EP0871455A4 - In vitro growth of functional islets of langerhans and in vivo uses thereof - Google Patents

In vitro growth of functional islets of langerhans and in vivo uses thereof

Info

Publication number
EP0871455A4
EP0871455A4 EP96936866A EP96936866A EP0871455A4 EP 0871455 A4 EP0871455 A4 EP 0871455A4 EP 96936866 A EP96936866 A EP 96936866A EP 96936866 A EP96936866 A EP 96936866A EP 0871455 A4 EP0871455 A4 EP 0871455A4
Authority
EP
European Patent Office
Prior art keywords
langerhans
vitro growth
vivo uses
functional islets
islets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96936866A
Other languages
German (de)
French (fr)
Other versions
EP0871455A1 (en
Inventor
Ammon B Peck
Janet G Cornelius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/547,746 external-priority patent/US6001647A/en
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of EP0871455A1 publication Critical patent/EP0871455A1/en
Publication of EP0871455A4 publication Critical patent/EP0871455A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP96936866A 1995-10-25 1996-10-23 In vitro growth of functional islets of langerhans and in vivo uses thereof Withdrawn EP0871455A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US547746 1995-10-25
US08/547,746 US6001647A (en) 1994-04-28 1995-10-25 In vitro growth of functional islets of Langerhans and in vivo uses thereof
PCT/US1996/016952 WO1997015310A1 (en) 1995-10-25 1996-10-23 In vitro growth of functional islets of langerhans and in vivo uses thereof

Publications (2)

Publication Number Publication Date
EP0871455A1 EP0871455A1 (en) 1998-10-21
EP0871455A4 true EP0871455A4 (en) 2003-05-14

Family

ID=24185961

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96936866A Withdrawn EP0871455A4 (en) 1995-10-25 1996-10-23 In vitro growth of functional islets of langerhans and in vivo uses thereof

Country Status (5)

Country Link
EP (1) EP0871455A4 (en)
JP (1) JPH11514877A (en)
AU (1) AU739771B2 (en)
CA (1) CA2235509A1 (en)
WO (1) WO1997015310A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144378A0 (en) 1999-02-04 2002-05-23 Univ Mcgill Platform for the differentiation of cells
GB9914890D0 (en) * 1999-06-25 1999-08-25 Univ Buckingham Methods and compositions relating to pancreatic islet and -cell dysfunction
EP1224259A4 (en) * 1999-09-27 2005-04-27 Univ Florida Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
WO2001032839A2 (en) * 1999-10-29 2001-05-10 Mcgill University Medium for preparing dedifferentiated cells
CA2392615A1 (en) 1999-12-06 2001-06-07 The General Hospital Corporation Pancreatic stem cells and their use in transplantation
US20030082155A1 (en) 1999-12-06 2003-05-01 Habener Joel F. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
JP2003517592A (en) * 1999-12-13 2003-05-27 ザ スクリプス リサーチ インスティチュート Markers for identification and isolation of islet α and β precursors
US6610535B1 (en) * 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
WO2002002750A1 (en) * 2000-06-30 2002-01-10 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
EP1385935A4 (en) 2001-03-29 2004-09-15 Ixion Biotechnology Inc Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
DE60231035D1 (en) * 2001-04-24 2009-03-19 Ajinomoto Kk STEM CELLS AND METHOD FOR THEIR SEPARATION
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
JP2005537803A (en) 2002-09-06 2005-12-15 アムサイト インコーポレーティッド CD56 positive human adult pancreatic endocrine precursor cells
KR20060032958A (en) * 2003-06-03 2006-04-18 올간 리커버리 시스템즈, 인코포레이티드 Selection and propagation of progenitor cells
EP1636348B1 (en) * 2003-06-20 2009-07-29 Vrije Universiteit Brussel VUB Method of generating islet beta-cells from exocrine pancreatic cells
US20060121512A1 (en) * 2004-12-02 2006-06-08 Organ Recovery Systems, Inc. Biological pathways in progenitor cells
WO2007039986A1 (en) 2005-10-05 2007-04-12 Osaka University Method of obtaining pancreatic endocrine cells from adipose tissue-origin cells
KR101452877B1 (en) * 2013-08-05 2014-10-22 사회복지법인 삼성생명공익재단 Method for Preparing Cell Implant comprising Early-Endothelial Progenitor Cells and Islet Cells
JP7081483B2 (en) * 2016-04-19 2022-06-07 凸版印刷株式会社 Evaluation method of angiogenesis inhibitory activity of the test compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029988A1 (en) * 1994-04-28 1995-11-09 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of langerhans and in vivo uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179821T3 (en) * 1991-06-24 2003-02-01 Hcell Technology Inc PANCREATIC CELLS SECRETORS OF HORMONES AND MAINTENANCE IN LONG-TERM CULTURE.
JP2813467B2 (en) * 1993-04-08 1998-10-22 ヒューマン・セル・カルチャーズ・インコーポレーテッド Cell culture methods and media

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029988A1 (en) * 1994-04-28 1995-11-09 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of langerhans and in vivo uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CORNELIUS J G ET AL: "In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas", HORMONE AND METABOLIC RESEARCH, THIEME-STRATTON, STUTTGART, DE, vol. 29, no. 6, 1997, pages 271 - 277, XP000864742, ISSN: 0018-5043 *
PECK AB & CORNELIUS JG: "In vitro growth of mature pancreatic islets of Langerhans from single, pluripotent stem cells isolated from prediabetic adult pancreas", DIABETES, ABSTRACT BOOK, 55TH ANNUAL MEETING AND SCIENTIFIC SESSIONS, vol. 44, no. Supp. 1, 10 June 1995 (1995-06-10) - 13 June 1995 (1995-06-13), pages A10, XP009006982 *
PECK AMMON B ET AL: "Pancreatic stem cells: Building blocks for a better surrogate islet to treat type 1 diabetes.", ANNALS OF MEDICINE, vol. 33, no. 3, April 2001 (2001-04-01), pages 186 - 192, XP009006630, ISSN: 0785-3890 *
PIPELEERS D G: "TRANSPLANTATION OF PURIFIED ISLET CELLS IN DIABETIC RATS. STANDARDIZATION OF ISLET CELL GRAFTS", DIABETES, NEW YORK, NY, US, vol. 40, no. 7, 1 July 1991 (1991-07-01), pages 908 - 919, XP000651349, ISSN: 0012-1797 *
RAMIYA VIJAYAKUMAR K ET AL: "Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells", NATURE MEDICINE, NATURE AMERICA, NEW YORK, US, vol. 6, no. 3, March 2000 (2000-03-01), pages 278 - 282, XP002228537, ISSN: 1078-8956 *
See also references of WO9715310A1 *

Also Published As

Publication number Publication date
AU7468396A (en) 1997-05-15
MX9803263A (en) 1998-09-30
EP0871455A1 (en) 1998-10-21
CA2235509A1 (en) 1997-05-01
AU739771B2 (en) 2001-10-18
JPH11514877A (en) 1999-12-21
WO1997015310A1 (en) 1997-05-01

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