EP0737070A4 - Vitamin d 3? analogues and pathway to mediate disorders - Google Patents

Vitamin d 3? analogues and pathway to mediate disorders

Info

Publication number
EP0737070A4
EP0737070A4 EP95906111A EP95906111A EP0737070A4 EP 0737070 A4 EP0737070 A4 EP 0737070A4 EP 95906111 A EP95906111 A EP 95906111A EP 95906111 A EP95906111 A EP 95906111A EP 0737070 A4 EP0737070 A4 EP 0737070A4
Authority
EP
European Patent Office
Prior art keywords
analogues
vitamin
pathway
mediate disorders
mediate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95906111A
Other languages
German (de)
French (fr)
Other versions
EP0737070A1 (en
Inventor
Anthony W Norman
William H Okamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP0737070A1 publication Critical patent/EP0737070A1/en
Publication of EP0737070A4 publication Critical patent/EP0737070A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95906111A 1993-12-23 1994-12-23 Vitamin d 3? analogues and pathway to mediate disorders Withdrawn EP0737070A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17356193A 1993-12-23 1993-12-23
US24938594A 1994-05-25 1994-05-25
PCT/US1994/014870 WO1995017197A1 (en) 1993-12-23 1994-12-23 Vitamin d3 analogues and pathway to mediate disorders
US249385 2000-11-16
US173561 2005-07-01

Publications (2)

Publication Number Publication Date
EP0737070A1 EP0737070A1 (en) 1996-10-16
EP0737070A4 true EP0737070A4 (en) 1999-03-17

Family

ID=26869286

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95906111A Withdrawn EP0737070A4 (en) 1993-12-23 1994-12-23 Vitamin d 3? analogues and pathway to mediate disorders

Country Status (5)

Country Link
EP (1) EP0737070A4 (en)
JP (1) JPH09507079A (en)
AU (1) AU1445295A (en)
CA (1) CA2179288A1 (en)
WO (1) WO1995017197A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26481A1 (en) * 1997-04-21 2004-12-20 Hoffmann La Roche ARYLSECOCHOLADIAN DERIVATIVES
WO1998051663A2 (en) * 1997-05-16 1998-11-19 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
EP1891944A1 (en) 2006-07-24 2008-02-27 Association pour la recherche à l'IGBMC (ARI) Use of Vitamin D3 agonist in a mammalian model for atopic diseases and of Vitamin D3 antagonists for the treatment of atopic diseases
CN114269348A (en) * 2019-08-22 2022-04-01 工业技术和生物技术公司 Hormone D (vitamin D) and its derivatives for the treatment and prevention of cancer
CN111830157B (en) * 2020-07-17 2022-02-25 大连美创药业有限公司 Gas chromatography detection method for synthesizing eldecalcitol intermediate
CN115850142A (en) * 2022-11-25 2023-03-28 甘肃皓天医药科技有限责任公司 Synthesis method of 7Z vitamin D compound

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AMBRECHT ET AL.: "1,25-Dihydroxyvitamin D Induction of Calbindin D Protein but not mRNA Decreases with Age in Rat Duodenum", FASEB J., vol. 5, no. 6, 1991, pages a1642, XP002086812 *
DE BOLAND ET AL.: "Ca2+-CHANNEL AGONIST BAY K8644 MIMICS 1,25(OH)2-VITAMIN D3 RAPID ENHANCEMENT OF Ca2+ TRANSPORT IN CHICK PERFUSED DUODENUM", BIOCHEM. BIOPHYS. RES. COMM., vol. 166, no. 1, 1990, pages 217 - 222, XP002086810 *
FARACH-CARSON ET AL.: "22-Oxacalcitriol: dissection of 1,25(OH)2D3 receptor-mediated and Ca2+ entry-stimulating pathways", AM. J. PHYSIOL., vol. 265, no. 5 part 2, 1993, pages F705 - F711, XP002086811 *
NEMERE ET AL.: "The Rapid, Hormonally Stimulated Transport of Calcium (Transcaltachia)", J. BONE MINER. RES., vol. 2, no. 3, 1987, pages 167 - 169, XP002086809 *
NEMERE ET AL.: "TRANSCALTACHIA, VESICULAR CALCIUM TRANSPORT, AND MICROTUBULE ASSOCIATED CALBINDIN-D28K", PROC. WORKSHOP VITAMIN D, vol. 7, 1988, pages 549 - 557, XP002086816 *
NEMERE ET AL.: "Vesicular Calcium Transport across the Intestine and its Initiation by 1,25-dihydroxyvitamin D3 during Transcaltachia", PROC. WORKSHOP VITAMIN D, vol. 8, 1991, pages 360 - 367, XP002086817 *
NORMAN ET AL.: "1beta,25(OH)2-VITAMIN D3 IS AN ANTAGONIST OF 1alpha,25(OH)2-VITAMIN D3 STIMULATED TRANSCALTACHIA (THE RAPID HORMONAL STIMULATION OF INTESTINAL CALCIUM TRANSPORT)", BIOCHEM. BIOPHYS. RES. COMM., vol. 189, no. 3, 1992, pages 1450 - 1456, XP002086813 *
NORMAN ET AL.: "Demonstration That 1beta,25-Dihydroxyvitamin D3 is an Antagonist of the Nongenomic but not Genomic Biological Responses and Biological Profile of the Three A-ring Diastereomers of 1alpha,25-Dihydroxyvitamin D3", J. BIOL. CHEM., vol. 268, no. 27, 1993, pages 20022 - 20030, XP002086815 *
NORMAN ET AL.: "Structure-Function Studies of 1,25-Dihydroxyvitamin D3 and the Vitamin D Endocrine System", J. BIOL. CHEM., vol. 268, no. 19, 1993, pages 13811 - 13819, XP002086814 *
See also references of WO9517197A1 *
ZHOU ET AL.: "1,25-Dihydroxyvitamin D3 Analog Structure-Function Assessment of the Rapid Stimulation of Intestinal Calcium Absorption (Transcaltachia)", J. BONE MINER. RES., vol. 7, no. 4, 1992, pages 457 - 463, XP002086808 *

Also Published As

Publication number Publication date
WO1995017197A1 (en) 1995-06-29
EP0737070A1 (en) 1996-10-16
JPH09507079A (en) 1997-07-15
AU1445295A (en) 1995-07-10
CA2179288A1 (en) 1995-06-29

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