EP0778899A4 - Anreicherung von fötalen zellen aus maternalem blut - Google Patents

Anreicherung von fötalen zellen aus maternalem blut

Info

Publication number
EP0778899A4
EP0778899A4 EP95933174A EP95933174A EP0778899A4 EP 0778899 A4 EP0778899 A4 EP 0778899A4 EP 95933174 A EP95933174 A EP 95933174A EP 95933174 A EP95933174 A EP 95933174A EP 0778899 A4 EP0778899 A4 EP 0778899A4
Authority
EP
European Patent Office
Prior art keywords
enrichment
fetal cells
maternal blood
maternal
fetal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95933174A
Other languages
English (en)
French (fr)
Other versions
EP0778899A1 (de
Inventor
Jurgen Busch
Andreas Radbruch
Stefan Miltenyi
Juergen Holtz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec Inc
Original Assignee
Miltenyi Biotec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miltenyi Biotec Inc filed Critical Miltenyi Biotec Inc
Publication of EP0778899A1 publication Critical patent/EP0778899A1/de
Publication of EP0778899A4 publication Critical patent/EP0778899A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP95933174A 1994-09-20 1995-09-19 Anreicherung von fötalen zellen aus maternalem blut Withdrawn EP0778899A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30922994A 1994-09-20 1994-09-20
PCT/US1995/011971 WO1996009409A1 (en) 1994-09-20 1995-09-19 Enrichment of fetal cells from maternal blood
US309229 1999-05-10

Publications (2)

Publication Number Publication Date
EP0778899A1 EP0778899A1 (de) 1997-06-18
EP0778899A4 true EP0778899A4 (de) 2001-08-29

Family

ID=23197274

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95933174A Withdrawn EP0778899A4 (de) 1994-09-20 1995-09-19 Anreicherung von fötalen zellen aus maternalem blut

Country Status (5)

Country Link
EP (1) EP0778899A4 (de)
JP (1) JPH10507632A (de)
AU (1) AU691040B2 (de)
CA (1) CA2200294A1 (de)
WO (1) WO1996009409A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294964B1 (it) * 1996-07-12 1999-04-23 Domenico Valerio Isolamento e cultura di cellule fetali dal sangue periferico materno
US6432630B1 (en) 1996-09-04 2002-08-13 Scandinanian Micro Biodevices A/S Micro-flow system for particle separation and analysis
FR2758884B1 (fr) * 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
EP0974056B1 (de) * 1997-03-08 2005-11-02 The University of Dundee Pränatale diagnostische verfahren in vitro
GB0009179D0 (en) * 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
GB0616045D0 (en) * 2006-08-11 2006-09-20 Univ Bristol Blood cell separation
GB2447255A (en) * 2007-03-02 2008-09-10 Oncoprobe Ltd Preparation of enriched target cell samples for use in a chemosensitivity assay
FR2963108B1 (fr) * 2010-07-21 2017-06-23 Diagast Procede magnetique d'immunodiagnostic et kit pour la mise en evidence de complexe anticorps/antigene de groupe/phenotype sanguin
RU2599419C2 (ru) * 2011-12-17 2016-10-10 БиДжиАй ДАЙЭГНОСИС КО., ЛТД. Способы и системы для определения того, является ли геном аномальным
EP2955521A1 (de) * 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Verfahren zur Trennung von Zellen
CN109718880A (zh) * 2019-02-20 2019-05-07 广州睿辰生物科技有限公司 基于双抗法分选胎儿有核红细胞额定微流控芯片及其分选方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016452A1 (en) * 1990-04-23 1991-10-31 Cellpro Incorporated A method for enriching fetal cells from maternal blood

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016452A1 (en) * 1990-04-23 1991-10-31 Cellpro Incorporated A method for enriching fetal cells from maternal blood

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BÜSCH J ET AL.: "Simple and fast 'Double-MACS' sorting of fetal erythroblasts from maternal blood for PCR-based paternity analysis", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 731, 1994, pages 144 - 146, XP001011400 *
CHUEH J AND GOLBUS M S: "Prenatal diagnosis using fetal cells in the maternal circulation", SEMINARS IN PERINATOLOGY, vol. 14, no. 6, 1990, pages 471 - 482, XP001011366 *
GÄNSHIRT-AHLERT D ET AL.: "Magnetic cell sorting and the transferrin receptor as potential means of prenatal diagnosis from maternal blood", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 166, May 1992 (1992-05-01), pages 1350 - 1355, XP001011368 *
HOLZGREVE W ET AL.: "Noninvasive prenatal diagnosis", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 731, 1994, pages 253 - 256, XP001011401 *
MILTENYI S ET AL: "HIGH GRADIENT MAGNETIC CELL SEPERATION WITH MACS", CYTOMETRY,ALAN LISS, NEW YORK,US, vol. 11, no. 11, 1990, pages 231 - 238, XP000999711, ISSN: 0196-4763 *
READING J P ET AL.: "Nucleated erythrocytes in maternal blood: quantity and quality of fetal cells in enriched populations", HUMAN REPRODUCTION, vol. 10, no. 9, September 1995 (1995-09-01), pages 2510 - 2515, XP001011367 *
See also references of WO9609409A1 *

Also Published As

Publication number Publication date
AU691040B2 (en) 1998-05-07
CA2200294A1 (en) 1996-03-28
JPH10507632A (ja) 1998-07-28
AU3593595A (en) 1996-04-09
EP0778899A1 (de) 1997-06-18
WO1996009409A1 (en) 1996-03-28

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Legal Events

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