL: "MODULATION OF TETRAPLEX FORMATION BY CHEMICAL MODIFICATIONS OF A G4-CONTAINING PHOSPHOROTHIOATE OLIGONUCLEOTIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 26, 1996, pages 6301 - 6302, XP002041657, ISSN: 0002-7863 *

Also Published As

Publication number Publication date
CA2279488A1 (en) 1998-08-06
AU6262598A (en) 1998-08-25
EP0971944A1 (de) 2000-01-19
WO1998033807A1 (en) 1998-08-06

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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