EP0759763A4 - Vermeidung der hyperakuten abstossung von organtransplantaten von schwein zum primaten - Google Patents

Vermeidung der hyperakuten abstossung von organtransplantaten von schwein zum primaten

Info

Publication number
EP0759763A4
EP0759763A4 EP95919185A EP95919185A EP0759763A4 EP 0759763 A4 EP0759763 A4 EP 0759763A4 EP 95919185 A EP95919185 A EP 95919185A EP 95919185 A EP95919185 A EP 95919185A EP 0759763 A4 EP0759763 A4 EP 0759763A4
Authority
EP
European Patent Office
Prior art keywords
pig
prevention
organ transplant
hyperacute rejection
primate organ
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95919185A
Other languages
English (en)
French (fr)
Other versions
EP0759763A1 (de
Inventor
Joseph R Leventhal
Jutta Mueller-Derlich
Wolfgang Boehm
Franz A Bieber
Marc Salit
Reiner Spaethe
R Morton Bolman Iii
Arthur J Matas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
University of Minnesota
Original Assignee
Baxter International Inc
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc, University of Minnesota filed Critical Baxter International Inc
Publication of EP0759763A1 publication Critical patent/EP0759763A1/de
Publication of EP0759763A4 publication Critical patent/EP0759763A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A61M2202/0417—Immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP95919185A 1994-05-13 1995-05-12 Vermeidung der hyperakuten abstossung von organtransplantaten von schwein zum primaten Withdrawn EP0759763A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US242208 1988-09-09
US24220894A 1994-05-13 1994-05-13
PCT/US1995/006028 WO1995031209A1 (en) 1994-05-13 1995-05-12 Prevention of hyperacute rejection in pig to primate organ transplant

Publications (2)

Publication Number Publication Date
EP0759763A1 EP0759763A1 (de) 1997-03-05
EP0759763A4 true EP0759763A4 (de) 1997-07-30

Family

ID=22913877

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95919185A Withdrawn EP0759763A4 (de) 1994-05-13 1995-05-12 Vermeidung der hyperakuten abstossung von organtransplantaten von schwein zum primaten

Country Status (3)

Country Link
EP (1) EP0759763A4 (de)
AU (1) AU2514595A (de)
WO (1) WO1995031209A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3161604B2 (ja) * 1994-05-13 2001-04-25 プラズマセレクト ゲーエムベーハー テテロウ 血液中の物質を結合してそれを除去するためのタンパク質を結合させた、無菌かつ発熱物質を含有しないカラム
EP0775493A3 (de) * 1995-11-22 1998-08-12 Baxter International Inc. Extrakorporeale xenogene Organperfusion nach Antikörper-Verringerung durch Immunoapherese
US6464976B1 (en) * 1999-09-07 2002-10-15 Canji, Inc. Methods and compositions for reducing immune response
AU2013204469B2 (en) * 2008-12-19 2015-04-09 Baxalta GmbH Systems and methods for obtaining immunoglobulin from blood
US20100158893A1 (en) * 2008-12-19 2010-06-24 Baxter International Inc. Systems and methods for obtaining immunoglobulin from blood
US20120219633A1 (en) * 2011-02-28 2012-08-30 Pall Corporation Removal of immunoglobulins and leukocytes from biological fluids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269279A2 (de) * 1986-11-21 1988-06-01 Imre Corporation Ausserkörperliche Beseitigung von Immunoglobulin-G und zirkulierenden Immunkomplexen
WO1993003735A1 (en) * 1991-08-23 1993-03-04 Alberta Research Council Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
WO1995031727A1 (en) * 1994-05-13 1995-11-23 Therasorb Medizinische Systeme Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144013A (en) * 1986-09-24 1992-09-01 Ube Industries, Ltd. Body fluid purifying material and method for purifying body fluid by use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269279A2 (de) * 1986-11-21 1988-06-01 Imre Corporation Ausserkörperliche Beseitigung von Immunoglobulin-G und zirkulierenden Immunkomplexen
WO1993003735A1 (en) * 1991-08-23 1993-03-04 Alberta Research Council Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
WO1995031727A1 (en) * 1994-05-13 1995-11-23 Therasorb Medizinische Systeme Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BENSINGER W.: "Plasma exchange and immunoadsorption for removal of antibodies prior to ABO incompatible bone marrow transplant", ARTIFICIAL ORGANS, vol. 5, no. 3, August 1981 (1981-08-01), pages 254 - 258, XP000673998 *
DANTAL J ET AL: "Effect of plasma protein absorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome.", NEW ENGLAND JOURNAL OF MEDICINE 330 (1). 1994. 7-14, XP000674269 *
FISCHEL R J ET AL: "CARDIAC XENOGRAFTING IN THE PIG-TO-RHESUS MONKEY MODEL MANIPULATION OF ANTIENDOTHELIAL ANTIBODY PROLONGS SURVIVAL.", J HEART LUNG TRANSPLANT 11 (5). 1992. 965-973, XP000673900 *
LEVENTHAL J R ET AL: "Removal of baboon and human antiporcine IgG and IgM natural antibodies by immunoadsorption: Results of in vitro and in vivo studies.", TRANSPLANTATION (BALTIMORE) 59 (2). 1995. 294-300, XP000674258 *
LOVELAND B E ET AL: "CD46 MCP CONFERS PROTECTION FROM LYSIS BY XENOGENETIC ANTIBODIES.", XIVTH INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY, PARIS, FRANCE, AUGUST 16-21, 1992. TRANSPLANT PROC 25 (1 BOOK 1-2). 1993. 396-397, XP000673901 *
NEETHLING F A ET AL: "Protection of pig kidney (PK15) cells from the cytotoxic effect of anti- pig antibodies by alpha-galactosyl oligosaccharides.", TRANSPLANTATION (BALTIMORE) 57 (6). 1994. 959-963, XP000674257 *
ORIOL R ET AL: "Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig -to-man organ xenotransplantation.", TRANSPLANTATION (BALTIMORE) 56 (6). 1993. 1433-1442, XP000674259 *
PALMER A ET AL: "REMOVAL OF ANTI-HLA ANTIBODIES BY EXTRACORPOREAL IMMUNOADSORPTION TO ENABLE RENAL TRANSPLANTATION.", LANCET 1 (8628). 1989. 10-12, XP002031721 *
SHAPIRO R. ET AL.: "Immunodepletion in Xenotransplantation", JOURNAL OF INVESTIGATIVE SURGERY, vol. 3, no. 1, 1990, pages 39 - 49, XP000673902 *

Also Published As

Publication number Publication date
EP0759763A1 (de) 1997-03-05
AU2514595A (en) 1995-12-05
WO1995031209A1 (en) 1995-11-23

Similar Documents

Publication Publication Date Title
PL333503A1 (en) Compositions of strongly branched primary alcohols and detergents susceptible to biodegradation obtained from such alcohols
GR3034784T3 (en) Hemorrhoidal compositions and method of use
ZA9169B (en) Methods and compositions to disinfect lenses
ZA931645B (en) Antitumor compositions and methods of treatment
GB2268935B (en) Diagnosis of rejection of transplanted organs
ZA915371B (en) Antitumor compositions and methods of treatment
AU2827795A (en) 1:1 soap compositions of acids and amines or ammonia useful in removal and prevention of scale
EP0759763A4 (de) Vermeidung der hyperakuten abstossung von organtransplantaten von schwein zum primaten
PL331713A1 (en) Azacycloalkylkanoylpeptides and pseudopeptides acting as antithrombotic agents
GB9124977D0 (en) Improvements in or relating to polyester compositions
SG44925A1 (en) Polyolefin composition of improved ductility and article therefrom
HUP9904332A3 (en) Compositions and articles of manufacture
GB9200284D0 (en) Suppression of"organ pipes"raster display distortions
GB9007879D0 (en) Treatment of thrombotic events
ZA9510785B (en) Use of lauric esters as activity-increasing substa
HU9500910D0 (en) Pyrazoline-derivatives and their use as plant desease-controlling agent
PL314588A1 (en) Application of pentoxyphyline in treatment of sclerosis multiplex
GB9012630D0 (en) Improvements in or relating to treatment of sewage
GB9303815D0 (en) Use of fabric treatment compositions
EP0929540A4 (de) Antitumor-zusamensetzungen und behandlungsverfahren
GB9315318D0 (en) Improvements in or relating to the playing of bingo
GB9607352D0 (en) Improvements in or relating to the processing of video signals
GB9308478D0 (en) Methods and compositions for amelioration of skin wrinkles
GB9200129D0 (en) Improvements in or relating to methods of lining pipework
GB9226327D0 (en) Improvements in or relating to methods of lining pipework

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19961129

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19970612

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB IT LI NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19991201