EP0880357A4 - Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis - Google Patents
Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesisInfo
- Publication number
- EP0880357A4 EP0880357A4 EP96919234A EP96919234A EP0880357A4 EP 0880357 A4 EP0880357 A4 EP 0880357A4 EP 96919234 A EP96919234 A EP 96919234A EP 96919234 A EP96919234 A EP 96919234A EP 0880357 A4 EP0880357 A4 EP 0880357A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- peptidomimetics
- peptides
- synthesis
- amino acids
- ring closing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1017096P | 1996-01-17 | 1996-01-17 | |
US10170P | 1996-01-17 | ||
PCT/US1996/009591 WO1997026002A1 (en) | 1996-01-17 | 1996-06-07 | Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0880357A1 EP0880357A1 (en) | 1998-12-02 |
EP0880357A4 true EP0880357A4 (en) | 1999-05-12 |
Family
ID=21744291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96919234A Withdrawn EP0880357A4 (en) | 1996-01-17 | 1996-06-07 | Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0880357A4 (en) |
AU (1) | AU6162996A (en) |
WO (1) | WO1997026002A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
US6582726B1 (en) * | 2000-06-21 | 2003-06-24 | Smithkline Beecham Corporation | Cross linked solid supports for solid phase synthesis |
US6680051B2 (en) * | 2000-08-19 | 2004-01-20 | University Of Florida | Functionalized polymers |
WO2008048121A2 (en) * | 2006-10-18 | 2008-04-24 | Lincoln University | Macrocyclic cysteine protease inhibitors and compositions thereof |
EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
US9206223B2 (en) * | 2008-09-22 | 2015-12-08 | Aileron Therapeutics, Inc. | Methods for preparing purified polypeptide compositions |
CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
TWI643868B (en) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | Peptidomimetic macrocycles |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
MX362492B (en) | 2012-02-15 | 2019-01-21 | Aileron Therapeutics Inc | Peptidomimetic macrocycles. |
EP2914256B1 (en) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
US10081654B2 (en) * | 2013-03-13 | 2018-09-25 | President And Fellows Of Harvard College | Stapled and stitched polypeptides and uses thereof |
AU2014278005B2 (en) | 2013-06-14 | 2018-11-22 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
WO2015179635A2 (en) | 2014-05-21 | 2015-11-26 | President And Fellows Of Harvard College | Ras inhibitory peptides and uses thereof |
SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
CN107106642B (en) | 2014-09-24 | 2021-02-26 | 艾瑞朗医疗公司 | Peptidomimetic macrocycles and formulations thereof |
AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
US11584956B2 (en) * | 2018-12-21 | 2023-02-21 | Microsoft Technology Licensing, Llc | Selectively controllable cleavable linkers |
-
1996
- 1996-06-07 AU AU61629/96A patent/AU6162996A/en not_active Abandoned
- 1996-06-07 WO PCT/US1996/009591 patent/WO1997026002A1/en not_active Application Discontinuation
- 1996-06-07 EP EP96919234A patent/EP0880357A4/en not_active Withdrawn
Non-Patent Citations (4)
Title |
---|
SCOTT J.MILLER ET AL.: "Synthesis of Conformationally Restricted Amino Acids and Peptides Employing Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 5855 - 6, XP002093028 * |
SCOTT.J.MILLER ET AL: "Catalytic Ring-Closing Metathesis of Dienes: Application to the Synthesis of Eight-Membered Rings", J.AM.CHEM.SOC, vol. 117, 1995, pages 2108 - 9, XP002093029 * |
See also references of WO9726002A1 * |
THOMAS D.CLERK ET AL.: "Supramolecular Design by Covalent Capture. Design of a Peptide cylinder via Hydrogen-Bond-Promoted Intermolecular Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 12364 - 5, XP002093030 * |
Also Published As
Publication number | Publication date |
---|---|
EP0880357A1 (en) | 1998-12-02 |
WO1997026002A1 (en) | 1997-07-24 |
AU6162996A (en) | 1997-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980813 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL PAYMENT 980813;LT PAYMENT 980813;LV PAYMENT 980813;SI PAYMENT 980813 |
|
RHK1 | Main classification (correction) |
Ipc: C07K 1/04 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19990325 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19990519 |