EP0866799A4 - Apolipoprotein e2 and treatment of alzheimer's disease - Google Patents

Apolipoprotein e2 and treatment of alzheimer's disease

Info

Publication number
EP0866799A4
EP0866799A4 EP96937887A EP96937887A EP0866799A4 EP 0866799 A4 EP0866799 A4 EP 0866799A4 EP 96937887 A EP96937887 A EP 96937887A EP 96937887 A EP96937887 A EP 96937887A EP 0866799 A4 EP0866799 A4 EP 0866799A4
Authority
EP
European Patent Office
Prior art keywords
apolipoprotein
alzheimer
disease
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96937887A
Other languages
German (de)
French (fr)
Other versions
EP0866799A1 (en
Inventor
Vassilis I Zannis
Sergie B Aleshkov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Kos Pharmaceuticals Inc
Original Assignee
Boston University
Kos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston University, Kos Pharmaceuticals Inc filed Critical Boston University
Publication of EP0866799A1 publication Critical patent/EP0866799A1/en
Publication of EP0866799A4 publication Critical patent/EP0866799A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP96937887A 1995-11-01 1996-10-31 Apolipoprotein e2 and treatment of alzheimer's disease Withdrawn EP0866799A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55172295A 1995-11-01 1995-11-01
US551722 1995-11-01
PCT/US1996/017629 WO1997016458A1 (en) 1995-11-01 1996-10-31 Apolipoprotein e2 and treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
EP0866799A1 EP0866799A1 (en) 1998-09-30
EP0866799A4 true EP0866799A4 (en) 2000-08-23

Family

ID=24202413

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96937887A Withdrawn EP0866799A4 (en) 1995-11-01 1996-10-31 Apolipoprotein e2 and treatment of alzheimer's disease

Country Status (7)

Country Link
EP (1) EP0866799A4 (en)
JP (1) JP2000500332A (en)
AU (1) AU720446B2 (en)
BR (1) BR9611329A (en)
CA (1) CA2236274A1 (en)
MX (1) MX9803422A (en)
WO (1) WO1997016458A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023587A2 (en) * 1998-10-16 2000-04-27 Introgene B.V. Gene therapy of alzheimer's disease by delivery of an encoded apolipoprotein e
CA2349229A1 (en) * 1998-11-25 2000-06-02 Scios Inc. Prevention and treatment of amyloid-associated disorders
CN1315402A (en) * 2000-03-28 2001-10-03 上海博德基因开发有限公司 Polypeptide-human amyloid precursor protein bindin 14 and polynucleotide for coding it
CN1315439A (en) * 2000-03-29 2001-10-03 上海博德基因开发有限公司 Polypeptide-human amyloid precursor protein bindin 9 and polynucleotide for coding it
WO2005032596A1 (en) * 2003-09-26 2005-04-14 Eli Lilly And Company Lentiviral apoe2 gene therapy
EP1991252A2 (en) * 2006-02-21 2008-11-19 Oklahoma Medical Research Foundation Treatment of alzheimer's disease with inhibitors of apoe binding to apoe receptor
WO2010020822A1 (en) * 2008-08-19 2010-02-25 University Of Patras Therapy for apolipoprotein-induced hypertriglyceridemia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002670A1 (en) * 1994-07-20 1996-02-01 Smithkline Beecham Plc Methods of prognosing the course and degree of dementia in patients with beta-amyloid-related diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002670A1 (en) * 1994-07-20 1996-02-01 Smithkline Beecham Plc Methods of prognosing the course and degree of dementia in patients with beta-amyloid-related diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 1994, 1994, Philadelphia, PA, US; abstract no. 345993, E H CORDER ET AL.: "Protective effect of apolioprotein E type 2 allele for late onset Alzheimer disease" XP002140639 *
C S HANLON & D C RUBINSZTEIN: "Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.", ATHEROSCLEROSIS, vol. 112, no. 1, 6 January 1995 (1995-01-06), AMSTERDAM, NL, pages 85 - 90, XP002005036, ISSN: 0021-9150, DOI: doi:10.1016/0021-9150(94)05402-5 *
C TALBOT ET AL.: "Protection against Alzheimer's disease with apoE epsilon 2", LANCET THE., vol. 343, 4 June 1994 (1994-06-04), LANCET LIMITED. LONDON., GB, pages 1432 - 1433, XP002140637, ISSN: 0140-6736 *
File Medline, abstract 95290021, 1995 *
NATURE GENETICS., vol. 7, no. 2, 1994, pages 180 - 184, ISSN: 1061-4036 *
See also references of WO9716458A1 *

Also Published As

Publication number Publication date
WO1997016458A1 (en) 1997-05-09
AU720446B2 (en) 2000-06-01
EP0866799A1 (en) 1998-09-30
AU7552696A (en) 1997-05-22
CA2236274A1 (en) 1997-05-09
JP2000500332A (en) 2000-01-18
MX9803422A (en) 1998-11-29
BR9611329A (en) 1999-12-28

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Legal Events

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