EP0967965A1 - Dentifrices therapeutiques a moussage faible presentant des qualites de nettoyage et d'abrasion ameliorees - Google Patents

Dentifrices therapeutiques a moussage faible presentant des qualites de nettoyage et d'abrasion ameliorees

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Publication number
EP0967965A1
EP0967965A1 EP97934943A EP97934943A EP0967965A1 EP 0967965 A1 EP0967965 A1 EP 0967965A1 EP 97934943 A EP97934943 A EP 97934943A EP 97934943 A EP97934943 A EP 97934943A EP 0967965 A1 EP0967965 A1 EP 0967965A1
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EP
European Patent Office
Prior art keywords
toothpaste
abrasive
therapeutic
low foaming
toothpastes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97934943A
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German (de)
English (en)
Other versions
EP0967965A4 (fr
Inventor
Ira D. Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WhiteHill Oral Technologies Inc
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WhiteHill Oral Technologies Inc
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Filing date
Publication date
Application filed by WhiteHill Oral Technologies Inc filed Critical WhiteHill Oral Technologies Inc
Publication of EP0967965A1 publication Critical patent/EP0967965A1/fr
Publication of EP0967965A4 publication Critical patent/EP0967965A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • Low foaming therapeutic toothpastes containing a therapeutic substance, an abrasive, a humectant, a low foam surfactant, and/or a foam control agent having improved cleaning and abrasion performance wherein: packing of the abrasive into the channels of a channeled bristle toothbrush, and abrasive/tooth surface contact, are substantially free from surfactant bubble interference such that Cleaning Efficiency Coefficient and Abrasion Efficiency Coefficient values greater than about 1.1 are achieved along with improvements in therapeutic efficacy.
  • the present invention relates to therapeutic toothpastes having improved cleaning and abrasion performance attributed to a low foam characteristic and the absence of substantial surfactant bubble interference with the abrasive/tooth surface interface during brushing. As a result of this improved cleaning and abrasion, the therapeutic activity of each of these low foaming toothpastes is generally improved.
  • toothbrushing is generally carried out with a toothbrush/toothpaste combination where the abrasive in the toothpaste is brought into contact with tooth surfaces by the bristles of the toothbrush.
  • the leading commercial toothpastes presently marketed are characterized by a controlled foam profile, resulting in foam initially filling a good part of the oral cavity, eventually dissipating at the end of the brushing cycle, such that the residue can be conveniently expectorated.
  • Examples of therapeutic toothpastes include “fluoride”, “anti-tartar”, “anti- plaque”, “baking soda”, “anti-gingivitis”, and “hypersensitivity treatment” toothpastes, some of which are described in the following U.S. Patents: 4,254,101; 4,515,772; 4,684,518; 4,806,339; 4,806,340; 4,842,165; 4,885,155; 4,889,712; 4,891,211; 4,999,184; 5,004,597; 5,180,576; 5,374,368; and 5,424,060. These patents are to be incorporated by reference in the present specification.
  • the toothpastes described in these patents generally use one or more abrasive substances to abrasively clean, polish and remove stains, plaque and tartar from the surfaces of teeth in preparation for imparting various therapeutic benefits to the oral cavity.
  • the primary function of the toothbrush bristles is to rub abrasive particles contained in the toothpaste across the surfaces of the teeth, thereby removing by abrasive action tooth deposits such as pellicle, stains, plaque, tartar and the like while delivering various active ingredients such as fluoride, anti-tartar, anti- gingivitis ingredients, etc. to the "cleaned" oral cavity.
  • Dental plaque is formed by oral microorganisms that synthesize harmful products that are destructive to the tooth and gums when not removed from the gingival sulcus.
  • the toxins formed by these microorganisms cause cellular damage to the gingiva with subsequent inflammation (gingivitis) and eventually destruction of the supporting structures (periodontitis).
  • gingivitis occurs, vascular dilation, capillary proliferation, engorged vessels and sluggish venous return causes a stretched and thinned epithelium that is sensitive to mechanical trauma such as aggressive brushing.
  • Dental plaque with associated gingivitis also causes exposure of the root surface (recession) with increased occurrence of cavities (dental caries). Exposure of the root surfaces can also occur due to faulty brushing by repeated direct trauma to the base of the sulcus (gingival abrasion). When a pathologically deepened gingival sulcus (periodontal pocket) occurs, the pathological condition may become exacerbated because plaque can more readily occur. If dental plaque is not removed, calculus (tartar) is formed by mineralization of the bacterial plaque. Calculus can form within several hours of plaque formation. Calculus has a bacterial plaque coating and exacerbates gingivitis and gingival recession by both chemical irritation from the formed toxins and destruction from the mechanical irritation of the calculus mass. Subgingival calculus usually extends near but does not reach the base of periodontal pockets in chronic periodontal lesions. Calculus holds the plaque against gingiva, and
  • improved toothpaste cleaning efficiency and improved toothpaste abrasion efficiency requires that the abrasive particles entrapped in these bristle channels be brought into direct contact without bubble interference with those tooth surfaces requiring cleaning, polishing, stain removal, etc. This contact is most effective when the bubbles produced by surfactants are minimal and preferably excluded from the abrasive/tooth surface interference.
  • the present invention has for its primary objective the enhancement in therapeutic toothpastes of tooth cleaning and polishing through improved toothpaste cleaning and abrasion efficiency wherein improved contact between toothpaste abrasives and tooth surfaces is achieved with a minimum of surfactant bubble interference and with a corresponding improvement in therapeutic results.
  • This improvement in cleaning efficiency is measured by a Cleaning Efficiency Coefficient (CEC).
  • CEC Cleaning Efficiency Coefficient
  • AEC Abrasion Efficiency Coefficient
  • a further objective of the present invention is to enhance the cleaning of those tooth surfaces contiguous to the gingival margin and to the interproximal surfaces while avoiding damaging the soft tissue by using generally lower RDA abrasives, which abrasives are presented to tooth surfaces substantially surfactant bubble free resulting in enhanced CEC and AEC scores.
  • a further objective of the present invention is to improve the abrasive/tooth surface contact of various commercial therapeutic toothpastes by reducing substantially the sudsing and bubble content of therapeutic toothpastes resulting in improved therapeutic performance.
  • These improved commercial therapeutic toothpastes include low foaming versions of the various toothpastes described in: U.S. 4,254,101; 4,515,772; 4,684,518; 4,806,339; 4,806,340; 4,842,165; 4,885,155; 4,889,712; 4,891,211; 4,999,184; 5,004,597; 5,180,576; 5,374,368; and 5,424,060.
  • Yet another objective of the invention is to provide an improved method of caring for teeth and gums using a low foaming therapeutic toothpaste with improved CEC and AEC values.
  • Figure 1 illustrates schematically the interference of surfactant bubbles with abrasive/tooth surface contact in a channeled bristle toothbrush.
  • Figure 2 illustrates schematically the interference of surfactant bubbles with abrasive packing in a channeled bristle toothbrush.
  • Figure 2(a) is a cross-sectional view of channeled bristle, 13.
  • Figure 3 illustrates schematically the improved abrasive/tooth surface contact achieved with low foaming therapeutic toothpastes of the present invention in a channeled bristle toothbrush.
  • Figure 4 illustrates schematically the improved abrasive packing in the bristle channels achieved with low foaming therapeutic toothpastes of the present invention.
  • Figure 4(a) is a cross-sectional view of channeled bristle, 13.
  • a low foaming toothpaste is defined as a toothpaste formulation containing an abrasive, a humectant, a surfactant and a foam controlling agent wherein the abrasive/tooth surface interface and abrasive packing in channeled bristle toothbrushes is rninimal resulting in CEC and AEC values of at least about 1.1.
  • a therapeutic toothpaste is defined as a toothpaste formulation containing one or more active ingredients for the treatment of oral conditions ranging from chronic plaque and tartar buildup to gingivitis, caries, hypersensitivity, etc.
  • the Cleaning Efficiency Coefficient is the cleaning improvement obtained with the low foaming toothpastes of the present invention as measured against a standard foaming toothpaste, with both toothpastes using the same channeled bristle toothbrush.
  • the CEC is a number that relates the cleaning efficiency of the novel low foaming therapeutic toothpastes of the present invention to a current standard commercial foaming toothpaste, where both toothpastes are tested using identical channeled toothbrushes.
  • the CEC is a ratio of the efficiency of the low foaming toothpaste to the efficiency of a standard foaming toothpaste under standardized brushing conditions.
  • the ratio is expressed as the reduction in the parameter measured, plaque for example, by the low foaming toothpaste, divided by the reduction in plaque produced by the standard toothpaste under identical toothbrushing test conditions.
  • Abrasion Efficiency Coefficient is defined as the ratio of the results of a standard RDA, Stain Index or Polishing Index procedure of low surfactant toothpaste to the results of an identical procedure using a standard foaming toothpaste with the same bristled toothbrush used in both instances.
  • AEC values for RDA, Stain Index and Polish Index above about 1.1 are preferred with values about 1.5 particularly preferred.
  • Relative Dental Abrasion has long been the standard measurement for predicting the performance of a given toothpaste formulation, and/or the functionality of a series of abrasives having varying particle sizes, compositions of matter, crystal structures, fracture edges, etc.
  • a measured number of strokes with a standard toothbrush with a fixed applied pressure against a piece of dental enamel fixed in a holding plate is the basis of the test.
  • a plate of soft metal, such as copper is substituted for the dental enamel as an inexpensive approximation method.
  • the dental enamel is measured for loss of surface enamel (or metal) by a variety of methods, including weight loss, optical comparison and radioactive techniques.
  • a similar measurement using artificially stained enamel measures the abrasive removal of stain.
  • the changing of the toothpaste to a low foaming toothpaste impacts abrasivity whether using RDA, Stain or Polishing measurements. It is suggested that because the delivery of the abrasive to the tooth surface is substantially bubble free and therefore more efficient, certain abrasives will have a higher RDA when used in the low foaming toothpastes of the present invention.
  • the advantage of these low foaming dentifrices is that the teeth are more efficiently cleaned without risking enamel or soft tissue damage that may occur with higher RDA abrasives.
  • the improved CEC and AEC values obtained with the low foaming therapeutic toothpastes of the present invention result in an improvement in various therapeutic effects ranging from plaque and tartar control to anti-gingivitis and anti-caries effects as well as improved hypersensitivity treatment.
  • the rate of "tubule" closure is improved with low foaming hypersensitivity treating toothpastes of the present invention.
  • the low foaming therapeutic toothpaste compositions of the present invention comprise an abrasive, a humectant, a surfactant, a foam control substance, water and an active therapeutic ingredient.
  • abrasive abrasive
  • humectant a humectant
  • surfactant a foam control substance
  • foam control substance a foam control substance
  • active therapeutic ingredient an active therapeutic ingredient
  • the therapeutic toothpaste compositions of the present invention contain from between about 1 % and about 90%, preferably from between about 10% and 50% by weight, of an abrasive material described in detail below.
  • These abrasives in the low foaming dentifrices of the present invention provide the unique abrasion benefits of exceptionally efficient cleaning, i.e. CEC values above about 1.1 along with exceptional polishing, stain removal and abrasion as indicated by AEC values of at least about 1.1.
  • the exceptional AEC values are obtained without unduly abrading tooth enamel or dentin.
  • Suitable abrasive materials for the low foaming therapeutic toothpastes of the present invention include: talc, calcium pyrophosphate, calcium hydrogen phosphate dihydrates, anhydrous dicalcium phosphate, calcium carbonate, alumina, tin dioxide, silica, zirconium silicate, sodium bicarbonate, sodium percarbonate, etc. , and mixtures thereof. Particularly preferred are abrasive mixtures where the secondary abrasive is the type used in translucent dentifrice gels at levels up to about 20%. Some of these are described in U.S.
  • abrasives include: sodium metaphosphate, potassium metaphosphate, magnesium orthophosphate, trimagnesium phosphate, alumina silicate and hetonite as described in U.S. 4,806,340 incorporated herein by reference. See also Thorpe's Dictionary of Applied Chemistry. Volume 9, 4th Edition, pp. 510-511.
  • Particularly preferred abrasives that are compatible with sources of soluble fluoride include those precipitated silica or silica gels such as the silica xerogels described in U.S. 3,538,230 incorporated herein by reference. Preferred are the silica/xerogels marketed under the tradename Syloid by W.R. Erecex Co., Davison Chemical Division. Especially preferred are the precipitated silica materials such as those marketed by the J.M. Huber Corporation under the tradename Zeodent, particularly the silica carrying the designation Zeodent 119. Other silica dental abrasives useful in the toothpastes of the present invention are disclosed in U.S. 3,862,307 and 4,340,583 incorporated herein by reference.
  • abrasives useful in the low foaming therapeutic dentifrice compositions of the present invention include calcium pyrophosphate including the B-phase calcium pyrophosphate prepared in accordance with the teaching of U.S. 3,112,247 incorporated herein by reference.
  • Another class of abrasives suitable for use with the low foaming toothpastes of the present invention include paniculate thermosetting polymerized resins as described in U.S. 3,0750,510 including melamines, phenolics, ureas, melamine-ureas, melamineformaldehydes, urea-formaldehydes, melamine-urea- formaldehydes, cross-linked epoxides and cross linked polyesters. See also U.S. 4,070,510 incorporated herein by reference.
  • the size of the abrasive particles are most commonly expressed in "mean diameter", i.e. the arithmetical average of the diameters of particles in a representative sample.
  • the mean diameter value of abrasive particles is usually described in microns.
  • Abrasives having particle sizes between about 3 and 25 microns and preferably between about 6 and about 20 microns are particularly preferred for the channel designs of the toothbrush bristles of the present invention.
  • suitable particle size abrasives can be accomplished by conventional techniques well known to the art. Basically, these techniques involve milling various abrasive materials, followed by standard screen sieving (or air separation) to segregate the desired particle size range. Other techniques employ crystallization or related techniques to control size and crystal variants.
  • Organic surface active substances are used in the low foaming therapeutic toothpastes of the present invention to achieve increased cleaning action, assist in complete dispersion of various active ingredients throughout the oral cavity, optimize therapeutic activity, etc.
  • Organic synthetic surfactants which may be so utilized can be non-soap, anionic, nonionic, cationic, zwitteronic or amphoteric in nature.
  • Low foaming nonionic surfactants are preferred for the low foaming therapeutic toothpastes of the present invention. Where high foaming surfactants are used, an appropriate level of a foam control substance along with a nonionic surfactant is added to the formulation to achieve the low foam interference abrasive "packing" and substantially bubble-free abrasive/tooth surface contact illustrated in Figures 3 and 4 of the drawings. These foam control substances are described in detail below.
  • Suitable surfactants are described in U.S. 3,959,458; 3,937,807; and 4,051,234.
  • Anionic surfactants useful herein include the water soluble salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having from 10 to 18 carbon atoms.
  • Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type. Mixture of anionic surfactants can also be employed.
  • nonionic surfactants which can be used in the compositions of the present invention can be broadly defined as compounds produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkylaromatic in nature.
  • suitable nonionic sudsing agents include the Pluronics, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phophine oxides, long chain dialkyl sulf oxides and mixtures of such materials.
  • the zwitteronic synthetic surfactants useful in the composition of the present invention can be broadly described as derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, in which the aliphatic radicals can be straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • the cationic surfactants useful in the compositions of the present invention can be broadly defined as quaternary ammonium compounds having one long alkyl chain containing from about 8 to 18 carbon atoms such as lauryl trimethylammonium chloride, cetyl pyridinium chloride, cetyl trimethylammomum bromide; di- isobutylphenoxyethoxyethyl-dimethylbenzylammonium chloride; coconut- alkyltrimethylammonium nitrite; cetyl pyridinium fluoride; etc.
  • amphoteric surfactants useful in the present invention can be broadly described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight chain or branched and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate.
  • an anionic water-solubilizing group e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate.
  • the humectant serves to keep the toothpaste compositions from hardening upon exposure to air. Certain humectants can also impact desirable sweetness or flavor to the toothpaste.
  • the humectant on a pure humectant basis, generally comprises from between 30% and 70%, preferably from between about 45 % and 65 % , by weight of the toothpaste compositions herein. (See Examples XI, XII and XIII.)
  • Suitable humectants for use in this invention include edible polyhydric polyols such as glycerin, sorbitol, xylitol, polyethylene glycol, polypropylene glycol, mannitol, maltitol, etc. Sorbitol is frequently employed as a 70% aqueous solution obtained from SPI Polyols, Inc., New Castle, Delaware. Mixtures of glycerin and sorbitol are particularly useful in the low foaming toothpastes of the present invention.
  • the humectant is selected from liquid oxyalkylated diols that have a molecular weight in the range between about 200 and 8000.
  • Polyethylene glycols are commercially available under tradenames such as Carbowax 200, 300, 400, 600, 900, 1000, 2000, 4000, 6000, and 8000 from Union Carbide where the number values are approximations at average molecular weight.
  • Polyethylene-propylene glycols are commercially available under tradenames such as Pluracare/Pluronic L-31 and L-35 from BASF.
  • the liquid vehicle may comprise water and humectant, typically in an amount from between about 10% and 90%, by weight of the toothpaste.
  • humectant typically in an amount from between about 10% and 90%, by weight of the toothpaste.
  • translucent low foaming gel toothpastes where the retractive index is an important consideration, it is preferred to use higher ratios of humectant to water than those used in opaque toothpastes.
  • low foaming toothpaste compositions of the invention that contains foam generating surfactants such as anionic and cationic surfactants
  • foam generating surfactants such as anionic and cationic surfactants
  • suitable foam control agents for the low foaming toothpastes of the present invention include alcohols such as ethanol, low molecular weight polydimethylsiloxanes such as Silicone, 350, and 1500 from Dow Corning Corporation, Midland, Texas.
  • Low HLB surfactants such as ARLACEL 186 surfactants, manufactured by ICI Specialty Chemicals, Wilmington, Delaware, when used at approximately 0.1 %, will effectively control most foaming in commercial toothpastes and produce abrasive packing and abrasive/tooth surface contact substantially free from bubble interference.
  • Preferred foam control agents for commercial toothpastes include lipophilic oleates and/or laureates with an HLB range from between about 1 and 8.
  • foam control agents can be used effectively to control the foam of various commercial toothpastes, it is preferred to substitute nonionic low foaming surfactants for the sodium lauryl sulfate-type surfactants generally used in most commercial toothpastes. Such substitution is illustrated in Examples I through XHI below.
  • Water is another essential element of the toothpastes of this invention.
  • Water employed in the preparation of commercially suitable low foaming, therapeutic toothpastes should preferably be deionized and free of organic impurities.
  • Water comprises from about 10% to 45%, preferably from about 20% to 35%, by weight of the toothpaste compositions herein. These amounts of water include die free water that is added plus that which is introduced with other materials.
  • Therapeutic ingredients for the treatment of hypersensitivity include potassium nitrate, stannous fluoride, zinc chloride and various abrasives that demonstrate a propensity for "tubule" closure during brushing with the low foaming toothpastes of the invention.
  • Typical materials include: stannous fluoride, potassium fluoride, lithium fluoride, cesium fluoride, ammonium fluoride, aluminum fluoride, capric fluoride, indium fluoride, stannous fluorozirconate, lead fluoride, ferric fluoride, nickel fluoride, paladium fluoride, silver fluoride, zinc fluoride, zirconium fluoride, hexylamine hydrofluoride, laurylamine hydrofluoride, myristylamine hydrofluoride, decanolamine hydrofluoride, octadecanylamine hydrofluoride, myristoxyamine hydrofluoride, diethylamino- ethyloleylamide hydrofluoride, diethanolamino-ethyloley
  • Anticalculus active ingredients include various pyrophosphate substances.
  • the pyrophosphate salts useful in the present composition include dialkali metal pyrophosphates and mixtures of the dialkali metal and tetraalkali metal pyrophosphate salts.
  • Na 2 H 2 P 2 O 7 , Na-P 2 O 7 and K,P 2 O 7 in their unhydrated as well as hydrated forms are the preferred species.
  • the levels of each of these species that preferably are used in the compositions are as follows (all are in the unhydrated form): Na 2 H 2 P 2 O 7 , 0.5% 13.8%
  • Preferred -? 2 3 , '4 in the present compositions is 1.5% which can be provided solely by Na 2 H 2 P 2 O 7 or mixtures of Na 2 H 2 P 2 O 7 with either or both of the tetra alkali metal salts.
  • Preferred are binary mixtures of the sodium salts and ternary mixtures of those with the tetra potassium salt.
  • the upper limits on the sodium species are determined by solubility considerations while the tetra potassium level is established for taste reasons.
  • This reference discloses sodium salts including tetrasodium pyrophosphate, disodium dihydrogen pyrophosphate, trisodium hydrogen phosphate and sodium trihydrogen pyrophosphate on the bottom of page 243 and the top of page 244; potassium pyrophosphate on page 249; and diammonium dihydrogen pyrophosphate, triammonium hydrogen phosphate and tetraammonium pyrophosphate on page 249.
  • the reference further discloses condensed phosphoric acids exemplified by pyrophosphoric acid on page 214. The solubilities of sodium pyrophosphates are presented in a diagram at the top of page 243.
  • Bis-biguanide antiplaque agents can also be added to the composition of this invention.
  • Such agents include chlorhexidine (l,6bis [N 5 -p-chlorophenyl-N'- biguanidojhexane), the soluble and insoluble salts thereof and related materials such as l,2-bis(n 5 -p-tri-fluoromethylphenyl-N 1 -biguanido)ethane are described more fully in Haefels, U.S. Pat. No. 3,923,002, U.S. Pat. No. 3,937,807, Belgian Pat. No. 843,244, and Belgian Pat. No. 844,764. These patents are incorporated herein by reference.
  • these antiplaque agents generally comprise from about 0% to about 5% by weight of the compositions herein.
  • Poloxamer polydimethylsiloxane emulsions which function as antiplaque active ingredients available under the trademarks MICRODENT ® and ULTRAMULSION ® from WhiteHill Manufacturing, Stafford, Texas, are also suitable therapeutic ingredients for the low foaming toothpastes or the present invention.
  • peroxy-containing toothpastes include: U.S. Pat. Nos. 2,275,979; 3,577,521; 3,657,413; 3,885,028; 3,886,265; 4,226,851; 4,302,441; 4,405,599; 4,426,108; 4,431,631; 4,521,403; 4,522,805; 4,528,180; 4,567,036; 4,592,487; 4,592,488; 4,592,489; 4,687,663; 4,812,308; 4,837,008; 4,839,152; 4,849,213; 4,867,988; 4,891,211; 4,897,258; 4,925,655; 4,971,782; 4,980,152; 4,988,450; 5,000,941; 5,041,280; 5,085,85
  • Low foaming therapeutic toothpastes, creams, gels and powders of the invention typically also contain a namral or synthetic thickener or gelling agent in proportions of about 0.1 % to about 10%, preferably about 0.5% to about 5%, by weight.
  • Suitable organic thickeners include sodium carboxymethyl cellulose, gum tragacanth, starch, carrageenan, polyvinylpyrrolidone, hydroxyethylpropyl cellulose, hydroxybutylmethyl cellulose, hydroxypropylmethyl cellulose or hydroxyethyl cellulose, and are usually used in concentrations of 0.1 % to 2.0%.
  • Inorganic thickeners such as hydrated silicas may also be used at levels of about 0.5% to 10%.
  • Suitable flavoring and sweetening agents may also be employed in the dentifrices of the invention.
  • suitable flavorants include the flavoring oils, for example, oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon and orange, as well as methylsalicylate.
  • Suitable sweeteners include sodium cyclamate, perillartine, saccharin, sodium saccharin and ammoniated glycyrrhizin (e.g. its monoammonium salt), and the like.
  • the flavoring and sweetening agent together comprise from about 0.01 % to 5% or more by weight of the dentifrice.
  • the amount of flavoring oil is above 0.3%, e.g. 0% to 1.2%.
  • the pH of the compositions herein is in the range of 6.0 to 10.0, preferably from 7.3 to 9.0.
  • the pH is preferably achieved through a proper balancing of the pyrophosphate salts or by the addition of an alkaline or acidic agent.
  • dentifrice compositions are representative of the present invention.
  • Titanium Dioxide 0.525 0.525 0.515 0.325
  • sorbitol and one half of the water are added to the mix tank and heating to 77°C initiated. Saccharin, titanium dioxide, and silica may be added to me mixture during this heating period. Sufficient agitation is maintained to prevent the settling of the insoluble components.
  • the glycerin is added to a separate vessel and is also heated to 77°C. When both the solutions have attained die required temperature, the carboxymethyl cellulose (CMC) and carrageenan are blended together and slowly added to the glycerin under vigorous agitation. When the CMC and carrageenan are sufficiently dispersed in d e glycerin, this mixture is added to the sorbitol/water mixture.
  • the resulting mixture is then blended for a sufficient period of time to allow complete hydration of the binders (about 15 minutes).
  • the flavor, Pluronic F127/Arlacel 186 mixture and color are added.
  • One half of the remaining water is then added to a separate mix tank and allowed to heat to 77°C.
  • the sodium gluconate is added under medium agitation and allowed to dissolve completely.
  • the stannous chloride dihydrate is then added to die gluconate solution and also allowed to dissolve. This mixture is added to the main mix.
  • the stannous fluoride is added to the remaining water (also at 77°C) and die resulting solution is added to the main mix and allowed to blend d oroughly before final pH adjustment wi i sodium hydroxide.
  • the completed paste is agitated for approximately 20 minutes before being milled and deaerated.
  • Inorganic Thickener 9.00 to 10.00 0.00 to 5.00
  • Nonionic Low Foam Surfactant 0.05 to 5.00 0.10 to 1.00
  • Sweetener 0.00 to 10.00 0.30 to 2.00
  • Fluoridating Agent as fluoride ion 23.00 to 3000 ppm 850 to 1500 ppm
  • Flavoring Agent 0.01 to 5.00 0.30 to 2.00
  • me following ingredients are incorporated in sodium bicarbonate/alkali metal pyrophosphate-containing, calculus inhibiting low foaming dental gels.
  • Inorganic Thickener 0.00 to 10.00 3.00 to 8.00
  • Nonionic Low Foam Surfactant 0.00 to 10.00 0.30 to 1.00
  • Sweetener 0.00 to 10.00 0.30 to 2.00
  • Fluoridating Agent as fluoride ion 15.00 to 5000 ppm 850 to 1500 ppm
  • Flavoring Agent 0.01 to 5.00 0.30 to 2.00
  • anticalculus low foaming tooth powders contain the following ingredients.
  • Nonionic Low Foam Surfactant 0.00 to 10.00 0.00 to 2.00
  • Sweetener 0.00 to 10.00 0.30 to 2.00
  • Fluoridating Agent as fluoride ion 25.00 to 3000 ppm 850 to 1500 ppm
  • Flavoring Agent 0.01 to 5.00 0.30 to 2.00
  • Ami-caking Agent 0.00 to 5.00 0.05 to 0.20

Abstract

L'invention concerne des dentifrices thérapeutiques à moussage faible contenant une substance thérapeutique, un humectant, un tensioactif à faible moussage, et/ou un agent de neutralisation de mousse qui présentent des qualités de nettoyage et d'abrasion améliorées. L'agent abrasif de tels dentifrices est contenu dans des canaux formés à l'intérieur des poils cannelés de la brosse à dents, si bien que le contact dentifrice/surface de la dent se fait pratiquement sans mousse de tensioactif, ce qui permet d'obtenir un degré d'élimination et d'abrasion dont la valeur est supérieure à environ 1.1; tout en améliorant l'efficacité thérapeutique du dentifrice.
EP97934943A 1996-07-25 1997-07-24 Dentifrices therapeutiques a moussage faible presentant des qualites de nettoyage et d'abrasion ameliorees Withdrawn EP0967965A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2270596P 1996-07-25 1996-07-25
US22705P 1996-07-25
PCT/US1997/012208 WO1998004234A1 (fr) 1996-07-25 1997-07-24 Dentifrices therapeutiques a moussage faible presentant des qualites de nettoyage et d'abrasion ameliorees

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EP (1) EP0967965A4 (fr)
JP (1) JP2000516216A (fr)
AU (1) AU3799297A (fr)
BR (1) BR9710528A (fr)
CA (1) CA2260930A1 (fr)
WO (1) WO1998004234A1 (fr)

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US6713049B1 (en) 1999-11-12 2004-03-30 The Procter & Gamble Company Oral compositions providing optimal surface conditioning
US6187295B1 (en) * 1996-11-21 2001-02-13 The Procter & Gamble Company Methods of reducing the astringency of stannous in dentifrice compositions
EP1058534A1 (fr) * 1998-03-06 2000-12-13 Fmc Corporation Gel dentifrice non fibreux comprenant comme liants du kappa-carraghenane et de la cellulose
JP3860471B2 (ja) 1999-11-12 2006-12-20 ザ プロクター アンド ギャンブル カンパニー 改良された第１錫系口腔組成物
US20040146466A1 (en) 1999-11-12 2004-07-29 The Procter & Gamble Company Method of protecting teeth against erosion
US10470985B2 (en) 1999-11-12 2019-11-12 The Procter & Gamble Company Method of protecting teeth against erosion
AU1479501A (en) 1999-11-12 2001-06-06 Procter & Gamble Company, The Improved dual phase stannous oral compositions
EP2246031B1 (fr) * 2008-06-10 2017-06-28 The Procter & Gamble Company Compositions de chlorure d'étain
US9220667B2 (en) 2009-06-08 2015-12-29 The Procter & Gamble Company Stannous chloride compositions
WO2013130104A1 (fr) * 2012-03-02 2013-09-06 Colgate-Palmolive Company Compositions de soin oral
US10123953B2 (en) 2012-06-21 2018-11-13 The Procter & Gamble Company Reduction of tooth staining derived from cationic antimicrobials
CN113631143B (zh) * 2019-03-28 2024-04-12 株式会社Lg生活健康 牙膏组合物
EP3958983A1 (fr) 2019-04-26 2022-03-02 The Procter & Gamble Company Réduction de coloration de dent dérivée d'antimicrobiens cationiques

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Also Published As

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BR9710528A (pt) 1999-08-17
JP2000516216A (ja) 2000-12-05
WO1998004234A1 (fr) 1998-02-05
CA2260930A1 (fr) 1998-02-05
AU3799297A (en) 1998-02-20
EP0967965A4 (fr) 2001-01-24

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