Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
  • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
  • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment

Definitions

• the present invention relates to a device and a method for evaluating the deformation of the surface of the skin, in particular of the skin m vivo More particularly, the invention relates to a device for profilometry of human skin, aiming to evaluate the mechanical properties of the dermis such as its elasticity and firmness or the state of skin aging, by measuring the depth of the folds induced by deformation, in a simple and rapid manner
• This device is also suitable for evaluation, in series, efficacy to combat skin aging, new raw materials and formulations developed in cosmetic or dermo-pharmaceutical laboratories Thanks to this new device, skin aging tests can also be performed at the dermatologist or in institutes cosmetic treatments, without the need for long and complicated procedures
• the device for evaluating the surface condition of the skin from resin replicas makes it possible to obtain precise results, but it is not suitable, on the one hand, for a serial evaluation, in particular m vivo, requiring the preparation and evaluation of aftershocks by a specialist, and, on the other hand, not allowing an evaluation in a short time
• the document FR-A-2 607 929 describes a unidirectional mechanical deformation system of the human skin, but does not in any way mention the optical processing of the results of this deformation. Furthermore, this document is relatively unclear on the type of deformation applied to the In addition, this system does not make it possible to adapt, in a simple manner, an optoelectronic device of the aforementioned kind
• the present invention aims to improve this known device and to adapt it to the serial evaluation of provoked deformations of the skin in a plurality of individuals, a device whose cost is advantageous.
• the invention aims at rapid evaluation. relief of the skin surface after deformation induced in vivo, it can be used in cosmetic institutes, medical analysis laboratories or hospitals by low-skilled people.
• the first object of the present invention is a device for evaluating skin wrinkling in vivo, in particular of human skin, comprising: a) mobile means for pleating an area of the skin to be examined parallel to its surface, b) movable means for scanning the folded skin area with an incident light beam emitted by a light source, c) means for detecting the light diffusedly emitted by the folded skin; d) means for converting the detected light into an electrical signal; and e) means for extracting from the electrical signal at least one parameter representative of the profile of the folded skin.
• the means for detecting the re-emitted light comprise one or, advantageously, several position detectors.
• the detection of the light re-emitted by the illuminated pleated skin is carried out according to the triangulation method (see the article by M. Assoul cited above and Lee CS, Kim SW, Yim DY, An in process measurement technique using the laser for non contact monitoring of roughness surface and form accurancy of ground surfaces (Annals CIRP 1987: 36: 332-339), or according to the focusing method.
• the triangulation method consists in sending a beam of light to a surface to be examined at a determined angle of incidence, for example 45 °.
• the position of the re-emitted light beam is recorded by a position detector. It is also possible to send a beam of incident light at an angle of substantially 0 ° and to record the re-emitted light by two position detectors placed at 45 ° from the axis of the incident light on a plane which contains the axis of the incident beam. For simplification, it is preferred to use a single detector.
• a so-called focusing method is used.
• a focusing lens of the incident light beam is moved relative to the surface to be examined, so as to always be focused on the surface to be studied, and the beam of light reflected by a detector arranged is recorded. , symmetrically to the incident beam, with respect to the normal of the surface to be studied.
• the parameter of the skin profile is chosen from the following parameters: R perpetratR a , S m , R and AR, etc., R, being the maximum height of a fold, R a being the arithmetic mean of the heights of all the points of the profile, evaluated with respect to the mean line of the folds, S m being the mean value of the horizontal spacing between the folds, evaluated at the level of the mean line of the profile, R being the mean depth of the set of folds and AR being the average spacing between the folds.
• the means for pleating the skin comprise two plates, located at a determined distance d 0 from each other, and means for bringing these plates together by reducing the distance d 0 , so that the area of skin has wrinkling on a reduced area of 1 t the movable means for scanning the pleated skin area (Z) moving parallel to the surface of the skin, in the direction of wrinkling
• the face of these platelets in contact with the skin can be covered with an adhesive to fix them temporarily on either side of said pleated skin area.
• the tests carried out by the applicant have shown that good results can be obtained by sticking these plates on the forearm of the person to be examined, for example using a double-sided adhesive.
• the wrinkling of the area of skin to be examined is carried out so that d 0 -d 1 represents approximately 2% to 50% of d 0
• d ⁇ of approximately 5 to 20% of d 0
• the approximation of the plates can be controlled by a first electric motor connected to a shaft provided, for example, with a portion comprising a straight thread and with a portion comprising a left thread
• a first electric motor connected to a shaft provided, for example, with a portion comprising a straight thread and with a portion comprising a left thread
• These portions of motor shaft each cooperate with a wafer element comprising a tapping complementary to the thread of the drive shaft
• the insert holders, as well as the motor can be mounted on a frame.
• this frame carries an optoelectronic system, movable in translation, in the direction of the folding of the skin. This translation can be ensured, automatically, by a second motor. electric equipped with a suitable drive mechanism
• the optoelectronic system comprises the means for detecting the light re-emitted by the folded illuminated skin, the detection means being formed, for example, of at least one position detector
• the optoelectronic system comprises the light source, constituting the means for illuminating the folded skin area, this light source emitting the incident light beam
• the light source as well as the means for detecting the re-emitted light are mounted fixed, one with respect to the other, and movable with respect to the area of skin to be examined.
• the means of detection of re-emitted light simultaneously execute the same translational movement as the light source
• the light source is mounted on the support so that the angle of incidence of the light beam on the skin is approximately 0 °
• the detector for recording the re-emitted light being arranged on an axis forming a reflection angle of approximately 45 ° relative to the incident light beam
• the light source is a laser beam source, but any other light source capable of emitting a light beam, monochromatic or not, could be used.
• the laser beam source is a laser diode whose incident light beam has a wavelength included, for example, in the range from 400 nm to 1100 nm, and preferably between 630 and 788 nm
• this light beam can be focused on the skin by a first focusing system (of the lens type) placed between the light source and the skin area to be examined.
• the means for recording the re-emitted light consist of one or more position detectors (position sensmg detectors - PSD), advantageously two in number, transforming the light collected into an electrical signal. In order to obtain greater measurement accuracy, it is advantageous to use several detectors This type of detector is capable of recording the intensity, as well as the position of a ray of re-emitted light incident on its surface
• a second focusing system is placed between the skin area and the position detector, a focusing system which collects and then focuses the light re-emitted by the skin, before detection
• the electrical signal supplied by the detector and corresponding to the light scattered on the surface of the detector is then transmitted to an information processing system where it is digitized.
• This processing system being programmed, moreover, to extract at least one of the parameters Rrust
• R a , S m , R and AR ... mentioned above of said electrical signal Means for viewing the parameters extracted can be provided, such as a screen or a printer
• a second object of the invention is constituted by a process for evaluating the relief induced from the deformation of the surface of the skin in vivo, comprising the steps a) exerting on an area of the skin to be examined a wrinkling parallel to its surface using mobile means, b) scanning the folded skin area with an incident light beam emitted by a light source, c) detecting the light re-emitted by the folded skin, d) converting the detected light into electrical signals, and e) extracting electrical signals from at least one of the parameters representative of the profile of the pleated skin.
• the parameter is chosen from the following parameters R perpetratR a , S m , R and AR ..., R, being the maximum height of a fold, R a being the arithmetic mean of the heights of all the points of the profile, evaluated with respect to the mean line of the folds, S m being the mean value of the horizontal spacing between the folds, evaluated at the level of the mean line of the profile, R being the mean depth of the set of folds and AR being the mean spacing between the folds
• the device and method of the invention it is possible to carry out, in series, the in vivo evaluation of the wrinkling of the surface of the skin of an individual or the action of a product on it.
• These device and method have the advantage of not requiring the use of a specialist and can provide results almost instantly, at moderate cost.
• the same area of skin can be scanned several times for comparative studies, by example before and after applying a treatment product.
• the reference Z has designated a skin area, for example of the forearm, of which the skin fold is to be examined.
• a frame S is placed on the skin, comprising a shaft 5 arranged parallel to the surface of skin and mobile in rotation.
• an electric motor M 2 is provided to rotate the shaft 5.
• the shaft 5 consists of two portions 5a and 5b, the portion 5a being provided with a left-hand thread and the portion 5b being provided with straight thread.
• the portions 5a and 5b pass through a tapping respectively 2a and 3a formed in a wafer-carrying element 2b, 3b.
• the wafer-carrying elements respectively support a wafer 2,3 of rectangular shape, and having a substantially flat face, intended to come into contact with the skin and constituting the means (E) for exerting wrinkling
• the flat face of the plates has an adhesive layer 4, for example a double-sided adhesive film. Thanks to this arrangement, the skin area Z to be examined can be immobilized relative to the frame S.
• the initial distance d 0 between the plates 2, 3 is, for example, 48 mm.
• these plates are brought closer to each other, until a distance d, ⁇ d 0 , for example 41 mm, is obtained.
• Means (D) for scanning the skin and the detection means (PSD ) re-emitted light is mounted on the frame (S)
• the frame also carries the means (E) for exerting wrinkling, as well as the light source (D)
• the frame S further comprises an optoelectronic system O mounted movable in translation along a shaft A relative to the frame, the shaft A being parallel to the shaft 5
• An electric motor M is provided to control this translational movement
• the optoelectronic system comprises, in addition, a light source, HERE a laser diode D, capable of emitting a laser beam L with a wavelength of 630 to 788 nm
• a focusing system F is provided between the diode D and the skin area Z to focus the beam L on the area Z
• the incident beam L is absorbed and re-emitted by the skin Z
• a PSD sensor position sensing detector
• a PSD sensor position sensing detector
• a fixed light source is used, the scanning of the area to be examined being obtained by directing the light beam on a rotating mirror, of the polygon type with several reflecting facets.
• the optoelectronic system O is moved along the axis A, by the distance d, during this translational movement, the beam L scans the skin area Z between the two wafers Simultaneously, the PSD sensor records, on the one hand, the intensity of the beam L, and on the other hand, the position at which they arrive on the detector Indeed, as a function of the depth of a fold or of a wrinkle P, the beam L, coming from a zone Z situated at the top of a plateau, falls on a part of the PSD detector different from that reached by the rays coming from the bottom of a fold
• the incident beams on the PSD detector are transformed into electrical signals which are transmitted to an information processing system T
• This processing system T is programmed according to a mathematical calculation, for example of the type taught by the document by M Assoul et al cited above.
• R t being the maximum height of a fold
• R a being the arithmetic mean of the heights of all the points of the profile, evaluated in relation to the mean line of folds
• S m being the average value of the horizontal spacing between the folds, evaluated at the level of the mean line of the profile
• R being the average depth of all the folds and AR being the average spacing between the folds.
• a screen V is provided to display these parameters.
• the device of the invention (outside the processing system T and outside the screen V) forms a small portable unit, connected to the processing system T by a connecting cable.
• a connecting cable As a result, its manipulation during measurements is easy, both for the individual to be examined and for the operator who performs the measurements.
• 1 - Device for evaluating the wrinkling of the skin comprising a) movable means (E) for pleating a skin area (Z) to be examined parallel to its surface, b) movable means for scanning the pleated skin area with an incident light beam (L) emitted by a light source (D), c) means for detecting (PSD) the light re-emitted (L,) by the pleated skin illuminated, d) means for converting the detected light as an electrical signal, and e) means (T) for extracting from the electrical signal at least one parameter representative of the profile of the pleated skin 2 - Device according to claim 1, characterized in that the detection of the re-emitted light is done according to a triangulation method
• the parameter (s) is (are) chosen from the following parameters R perpetratR a , S m , R and AR, R, being the maximum height of a fold (P), R a being the arithmetic mean of the heights of all the points of the profile, evaluated with respect to the mean line of the folds, S m being the mean value of the horizontal spacing between the folds , evaluated at the level of the mean line of the profile, R being the mean depth of the set of folds and AR being the mean spacing between the folds
• ia value do-d represents approximately 2% to 50% of d 0 9 - Device according to one of claims 6 to 8, characterized in that the value d ⁇ represents approximately 5% to 20% of d 0
• the light source (D) is a laser beam source
• the light source (D) is capable of emitting a light beam having a wavelength in the range from 400 nm to 1100 nm
• the light source (D) consists of a laser diode whose light radiation has a wavelength between 630 nm and 788 nm
• the detection means comprise at least one position detector (PSD)
• the skin is pleated in one direction
• the means (T) for extracting at least one of the parameters comprise a system for processing the information supplied by the detection means (PSD)
• any one of the preceding claims characterized in that it further comprises means (V) for displaying the extracted parameter 21 - Device according to any one of the preceding claims, characterized in that it further comprises a focusing system (F,) of the incident beam (L) on the area (Z) phssee of the skin
• the parameter (s) is (are) chosen from the following parameters R réelleR a , S,. ,, R and AR, R , being the maximum height of a fold (P), R a being the arithmetic mean of the heights of all the points of the profile, evaluated with respect to the mean line of the folds, S m being the mean value of the horizontal spacing between the folds, evaluated at the level of the mean line of the profile, R being the average depth of all the folds and AR being the mean spacing between the folds

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Heart & Thoracic Surgery (AREA)
• Surgery (AREA)
• Biophysics (AREA)
• Pathology (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Dermatology (AREA)
• Medical Informatics (AREA)
• Molecular Biology (AREA)
• Physics & Mathematics (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
• Length Measuring Devices By Optical Means (AREA)
• Radiation-Therapy Devices (AREA)

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• 1997
  • 1997-02-13 US US08/930,577 patent/US5944667A/en not_active Expired - Fee Related
  • 1997-02-13 EP EP97905201A patent/EP0821565A1/fr not_active Withdrawn
  • 1997-02-13 WO PCT/FR1997/000278 patent/WO1997029686A1/fr not_active Application Discontinuation
  • 1997-02-13 JP JP52905297A patent/JP3211835B2/ja not_active Expired - Fee Related

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