EP0777717A2 - Surface-active formulations - Google Patents
Surface-active formulationsInfo
- Publication number
- EP0777717A2 EP0777717A2 EP95929863A EP95929863A EP0777717A2 EP 0777717 A2 EP0777717 A2 EP 0777717A2 EP 95929863 A EP95929863 A EP 95929863A EP 95929863 A EP95929863 A EP 95929863A EP 0777717 A2 EP0777717 A2 EP 0777717A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- component
- formulation according
- weight
- hydrogen
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0063—Photo- activating compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Definitions
- novel surface-active surfactant formulations comprise
- the antimicrobial activity of the deblocked surfactant systems reaches upon gram-positive and gram-negative bacteria as well as yeasts, dermatophytes and the like.
- the compounds of component (a j ) preferably correspond to the general formula
- R j is hydrogen, hydroxy, C 1 -C 4 alkyl, chloro, nitro, phenyl oder benzyl,
- R 2 is hydrogen, hydroxy, C 1 -C 6 alkyl or halogen
- R 3 is hydrogen, C 1 -C 6 alkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof, R 4 is hydrogen or methyl, R 5 is hydrogen or nitro.
- Halogen is bromo or, preferably, chloro.
- Such compounds are typically chlorophenols (o-, m-, p-chlorophenols), 2,4-dichlorophenol, p-nitrophenol, picric acid, xylenol, p-chloro-m-xylenol, cresols (o-, m-, p-cresols), p-chloro-m-cresol, pyrocatechin, resorcinol, orcinol, 4-n-hexylresorcinol, pyrogallol, phloroglucine, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-benzylphenol, p-chloro-o-benzylphenol and 4-phenolsulfonic acid.
- the compounds of component (a 2 ) preferably correspond to the general formula
- X is sulfur or the methylene group, Ri and R are hydroxy, and
- R 3 , ' 3 , R , R'4, R 5 and R' 5 arc each independently of one another hydrogen or halogen.
- Typical examples of compounds of formula (2) are hexachlorophene, tetrachlorophene, dichlorophene, 2,3-dihydroxy-5,5'-dichlorodiphenylsulfide, 2,2 ' -dihydroxy-3 ,3 ' ,5 ,5 ' -tetrachlorodiphenylsulf ⁇ de, 2,2 , -dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylsulfide and 3,3'-dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylamine.
- the compounds of component (a 3 ) preferably correspond to the general formula
- Rj, R 2 , R 3 , R 4 and R 5 arc each independently of one another hydrogen or chloro.
- Illustrative examples of compounds of formula (3) are benzyl alcohol, 2,4-, 3,5- or 2,6-dichlorobenzyl alcohol and trichlorobenzyl alcohol.
- Component (8 4 ) is chlorohexidine and salts thereof together with organic and inorganic acids, which type of compound may preferably be incorporated into syndet systems.
- Component (& 5 ) is typically Cg-C ⁇ cocamidopropylbetaine.
- Amphoteric surfactants corresponding to component (a $ ) are suitably C ⁇ alkylaminocarboxylic and Ci ⁇ alkanecarboxylic acids such as alkylaminoacetates or alkylaminopropionates.
- the compounds of component (a 7 ) preferably correspond to the general formula
- Hal is chloro or bromo, n and m are 1 or 2, and n + m are 3.
- the quaternary ammonium salts of component (a 8 ) preferably correspond to formula
- R , R 7 , R 8 and Ro arc each independently of one another Ci- galkyl, -Cx alkoxy or phenyl-lower alkyl, and
- Hal is chloro or bromo.
- n is an integer from 7 to 17, is very particularly preferred.
- C 3 -Ci 2 di- or polycarboxylic acids typically malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acid, undecanecarboxylic and dodecanedicarboxylic acid, fumaric, maleic, tartaric and malic acid as well as citric and aconitic acid;
- aminocarboxylic acids typically ethylenediaminetetracetic acid, hydroxyethyl- ethylenediaminetetracetic acid and nitrilotriacetic acid;
- aromatic carboxylic acids typically benzyl, phenylacetic, phenoxyacetic and cinnamic acid, 2-, 3- and 4-hydroxybenzoic acid, anilinic acid as well as o-, m- and p-chlorophenylacetic acid and o-, m- and p-chlorophenoxyacetic acid;
- alkali metal salts and amine salts of inorganic acids typically the sodium or potassium salts and amine(R 1 R 2 R 3 ) salts of hydrochloric, sulfuric, phosphoric, C C 10 alkylphosphoric acid and boric acid, in which amine salts Rj, R 2 and R 3 have the meaning indicated above;
- Rj is hydrogen or -C- ⁇ alkyl
- R 2 and R 3 are each independently of the other hydrogen, C j -C ⁇ alkyl, C 2 -C 12 alkenyl, C 2 -Ci 2 hydroxyalkyl, or a polyglycol ether chain containing 1 to 30 -CH 2 -CH 2 -O- or -CHY r CHY 2 -O- groups, wherein Yj or Y 2 is a hydrogen radical and the other is methyl, e.g.N-methylacetamide;
- R j , R 2 , R 3 and R 4 are each independently of one another hydrogen, C r C 8 alkyl,
- C 4 -C 18 aliphatic and monocyclic alcohols typically C 2 -C 18 alkanols, C 2 -C 18 alkenols and terpene alcohols e.g. ethanol, propanol, isopropanol, hexanol, cis-3-hexen-l-ol, trans-2-hexen-l-ol, l-octen-3-ol, heptanol, octanol, trans-2-cis-6-nonadien-l-ol, decanol, linalol, geraniol, dihydroterpineol, myrcenol, nopol and terpineol;
- Rj, R and R 3 arc each independently of one another hydrogen, hydroxy, halogen or C j - alkoxy, typically benzyl alcohol, 2,4-dichlorobenzyl alcohol, phenoxyethanol, l-phenoxy-2-propanol (phenoxyisopropanol) and cinnamyl alcohol;
- R j and R 2 are each independently of the other hydrogen, C r C 12 alkyl, C 2 -C 12 alkenyl, C r C 8 alkanoyl, C 3 -C 18 alkenoyl, R 3 -(OCH-CH 2 - 7 5 7j-, wherein
- R 3 is hydrogen, Cj-C 12 alkyl or C ⁇ -C ⁇ alkenyl, and R 4 is hydrogen or -CH 3 , and
- X is C 2 -C 10 alkylene or -( H 2 CH O)f3fjCH 2 -CH2- or -(CH 2 -CH-O) ⁇ 3 ⁇ -CH 2 -CH- . CH 3 CH 3
- All organic acids mentioned under (b) may also be obtained in the form of their water-soluble salts, such as the alkali metal salts, preferably the sodium or potassium salts or the amine(NRjR 2 R 3 ) salts, wherein
- Ri, R 2 and R 3 are each independently of one another hydrogen
- C r C 8 alkyl C ⁇ - alkenyl, C C 8 hydroxyalkyl, C 5 -C 8 cycloalkyl or polyalkenylenoxy- -Cigalkyl, or
- Component (b) can consist of only one compound of subclass (b j ) or also of mixtures of one or more than one compound of subclass (b j ), also together with components of further subclasses.
- a special antimicrobial activity is achieved with a combination of one or more than one compound of subclass (bj) and one or more than one compound of subclass b ⁇ ). Particularly preferred in this connection is a combination of cumene sulfonate and citric acid monohydrate.
- Suitable components (c) are anionic, nonionic or zwitterionic and amphoteric synthetic, surface-active substances.
- Suitable anionic surface-active substances are:
- - sulfates typically fatty alcohol sulfates, which contain 8 to 18 carbon atoms in the alkyl chain, e.g. sulfated lauryl alcohol;
- - C 8 -C 22 fatty alcohol ether sulfates typically the acid esters or the salts thereof of a polyadduct of 2 to 30 mol of ethylene oxide with 1 mol of a -C ⁇ fatty alcohol;
- alkane sulfonates containing 8 to 20 carbon atoms in the alkyl chain, e.g. dodecyl sulfonate; alkylamide sulfonates; alkylaryl sulfonates; ⁇ -olefin sulfonates; sulfosuccinic acid derivatives, typically alkyl sulfosuccinates, alkyl ether sulfosuccinates or alkyl sulfosuccinamide derivatives;
- X is hydrogen, C r C 4 alkyl or -COO M + ,
- Y is hydrogen or C ⁇ -C alkyl
- Z is -(CH 2 ) m 1 - m l is 1 to 5
- n is an integer from 6 to 18, and
- M is an alkali metal ion or an amine ion; alkyl ether carboxylates and alkylaryl ether carboxylates of formula
- X is a radical
- R is hydrogen or C ⁇ -C 4 alkyl
- M is an alkali metal cation or amine cation.
- the anionic surfactants used may furthermore be fatty acid methyl taurides, alkylisothionates, fatty acid polypeptide condensates and fatty alcohol phosphoric acid esters.
- the alkyl radicals in these compounds preferably contain 8 to 24 carbon atoms.
- the fatty alcohols which may be present in the above-mentioned surfactants are those containing 8 to 22, preferably 8 to 18 carbon atoms, typically octyl, decyl, lauryl, tridecyl, miristyl, cetyl, stearyl, oleyl, arachidyl or behenyl alcohol.
- the anionic surfactants are usually obtained in the form of their water-soluble salts, such as the alkali metal, ammonium or amine salts.
- Typical examples of such salts are lithium, sodium, potassium, ammonium, triethylamine, ethanolamine, diethanolamine or triethanolamine salts. It is preferred to use the sodium or potassium salts or the ammonium-(NR 1 R 2 R 3 ) salts, wherein R t , R 2 and R 3 are each independently of one another hydrogen, C ⁇ -C 4 alkyl or C Qhydroxyalkyl.
- the anionic surfactants preferably used in the formulation of this invention are Cg-C ⁇ fatty acid alcohol ether sulfates, more particularly the alkali metal salts of lauryl ether sulfate.
- Very particularly preferred anionic surfactants in the novel formulation are monoethanolamine lauryl sulfate or the alkali metal salts of fatty alcohol sulfates, preferably the sodium lauryl sulfate and the reaction product of 2 to 4 mol of ethylene oxide and sodium lauryl ether sulfate.
- Suitable zwitterionic and amphoteric surfactants are C -C ⁇ 8 betaines, C 8 -C 18 sulfobetaines, C 8 -C 4 alkylamido-C 1 -C 4 alkylenebetaines, imidazoline carboxylates, alkylamphocarboxy carboxylic acids, alkylamphocarboxylic acids (e.g. lauroamphoglycinate) and N-alkyl- ⁇ - aminopropionates or N-alkyl- ⁇ -iminodipropionates. It is preferred to use the C 1 o-C 2 oalkylamido-C ⁇ -C 4 alkylenebetaines and, more particularly, cocoamidopropylbetaine.
- Nonionic surfactants are typically derivatives of the adducts of propylene oxide/ethylene oxide having a molecular weight of 1000 to 15000, fatty alcohol ethoxylatcs (1-50 EO), alkylphenol polyglycol ethers (1-50 EO), ethoxylated carbohydrates, fatty acid glycol partial esters, typically diethylene glycol monstearate, fatty acid alkanolamides and fatty acid dialkanolamides, fatty acid alkanolamide ethoxylates and fatty acid amine oxides.
- the fatty acid alkanolamides and fatty acid dialkanolamides and, preferably, cocodiethanolamide are to be particularly highlighted.
- Suitable components (d) are the salts of saturated and unsaturated C 12 -C 22 fatty acids, typically lauric, myristic, palmitic, stearic, arachic, behenic, dodecenoic, tetradecenoic, octadecenoic, oleic, eicosanic and erucic acid, as well as the technical mixtures of such acids, typically coconut fatty acid which is preferably used in the novel formulation.
- saturated and unsaturated C 12 -C 22 fatty acids typically lauric, myristic, palmitic, stearic, arachic, behenic, dodecenoic, tetradecenoic, octadecenoic, oleic, eicosanic and erucic acid, as well as the technical mixtures of such acids, typically coconut fatty acid which is preferably used in the novel formulation.
- acids may be obtained in the form of salts, suitable cations being alkali metal cations such as sodium and potassium cations, metal atoms such as zinc atoms and aluminium atoms or nitrogen-containing organic compounds of sufficient alkalinity, typically amines or ethoxylated amines.
- suitable cations being alkali metal cations such as sodium and potassium cations, metal atoms such as zinc atoms and aluminium atoms or nitrogen-containing organic compounds of sufficient alkalinity, typically amines or ethoxylated amines.
- suitable cations being alkali metal cations such as sodium and potassium cations, metal atoms such as zinc atoms and aluminium atoms or nitrogen-containing organic compounds of sufficient alkalinity, typically amines or ethoxylated amines.
- These salt can also be prepared in situ.
- Component (d) can also be a mixture of the indicated salts.
- Suitable components (e) are dihydric alcohols, preferably those containing 2 to 6 carbon atoms in the alkylene radical, typically ethylene glycol, 1,2- or 1,3-propanediol, 1,3-, 1,4- or 2,3-butanediol, 1,5-pentanediol and 1,6-hexanediol. 1,2-propanediol (propylene glycol) is preferred.
- Component (f) is preferably ethanol, n-propanol and isopropanol or a mixture of these alcohols.
- Preferred novel formulations are those comprising
- Rj is hydrogen, hydroxy, Cj-Qalkyl, chloro, nitro, phenyl or benzyl,
- R 2 is hydrogen, hydroxy, C j -C ⁇ alkyl or chloro
- R 3 is hydrogen, Cj-Cgalkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof,
- R 4 is hydrogen or methyl
- R 5 is hydrogen or nitro
- the pH of the novel formulation is 3 to 10, preferably 4.5 to 6.
- novel formulations obtained as soap or syndet solutions may additionally comprise customary additives, typically sequestrants, dyes, perfume oils, thickeners or solidifiers (consistency regulators), emollients, UV absorbers, skin-protection agents, antioxidants, additives which improve the mechanical properties, such as dicarboxylic acids and/or Al, Zn, Ca, Mg salts of C 14 -C 22 f tty acids and, if desired, preservatives.
- customary additives typically sequestrants, dyes, perfume oils, thickeners or solidifiers (consistency regulators), emollients, UV absorbers, skin-protection agents, antioxidants, additives which improve the mechanical properties, such as dicarboxylic acids and/or Al, Zn, Ca, Mg salts of C 14 -C 22 f tty acids and, if desired, preservatives.
- novel soap bars can be fabricated in per se known manner, typically by mixing the novel components (a) and (b) and, optionally, (c), (d), (e) and (f), as well as any additives in a jerk mixer at 18-25°C. After the composition obtained has been processed, it is extruded at 40 to 60°, preferably from 45 to 50°C, and then cut and stamped in moulds.
- Soap formulations of the invention can be prepared by mixing components (a) and (b) and, optionally, (c), (d), (e) and (f), in any order, with the requisite amount of water and stirring the mixture to homogeneity.
- the mixture is bulked to 100% with additional water. This procedure is a purely physical procedure. Accordingly, there is no chemical reaction of the individual components.
- the novel soap formulations can be applied thereto in dilute or undilute form, suitably in an amount of at least 2 ml, preferably in the undilute form, for hand disinfection.
- the invention is illustrated by the following Examples. Parts and percentages are by weight.
- citric acid monohydrate 8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added.
- the pH is adjusted to 5.5 with monoethanolamine.
- Deionised water is then added to the solution to make up a total of 100 parts.
- the pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
- citric acid monohydrate 8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added.
- the pH is adjusted to 5.5 with monoethanolamine.
- Deionised water is then added to the solution to make up a total of 100 parts.
- the pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
- citric acid monohydrate 8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added.
- the pH is adjusted to 5.5 with monoethanolamine.
- Deionised water is then added to the solution to make up a total of 100 parts.
- the pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
- citric acid monohydrate 8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added.
- the pH is adjusted to 5.5 with monoethanolamine.
- Deionised water is then added to the solution to make up a total of 100 parts.
- the pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
- n is an integer from 7 to 17, 4.0 parts cocamidopropylbetaine,
- Example 12 Test of the microbicidal activity of the novel formulations The microbicidal activity (in decimal logarithms) of the novel formulations according to Examples 1 to 11 is determined with a suspension test. This test is used to assess the bactericidal activity of water-soluble antiseptics, disinfectants and of liquid soaps.
- the test consists in seeding the test product in selected dilutions with the test bacillus. After a certain contact time, aliquots is taken and the number of surviving bacilli is determined. The difference between the number of the bacilli added and the number of the surviving bacilli is expressed as bacilli reduction in decimal logarithms. The concentration is 90%, the contact time is 30 seconds.
Abstract
The invention relates to surface-active soap formulations, comprising: (a) 0.01 to 5 % by weight of a microbicidal active substance selected from the group consisting of (a1) phenol derivatives (a2) diphenyl compounds (a3) benzyl alcohols (a4) chlorohexidine (a5) C12-C14alkylbetaines and C8-C18fatty acid amidoalkylbetaines (a6) amphoteric surfactants and (a7) trihalocarbanilides; (b) 0.1 to 25 % by weight of one or more than one hydrotropic agent; (c) 0 to 10 % by weight of one or more than one synthetic surface-active substance or of a soap or of combinations of the cited substances; (d) 0 to 8 % by weight of a salt of a saturated and/or unsaturated C8-C22fatty acid; (e) 0 to 50 % by weight of a dihydric alcohol; (f) 0 to 70 % by weight of a monohydric alcohol or of a mixture of several monohydric alcohols; and (g) mains water or deionised water to make up 100 %, with the proviso that the formulations contain at least one of components (c) and (d). The formulations are used for the disinfection and cleansing of the human skin and hands and of hard objects.
Description
Surface- active formulations
It is commonly knowledge that the antimicrobial/microbicidal properties of active substances in aqueous solutions of soaps or surfactants are strongly influenced by micell systems and may even be almost totally blocked.
Surprisingly, it has now been found that certain hydrotropic suppress the microbicidal inhibiting activity of the micells of soap and surfactant systems (so-called "deblocked surfactant systems"). Accordingly, the antimicrobial/microbicidal activity of different active ingredients can be significantly enhanced in many surfactant systems.
The novel surface-active surfactant formulations comprise
(a) 0.01 to 5% by weight of a microbicidal active substance selected from the group consisting of
(ai) phenol derivatives,
(a2) diphenyl compounds,
(a3) benzyl alcohols,
(a4) chlorohexidine,
(a5) C-^-C-^alkylbetaines and Cg-Cigfatty acid amidoalkylbetaines,
(a$) amphoteric surfactants,
(a7) trihalocarbanilides, and
(ag) quaternary ammonium salts;
(b) 0.1 to 25% by weight of one or more than one hydrotropic agent;
(c) 0 to 10% by weight of one or more than one synthetic surface- active substance or of a soap or of combinations of the cited substances;
(d) 0 to 8% by weight of a salt of a saturated and/or unsaturated Cg- ^fatty acid;
(e) 0 to 50% by weight of a dihydric alcohol;
(0 0 to 70% by weight of a monohydric alcohol or of a mixture of several monohydric alcohols; and (g) mains water or deionised water to make up 100%, with the proviso that the formulations contain at least one of components (c) and (d).
Soap formulations will be understood as meaning aqueous soap solutions which may be obtained as soap or so-called syndet solutions (= synthetic detergents).
The antimicrobial activity of the deblocked surfactant systems reaches upon gram-positive
and gram-negative bacteria as well as yeasts, dermatophytes and the like.
The compounds of component (aj) preferably correspond to the general formula
wherein
Rj is hydrogen, hydroxy, C1-C4alkyl, chloro, nitro, phenyl oder benzyl,
R2 is hydrogen, hydroxy, C1-C6alkyl or halogen,
R3 is hydrogen, C1-C6alkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof, R4 is hydrogen or methyl, R5 is hydrogen or nitro.
Halogen is bromo or, preferably, chloro.
Such compounds are typically chlorophenols (o-, m-, p-chlorophenols), 2,4-dichlorophenol, p-nitrophenol, picric acid, xylenol, p-chloro-m-xylenol, cresols (o-, m-, p-cresols), p-chloro-m-cresol, pyrocatechin, resorcinol, orcinol, 4-n-hexylresorcinol, pyrogallol, phloroglucine, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-benzylphenol, p-chloro-o-benzylphenol and 4-phenolsulfonic acid.
The compounds of component (a2) preferably correspond to the general formula
wherein
X is sulfur or the methylene group,
Ri and R are hydroxy, and
R2, R'2. R3, '3, R , R'4, R5 and R'5 arc each independently of one another hydrogen or halogen.
Typical examples of compounds of formula (2) are hexachlorophene, tetrachlorophene, dichlorophene, 2,3-dihydroxy-5,5'-dichlorodiphenylsulfide, 2,2 ' -dihydroxy-3 ,3 ' ,5 ,5 ' -tetrachlorodiphenylsulfϊde, 2,2,-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylsulfide and 3,3'-dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylamine.
The compounds of component (a3) preferably correspond to the general formula
wherein
Rj, R2, R3, R4 and R5 arc each independently of one another hydrogen or chloro.
Illustrative examples of compounds of formula (3) are benzyl alcohol, 2,4-, 3,5- or 2,6-dichlorobenzyl alcohol and trichlorobenzyl alcohol.
Component (84) is chlorohexidine and salts thereof together with organic and inorganic acids, which type of compound may preferably be incorporated into syndet systems.
Component (&5) is typically Cg-C^cocamidopropylbetaine.
Amphoteric surfactants corresponding to component (a$) are suitably C^alkylaminocarboxylic and Ci^alkanecarboxylic acids such as alkylaminoacetates or alkylaminopropionates.
The compounds of component (a7) preferably correspond to the general formula
wherein
Hal is chloro or bromo, n and m are 1 or 2, and n + m are 3.
The quaternary ammonium salts of component (a8) preferably correspond to formula
(5) R6- N+- R8 j
R7
wherein
R , R7, R8 and Ro arc each independently of one another Ci- galkyl, -Cx alkoxy or phenyl-lower alkyl, and
Hal is chloro or bromo.
Among these salts, the compound of formula
wherein n is an integer from 7 to 17, is very particularly preferred.
The following compounds are suitable for use as component (b):
(bi): sulfonates, preferably the salts thereof of terpenoids, or mono- or binuclear aromatic compounds, typically sulfonates of camphor, toluene, xylene, cumene or naphthene; (b2): saturated or unsaturated C3-C12di- or polycarboxylic acids, typically malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acid, unde- canedicarboxylic acid and dodecanedicarboxylic acid, fumaric, maleic, tartaric
and malic acid as well as citric and aconitic acid; (b3): - aliphatic saturated or unsaturated Cj-Cumonocarboxylic acids, typically acetic, propionic, hexanoic, capric or undecylenoic acid;
- saturated or unsaturated C3-Ci2di- or polycarboxylic acids, typically malonic, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acid, undecanecarboxylic and dodecanedicarboxylic acid, fumaric, maleic, tartaric and malic acid as well as citric and aconitic acid;
- aminocarboxylic acids, typically ethylenediaminetetracetic acid, hydroxyethyl- ethylenediaminetetracetic acid and nitrilotriacetic acid;
- cycloaliphatic carboxylic acids such as camphoric acid;
- aromatic carboxylic acids, typically benzyl, phenylacetic, phenoxyacetic and cinnamic acid, 2-, 3- and 4-hydroxybenzoic acid, anilinic acid as well as o-, m- and p-chlorophenylacetic acid and o-, m- and p-chlorophenoxyacetic acid;
- alkali metal salts and amine salts of inorganic acids, typically the sodium or potassium salts and amine(R1R2R3) salts of hydrochloric, sulfuric, phosphoric, C C10alkylphosphoric acid and boric acid, in which amine salts Rj, R2 and R3 have the meaning indicated above;
- isethionic acid;
- tannic acid;
- acid amides of formula
(7) RrCO-N
X R3 wherein
Rj is hydrogen or -C-^alkyl, and
R2 and R3 are each independently of the other hydrogen, Cj-C^alkyl, C2-C12alkenyl,
C2-Ci2hydroxyalkyl, or a polyglycol ether chain containing 1 to 30 -CH2-CH2-O- or -CHYrCHY2-O- groups, wherein Yj or Y2 is a hydrogen radical and the other is methyl, e.g.N-methylacetamide;
- urea derivatives of formula
(8) N-CO-N
R2 R4
wherein
Rj, R2, R3 and R4 are each independently of one another hydrogen, CrC8alkyl,
C2-C8alkenyl, Cj-Cghydroxyalkyl or C2-C8hydroxyalkenyl;
- monohydric C4-C18aliphatic and monocyclic alcohols, typically C2-C18alkanols, C2-C18alkenols and terpene alcohols e.g. ethanol, propanol, isopropanol, hexanol, cis-3-hexen-l-ol, trans-2-hexen-l-ol, l-octen-3-ol, heptanol, octanol, trans-2-cis-6-nonadien-l-ol, decanol, linalol, geraniol, dihydroterpineol, myrcenol, nopol and terpineol;
- aromatic alcohols of formula
wherein
Rj, R and R3 arc each independently of one another hydrogen, hydroxy, halogen or Cj- alkoxy, typically benzyl alcohol, 2,4-dichlorobenzyl alcohol, phenoxyethanol, l-phenoxy-2-propanol (phenoxyisopropanol) and cinnamyl alcohol;
- polyhydric alcohols and polyhydric alkoxylated, preferably ethoxylated and/or propoxylated alcohols as well as the ethers and esters thereof of the general formula
(10) RrO-X-O-R2,
wherein
Rj and R2 are each independently of the other hydrogen, CrC12alkyl, C2-C12alkenyl, CrC8alkanoyl, C3-C18alkenoyl, R3-(OCH-CH2-7 57j-, wherein
I
R4
R3 is hydrogen, Cj-C12alkyl or C^-C^alkenyl, and R4 is hydrogen or -CH3, and
X is C2-C10alkylene or
-( H2CH O)f3fjCH2-CH2- or
-(CH2-CH-O)τ3δ-CH2-CH- . CH3 CH3
All organic acids mentioned under (b) may also be obtained in the form of their water-soluble salts, such as the alkali metal salts, preferably the sodium or potassium salts or the amine(NRjR2R3) salts, wherein
Ri, R2 and R3 are each independently of one another hydrogen,
CrC8alkyl, C^- alkenyl, C C8hydroxyalkyl, C5-C8cycloalkyl or polyalkenylenoxy- -Cigalkyl, or
Ri, R2 and R3, together with the linking nitrogen atom, are unsubstituted or
C1-C4alkyl-substituted morpholino.
Component (b) can consist of only one compound of subclass (bj) or also of mixtures of one or more than one compound of subclass (bj), also together with components of further subclasses.
A special antimicrobial activity is achieved with a combination of one or more than one compound of subclass (bj) and one or more than one compound of subclass b^). Particularly preferred in this connection is a combination of cumene sulfonate and citric acid monohydrate.
Suitable components (c) are anionic, nonionic or zwitterionic and amphoteric synthetic, surface-active substances.
Suitable anionic surface-active substances are:
- sulfates, typically fatty alcohol sulfates, which contain 8 to 18 carbon atoms in the alkyl chain, e.g. sulfated lauryl alcohol;
- C8-C22fatty alcohol ether sulfates, typically the acid esters or the salts thereof of a polyadduct of 2 to 30 mol of ethylene oxide with 1 mol of a -C^fatty alcohol;
- the alkali metal salts, ammonium salts or amine salts of C8-C2θfatty acids, which are termed soaps, typically coconut fatty acid;
- alkylamide sulfates;
- alkylamide ether sulfates;
- alkylaryl polyether sulfates;
- monoglyceride sulfates;
alkane sulfonates, containing 8 to 20 carbon atoms in the alkyl chain, e.g. dodecyl sulfonate; alkylamide sulfonates; alkylaryl sulfonates; α-olefin sulfonates; sulfosuccinic acid derivatives, typically alkyl sulfosuccinates, alkyl ether sulfosuccinates or alkyl sulfosuccinamide derivatives;
N-[ alky lamidoalkyl] amino acids of formula
Y /
CH3(CH2)n-CO-N
(11) \
N CH-Z-COO M+
X
wherein
X is hydrogen, CrC4alkyl or -COO M+,
Y is hydrogen or Cι-C alkyl, Z is -(CH2) m 1 - ml is 1 to 5, n is an integer from 6 to 18, and
M is an alkali metal ion or an amine ion; alkyl ether carboxylates and alkylaryl ether carboxylates of formula
(12) CH3-X-Y-A ,
wherein
X is a radical
R is hydrogen or Cι-C4alkyl,
Y is -(CHCHO)πo-,
II O M+ A is -(CH ) — COO M+ or ■ vm*Λ -p O M+ m2 is 1 to 6, and
M is an alkali metal cation or amine cation.
The anionic surfactants used may furthermore be fatty acid methyl taurides, alkylisothionates, fatty acid polypeptide condensates and fatty alcohol phosphoric acid esters. The alkyl radicals in these compounds preferably contain 8 to 24 carbon atoms.
The fatty alcohols which may be present in the above-mentioned surfactants are those containing 8 to 22, preferably 8 to 18 carbon atoms, typically octyl, decyl, lauryl, tridecyl, miristyl, cetyl, stearyl, oleyl, arachidyl or behenyl alcohol.
The anionic surfactants are usually obtained in the form of their water-soluble salts, such as the alkali metal, ammonium or amine salts. Typical examples of such salts are lithium, sodium, potassium, ammonium, triethylamine, ethanolamine, diethanolamine or triethanolamine salts. It is preferred to use the sodium or potassium salts or the ammonium-(NR1R2R3) salts, wherein Rt, R2 and R3 are each independently of one another hydrogen, Cι-C4alkyl or C Qhydroxyalkyl.
The anionic surfactants preferably used in the formulation of this invention are Cg-C^fatty acid alcohol ether sulfates, more particularly the alkali metal salts of lauryl ether sulfate.
Very particularly preferred anionic surfactants in the novel formulation are monoethanolamine lauryl sulfate or the alkali metal salts of fatty alcohol sulfates, preferably the sodium lauryl sulfate and the reaction product of 2 to 4 mol of ethylene oxide and sodium lauryl ether sulfate.
Suitable zwitterionic and amphoteric surfactants are C -Cι8betaines, C8-C18sulfobetaines, C8-C 4alkylamido-C1-C4alkylenebetaines, imidazoline carboxylates, alkylamphocarboxy carboxylic acids, alkylamphocarboxylic acids (e.g. lauroamphoglycinate) and N-alkyl-β- aminopropionates or N-alkyl-β-iminodipropionates. It is preferred to use the C1o-C2oalkylamido-Cι-C4alkylenebetaines and, more particularly,
cocoamidopropylbetaine.
Nonionic surfactants are typically derivatives of the adducts of propylene oxide/ethylene oxide having a molecular weight of 1000 to 15000, fatty alcohol ethoxylatcs (1-50 EO), alkylphenol polyglycol ethers (1-50 EO), ethoxylated carbohydrates, fatty acid glycol partial esters, typically diethylene glycol monstearate, fatty acid alkanolamides and fatty acid dialkanolamides, fatty acid alkanolamide ethoxylates and fatty acid amine oxides. The fatty acid alkanolamides and fatty acid dialkanolamides and, preferably, cocodiethanolamide are to be particularly highlighted.
Suitable components (d) are the salts of saturated and unsaturated C12-C22fatty acids, typically lauric, myristic, palmitic, stearic, arachic, behenic, dodecenoic, tetradecenoic, octadecenoic, oleic, eicosanic and erucic acid, as well as the technical mixtures of such acids, typically coconut fatty acid which is preferably used in the novel formulation. These acids may be obtained in the form of salts, suitable cations being alkali metal cations such as sodium and potassium cations, metal atoms such as zinc atoms and aluminium atoms or nitrogen-containing organic compounds of sufficient alkalinity, typically amines or ethoxylated amines. These salt can also be prepared in situ. Component (d) can also be a mixture of the indicated salts.
Suitable components (e) are dihydric alcohols, preferably those containing 2 to 6 carbon atoms in the alkylene radical, typically ethylene glycol, 1,2- or 1,3-propanediol, 1,3-, 1,4- or 2,3-butanediol, 1,5-pentanediol and 1,6-hexanediol. 1,2-propanediol (propylene glycol) is preferred.
Component (f) is preferably ethanol, n-propanol and isopropanol or a mixture of these alcohols.
Preferred novel formulations are those comprising
(a*^) a compound of formula
wherein
Rj is hydrogen, hydroxy, Cj-Qalkyl, chloro, nitro, phenyl or benzyl,
R2 is hydrogen, hydroxy, Cj-C^alkyl or chloro,
R3 is hydrogen, Cj-Cgalkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof,
R4 is hydrogen or methyl, and
R5 is hydrogen or nitro,
(b) 0.1 to 25% by weight of a mixture of sodium cumene sulfonate and citric acid monohydrate,
(c) 1 to 10% by weight of a C -C22fatty acid alcohol ether sulfate,
(e) 0 to 50% by weight of a dihydric alcohol;
(f) 0 to 70% by weight of a monohydric alcohol or of a mixture of several monohydric alcohols; and
(g) mains water or deionised water to make up 100%.
The pH of the novel formulation is 3 to 10, preferably 4.5 to 6.
The novel formulations obtained as soap or syndet solutions may additionally comprise customary additives, typically sequestrants, dyes, perfume oils, thickeners or solidifiers (consistency regulators), emollients, UV absorbers, skin-protection agents, antioxidants, additives which improve the mechanical properties, such as dicarboxylic acids and/or Al, Zn, Ca, Mg salts of C14-C22f tty acids and, if desired, preservatives.
The novel soap bars can be fabricated in per se known manner, typically by mixing the novel components (a) and (b) and, optionally, (c), (d), (e) and (f), as well as any additives in a jerk mixer at 18-25°C. After the composition obtained has been processed, it is extruded at 40 to 60°, preferably from 45 to 50°C, and then cut and stamped in moulds.
Soap formulations of the invention can be prepared by mixing components (a) and (b) and, optionally, (c), (d), (e) and (f), in any order, with the requisite amount of water and stirring
the mixture to homogeneity. The mixture is bulked to 100% with additional water. This procedure is a purely physical procedure. Accordingly, there is no chemical reaction of the individual components.
For disinfection and cleansing of the human skin and hands and of hard objects, the novel soap formulations can be applied thereto in dilute or undilute form, suitably in an amount of at least 2 ml, preferably in the undilute form, for hand disinfection.
The invention is illustrated by the following Examples. Parts and percentages are by weight.
Example 1:
1.0 part o-phenylphenol,
4.0 parts sodium lauryl ether-2-sulfate,
8.0 parts sodium cumene sulfonate powder,
8.0 parts citric acid monohydrate,
10.0 parts propylene glycol, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 2:
1.0 part o-phenylphenol,
4.0 parts sodium lauryl ether-4-sulfate,
8.0 parts sodium cumene sulfonate powder,
8.0 parts citric acid monohydrate,
10.0 parts propylene glycol, and water to make up 100 parts is stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 3:
1.0 part p-chloro-m-xylene,
4.0 parts sodium lauryl ether-2-sulfate
8.0 parts sodium cumene sulfonate powder,
8.0 parts citric acid monohydrate,
10.0 parts propylene glycol, and water to make up 100 parts are mixed to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 4:
1.0 part p-chloro-o-benzylphenol,
4.0 parts sodium lauryl ether-2-sulfate
8.0 parts sodium cumene sulfonate powder,
8.0 parts citric acid monohydrate,
10.0 parts propylene glycol, and water to make up 100 parts arc stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 5:
2.0 parts benzyl alcohol,
4.0 parts sodium lauryl sulfate
5.0 parts sodium cumene sulfonate powder,
8.0 parts citric acid monohydrate,
10.0 parts propylene glycol, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 6:
4.0 parts cocamidopropylbetaine,
5.0 parts sodium cumene sulfonate,
10.0 parts propylene glycol,
8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
Example 7:
4.0 parts cocamidopropylbetaine,
12.0 parts ethanol,
8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
Example 8:
4.0 parts sodium lauraminopropionate,
5.0 parts sodium cumene sulfonate,
10.0 parts propylene glycol,
8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
Example 9:
4.0 parts sodium lauraminopropionate,
12.0 parts ethanol,
8.0 parts citric acid monohydrate, and
water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 4.0.
Example 10:
1.0 part of the compound of formula
wherein n is an integer from 7 to 17, 4.0 parts cocamidopropylbetaine,
12.0 parts ethanol,
8.0 parts citric acid monohydrate, and water to make up 100 parts arc stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 11:
1.0 part 2,4-dichlorobenzyl alcohol
4.0 parts sodium laurylsulfate,
5.0 parts sodium cumene sulfonate,
1.0 part propylene glycol,
8.0 parts citric acid monohydrate, and water to make up 100 parts are stirred to homogeneity and about 90% of the requisite water is then added. The pH is adjusted to 5.5 with monoethanolamine. Deionised water is then added to the solution to make up a total of 100 parts. The pH is checked again and, if necessary, monoethanolamine is added to adjust the pH to 5.5.
Example 12: Test of the microbicidal activity of the novel formulations The microbicidal activity (in decimal logarithms) of the novel formulations according to Examples 1 to 11 is determined with a suspension test. This test is used to assess the bactericidal activity of water-soluble antiseptics, disinfectants and of liquid soaps. The test consists in seeding the test product in selected dilutions with the test bacillus. After a certain contact time, aliquots is taken and the number of surviving bacilli is determined. The difference between the number of the bacilli added and the number of the surviving bacilli is expressed as bacilli reduction in decimal logarithms. The concentration is 90%, the contact time is 30 seconds.
The following test bacilli are used:
Example Staph. aureus Strept. faecalis E. Coli P.aeruginosa Serratia mar ATCC 9144 ATCC 10,541 ATCC 10,536 CIP A-22 cescens ATCC 13,8
1 4.6 >5.1 >5.3 >5.3 >5.4
2 >5.5 >5.2 >5.1 >5.3 >5.5
3 >5.5 >5.2 >5.1 >5.3 >5.5
4 >5.5 >5.2 >5.1 >5.3 >5.5
5 >6 >6 >6 >6 >6
6 2.0 0.2 1.4 >6 2.7
7 0 0.5 2.6 >6 1.3
8 0.1 0.3 0.7 >6 2.5
9 3.5 >6 >6 >6 4.2
10 1.0 1.7 >6 >6 4.7
11 3.4 >6 >6 >6 >6
Claims
1. A surface-active surfactant formulation, comprising
(a) 0.01 to 5% by weight of a microbicidal active substance selected from the group consisting of
(aj) phenol derivatives,
(a2) diphenyl compounds,
(a3) benzyl alcohols,
(a4) chlorohexidine,
(a5) C12-C1 alkylbetaines and C8-C18fatty acid amidoalkylbetaines,
(ag) amphoteric surfactants,
(a7) trihalocarbanilides, and
(a8) quaternary ammonium salts;
(b) 0.1 to 25% by weight of one or more than one hydrotropic agent;
(c) 0 to 10% by weight of one or more than one synthetic surface-active substance or of a soap or of combinations of the cited substances;
(d) 0 to 8% by weight of a salt of a saturated and/or unsaturated Cg-C^fatty acid;
(e) 0 to 50% by weight of a dihydric alcohol;
(f) 0 to 70% by weight of a monohydric alcohol or of a mixture of several monohydric alcohols; and
(g) mains water or deionised water to make up 100%, with the proviso that said formulations contain at least one of components (c) and (d).
2. A formulation according to claim 1, wherein the compounds used for component (& ) are those of the general formula
wherein
R is hydrogen, hydroxy, CrC alkyl, chloro, nitro, phenyl oder benzyl,
R2 is hydrogen, hydroxy, CrC6alkyl or halogen,
R3 is hydrogen, C1-C6alkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof, R4 is hydrogen or methyl, R5 is hydrogen or nitro.
3. A formulation according to claim 1, wherein the compounds used for component (a^ are those of formula
wherein
X is sulfur or the methylene group,
Rj and R are hydroxy, and
R2, R'2» R3, R'3- R4, R'4, R5 and R'5 are each independently of one another hydrogen or halogen.
4. A formulation according to claim 1, wherein the compounds used for component (a3) are those of formula
wherein
Ri, R2, R3, R4 and R5 are each independently of one another hydrogen or chloro.
5. A formulation according to claim 1, wherein component (a4) is chlorohexidine or a salt thereof with an organic or inorganic acid.
6. A formulation according to claim 1, wherein component (a5) is cocamidopropylbetaine.
7. A formulation according to claim 1, wherein component (ag) is a C^alkylaminocarboxylic acid or a Cι-C3alkanecarboxylic acid.
8. A formulation according to claim 1, wherein the compounds used for component (a7) are those of the general formula
wherein Hal is chloro or bromo, n and m are 1 or 2, and n + m are 3.
9. A formulation according to claim 1, wherein the compound used for component (a8) is a compound of formula
wherein n is an integer from 7 to 17.
10. A formulation according to any one of claims 1 to 9, wherein component (bj) is a sulfonate, preferably a salt thereof of a terpenoid or of a mono- or binuclear aromatic compound.
11. A formulation according to claim 10, wherein the mono- or binuclear aromatic compounds are the sulfonates of camphor, toluene, xylene, cumene or naphthene.
12. A formulation according to any one of claims 1 to 11, wherein component (b) consists of only one compound of subclass (b ) or also of a mixture of one or more than one compound of subclass (bj) together with components of further subclasses.
13. A formulation according to any one of claims 1 to 11, wherein component (b) is a combination of one or more than one compound of subclass (bj) and one or more than one compound of subclass (b ).
14. A formulation according to claim 13, wherein a combination of cumene sulfonate and citric acid monohydrate is used.
15. A formulation according to any one of claims 1 to 14, wherein component (c) is an anionic surfactant in the form of the water-soluble salt thereof.
16. A formulation according to claim 15, wherein component (c) is C8-C22fatty alcohol ether sulfate.
17. A formulation according to claim 16, wherein component (c) is an alkali metal salt of lauryl ether sulfate.
18. A formulation according to any one of claims 1 to 17, wherein component (d) is selected from the group consisting of lauric, myristic, palmitic, stearic, arachic, behenic, dodecenic, tetradecenic, octadecenic, oleic, eicosenic and erucic acid.
19. A formulation according to any one of claims 1 to 18, wherein component (e) is propylene glycol.
20. A formulation according to any one of claims 1 to 19, wherein component (f) is selected from the group consisting of ethanol, propanol, isopropanol, and mixtures of these alcohols.
21. A surface-active formulation comprising (aj) a compound of formula
wherein
Ri is hydrogen, hydroxy, Cj- alkyl, chloro, nitro, phenyl oder benzyl,
R2 is hydrogen, hydroxy, Cι-C6alkyl or halogen,
R3 is hydrogen, Cι-C6alkyl, hydroxy, chloro, nitro or a sulfo group in the form of the alkali metal salts or ammonium salts thereof, R is hydrogen or methyl, R5 is hydrogen or nitro,
(b) 0.1 to 25% by weight of a mixture of sodium cumene sulfonate and citric acid monohydrate,
(c) 0 to 10% by weight of a -C^fatty alcohol ether sulfate,
(d) 0 to 50% by weight of a dihydric alcohol,
(e) 0 to 70% by weight of a monohydric alcohol or of a mixture of several monohydric alcohols, and
(f) mains water or deionised water to make up 100%.
22. Use of an antimicrobial soap formulation as claimed in any one of claims 1 to 21 for the disinfection and cleansing of the human skin and hands and of hard objects.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2611/94 | 1994-08-25 | ||
CH261194 | 1994-08-25 | ||
PCT/EP1995/003211 WO1996006153A2 (en) | 1994-08-25 | 1995-08-14 | Surface-active formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0777717A2 true EP0777717A2 (en) | 1997-06-11 |
Family
ID=4237670
Family Applications (1)
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EP95929863A Withdrawn EP0777717A2 (en) | 1994-08-25 | 1995-08-14 | Surface-active formulations |
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JP (1) | JPH10504592A (en) |
AU (1) | AU3345295A (en) |
BG (1) | BG101308A (en) |
BR (1) | BR9508775A (en) |
CA (1) | CA2196771A1 (en) |
CZ (1) | CZ55697A3 (en) |
FI (1) | FI970742A (en) |
HU (1) | HUT76688A (en) |
MX (1) | MX9701416A (en) |
SK (1) | SK24497A3 (en) |
WO (1) | WO1996006153A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221823B1 (en) † | 1995-10-25 | 2001-04-24 | Reckitt Benckiser Inc. | Germicidal, acidic hard surface cleaning compositions |
JP2002514163A (en) * | 1996-07-10 | 2002-05-14 | ステリス インコーポレイテッド | Triclosan skin wash with improved efficacy |
JPH1071190A (en) * | 1996-08-30 | 1998-03-17 | Tomey Technol Corp | Liquid agent for contact lens |
US6197315B1 (en) | 1997-06-04 | 2001-03-06 | Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria |
US6214363B1 (en) | 1997-11-12 | 2001-04-10 | The Procter & Gamble Company | Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria |
US5968539A (en) * | 1997-06-04 | 1999-10-19 | Procter & Gamble Company | Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria |
US6190675B1 (en) | 1997-06-04 | 2001-02-20 | Procter & Gamble Company | Mild, rinse-off antimicrobial liquid cleansing compositions which provide improved residual benefit versus gram positive bacteria |
US6287577B1 (en) | 1997-11-12 | 2001-09-11 | The Procter & Gamble Company | Leave-on antimicrobial compositions which provide improved residual benefit versus gram positive bacteria |
US6183763B1 (en) | 1997-06-04 | 2001-02-06 | Procter & Gamble Company | Antimicrobial wipes which provide improved immediate germ reduction |
US6210695B1 (en) | 1997-06-04 | 2001-04-03 | The Procter & Gamble Company | Leave-on antimicrobial compositions |
US6183757B1 (en) | 1997-06-04 | 2001-02-06 | Procter & Gamble Company | Mild, rinse-off antimicrobial cleansing compositions which provide improved immediate germ reduction during washing |
US6190674B1 (en) | 1997-06-04 | 2001-02-20 | Procter & Gamble Company | Liquid antimicrobial cleansing compositions |
US6284259B1 (en) | 1997-11-12 | 2001-09-04 | The Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus Gram positive bacteria |
DE59809191D1 (en) * | 1997-09-17 | 2003-09-11 | Ciba Sc Holding Ag | Antimicrobial detergent additive |
EP0903401B1 (en) * | 1997-09-17 | 2003-08-06 | Ciba SC Holding AG | Antimicrobial additive for washing agents |
US6287583B1 (en) | 1997-11-12 | 2001-09-11 | The Procter & Gamble Company | Low-pH, acid-containing personal care compositions which exhibit reduced sting |
CA2311772C (en) * | 1997-11-28 | 2007-05-08 | Reckitt Benckiser Inc. | Concentrated liquid cleaner for hard surfaces |
GB2331758B (en) | 1997-11-28 | 2002-04-17 | Reckitt & Colman Inc | Disinfectant compositions |
GB2331703B (en) * | 1997-11-28 | 2002-01-23 | Reckitt & Colman Inc | Disinfectant compositions |
GB2331760B (en) * | 1997-11-28 | 2002-05-15 | Reckitt & Colman Inc | Hard surface cleaning compositions |
JPH11189784A (en) * | 1997-12-26 | 1999-07-13 | Kose Corp | Detergent composition |
IL137891A (en) * | 1998-03-19 | 2005-03-20 | Bifodan As | Disinfecting composition |
US6107261A (en) | 1999-06-23 | 2000-08-22 | The Dial Corporation | Compositions containing a high percent saturation concentration of antibacterial agent |
CA2371925C (en) * | 1999-06-23 | 2009-02-17 | The Dial Corporation | Antibacterial compositions |
US6861397B2 (en) | 1999-06-23 | 2005-03-01 | The Dial Corporation | Compositions having enhanced deposition of a topically active compound on a surface |
DE19937295C2 (en) * | 1999-08-06 | 2002-11-21 | Cognis Deutschland Gmbh | syndet soaps |
US20020123440A1 (en) * | 2000-04-04 | 2002-09-05 | Hoang Minh Q. | Foamable antimicrobial formulation |
AU2001249365A1 (en) * | 2000-04-04 | 2001-10-15 | Becton, Dickinson And Company | Foamable antimicrobial formulation |
DE102004038104A1 (en) * | 2004-08-05 | 2006-02-23 | Henkel Kgaa | Use of ortho-phenylphenol and / or its derivatives for inhibiting the asexual propagation of fungi |
EP1987120B2 (en) † | 2006-02-24 | 2013-09-11 | Unilever PLC | Fast release granules |
JP2008106022A (en) * | 2006-10-27 | 2008-05-08 | Miura Co Ltd | Bactericide for skin |
EP2727991A1 (en) * | 2012-10-30 | 2014-05-07 | The Procter & Gamble Company | Cleaning and disinfecting liquid hand dishwashing detergent compositions |
JP5752220B2 (en) * | 2013-12-16 | 2015-07-22 | 花王株式会社 | Bactericidal detergent composition for hard surfaces |
CA3018865A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
EP3544575A1 (en) | 2016-11-23 | 2019-10-02 | GOJO Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
JP7071999B2 (en) | 2017-05-01 | 2022-05-19 | ゴジョ・インダストリーズ・インコーポレイテッド | Alcohol containing non-antibacterial cleaning composition |
JP7219583B2 (en) * | 2018-10-19 | 2023-02-08 | 大日本除蟲菊株式会社 | Fungicide composition |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1467619A1 (en) * | 1965-11-27 | 1969-02-13 | Henkel & Cie Gmbh | Color stable liquid detergents, cleaning agents and dishwashing agents containing disinfectants |
GB1266060A (en) * | 1969-09-12 | 1972-03-08 | ||
BE768041R (en) * | 1971-06-03 | 1971-12-03 | Ciba Geigy Ag | COMPOSITION TO FIGHT THE |
SE376929B (en) * | 1971-12-13 | 1975-06-16 | Basf Wyandotte Corp | |
GB1539031A (en) * | 1975-02-22 | 1979-01-24 | Beecham Group Ltd | Pharmaceutical compositions |
US4310433A (en) * | 1980-09-02 | 1982-01-12 | The Procter & Gamble Company | Superfatted liquid soap skin cleansing compositions |
DE3117792C2 (en) * | 1981-05-06 | 1990-08-23 | Schülke & Mayr GmbH, 2000 Norderstedt | The use of an aqueous solution of alcohols, phenols and surfactants as a virucidal agent |
DE3723990A1 (en) * | 1986-07-23 | 1988-02-04 | Ciba Geigy Ag | Microbicidal preparation |
DE3723994A1 (en) * | 1986-07-23 | 1988-02-04 | Ciba Geigy Ag | Microbicidal preparation |
JPH0753657B2 (en) * | 1986-12-03 | 1995-06-07 | ライオン株式会社 | Skin cleanser |
BR8900685A (en) * | 1988-02-17 | 1989-10-10 | Ciba Geigy Ag | COMPOSITION OF ANTIMICROBIAL SOAP AND APPLICATION |
US4832861A (en) * | 1988-05-27 | 1989-05-23 | Lever Brothers Company | Soap compositions of enhanced antimicrobial effectiveness |
JPH03193727A (en) * | 1989-12-22 | 1991-08-23 | Kao Corp | Underarm deodorant |
JPH05279693A (en) * | 1992-04-02 | 1993-10-26 | Shin Etsu Chem Co Ltd | Antimicrobial detergent |
JPH08503209A (en) * | 1992-11-09 | 1996-04-09 | ウエスト・アグロ・インコーポレーテッド | Improved acid disinfectant composition |
-
1995
- 1995-08-14 JP JP8507758A patent/JPH10504592A/en active Pending
- 1995-08-14 BR BR9508775A patent/BR9508775A/en not_active Application Discontinuation
- 1995-08-14 CA CA002196771A patent/CA2196771A1/en not_active Abandoned
- 1995-08-14 WO PCT/EP1995/003211 patent/WO1996006153A2/en not_active Application Discontinuation
- 1995-08-14 SK SK244-97A patent/SK24497A3/en unknown
- 1995-08-14 EP EP95929863A patent/EP0777717A2/en not_active Withdrawn
- 1995-08-14 AU AU33452/95A patent/AU3345295A/en not_active Abandoned
- 1995-08-14 CZ CZ97556A patent/CZ55697A3/en unknown
- 1995-08-14 HU HU9701263A patent/HUT76688A/en unknown
- 1995-08-14 MX MX9701416A patent/MX9701416A/en unknown
-
1997
- 1997-02-21 FI FI970742A patent/FI970742A/en not_active Application Discontinuation
- 1997-03-11 BG BG101308A patent/BG101308A/en unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9606153A2 * |
Also Published As
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BR9508775A (en) | 1997-12-23 |
JPH10504592A (en) | 1998-05-06 |
HUT76688A (en) | 1997-10-28 |
FI970742A0 (en) | 1997-02-21 |
SK24497A3 (en) | 1997-07-09 |
WO1996006153A2 (en) | 1996-02-29 |
AU3345295A (en) | 1996-03-14 |
WO1996006153A3 (en) | 1996-05-02 |
MX9701416A (en) | 1997-05-31 |
CZ55697A3 (en) | 1997-06-11 |
FI970742A (en) | 1997-02-21 |
BG101308A (en) | 1997-09-30 |
CA2196771A1 (en) | 1996-02-29 |
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