EP0859761A4 - 4-azasteroides utilises pour le traitement d'etats hyperandrogeniques - Google Patents
4-azasteroides utilises pour le traitement d'etats hyperandrogeniquesInfo
- Publication number
- EP0859761A4 EP0859761A4 EP96930822A EP96930822A EP0859761A4 EP 0859761 A4 EP0859761 A4 EP 0859761A4 EP 96930822 A EP96930822 A EP 96930822A EP 96930822 A EP96930822 A EP 96930822A EP 0859761 A4 EP0859761 A4 EP 0859761A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- azasteroids
- treatment
- hyperandrogenic conditions
- hyperandrogenic
- conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US382695P | 1995-09-15 | 1995-09-15 | |
US3826 | 1995-09-15 | ||
GB9603487 | 1996-02-20 | ||
GBGB9603487.1A GB9603487D0 (en) | 1996-02-20 | 1996-02-20 | 4-azasteroids for the treatment of hyperandrogenic conditions |
PCT/US1996/014564 WO1997010217A1 (fr) | 1995-09-15 | 1996-09-11 | 4-azasteroides utilises pour le traitement d'etats hyperandrogeniques |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0859761A1 EP0859761A1 (fr) | 1998-08-26 |
EP0859761A4 true EP0859761A4 (fr) | 2000-01-26 |
Family
ID=26308763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96930822A Ceased EP0859761A4 (fr) | 1995-09-15 | 1996-09-11 | 4-azasteroides utilises pour le traitement d'etats hyperandrogeniques |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0859761A4 (fr) |
JP (1) | JPH11512434A (fr) |
AU (1) | AU707324B2 (fr) |
CA (1) | CA2231041A1 (fr) |
WO (1) | WO1997010217A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6137399A (en) * | 1998-09-09 | 2000-03-27 | Merck & Co., Inc. | Method of determining and reducing the risk of bph-related urologic events |
US6645974B2 (en) | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
JP4490689B2 (ja) * | 2001-10-03 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | アンドロゲン受容体調節剤としてのアンドロスタン17β−カルボキサミド類 |
JP4516316B2 (ja) * | 2002-03-13 | 2010-08-04 | メルク・シャープ・エンド・ドーム・コーポレイション | アンドロゲン受容体モジュレーターとしてのフッ化4−アザステロイド誘導体 |
EP1636183A1 (fr) | 2003-05-16 | 2006-03-22 | Ambit Biosciences Corporation | Composes pyrroliques et leurs utilisations |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
JP2008534505A (ja) * | 2005-03-25 | 2008-08-28 | メルク エンド カムパニー インコーポレーテッド | テストステロンサプリメントおよび5アルファ−レダクターゼインヒビターによる男性の治療方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994007861A1 (fr) * | 1992-10-06 | 1994-04-14 | Merck & Co., Inc. | 17β-CARBOXANILIDES DE 4-AZA-5α-ANDROSTAN-3-ONES UTILISES COMME INHIBITEURS DE 5α-REDUCTASE |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US5151429A (en) * | 1984-02-27 | 1992-09-29 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors |
US4760071A (en) * | 1984-02-27 | 1988-07-26 | Merck & Co., Inc. | 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors |
IE76452B1 (en) * | 1990-10-29 | 1997-10-22 | Sankyo Co | Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use |
US5304562A (en) * | 1991-10-09 | 1994-04-19 | Ciba-Geigy Corporation | 17β-substituted Aza-androstane derivatives |
US5468860A (en) * | 1992-11-19 | 1995-11-21 | Merck & Co., Inc. | New finasteride processes |
-
1996
- 1996-09-11 WO PCT/US1996/014564 patent/WO1997010217A1/fr not_active Application Discontinuation
- 1996-09-11 JP JP9512068A patent/JPH11512434A/ja active Pending
- 1996-09-11 CA CA002231041A patent/CA2231041A1/fr not_active Abandoned
- 1996-09-11 EP EP96930822A patent/EP0859761A4/fr not_active Ceased
- 1996-09-11 AU AU69737/96A patent/AU707324B2/en not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994007861A1 (fr) * | 1992-10-06 | 1994-04-14 | Merck & Co., Inc. | 17β-CARBOXANILIDES DE 4-AZA-5α-ANDROSTAN-3-ONES UTILISES COMME INHIBITEURS DE 5α-REDUCTASE |
Non-Patent Citations (8)
Title |
---|
BAKSHI ET AL: "Erratum to J. Med. Chem. Vol 38, Nr 17, pages 3189-3192, 18 August 1995", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 5, 1 March 1996 (1996-03-01), WASHINGTON US, pages 1192, XP002089558 * |
BAKSHI R K ET AL: "4-Aza-3-oxo-5.alpha.-androst-1-ene-17.beta.-N-arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5.alpha.-Reductases. Dramatic Effect of N-Aryl Substituents on Type 1 and Type 2 5.alpha.-Reductase Inhibitory Potency", JOURNAL OF MEDICINAL CHEMISTRY., vol. 38, no. 17, 18 August 1995 (1995-08-18), WASHINGTON US, XP002087243 * |
CHEMICAL ABSTRACTS, vol. 122, no. 25, 19 June 1995, Columbus, Ohio, US; abstract no. 314919, ZHENG, JINHONG ET AL: "Synthesis of N-substituted-4-methyl-3-oxo-4-aza-5.alpha.-androstane- 17.beta.-carboxamide compounds" XP002121894 * |
KURATA H ET AL: "SYNTHESIS AND TESTOSTERONE 5ALPHA-REDUCTASE-INHIBITORY ACTIVITY OF 4-AZA-5ALPHA-ANDROSTANE-17-CARBOXAMIDE COMPOUND WITH AN AROMATIC MOIETY IN THE C-17 CARBAMOYL GROUP", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 44, no. 1, pages 115-121, XP000569266, ISSN: 0009-2363 * |
MELLIN T N ET AL: "AZASTEROIDS AS INHIBITORS OF TESTOSTERONE 5ALPHA-REDUCTASE IN MAMMALIAN SKIN", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 44, no. 2, February 1993 (1993-02-01), pages 121 - 131, XP002028037 * |
RASMUSSON G H ET AL: "AZASTEROIDS AS INHIBITORS OF RAT PROSTATIC 5ALPHA-REDUCTASE", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 12, December 1984 (1984-12-01), pages 1690 - 1701, XP002043194 * |
See also references of WO9710217A1 * |
ZHONGGUO YAOKE DAXUE XUEBAO (1995), 26(1), 1-4 * |
Also Published As
Publication number | Publication date |
---|---|
JPH11512434A (ja) | 1999-10-26 |
AU6973796A (en) | 1997-04-01 |
CA2231041A1 (fr) | 1997-03-20 |
AU707324B2 (en) | 1999-07-08 |
EP0859761A1 (fr) | 1998-08-26 |
WO1997010217A1 (fr) | 1997-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980415 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19991209 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20030117 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20041119 |