EP0845045A4 - Regulation zellulärer funktionen durch ektopische expression nicht-endogener zellsignalisierungsrezeptoren - Google Patents
Regulation zellulärer funktionen durch ektopische expression nicht-endogener zellsignalisierungsrezeptorenInfo
- Publication number
- EP0845045A4 EP0845045A4 EP96928135A EP96928135A EP0845045A4 EP 0845045 A4 EP0845045 A4 EP 0845045A4 EP 96928135 A EP96928135 A EP 96928135A EP 96928135 A EP96928135 A EP 96928135A EP 0845045 A4 EP0845045 A4 EP 0845045A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- regulation
- cellular functions
- ectopic expression
- cell signalling
- endogenous cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US225495P | 1995-08-14 | 1995-08-14 | |
US2254 | 1995-08-14 | ||
PCT/US1996/013077 WO1997007233A1 (en) | 1995-08-14 | 1996-08-12 | Regulation of cellular functions by ectopic expression of non-endogenous cell signalling receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0845045A1 EP0845045A1 (de) | 1998-06-03 |
EP0845045A4 true EP0845045A4 (de) | 1999-11-24 |
Family
ID=21699924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96928135A Withdrawn EP0845045A4 (de) | 1995-08-14 | 1996-08-12 | Regulation zellulärer funktionen durch ektopische expression nicht-endogener zellsignalisierungsrezeptoren |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0845045A4 (de) |
JP (1) | JPH11510704A (de) |
AU (1) | AU716407B2 (de) |
CA (1) | CA2229287A1 (de) |
WO (1) | WO1997007233A1 (de) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
WO1994026915A1 (en) * | 1993-05-10 | 1994-11-24 | The Regents Of The University Of Michigan | Gene transfer into pancreatic and biliary epithelial cells |
WO1994029447A2 (en) * | 1993-06-09 | 1994-12-22 | Medical Research Council | Dna coding for the human thyrotropin-releasing hormone receptor |
WO1995016772A1 (en) * | 1993-12-14 | 1995-06-22 | Cornell Research Foundation, Inc. | Adenovirus gene expression system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
WO1989007136A2 (en) * | 1988-02-05 | 1989-08-10 | Whitehead Institute For Biomedical Research | Modified hepatocytes and uses therefor |
US5462856A (en) * | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
-
1996
- 1996-08-12 CA CA002229287A patent/CA2229287A1/en not_active Abandoned
- 1996-08-12 JP JP9509404A patent/JPH11510704A/ja active Pending
- 1996-08-12 EP EP96928135A patent/EP0845045A4/de not_active Withdrawn
- 1996-08-12 WO PCT/US1996/013077 patent/WO1997007233A1/en not_active Application Discontinuation
- 1996-08-12 AU AU67721/96A patent/AU716407B2/en not_active Ceased
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
WO1994026915A1 (en) * | 1993-05-10 | 1994-11-24 | The Regents Of The University Of Michigan | Gene transfer into pancreatic and biliary epithelial cells |
WO1994029447A2 (en) * | 1993-06-09 | 1994-12-22 | Medical Research Council | Dna coding for the human thyrotropin-releasing hormone receptor |
WO1995016772A1 (en) * | 1993-12-14 | 1995-06-22 | Cornell Research Foundation, Inc. | Adenovirus gene expression system |
Non-Patent Citations (11)
Title |
---|
ATHARI A. & JUNGERMANN K.: "Direct activation by prostaglandin F2a but not thromboxane a2 of glycogenolysis via an increase in inositol 1,4,5-triphosphate in rat hepatocytes.", BIOCHEM. BIOPHYS. RES. COMM., vol. 163, no. 3, 29 September 1989 (1989-09-29), pages 1235 - 1242, XP002105455 * |
DIPALMA J.R. ET AL., EDS.: "Basic pharmacology in medicine, 4th ed.", 1994, MEDICAL SURVEILLANCE IN., WEST CHESTER, PA, XP002105459 * |
FALCK-PEDERSEN E. ET AL.: "Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin releasing hormone desensitization is cell-specific.", MOLECULAR PHARMACOLOGY, vol. 45, no. 4, April 1994 (1994-04-01), pages 684 - 689, XP002105449 * |
GANDHI C.R. ET AL.: "Endothelin, a potent peptide agonist in the liver.", J. BIOL. CHEM., vol. 265, no. 29, 15 October 1990 (1990-10-15), pages 17432 - 17435, XP002105452 * |
GERSHENGORN M.C. ET AL.: "Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool.", J. BIOL. CHEM., vol. 269, no. 9, 4 March 1994 (1994-03-04), pages 6779 - 6783, XP002105450 * |
HEINFLINK M. ET AL.: "Thyrotropin-releasing hormone receptor activation does not elevate intracellular cyclic adenosine 3'5'-monophosphate in cells expressing high levels of receptors", J. CLIN. ENDOCRIN. METAB., vol. 79, no. 2, August 1994 (1994-08-01), pages 650 - 652, XP002105451 * |
MINE T. ET AL.: "Calcium rather than cyclic AMP is an intracellular messenger of parathyroid hormone action on glycogen metabolism in rat hepatocytes.", BIOCHEM. J., vol. 258, 15 March 1989 (1989-03-15), pages 889 - 894, XP002105456 * |
See also references of WO9707233A1 * |
TOHKIN M. ET AL.: "Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic Ca++ concentration but not by an increase of cAMP in rat hepatocytes", FEBS LETTERS, vol. 260, no. 2, January 1990 (1990-01-01), pages 179 - 182, XP002105454 * |
WAKELAM M.J.O. ET AL.: "Activation of two signal-transduction systems in hepatocytes by glucagon.", NATURE, vol. 323, no. 4, 4 September 1986 (1986-09-04), pages 68 - 71, XP002105453 * |
WOLFF G. ET AL.: "Ectopic expression of thyrptropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH.", NATURE GENETICS, vol. 12, no. 3, March 1996 (1996-03-01), pages 274 - 279, XP002105457 * |
Also Published As
Publication number | Publication date |
---|---|
AU6772196A (en) | 1997-03-12 |
JPH11510704A (ja) | 1999-09-21 |
WO1997007233A1 (en) | 1997-02-27 |
EP0845045A1 (de) | 1998-06-03 |
CA2229287A1 (en) | 1997-02-27 |
AU716407B2 (en) | 2000-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980310 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IE IT LI NL SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 6C 12N 5/10 A, 6C 12P 21/06 B, 6C 12N 5/00 B, 6C 12N 15/00 B, 6C 07K 14/72 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19991008 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IE IT LI NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 20020610 |