EP0855909A4 - Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques - Google Patents

Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques

Info

Publication number
EP0855909A4
EP0855909A4 EP96930833A EP96930833A EP0855909A4 EP 0855909 A4 EP0855909 A4 EP 0855909A4 EP 96930833 A EP96930833 A EP 96930833A EP 96930833 A EP96930833 A EP 96930833A EP 0855909 A4 EP0855909 A4 EP 0855909A4
Authority
EP
European Patent Office
Prior art keywords
radiosensitizing
taxanes
pharmaceutical preparations
preparations
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96930833A
Other languages
German (de)
English (en)
Other versions
EP0855909A1 (fr
Inventor
Robert A Holton
Hossain Nadizadeh
Kurt G Hofer
Li-Xi Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University filed Critical Florida State University
Priority claimed from PCT/US1996/014613 external-priority patent/WO1997009979A1/fr
Publication of EP0855909A1 publication Critical patent/EP0855909A1/fr
Publication of EP0855909A4 publication Critical patent/EP0855909A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96930833A 1995-09-13 1996-09-13 Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques Withdrawn EP0855909A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US368795P 1995-09-13 1995-09-13
US3687P 1995-09-18
PCT/US1996/014613 WO1997009979A1 (fr) 1995-09-13 1996-09-13 Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
EP0855909A1 EP0855909A1 (fr) 1998-08-05
EP0855909A4 true EP0855909A4 (fr) 2000-06-07

Family

ID=34810323

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96930833A Withdrawn EP0855909A4 (fr) 1995-09-13 1996-09-13 Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques

Country Status (3)

Country Link
EP (1) EP0855909A4 (fr)
JP (1) JP2001524067A (fr)
AU (1) AU728057B2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534709A1 (fr) * 1991-09-23 1993-03-31 Florida State University Taxanes substitués comme agents antitumoraux
WO1993014787A1 (fr) * 1992-01-31 1993-08-05 The Trustees Of Columbia University In The City Of New York Taxol utilise comme sensibilisateur aux rayonnements
EP0617034A1 (fr) * 1993-03-11 1994-09-28 Virginia Tech Intellectual Properties, Inc. Dérivés 2-débenzoyl-2-acyle de taxol et des procédés pour leur préparation
WO1994021250A1 (fr) * 1993-03-22 1994-09-29 Florida State University Taxanes presentant une chaine laterale a substitution alcoxy, alcenoxy ou aryloxy et compositions pharmaceutiques contenant de tels composes
WO1996040091A1 (fr) * 1995-06-07 1996-12-19 Vivorx Pharmaceuticals, Inc. Composes d'agents de sensibilisation radiologiques/cytotoxiques adouble fonction et leurs procedes de preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
DE69230379T2 (de) * 1991-09-23 2000-05-25 Univ Florida State 10-disacetoxytaxolderivate

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534709A1 (fr) * 1991-09-23 1993-03-31 Florida State University Taxanes substitués comme agents antitumoraux
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
WO1993014787A1 (fr) * 1992-01-31 1993-08-05 The Trustees Of Columbia University In The City Of New York Taxol utilise comme sensibilisateur aux rayonnements
EP0617034A1 (fr) * 1993-03-11 1994-09-28 Virginia Tech Intellectual Properties, Inc. Dérivés 2-débenzoyl-2-acyle de taxol et des procédés pour leur préparation
US5614645A (en) * 1993-03-11 1997-03-25 Virginia Tech Intellectual Properties, Inc. Methods for making 2-debenzoyl and -2-acyl taxol derivatives
WO1994021250A1 (fr) * 1993-03-22 1994-09-29 Florida State University Taxanes presentant une chaine laterale a substitution alcoxy, alcenoxy ou aryloxy et compositions pharmaceutiques contenant de tels composes
WO1996040091A1 (fr) * 1995-06-07 1996-12-19 Vivorx Pharmaceuticals, Inc. Composes d'agents de sensibilisation radiologiques/cytotoxiques adouble fonction et leurs procedes de preparation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MILAS L. ET AL.: "Enhancement of tumor radioresponse of a murine mammary carcinoma by paclitaxel", CANCER RESEARCH, US, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 54, no. 13, 1 July 1994 (1994-07-01), pages 3506 - 3510, XP000882929 *
See also references of WO9709979A1 *
TISHLER R.B. & LAMPPU D.M.: "The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1", BRITISH JOURNAL OF CANCER, GB, LONDON, vol. 74, (Suppl. XXVII), 1996, pages S82 - S85, XP002911789, ISSN: 0007-0920 *
TISHLER R.B. ET AL.: "Taxol sensitizes human astrocytoma cells to radiation", CANCER RESEARCH, US, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 52, no. 12, 15 June 1992 (1992-06-15), pages 3495 - 3497, XP000490994, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
EP0855909A1 (fr) 1998-08-05
JP2001524067A (ja) 2001-11-27
AU728057B2 (en) 2001-01-04
AU6974696A (en) 1997-04-01

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