EP0760849A4 - Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations - Google Patents
Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisationsInfo
- Publication number
- EP0760849A4 EP0760849A4 EP19940917901 EP94917901A EP0760849A4 EP 0760849 A4 EP0760849 A4 EP 0760849A4 EP 19940917901 EP19940917901 EP 19940917901 EP 94917901 A EP94917901 A EP 94917901A EP 0760849 A4 EP0760849 A4 EP 0760849A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- same
- lbp
- nucleic acid
- methods
- acid molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5629293A | 1993-04-30 | 1993-04-30 | |
US16571793A | 1993-12-10 | 1993-12-10 | |
PCT/US1994/004709 WO1994025476A1 (fr) | 1993-04-30 | 1994-04-29 | Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations |
US165717 | 1998-10-02 | ||
US56292 | 2002-01-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0760849A4 true EP0760849A4 (fr) | 1996-12-02 |
EP0760849A1 EP0760849A1 (fr) | 1997-03-12 |
Family
ID=26735192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94917901A Withdrawn EP0760849A1 (fr) | 1993-04-30 | 1994-04-29 | Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0760849A1 (fr) |
JP (1) | JPH08511682A (fr) |
AU (1) | AU6942994A (fr) |
CA (1) | CA2161971A1 (fr) |
WO (1) | WO1994025476A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265187B1 (en) * | 1989-02-14 | 2001-07-24 | Incyte Pharmaceuticals, Inc. | Recombinant endotoxin-neutralizing proteins |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
US5484705A (en) * | 1994-01-24 | 1996-01-16 | Xoma Corporation | Method for quantifying lipopolysaccharide binding protein |
US5891618A (en) | 1994-01-24 | 1999-04-06 | Xoma Corporation | Method for quantifying LBP in body fluids |
US5786324A (en) * | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
WO1997004008A1 (fr) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Peptides antifongiques |
US5780429A (en) * | 1995-12-22 | 1998-07-14 | Marine Biological Laboratory | Anti-LPS factor from horseshoe crabs and methods of use |
US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
NZ505070A (en) * | 1996-05-10 | 2005-01-28 | Xoma Corp | An in vitro method for inhibiting Neisseria meningitidis bacteria of serogroups A, B, C and W135 using BPI |
JP2000511190A (ja) * | 1996-05-23 | 2000-08-29 | ゾーマ コーポレイション | 外傷に起因する出血に見舞われたヒトにおけるbpiタンパク質産物の治療用途 |
WO1997044354A2 (fr) | 1996-05-24 | 1997-11-27 | Regents Of The University Of Minnesota | Synthese de peptides formant des feuillets beta solubles |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
US6482796B2 (en) | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US5846789A (en) * | 1996-12-10 | 1998-12-08 | Council Of Scientific And Industrial Research | Process for preparing nontoxic lipopolysaccharides from acidiphilium species |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
DE19729810C2 (de) * | 1997-07-11 | 2000-01-13 | Max Delbrueck Centrum | Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung |
US5990082A (en) | 1997-10-22 | 1999-11-23 | Xoma Corporation | Uses of lipopolysaccharide binding protein |
US6013631A (en) * | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
US7056514B2 (en) | 2002-02-20 | 2006-06-06 | Regents Of The University Of Minnesota | Partial peptide mimetics and methods |
US8703134B2 (en) | 2003-05-15 | 2014-04-22 | Iogenetics, Llc | Targeted cryptosporidium biocides |
US8394379B2 (en) | 2003-05-15 | 2013-03-12 | Iogenetics, Llc | Targeted cryptosporidium biocides |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009183A1 (fr) * | 1989-02-14 | 1990-08-23 | Invitron Corporation | Utilisation d'une proteine bactericide/accroissant la permeabilite ou d'analogues biologiquement actifs de cette proteine pour traiter la lipopolysaccharide associee aux infections gram negatives |
EP0464533A1 (fr) * | 1990-06-28 | 1992-01-08 | BEHRINGWERKE Aktiengesellschaft | Protéines fusionnées avec des portions d'immunoglobulines, leurs production et utilisation |
WO1992003535A1 (fr) * | 1990-08-13 | 1992-03-05 | Incyte Pharmaceuticals, Inc. | Proteines bpi recombinees, utilisation et procedes de preparation de ces proteines |
WO1993006228A1 (fr) * | 1991-09-26 | 1993-04-01 | Incyte Pharmaceuticals, Inc. | Nouvelle forme de proteine fixatrice des liposaccharides |
WO1993005797A1 (fr) * | 1991-09-27 | 1993-04-01 | Incyte Pharmaceuticals, Inc. | Compositions comprenant une proteine a action bactericide/accroissant la permeabilite et un excipient lipidique, procedes pour leur production et utilisations |
WO1993023434A2 (fr) * | 1992-05-19 | 1993-11-25 | Xoma Corporation | Proteines de fusion de l'immunoglobuline bactericides augmentant la permeabilite |
-
1994
- 1994-04-29 WO PCT/US1994/004709 patent/WO1994025476A1/fr not_active Application Discontinuation
- 1994-04-29 JP JP6524554A patent/JPH08511682A/ja active Pending
- 1994-04-29 EP EP94917901A patent/EP0760849A1/fr not_active Withdrawn
- 1994-04-29 AU AU69429/94A patent/AU6942994A/en not_active Abandoned
- 1994-04-29 CA CA002161971A patent/CA2161971A1/fr not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009183A1 (fr) * | 1989-02-14 | 1990-08-23 | Invitron Corporation | Utilisation d'une proteine bactericide/accroissant la permeabilite ou d'analogues biologiquement actifs de cette proteine pour traiter la lipopolysaccharide associee aux infections gram negatives |
EP0464533A1 (fr) * | 1990-06-28 | 1992-01-08 | BEHRINGWERKE Aktiengesellschaft | Protéines fusionnées avec des portions d'immunoglobulines, leurs production et utilisation |
WO1992003535A1 (fr) * | 1990-08-13 | 1992-03-05 | Incyte Pharmaceuticals, Inc. | Proteines bpi recombinees, utilisation et procedes de preparation de ces proteines |
WO1993006228A1 (fr) * | 1991-09-26 | 1993-04-01 | Incyte Pharmaceuticals, Inc. | Nouvelle forme de proteine fixatrice des liposaccharides |
WO1993005797A1 (fr) * | 1991-09-27 | 1993-04-01 | Incyte Pharmaceuticals, Inc. | Compositions comprenant une proteine a action bactericide/accroissant la permeabilite et un excipient lipidique, procedes pour leur production et utilisations |
WO1993023434A2 (fr) * | 1992-05-19 | 1993-11-25 | Xoma Corporation | Proteines de fusion de l'immunoglobuline bactericides augmentant la permeabilite |
Non-Patent Citations (2)
Title |
---|
AU-YOUNG J ET AL.: "A novel LBP-BPI fusion protein with in vivo efficacy and longer half life.", JOURNAL OF ENDOTOXIN RESEARCH, vol. 2, June 1995 (1995-06-01), pages 209 - 212, XP000611392 * |
See also references of WO9425476A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0760849A1 (fr) | 1997-03-12 |
JPH08511682A (ja) | 1996-12-10 |
AU6942994A (en) | 1994-11-21 |
WO1994025476A1 (fr) | 1994-11-10 |
CA2161971A1 (fr) | 1994-11-10 |
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Legal Events
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A4 | Supplementary search report drawn up and despatched | ||
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18D | Application deemed to be withdrawn |
Effective date: 19981031 |