EP0766579A1 - Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire - Google Patents

Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire

Info

Publication number
EP0766579A1
EP0766579A1 EP95925294A EP95925294A EP0766579A1 EP 0766579 A1 EP0766579 A1 EP 0766579A1 EP 95925294 A EP95925294 A EP 95925294A EP 95925294 A EP95925294 A EP 95925294A EP 0766579 A1 EP0766579 A1 EP 0766579A1
Authority
EP
European Patent Office
Prior art keywords
tissue
drug
duration
agent
pulse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95925294A
Other languages
German (de)
English (en)
Inventor
Ooi Wong
Tung-Fen Chen
Russell O. Potts
Durairaj Bommi Bommannan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cygnus Therapeutic Systems
Cygnus Inc
Original Assignee
Cygnus Therapeutic Systems
Cygnus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems, Cygnus Inc filed Critical Cygnus Therapeutic Systems
Publication of EP0766579A1 publication Critical patent/EP0766579A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs

Abstract

Procédé d'entraînement pulsé d'une substance dans un tissu, consistant: (a) à soumettre le tissu à au moins une impulsion électrique afin de provoquer l'électroporation de la zone tissulaire, la durée de l'impulsion électrique étant égale à la durée d'impulsion d'électroporation, et la durée d'impulsion d'électroporation étant inférieure à la durée d'une force motrice; (b) à soumettre la zone tissulaire à une force motrice de sorte que celle-ci provoque l'entraînement pulsé de la substance dans le tissu, et ce pendant la durée de la force motrice; et (c) à répéter l'étape (a) pendant la durée de la force motrice.
EP95925294A 1994-06-24 1995-06-23 Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire Withdrawn EP0766579A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26530694A 1994-06-24 1994-06-24
US265306 1994-06-24
PCT/US1995/007951 WO1996000111A1 (fr) 1994-06-24 1995-06-23 Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire

Publications (1)

Publication Number Publication Date
EP0766579A1 true EP0766579A1 (fr) 1997-04-09

Family

ID=23009917

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95925294A Withdrawn EP0766579A1 (fr) 1994-06-24 1995-06-23 Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire

Country Status (5)

Country Link
EP (1) EP0766579A1 (fr)
JP (1) JPH10511008A (fr)
AU (1) AU2947795A (fr)
CA (1) CA2194010A1 (fr)
WO (1) WO1996000111A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6009345A (en) * 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
DK1314400T3 (da) * 1996-12-31 2007-10-15 Altea Therapeutics Corp Mikroporering af væv til levering af bioaktive midler
DE69826124T3 (de) 1997-06-30 2007-10-11 Institut Gustave Roussy Verabreichung der nukleinsäure in den quergestreiften muskel
KR20010020570A (ko) 1997-06-30 2001-03-15 자끄 사비나 다세포 진핵 생물 세포중으로 개선된 핵산 전달방법 및이를 위한 콤비네이션
AU4335897A (en) * 1997-09-08 1999-03-29 Becton Dickinson & Company Iontophoretic delivery of buprenorphine
TW368420B (en) * 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
ATE220935T1 (de) * 1997-11-04 2002-08-15 Genetronics Inc Kombinierte elektroporation-und iontophoresevorrichtung zur medikament-und genverabreichung
WO2003046171A1 (fr) 2001-11-27 2003-06-05 Cellectricon Ab Procede servant a combiner l'administration sequentielle d'un agent et l'electroporation de structures cellulaires et mise en application
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6192270B1 (en) * 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6424862B1 (en) * 1999-02-10 2002-07-23 Gmp Drug Delivery, Inc. Iontophoresis electroporation and combination patches for local drug delivery to body tissues
ATE354376T1 (de) 1999-10-14 2007-03-15 Pola Chem Ind Inc Zusammensetzungen für die elektroporation
JP4566496B2 (ja) * 1999-12-15 2010-10-20 ユニヴァーシティ オブ サウス フロリダ 電気穿孔素子及び電気穿孔方法
WO2004036202A1 (fr) 2002-10-16 2004-04-29 Cellectricon Ab Electrodes nanometriques et pointes nanometriques pour l'enregistrement de courants transmembranaires dans plusieurs cellules
US20040253249A1 (en) * 2003-04-02 2004-12-16 Rudnic Edward M. Pulsatile transdermally administered antigens and adjuvants
MXPA06005509A (es) * 2003-11-13 2007-05-23 Johnson & Johnson Sistema y metodo para distribucion transdermica.
ES2334681T3 (es) * 2004-03-19 2010-03-15 Mcneil Ab Medios para la administracion transdermica de nicotina.
CA2696227A1 (fr) 2007-10-17 2009-04-23 Transpharma Medical Ltd. Verification de la vitesse de dissolution

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0615461B1 (fr) * 1991-12-03 1996-09-25 Alza Corporation Dispositif d'administration iontophoretique et son alimentation
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9600111A1 *

Also Published As

Publication number Publication date
CA2194010A1 (fr) 1996-01-04
AU2947795A (en) 1996-01-19
WO1996000111A1 (fr) 1996-01-04
JPH10511008A (ja) 1998-10-27

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19970116

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Effective date: 19980103