EP0777476A4 - Methods of inhibiting endometrial cancer - Google Patents

Methods of inhibiting endometrial cancer

Info

Publication number
EP0777476A4
EP0777476A4 EP95930243A EP95930243A EP0777476A4 EP 0777476 A4 EP0777476 A4 EP 0777476A4 EP 95930243 A EP95930243 A EP 95930243A EP 95930243 A EP95930243 A EP 95930243A EP 0777476 A4 EP0777476 A4 EP 0777476A4
Authority
EP
European Patent Office
Prior art keywords
methods
endometrial cancer
inhibiting endometrial
inhibiting
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95930243A
Other languages
German (de)
French (fr)
Other versions
EP0777476A1 (en
Inventor
Susan Margaret Boss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0777476A1 publication Critical patent/EP0777476A1/en
Publication of EP0777476A4 publication Critical patent/EP0777476A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
EP95930243A 1994-08-22 1995-08-21 Methods of inhibiting endometrial cancer Withdrawn EP0777476A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US293853 1981-08-18
US29385394A 1994-08-22 1994-08-22
PCT/US1995/010651 WO1996005833A1 (en) 1994-08-22 1995-08-21 Methods of inhibiting endometrial cancer

Publications (2)

Publication Number Publication Date
EP0777476A1 EP0777476A1 (en) 1997-06-11
EP0777476A4 true EP0777476A4 (en) 1999-06-23

Family

ID=23130867

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95930243A Withdrawn EP0777476A4 (en) 1994-08-22 1995-08-21 Methods of inhibiting endometrial cancer

Country Status (17)

Country Link
EP (1) EP0777476A4 (en)
JP (1) JPH10504824A (en)
KR (1) KR970705387A (en)
AU (1) AU688112B2 (en)
CA (1) CA2198119A1 (en)
CZ (1) CZ51897A3 (en)
FI (1) FI970717A (en)
HU (1) HUT76890A (en)
IL (1) IL115022A (en)
MX (1) MX9701327A (en)
MY (1) MY113757A (en)
NO (1) NO970783L (en)
NZ (1) NZ292017A (en)
RU (1) RU2161964C2 (en)
TW (1) TW404834B (en)
WO (1) WO1996005833A1 (en)
ZA (1) ZA956994B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856340A (en) * 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
KR20160066490A (en) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 Heterocyclic derivatives and use thereof
CN115825414B (en) * 2023-01-09 2023-04-25 中国医学科学院北京协和医院 Blood or urine metabolic marker and application thereof in endometrial cancer early screening

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
EP0617030A1 (en) * 1993-03-19 1994-09-28 Eli Lilly And Company Sulfonate and carbamate derivatives of 3-aroylbenzo (beta) thiophenes
WO1994023068A1 (en) * 1993-04-07 1994-10-13 Ligand Pharmaceuticals, Incorporated Method for screening for receptor agonists
EP0652004A1 (en) * 1993-10-15 1995-05-10 Eli Lilly And Company Methods for treating resistant neoplasms
WO1996005832A1 (en) * 1994-08-22 1996-02-29 Eli Lilly And Company Methods of inhibiting primary endometrial hyperplasia
WO1996009050A1 (en) * 1994-09-22 1996-03-28 Eli Lilly And Company Methods of inhibiting endometrial mitoses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3157882B2 (en) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 New benzothiophene derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
EP0617030A1 (en) * 1993-03-19 1994-09-28 Eli Lilly And Company Sulfonate and carbamate derivatives of 3-aroylbenzo (beta) thiophenes
WO1994023068A1 (en) * 1993-04-07 1994-10-13 Ligand Pharmaceuticals, Incorporated Method for screening for receptor agonists
EP0652004A1 (en) * 1993-10-15 1995-05-10 Eli Lilly And Company Methods for treating resistant neoplasms
WO1996005832A1 (en) * 1994-08-22 1996-02-29 Eli Lilly And Company Methods of inhibiting primary endometrial hyperplasia
WO1996009050A1 (en) * 1994-09-22 1996-03-28 Eli Lilly And Company Methods of inhibiting endometrial mitoses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOTTARDIS M M ET AL: "EFFECT OFSTEORIDAL AND NONSTEORIDAL ANTIESTROGENS ON THE GROWTH OF A TAMOXIFEN-STIMULATED HUMAN ENDOMETRIAL CARCINOMA (ENCA101) IN ATHYMIC MICE", CANCER RESEARCH, vol. 50, no. 11, pages 3189 - 3192, XP002041037 *
JORDAN V C: ""STUDIES ON THE ESTROGEN RECEPTOR IN BREAST CANCER" - 20 YEARS AS A TARGET FOR THE TREATMENT AND PREVENTION OF CANCER", BREAST CANCER RESEARCH AND TREATMENT, vol. 36, no. 3, 1995, pages 267 - 285, XP000654844 *
See also references of WO9605833A1 *

Also Published As

Publication number Publication date
WO1996005833A1 (en) 1996-02-29
FI970717A0 (en) 1997-02-20
MX9701327A (en) 1997-05-31
EP0777476A1 (en) 1997-06-11
RU2161964C2 (en) 2001-01-20
IL115022A (en) 2000-07-31
ZA956994B (en) 1997-02-21
CZ51897A3 (en) 1997-06-11
AU3370095A (en) 1996-03-14
HUT76890A (en) 1997-12-29
NO970783D0 (en) 1997-02-20
AU688112B2 (en) 1998-03-05
NZ292017A (en) 2000-07-28
CA2198119A1 (en) 1996-02-29
JPH10504824A (en) 1998-05-12
FI970717A (en) 1997-02-20
KR970705387A (en) 1997-10-09
IL115022A0 (en) 1998-06-15
TW404834B (en) 2000-09-11
MY113757A (en) 2002-05-31
NO970783L (en) 1997-02-20

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