AU3279395A - Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes - Google Patents
Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenesInfo
- Publication number
- AU3279395A AU3279395A AU32793/95A AU3279395A AU3279395A AU 3279395 A AU3279395 A AU 3279395A AU 32793/95 A AU32793/95 A AU 32793/95A AU 3279395 A AU3279395 A AU 3279395A AU 3279395 A AU3279395 A AU 3279395A
- Authority
- AU
- Australia
- Prior art keywords
- thioxanthenes
- phenothiazines
- disease
- treating
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28733994A | 1994-08-08 | 1994-08-08 | |
US08/287339 | 1994-08-08 | ||
US34675794A | 1994-11-30 | 1994-11-30 | |
US08/346757 | 1994-11-30 | ||
PCT/US1995/010110 WO1996004915A1 (en) | 1994-08-08 | 1995-08-07 | Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3279395A true AU3279395A (en) | 1996-03-07 |
AU708682B2 AU708682B2 (en) | 1999-08-12 |
Family
ID=26964404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU32793/95A Ceased AU708682B2 (en) | 1994-08-08 | 1995-08-07 | Methods for treating and/or preventing Alzheimer's disease using phenothiazines and/or thioxanthenes |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0778773A1 (en) |
KR (1) | KR970704445A (en) |
AU (1) | AU708682B2 (en) |
CA (1) | CA2196529A1 (en) |
WO (1) | WO1996004915A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
GB9713484D0 (en) * | 1997-06-27 | 1997-09-03 | Smithkline Beecham Plc | Neuroprotective vanilloid compounds |
DE19842416A1 (en) * | 1998-09-16 | 2000-04-13 | Max Planck Gesellschaft | Secondary amines for the prevention and therapy of diseases caused or intensified by oxidation processes |
GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
PT1470818E (en) * | 2003-04-25 | 2006-11-30 | Neuro3D | Use of piperazine phenothiazine derivatives in the manufacture of a medicament with neuroprotector and/or neurotrophic effects on cns and/or pns |
JP5186212B2 (en) | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | Method for chemical synthesis and purification of diaminophenothiazinium compounds such as methylthioninium chloride (MTC) |
EP1836161B1 (en) | 2004-12-22 | 2016-07-20 | BHI Limited Partnership | Methods and compositions for treating amyloid-related diseases |
CA2645919C (en) * | 2006-03-29 | 2016-05-31 | Wista Laboratories Ltd. | Thioninium compounds and their use |
ATE478058T3 (en) | 2006-03-29 | 2010-09-15 | Wista Lab Ltd | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE |
DK2004155T3 (en) | 2006-03-29 | 2018-04-30 | Wista Lab Ltd | PROTEIN AGGREGATION INHIBITORS |
PT3851447T (en) | 2006-10-12 | 2023-12-11 | Bellus Health Inc | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
GB0701970D0 (en) * | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
ES2331282B1 (en) * | 2008-06-25 | 2010-10-21 | Consejo Superior De Investigaciones Cientificas (Csic) (45%) | HYDRAZIDS OF HETEROCICLICAL SYSTEMS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES. |
DE102010062810B4 (en) * | 2010-09-07 | 2014-03-13 | Immungenetics Ag | 2- (R2-thio) -10- [3- (4-R1-piperazin-1-yl) -propyl] -10H-phenothiazines for the treatment of neurodegenerative diseases selected from beta-amyloidopathies and alpha-synucleinopathies |
CN105853439A (en) | 2011-02-11 | 2016-08-17 | 维斯塔实验室有限公司 | Phenothiazine diaminium salts and their use |
WO2012166862A1 (en) | 2011-06-01 | 2012-12-06 | Wisconsin Alumni Research Foundation | Compositions and methods for treating alzheimer's disease |
EP4241774A1 (en) * | 2020-11-04 | 2023-09-13 | Gliacelltech Inc. | Composition for preventing or treating neuroinflammatory diseases, comprising chlorpromazine |
US20240025868A1 (en) * | 2020-11-13 | 2024-01-25 | Icahn School Of Medicine At Mount Sinai | Phenothiazine compounds for the treatment of alzheimer's disease and other age-related and neurological diseases |
WO2023131606A1 (en) * | 2022-01-04 | 2023-07-13 | Immungenetics Ag | Specific dosage of phenothiazine compounds for use in treatment or prevention of alzheimer's dementia |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2837518A (en) * | 1958-06-03 | Phenthiazine compounds | ||
US2902484A (en) * | 1954-04-27 | 1959-09-01 | Rhone Poulenc Sa | Phenthiazine derivatives and processes for their preparation |
NL108827C (en) * | 1956-04-09 |
-
1995
- 1995-08-07 EP EP95929441A patent/EP0778773A1/en not_active Withdrawn
- 1995-08-07 CA CA002196529A patent/CA2196529A1/en not_active Abandoned
- 1995-08-07 AU AU32793/95A patent/AU708682B2/en not_active Ceased
- 1995-08-07 WO PCT/US1995/010110 patent/WO1996004915A1/en not_active Application Discontinuation
-
1997
- 1997-02-10 KR KR1019970700943A patent/KR970704445A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR970704445A (en) | 1997-09-06 |
AU708682B2 (en) | 1999-08-12 |
WO1996004915A1 (en) | 1996-02-22 |
CA2196529A1 (en) | 1996-02-22 |
EP0778773A1 (en) | 1997-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |