EP0746315A4 - Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation - Google Patents
Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferationInfo
- Publication number
- EP0746315A4 EP0746315A4 EP93920350A EP93920350A EP0746315A4 EP 0746315 A4 EP0746315 A4 EP 0746315A4 EP 93920350 A EP93920350 A EP 93920350A EP 93920350 A EP93920350 A EP 93920350A EP 0746315 A4 EP0746315 A4 EP 0746315A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- carbazolyl
- inhibition
- treatment
- cell proliferation
- smooth muscle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
WOPCT/US93/02062 | 1993-03-05 | ||
PCT/US1993/002062 WO1994020096A1 (en) | 1993-03-05 | 1993-03-05 | Method of employing carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
US26892 | 1993-03-05 | ||
US08/026,892 US5308862A (en) | 1993-03-05 | 1993-03-05 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
PCT/US1993/008019 WO1994020097A1 (en) | 1993-03-05 | 1993-08-27 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0746315A1 EP0746315A1 (en) | 1996-12-11 |
EP0746315A4 true EP0746315A4 (en) | 1999-01-07 |
Family
ID=26701782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93920350A Withdrawn EP0746315A4 (en) | 1993-03-05 | 1993-08-27 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0746315A4 (en) |
JP (1) | JPH08508013A (en) |
AU (1) | AU679462B2 (en) |
NO (1) | NO307865B1 (en) |
RU (1) | RU2147433C1 (en) |
UA (1) | UA41915C2 (en) |
WO (2) | WO1994020096A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4503067A (en) * | 1978-04-13 | 1985-03-05 | Boehringer Mannheim Gmbh | Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3319027A1 (en) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | METHOD FOR PRODUCING OPTICALLY ACTIVE CARBAZOL DERIVATIVES, NEW R- AND S-CARBAZOL DERIVATIVES, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
US4970227A (en) * | 1984-11-20 | 1990-11-13 | Burroughs Wellcome Co. | Carbazole derivatives |
-
1993
- 1993-03-05 WO PCT/US1993/002062 patent/WO1994020096A1/en active Application Filing
- 1993-08-27 EP EP93920350A patent/EP0746315A4/en not_active Withdrawn
- 1993-08-27 AU AU50923/93A patent/AU679462B2/en not_active Ceased
- 1993-08-27 RU RU95121695A patent/RU2147433C1/en not_active IP Right Cessation
- 1993-08-27 WO PCT/US1993/008019 patent/WO1994020097A1/en not_active Application Discontinuation
- 1993-08-27 UA UA95083997A patent/UA41915C2/en unknown
- 1993-08-27 JP JP6519937A patent/JPH08508013A/en active Pending
-
1995
- 1995-09-04 NO NO953480A patent/NO307865B1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4503067A (en) * | 1978-04-13 | 1985-03-05 | Boehringer Mannheim Gmbh | Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions |
Non-Patent Citations (3)
Title |
---|
MCTAVISH D ET AL: "CARVEDILOL A REVIEW OF ITS PHAMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, ANDTHERAPEUTIC EFFICACY", DRUGS, vol. 45, no. 2, 1 February 1993 (1993-02-01), pages 232 - 258, XP000578564 * |
RUFFOLO R R ET AL: "CARVEDILOL: A NOVEL CARDIOVASCULAR DRUG WITH MULTIPLE ACTIONS", CARDIOVASCULAR DRUG REVIEWS, vol. 10, no. 2, 1 January 1992 (1992-01-01), pages 127 - 157, XP000578562 * |
See also references of WO9420097A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994020096A1 (en) | 1994-09-15 |
NO953480L (en) | 1995-11-03 |
UA41915C2 (en) | 2001-10-15 |
AU5092393A (en) | 1994-09-26 |
AU679462B2 (en) | 1997-07-03 |
WO1994020097A1 (en) | 1994-09-15 |
NO307865B1 (en) | 2000-06-13 |
JPH08508013A (en) | 1996-08-27 |
RU2147433C1 (en) | 2000-04-20 |
EP0746315A1 (en) | 1996-12-11 |
NO953480D0 (en) | 1995-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950905 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19981119 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 19990414 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20011001 |
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REG | Reference to a national code |
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