EP0738151A1 - Traitement a base de metabolite d'acide arachidonique et formulations particulaires - Google Patents
Traitement a base de metabolite d'acide arachidonique et formulations particulairesInfo
- Publication number
- EP0738151A1 EP0738151A1 EP95908028A EP95908028A EP0738151A1 EP 0738151 A1 EP0738151 A1 EP 0738151A1 EP 95908028 A EP95908028 A EP 95908028A EP 95908028 A EP95908028 A EP 95908028A EP 0738151 A1 EP0738151 A1 EP 0738151A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- particle
- disorder
- endocytosable
- metabolite
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical compound CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention a pour objet un procédé pour administrer un métabolite d'acide arachidonique libre à un animal, ce procédé consistant à administrer le métabolite libre et une particule capable d'endocytose. Ce procédé peut être utilisé pour traiter les animaux souffrant de troubles caractérisés par une activation et une adhérence cellulaires, des inflammations et des toxémies. L'invention a également pour objet un procédé pour traiter un animal contre ces troubles en lui administrant une composition renfermant une quantité d'une particule capable d'endocytose, efficace contre ces troubles.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17973994A | 1994-01-11 | 1994-01-11 | |
| US179739 | 1994-01-11 | ||
| US20334194A | 1994-02-28 | 1994-02-28 | |
| US203341 | 1994-02-28 | ||
| PCT/US1995/000370 WO1995018620A1 (fr) | 1994-01-11 | 1995-01-11 | Traitement a base de metabolite d'acide arachidonique et formulations particulaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0738151A1 true EP0738151A1 (fr) | 1996-10-23 |
Family
ID=26875610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP95908028A Ceased EP0738151A1 (fr) | 1994-01-11 | 1995-01-11 | Traitement a base de metabolite d'acide arachidonique et formulations particulaires |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0738151A1 (fr) |
| JP (1) | JPH10507737A (fr) |
| AU (1) | AU682753B2 (fr) |
| CA (1) | CA2179986A1 (fr) |
| FI (1) | FI962806A (fr) |
| NO (1) | NO962911L (fr) |
| WO (1) | WO1995018620A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995012388A1 (fr) * | 1993-11-04 | 1995-05-11 | The Liposome Company, Inc. | Procedes de traitement faisant appel a des formulations de metabolite d'acide arachidonique liposomique unilamellaire |
| WO1995013797A1 (fr) * | 1993-11-16 | 1995-05-26 | The Liposome Company, Inc. | Liposomes d'interdigitation-fusion comportant des metabolites d'acide arachidonique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0512916B1 (fr) * | 1991-05-07 | 1999-02-03 | The Liposome Company, Inc. | Formulation de liposomes contenant des prostaglandines |
| DE4125255A1 (de) * | 1991-07-31 | 1993-02-04 | Knoll Ag | Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung |
-
1995
- 1995-01-11 EP EP95908028A patent/EP0738151A1/fr not_active Ceased
- 1995-01-11 JP JP7518686A patent/JPH10507737A/ja active Pending
- 1995-01-11 WO PCT/US1995/000370 patent/WO1995018620A1/fr not_active Application Discontinuation
- 1995-01-11 AU AU16018/95A patent/AU682753B2/en not_active Ceased
- 1995-01-11 CA CA002179986A patent/CA2179986A1/fr not_active Abandoned
-
1996
- 1996-07-10 FI FI962806A patent/FI962806A/fi unknown
- 1996-07-10 NO NO962911A patent/NO962911L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995012388A1 (fr) * | 1993-11-04 | 1995-05-11 | The Liposome Company, Inc. | Procedes de traitement faisant appel a des formulations de metabolite d'acide arachidonique liposomique unilamellaire |
| WO1995012389A1 (fr) * | 1993-11-04 | 1995-05-11 | The Liposome Company, Inc. | Formulations de liposome multilamellaire contenant un metabolite d'acide arachidonique |
| WO1995013797A1 (fr) * | 1993-11-16 | 1995-05-26 | The Liposome Company, Inc. | Liposomes d'interdigitation-fusion comportant des metabolites d'acide arachidonique |
Non-Patent Citations (3)
| Title |
|---|
| LIU D, HUANG L: "Size homogeneity of a liposome preparation is crucial for liposome biodistribution in vivo", J LIPOSOME RESEARCH, vol. 2, 1992, pages 57 - 66, XP000246008 * |
| OSTRO M.J: "Liposomes", 1983, MARCEL DEKKER, INC., NEW YORK * |
| See also references of WO9518620A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2179986A1 (fr) | 1995-07-13 |
| NO962911L (no) | 1996-09-03 |
| JPH10507737A (ja) | 1998-07-28 |
| AU682753B2 (en) | 1997-10-16 |
| AU1601895A (en) | 1995-08-01 |
| FI962806A0 (fi) | 1996-07-10 |
| FI962806A (fi) | 1996-09-10 |
| NO962911D0 (no) | 1996-07-10 |
| WO1995018620A1 (fr) | 1995-07-13 |
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