EP0827501A1 - Nichtnukleosidische cumarinderivate als polynukleotidevernetzer - Google Patents

Nichtnukleosidische cumarinderivate als polynukleotidevernetzer

Info

Publication number
EP0827501A1
EP0827501A1 EP96908709A EP96908709A EP0827501A1 EP 0827501 A1 EP0827501 A1 EP 0827501A1 EP 96908709 A EP96908709 A EP 96908709A EP 96908709 A EP96908709 A EP 96908709A EP 0827501 A1 EP0827501 A1 EP 0827501A1
Authority
EP
European Patent Office
Prior art keywords
compound
formula
group
carbon atoms
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96908709A
Other languages
English (en)
French (fr)
Other versions
EP0827501A4 (de
Inventor
Michael L. Wood
Peter C. Cheng
Douglas Y. Thein
David Albagli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naxcor Inc
Original Assignee
Naxcor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/401,630 external-priority patent/US6005093A/en
Application filed by Naxcor Inc filed Critical Naxcor Inc
Publication of EP0827501A1 publication Critical patent/EP0827501A1/de
Publication of EP0827501A4 publication Critical patent/EP0827501A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
EP96908709A 1995-03-09 1996-03-08 Nichtnukleosidische cumarinderivate als polynukleotidevernetzer Withdrawn EP0827501A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US401630 1995-03-09
US08/401,630 US6005093A (en) 1993-04-13 1995-03-09 Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
PCT/US1996/003134 WO1996028438A1 (en) 1995-03-09 1996-03-08 Non-nucleosidic coumarin derivatives as polynucleotide-cross-linking agents

Publications (2)

Publication Number Publication Date
EP0827501A1 true EP0827501A1 (de) 1998-03-11
EP0827501A4 EP0827501A4 (de) 1998-06-10

Family

ID=23588553

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96908709A Withdrawn EP0827501A4 (de) 1995-03-09 1996-03-08 Nichtnukleosidische cumarinderivate als polynukleotidevernetzer

Country Status (6)

Country Link
EP (1) EP0827501A4 (de)
JP (1) JPH11501927A (de)
CN (1) CN1181078A (de)
AU (1) AU719277B2 (de)
CA (1) CA2214835A1 (de)
WO (1) WO1996028438A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105539A2 (de) 1998-08-21 2001-06-13 Naxcor Testverfahren unter verwendung von vernetzbaren immobilisierten nukleinsäuren
US6303799B1 (en) * 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US8053777B2 (en) 2005-03-31 2011-11-08 General Electric Company Thin film transistors for imaging system and method of making the same
US7868161B2 (en) 2005-07-29 2011-01-11 North Carolina State University Photocrosslinking probes and uses of the same
BR112017013027A2 (pt) 2015-01-20 2018-01-09 Biosearch Tech Inc compostos à base de cumarina e métodos relacionados
US10781175B2 (en) 2016-07-15 2020-09-22 Am Chemicals Llc Solid supports and phosphoramidite building blocks for oligonucleotide conjugates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012020A1 (en) * 1989-04-05 1990-10-18 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
WO1994024120A1 (en) * 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
EP0324616B1 (de) * 1988-01-13 1995-03-29 Amoco Corporation Matrizen-dirigierte Photoligation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
DE3738460A1 (de) * 1987-11-12 1989-05-24 Max Planck Gesellschaft Modifizierte oligonukleotide
FR2642074B1 (fr) * 1989-01-20 1994-04-29 Oris Ind Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324616B1 (de) * 1988-01-13 1995-03-29 Amoco Corporation Matrizen-dirigierte Photoligation
WO1990012020A1 (en) * 1989-04-05 1990-10-18 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
WO1994024120A1 (en) * 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9628438A1 *

Also Published As

Publication number Publication date
WO1996028438A1 (en) 1996-09-19
AU719277B2 (en) 2000-05-04
CA2214835A1 (en) 1996-09-19
CN1181078A (zh) 1998-05-06
AU5186496A (en) 1996-10-02
EP0827501A4 (de) 1998-06-10
JPH11501927A (ja) 1999-02-16

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