EP0950044A4 - Preparation of gabapentin - Google Patents

Preparation of gabapentin

Info

Publication number
EP0950044A4
EP0950044A4 EP97954134A EP97954134A EP0950044A4 EP 0950044 A4 EP0950044 A4 EP 0950044A4 EP 97954134 A EP97954134 A EP 97954134A EP 97954134 A EP97954134 A EP 97954134A EP 0950044 A4 EP0950044 A4 EP 0950044A4
Authority
EP
European Patent Office
Prior art keywords
gabapentin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97954134A
Other languages
German (de)
French (fr)
Other versions
EP0950044A1 (en
Inventor
Michael Pesachovich
Claude Singer
Gideon Pilarski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of EP0950044A1 publication Critical patent/EP0950044A1/en
Publication of EP0950044A4 publication Critical patent/EP0950044A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
EP97954134A 1996-12-24 1997-12-24 Preparation of gabapentin Withdrawn EP0950044A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11989096A IL119890A (en) 1996-12-24 1996-12-24 Gabapentin form iii and preparation of gabapentin form ii
IL11989096 1996-12-24
PCT/US1997/023164 WO1998028255A1 (en) 1996-12-24 1997-12-24 Preparation of gabapentin

Publications (2)

Publication Number Publication Date
EP0950044A1 EP0950044A1 (en) 1999-10-20
EP0950044A4 true EP0950044A4 (en) 2003-03-26

Family

ID=11069615

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97954134A Withdrawn EP0950044A4 (en) 1996-12-24 1997-12-24 Preparation of gabapentin

Country Status (7)

Country Link
EP (1) EP0950044A4 (en)
AU (1) AU5799098A (en)
CA (1) CA2275912A1 (en)
DE (1) DE97954134T1 (en)
ES (1) ES2204362T1 (en)
IL (1) IL119890A (en)
WO (1) WO1998028255A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137137B1 (en) * 1998-05-25 2000-08-16 Medichem Sa NEW POLYMORPH OF UNHYDRATED GABAPENTINE, ITS PROCEDURE FOR OBTAINING AND ITS USE FOR THE OBTAINING OF PHARMACEUTICAL QUALITY GABAPENTINE.
IT1311984B1 (en) * 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi PROCEDURE FOR THE PREPARATION OF GABAPENTIN.
EP1169060B1 (en) 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
ES2164527B1 (en) * 1999-04-26 2003-04-01 Medichen S A PROCEDURE FOR OBTAINING GABAPENTINA OF PHARMACEUTICAL QUALITY.
US6294198B1 (en) 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
EP1384473A1 (en) * 2000-06-16 2004-01-28 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 20 ppm of chlorine ion
WO2001097612A1 (en) * 2000-06-16 2001-12-27 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 2o ppm of chlorine ion
CA2411787C (en) * 2000-06-16 2007-03-20 Teva Pharmaceuticals Industries Ltd. Stable gabapentin having ph within a controlled range
EP1430893A1 (en) * 2000-06-16 2004-06-23 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 20 ppm of chloride ion
US7056951B2 (en) 2000-09-26 2006-06-06 Mutual Pharmaceutical Co., Inc. Stable solid dosage forms of amino acids and processes for producing same
IT1319674B1 (en) * 2000-12-01 2003-10-23 Erregierre Spa PROCESS FOR THE PREPARATION OF CYCLOHEXANACETIC ACID1- (AMINOMETHYL).
WO2003020273A2 (en) 2001-09-03 2003-03-13 Newron Pharmaceuticals Spa Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use
US6800782B2 (en) 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
US20030158254A1 (en) * 2002-01-24 2003-08-21 Xenoport, Inc. Engineering absorption of therapeutic compounds via colonic transporters
AU2002356424A1 (en) 2002-11-18 2004-06-15 Nicholas Piramal India Limited Improved process for preparation of gabapentin
EP1603863B1 (en) 2002-11-20 2010-01-13 Hikal Ltd. Process for the preparation of amino methyl cyclo alkane acetic acids
WO2004093779A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii
WO2004093780A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii
WO2004106281A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Crystalline gabapentin
WO2004110981A1 (en) * 2003-06-12 2004-12-23 Matrix Laboratories Ltd A process for the preparation of gabapentin form-ii
WO2004110342A2 (en) * 2003-06-12 2004-12-23 Matrix Laboratories Ltd Novel polymorph of gabapentin and its conversion to gabapentin form-ii
US7169812B2 (en) 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
ITMI20040579A1 (en) 2004-03-25 2004-06-25 Zambon Spa GABAPENTINA PREPARATION PROCESS
GB0415076D0 (en) * 2004-07-05 2004-08-04 Sandoz Ind Products S A Process for the preparation of gabapentin
GB0416228D0 (en) * 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
US20080207945A1 (en) * 2007-02-28 2008-08-28 Ziv Dee-Noor Preparation of gabapentin by liquid-liquid extraction
WO2009015685A1 (en) 2007-07-27 2009-02-05 Medichem, S.A. Method for preparing polymorph form ii of gabapentin
CN102363598B (en) * 2011-11-25 2014-02-12 浙江精进药业有限公司 Method for preparing high-purity gabapentin
ITMI20131757A1 (en) 2013-10-22 2015-04-23 Zach System Spa GABAPENTINE PREPARATION PROCESS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (en) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-aminomethyl-1-cycloalkaneacetic acids and their esters, processes for their preparation and medicaments containing these compounds
US4960931A (en) * 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (en) * 1989-08-25 1991-02-28 Goedecke Ag METHOD FOR PRODUCING CYCLIC AMINO ACID DERIVATIVES AND INTERMEDIATE PRODUCTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
WO1998028255A1 (en) 1998-07-02
IL119890A (en) 2002-03-10
ES2204362T1 (en) 2004-05-01
EP0950044A1 (en) 1999-10-20
IL119890A0 (en) 1997-03-18
DE97954134T1 (en) 2004-04-15
CA2275912A1 (en) 1998-07-02
AU5799098A (en) 1998-07-17

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