EP0863764A4 - Verfahren zur analyse von enalapril- und enalaprilat-isomeren - Google Patents

Verfahren zur analyse von enalapril- und enalaprilat-isomeren

Info

Publication number
EP0863764A4
EP0863764A4 EP96932204A EP96932204A EP0863764A4 EP 0863764 A4 EP0863764 A4 EP 0863764A4 EP 96932204 A EP96932204 A EP 96932204A EP 96932204 A EP96932204 A EP 96932204A EP 0863764 A4 EP0863764 A4 EP 0863764A4
Authority
EP
European Patent Office
Prior art keywords
enalaprilat
enalapril
isomers
analyzing
analyzing isomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96932204A
Other languages
English (en)
French (fr)
Other versions
EP0863764A1 (de
Inventor
Xue-Zhi Qin
Giuseppina Visentini
Qingxi Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Merck and Co Inc
Original Assignee
Merck Frosst Canada and Co
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9606503.2A external-priority patent/GB9606503D0/en
Application filed by Merck Frosst Canada and Co, Merck and Co Inc filed Critical Merck Frosst Canada and Co
Publication of EP0863764A1 publication Critical patent/EP0863764A1/de
Publication of EP0863764A4 publication Critical patent/EP0863764A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
EP96932204A 1995-09-15 1996-09-11 Verfahren zur analyse von enalapril- und enalaprilat-isomeren Withdrawn EP0863764A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US382595P 1995-09-15 1995-09-15
US3825P 1995-09-15
GB9606503 1996-03-28
GBGB9606503.2A GB9606503D0 (en) 1996-03-28 1996-03-28 Method for analyzing isomers of enalapril and enalapril and enalaprilat
PCT/US1996/014566 WO1997009993A1 (en) 1995-09-15 1996-09-11 Method for analyzing isomers of enalapril and enalaprilat

Publications (2)

Publication Number Publication Date
EP0863764A1 EP0863764A1 (de) 1998-09-16
EP0863764A4 true EP0863764A4 (de) 1999-04-07

Family

ID=26309007

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96932204A Withdrawn EP0863764A4 (de) 1995-09-15 1996-09-11 Verfahren zur analyse von enalapril- und enalaprilat-isomeren

Country Status (5)

Country Link
EP (1) EP0863764A4 (de)
JP (1) JPH11512522A (de)
AU (1) AU702718B2 (de)
CA (1) CA2231043A1 (de)
WO (1) WO1997009993A1 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0523449A2 (de) * 1991-07-13 1993-01-20 Degussa Ag Reduktive Aminierung einer Aminosäure oder eines Aminosäure-Derivates mit einer Alpha-Ketosäure oder einem Alpha-Ketosäurederivat
US5670655A (en) * 1995-09-15 1997-09-23 Merck & Co. Inc. Method for analyzing isomers of enalapril and enalaprilat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0523449A2 (de) * 1991-07-13 1993-01-20 Degussa Ag Reduktive Aminierung einer Aminosäure oder eines Aminosäure-Derivates mit einer Alpha-Ketosäure oder einem Alpha-Ketosäurederivat
US5670655A (en) * 1995-09-15 1997-09-23 Merck & Co. Inc. Method for analyzing isomers of enalapril and enalaprilat

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLACKLOCK,T.J. ET AL.: "Synthesis of semisyntehtic Dipeptides Using N-Carboxyanhydrides and Chiral Induction on Raney Nickel. A Method Practical for Large Scale", J.ORG.CHEM., vol. 53, 1988, WASHINGTON, pages 836 - 844, XP002091023 *
IWASAKI,G. ET AL.: "A Practical and Disasteroselective Synthesis of angiotensin Converting Enzyme Inhibitors", CHEM.PHARM.BULL., vol. 37, no. 2, 1989, TOKYO, pages 280 - 283, XP002091022 *
IWASAKI,G. ET AL.: "A Stereoselective Synthesis of N-[(S)-1-Ethoxycarbonyl-3- phenylpropyl]-L-alanine Derivatives by Means of Reductive Amination", CHEMISTRY LETTERS, 1988, TOKYO, pages 1691 - 1694, XP002089878 *
QUIN,X.-E. ET AL.: "Detection and Identification of an Enalaprilat Isomer in Enalalpril Formulations", ISOLATION & PURIFICATION, vol. 2, 1997, AMSTERDAM, pages 275 - 288, XP002089863 *
See also references of WO9709993A1 *

Also Published As

Publication number Publication date
JPH11512522A (ja) 1999-10-26
AU702718B2 (en) 1999-03-04
WO1997009993A1 (en) 1997-03-20
AU7108296A (en) 1997-04-01
CA2231043A1 (en) 1997-03-20
EP0863764A1 (de) 1998-09-16

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19980415

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RHK1 Main classification (correction)

Ipc: C07D207/16

A4 Supplementary search report drawn up and despatched

Effective date: 19990218

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Effective date: 20020221