EP0785786A4 - Synthese microbienne d'inhibiteurs de la protease du vih - Google Patents
Synthese microbienne d'inhibiteurs de la protease du vihInfo
- Publication number
- EP0785786A4 EP0785786A4 EP95937602A EP95937602A EP0785786A4 EP 0785786 A4 EP0785786 A4 EP 0785786A4 EP 95937602 A EP95937602 A EP 95937602A EP 95937602 A EP95937602 A EP 95937602A EP 0785786 A4 EP0785786 A4 EP 0785786A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- protease inhibitors
- hiv protease
- microbial synthesis
- microbial
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32863494A | 1994-10-25 | 1994-10-25 | |
US328634 | 1994-10-25 | ||
PCT/US1995/013628 WO1996012492A1 (fr) | 1994-10-25 | 1995-10-20 | Synthese microbienne d'inhibiteurs de la protease du vih |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0785786A1 EP0785786A1 (fr) | 1997-07-30 |
EP0785786A4 true EP0785786A4 (fr) | 1998-01-28 |
Family
ID=23281761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95937602A Withdrawn EP0785786A4 (fr) | 1994-10-25 | 1995-10-20 | Synthese microbienne d'inhibiteurs de la protease du vih |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0785786A4 (fr) |
JP (1) | JPH10507917A (fr) |
AU (1) | AU702122B2 (fr) |
WO (1) | WO1996012492A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5612217A (en) * | 1994-10-25 | 1997-03-18 | Merck & Co., Inc. | Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors |
US5763196A (en) * | 1996-01-26 | 1998-06-09 | Boehringer Mannheim Corporation | Assays using cross-linked polypeptide fragments of β-galactosidase |
AU1837897A (en) * | 1996-01-26 | 1997-08-20 | Boehringer Mannheim Corporation | Bis-maleimido cross-linking agents |
US5976857A (en) * | 1996-01-26 | 1999-11-02 | Boehringer Mannheim Corporation | Cross-linked polypeptide fragments of β-galactosidase |
JP2004115510A (ja) * | 2002-09-05 | 2004-04-15 | Toray Fine Chemicals Co Ltd | ピペラジン誘導体の製造方法 |
AU2003264365A1 (en) * | 2002-09-05 | 2004-03-29 | Toray Fine Chemicals Co, . Ltd. | Process for producing oxycarbonyl-substituted piperazine derivative |
CN101497608B (zh) * | 2009-03-05 | 2011-11-09 | 中国科学院广州生物医药与健康研究院 | 一类hiv蛋白酶抑制剂衍生物及其制备方法和在制备抗肿瘤药中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996012790A1 (fr) * | 1994-10-25 | 1996-05-02 | Merck & Co., Inc. | Synthese microbienne d'inhibiteurs de protease de hiv |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3160560A (en) * | 1957-08-23 | 1964-12-08 | Upjohn Co | Streptolydigin and production thereof |
JPS5774090A (en) * | 1980-10-27 | 1982-05-10 | Shionogi & Co Ltd | Novel beta-galactosidase inhibitor, gt-2558, its derivative, and production |
CA2195027C (fr) * | 1991-11-08 | 2000-01-11 | Joseph P. Vacca | Inhibiteurs de la protease du vih utiles pour le traitement du sida |
CA2110827A1 (fr) * | 1992-12-14 | 1994-06-15 | Maki Nishio | Antibiotique antiviral bu-4724v et preparation en contenant |
CN1090186C (zh) * | 1993-03-31 | 2002-09-04 | 麦克公司 | 治疗aids药物组合物中的hiv蛋白酶抑制剂 |
-
1995
- 1995-10-20 EP EP95937602A patent/EP0785786A4/fr not_active Withdrawn
- 1995-10-20 JP JP8514082A patent/JPH10507917A/ja active Pending
- 1995-10-20 AU AU39663/95A patent/AU702122B2/en not_active Ceased
- 1995-10-20 WO PCT/US1995/013628 patent/WO1996012492A1/fr not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996012790A1 (fr) * | 1994-10-25 | 1996-05-02 | Merck & Co., Inc. | Synthese microbienne d'inhibiteurs de protease de hiv |
Non-Patent Citations (1)
Title |
---|
See also references of WO9612492A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH10507917A (ja) | 1998-08-04 |
EP0785786A1 (fr) | 1997-07-30 |
WO1996012492A1 (fr) | 1996-05-02 |
AU3966395A (en) | 1996-05-15 |
AU702122B2 (en) | 1999-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970526 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
RHK1 | Main classification (correction) |
Ipc: C07D401/06 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19971215 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19981210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020501 |