EP0743308A3 - Chinazolinverbindung und diese als Wirkstoff enthaltendes Antitumormittel - Google Patents

Chinazolinverbindung und diese als Wirkstoff enthaltendes Antitumormittel Download PDF

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Publication number
EP0743308A3
EP0743308A3 EP96106839A EP96106839A EP0743308A3 EP 0743308 A3 EP0743308 A3 EP 0743308A3 EP 96106839 A EP96106839 A EP 96106839A EP 96106839 A EP96106839 A EP 96106839A EP 0743308 A3 EP0743308 A3 EP 0743308A3
Authority
EP
European Patent Office
Prior art keywords
compound
active ingredient
tumor agent
agent containing
quinazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96106839A
Other languages
English (en)
French (fr)
Other versions
EP0743308A2 (de
Inventor
Yoshikazu Jinbo
Tomohiro Miyasaka
Yoshiaki Ikeda
Takashi Sekida
Kei Naruse
Masayuki Ando
Shigeru Iwaki
Kohichiro Yoshino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of EP0743308A2 publication Critical patent/EP0743308A2/de
Publication of EP0743308A3 publication Critical patent/EP0743308A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96106839A 1995-05-16 1996-04-30 Chinazolinverbindung und diese als Wirkstoff enthaltendes Antitumormittel Withdrawn EP0743308A3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP142559/95 1995-05-16
JP142560/95 1995-05-16
JP14256095 1995-05-16
JP14255995 1995-05-16
JP14256095 1995-05-16
JP14255995 1995-05-16

Publications (2)

Publication Number Publication Date
EP0743308A2 EP0743308A2 (de) 1996-11-20
EP0743308A3 true EP0743308A3 (de) 2000-04-05

Family

ID=26474523

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96106839A Withdrawn EP0743308A3 (de) 1995-05-16 1996-04-30 Chinazolinverbindung und diese als Wirkstoff enthaltendes Antitumormittel

Country Status (5)

Country Link
US (1) US5912247A (de)
EP (1) EP0743308A3 (de)
KR (1) KR960041178A (de)
CN (1) CN1145361A (de)
TW (1) TW334434B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194181T3 (es) 1996-02-13 2003-11-16 Astrazeneca Ab Derivados de quinazolina como inhibidores de vegf.
DK0885198T3 (da) 1996-03-05 2002-03-25 Astrazeneca Ab 4-Anilinoquinazolinderivater
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6294532B1 (en) 1997-08-22 2001-09-25 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
KR100860295B1 (ko) 1998-10-08 2008-09-25 아스트라제네카 아베 퀴나졸린 유도체
ATE339406T1 (de) 1999-09-23 2006-10-15 Astrazeneca Ab Chinazoline verbindungen als heilmittel
KR100881105B1 (ko) 1999-11-05 2009-02-02 아스트라제네카 아베 Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체
US6140516A (en) * 1999-12-15 2000-10-31 Eastman Chemical Company Process for the preparation of trans-3-alkyloxy-4-hydroxytetrahydrofuran
DE60121931T2 (de) 2000-04-07 2007-03-01 Astrazeneca Ab Chinazolinverbindungen
CN1531441A (zh) * 2001-01-12 2004-09-22 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 抑制血管增殖的药物组合物及其使用方法
EP1852107A1 (de) 2006-04-19 2007-11-07 Nanobiotix Zusammensetzungen enthaltend magnetische Nanopartikel sowie deren Verwendung
EP2508171B1 (de) 2011-03-25 2014-05-07 Universitätsklinikum Erlangen Pharmazeutische Zusammensetzung mit magnetischen Nanopartikeln

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322133A1 (de) * 1987-12-03 1989-06-28 SmithKline Beecham Intercredit B.V. Chinazolinon-Derivate
US4877790A (en) * 1987-12-15 1989-10-31 Kanebo Limited Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient
WO1992007844A1 (en) * 1990-11-06 1992-05-14 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
EP0635498A1 (de) * 1993-07-19 1995-01-25 Zeneca Limited Quinazoline Derivate und ihre Anwendung als Krebsmittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
US3812127A (en) * 1966-10-31 1974-05-21 Pfizer 4-(quinolin-4-yl)piperazine-1-carboxylic acid esters
CH651027A5 (de) * 1982-11-12 1985-08-30 Sandoz Ag Heterocyclische verbindungen, ihre herstellung und verwendung.
US4672116A (en) * 1985-12-20 1987-06-09 Ortho Pharmaceutical Corporation Substituted 5,6-dialkoxyquinazoline derivatives
JPH07138238A (ja) * 1993-11-16 1995-05-30 Kanebo Ltd 新規キナゾリン誘導体およびそれを有効成分とする抗腫瘍剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322133A1 (de) * 1987-12-03 1989-06-28 SmithKline Beecham Intercredit B.V. Chinazolinon-Derivate
US4877790A (en) * 1987-12-15 1989-10-31 Kanebo Limited Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient
WO1992007844A1 (en) * 1990-11-06 1992-05-14 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
EP0635498A1 (de) * 1993-07-19 1995-01-25 Zeneca Limited Quinazoline Derivate und ihre Anwendung als Krebsmittel

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MANABU HORI ET AL.: "Nootropic agents, 4-Alkoxy-2-(1-piperazinyl)quinazoline Derivatives", CHEM. PHARM. BULL., vol. 39, no. 2, 1991, japan, pages 367 - 371, XP002128281 *
MANABU HORI ET AL.: "Novel 4-Substituted 2-Piperazinylquinazolines as potent Anticonvulsive and Antihypoxic Agents.", CHEM. PHARM. BULL., vol. 38, no. 5, 1990, japan, pages 1286 - 1291, XP002128282 *

Also Published As

Publication number Publication date
TW334434B (en) 1998-06-21
US5912247A (en) 1999-06-15
EP0743308A2 (de) 1996-11-20
CN1145361A (zh) 1997-03-19
KR960041178A (ko) 1996-12-19

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