EP0939900A4 - DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES - Google Patents

DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES

Info

Publication number
EP0939900A4
EP0939900A4 EP97947553A EP97947553A EP0939900A4 EP 0939900 A4 EP0939900 A4 EP 0939900A4 EP 97947553 A EP97947553 A EP 97947553A EP 97947553 A EP97947553 A EP 97947553A EP 0939900 A4 EP0939900 A4 EP 0939900A4
Authority
EP
European Patent Office
Prior art keywords
gpiib
antagonist
dependent
detection
receptor antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97947553A
Other languages
German (de)
French (fr)
Other versions
EP0939900A1 (en
Inventor
Bohumil Bednar
Robert J Gould
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9702822.9A external-priority patent/GB9702822D0/en
Priority claimed from GBGB9705856.4A external-priority patent/GB9705856D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0939900A1 publication Critical patent/EP0939900A1/en
Publication of EP0939900A4 publication Critical patent/EP0939900A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
EP97947553A 1996-11-21 1997-11-17 DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES Withdrawn EP0939900A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US3166196P 1996-11-21 1996-11-21
US31661P 1996-11-21
US3546197P 1997-01-14 1997-01-14
US35461P 1997-01-14
GB9702822 1997-02-12
GBGB9702822.9A GB9702822D0 (en) 1997-02-12 1997-02-12 Anticoagulant test
GBGB9705856.4A GB9705856D0 (en) 1997-03-21 1997-03-21 Anticoagulant test
GB9705856 1997-03-21
PCT/US1997/020954 WO1998022821A1 (en) 1996-11-21 1997-11-17 DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES

Publications (2)

Publication Number Publication Date
EP0939900A1 EP0939900A1 (en) 1999-09-08
EP0939900A4 true EP0939900A4 (en) 2003-01-08

Family

ID=27451602

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97947553A Withdrawn EP0939900A4 (en) 1996-11-21 1997-11-17 DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES

Country Status (4)

Country Link
EP (1) EP0939900A4 (en)
JP (1) JP2001504584A (en)
CA (1) CA2271684A1 (en)
WO (1) WO1998022821A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623981B2 (en) 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
US20020132276A1 (en) * 1999-01-26 2002-09-19 Dicker Ira B. FACS method for detecton of GPIIb/IIIa inhibitor dependent activators in plasma samples

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717654A (en) * 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
FR2665769A1 (en) * 1990-08-09 1992-02-14 Serbio DETERMINATION OF THROMBOPENIA PARTICULARLY INDUCED BY HEPARIN BY MEANS OF PLATELET FACTOR 4.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5585243A (en) * 1993-09-15 1996-12-17 The Blood Center Of Southeastern Wisconsin, Inc. Method of detecting cytopenia that is mediated by drug-dependent antibody binding to blood cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717654A (en) * 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
FR2665769A1 (en) * 1990-08-09 1992-02-14 Serbio DETERMINATION OF THROMBOPENIA PARTICULARLY INDUCED BY HEPARIN BY MEANS OF PLATELET FACTOR 4.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEDNAR B ET AL: "DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB/IIIA INDUCE THROMBOCYTOPENIA", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 94, no. 8, SUPPL 1, 15 October 1996 (1996-10-15), pages 571, XP001029709, ISSN: 0009-7322 *
CURTIS BRIAN R ET AL: "Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex.", BLOOD, vol. 84, no. 1, 1994, pages 176 - 183, XP001029348, ISSN: 0006-4971 *
See also references of WO9822821A1 *
VISENTIN G P ET AL: "DETECTION OF DRUG-DEPENDENT, PLATELET-REACTIVE ANTIBODIES BY ANTIGEN-CAPTURE ELISA AND FLOW CYTOMETRY", TRANSFUSION, AMERICAN ASSOCIATION OF BLOOD BANKS, BETHESDA, MD, US, vol. 30, no. 8, October 1990 (1990-10-01), pages 694 - 700, XP000983195, ISSN: 0041-1132 *

Also Published As

Publication number Publication date
EP0939900A1 (en) 1999-09-08
WO1998022821A1 (en) 1998-05-28
JP2001504584A (en) 2001-04-03
CA2271684A1 (en) 1998-05-28

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