EP0726777A4 - Expression procaryote de proteines du cmh - Google Patents

Expression procaryote de proteines du cmh

Info

Publication number
EP0726777A4
EP0726777A4 EP94932028A EP94932028A EP0726777A4 EP 0726777 A4 EP0726777 A4 EP 0726777A4 EP 94932028 A EP94932028 A EP 94932028A EP 94932028 A EP94932028 A EP 94932028A EP 0726777 A4 EP0726777 A4 EP 0726777A4
Authority
EP
European Patent Office
Prior art keywords
prokaryotic expression
mhc proteins
mhc
proteins
prokaryotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94932028A
Other languages
German (de)
English (en)
Other versions
EP0726777A1 (fr
Inventor
Eric T Rhodes
Bishwajit Nag
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anergen Inc
Original Assignee
Anergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anergen Inc filed Critical Anergen Inc
Publication of EP0726777A1 publication Critical patent/EP0726777A1/fr
Publication of EP0726777A4 publication Critical patent/EP0726777A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP94932028A 1993-10-25 1994-10-25 Expression procaryote de proteines du cmh Withdrawn EP0726777A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14357593A 1993-10-25 1993-10-25
PCT/US1994/012231 WO1995011702A1 (fr) 1993-10-25 1994-10-25 Expression procaryote de proteines du cmh
US143575 2002-05-13

Publications (2)

Publication Number Publication Date
EP0726777A1 EP0726777A1 (fr) 1996-08-21
EP0726777A4 true EP0726777A4 (fr) 2002-04-24

Family

ID=22504655

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94932028A Withdrawn EP0726777A4 (fr) 1993-10-25 1994-10-25 Expression procaryote de proteines du cmh

Country Status (5)

Country Link
EP (1) EP0726777A4 (fr)
JP (1) JPH09504432A (fr)
KR (1) KR100369286B1 (fr)
CA (1) CA2175089A1 (fr)
WO (1) WO1995011702A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US5820866A (en) * 1994-03-04 1998-10-13 National Jewish Center For Immunology And Respiratory Medicine Product and process for T cell regulation
WO2000015665A2 (fr) * 1998-09-14 2000-03-23 Pedersen Lars Oestergaard Procede de production d'une proteine fonctionnelle de la superfamille des immunoglobulines
US6217871B1 (en) * 1998-10-28 2001-04-17 The Regents Of The University Of California Antigenic epitopes with LYM-1 reactivity and uses thereof
US7521202B2 (en) 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
WO2002062846A2 (fr) * 1999-12-17 2002-08-15 The Board Of Regents Of The University Of Oklahoma Procede et dispositif de production d'antigenes et utilisation de ceux-ci
JP2004536554A (ja) 2000-10-10 2004-12-09 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ Ｍｈｃ陽性細胞からの比較リガンドマッピング
US20070026433A1 (en) 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
WO2002056908A2 (fr) * 2001-01-16 2002-07-25 Hildebrand William H Cellules de presentation d'antigene
CA2486545A1 (fr) * 2001-09-17 2003-03-27 Nalan Utku Peptides capables de moduler une reponse immunitaire
US10857219B2 (en) 2014-03-28 2020-12-08 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018150A1 (fr) * 1991-04-23 1992-10-29 Anergen, Inc. Conjugues cmh permettant de traiter l'auto-immunite

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018150A1 (fr) * 1991-04-23 1992-10-29 Anergen, Inc. Conjugues cmh permettant de traiter l'auto-immunite

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALTMAN JOHN D ET AL: "Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 21, November 1993 (1993-11-01), 1993, pages 10330 - 10334, XP002190823, ISSN: 0027-8424 *
ALTMAN JOHN D ET AL: "Reconstitution of specific peptide binding and T cell recognition of class II I-E-k heterodimers from subunits produced in Escherichia coli.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, no. 17 PART C, 1993, Keystone Symposium on Emerging Principles for Vaccine Development: Antigen Processing and Presentations;Taos, New Mexico, USA; February 8-14, 1993, pages 89, XP001056801, ISSN: 0733-1959 *
GARBOCZI D N ET AL: "HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, no. 9, 15 April 1992 (1992-04-15), pages 3429 - 3433, XP002131059, ISSN: 0027-8424 *
GODEAU F ET AL: "PURIFICATION AND LIGAND BINDING OF A SOLUBLE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE CONSISTING OF THE FIRST THREE DOMAINS OF H-2KD FUSED TO BETA2-MICROGLOBULIN EXPRESSED IN THE BACULOVIRUS-INSECT CELL SYSTEM", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 34, 5 December 1992 (1992-12-05), pages 24223 - 24229, XP002051156, ISSN: 0021-9258 *
PARKER K C ET AL: "AN HLA-A2/BETA2-MICROGLOBULIN/PEPTIDE COMPLEX ASSEMBLED FROM SUBUNITS EXPRESSED SEPARATELY IN ESCHERICHIA COLI", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 29, no. 3, March 1992 (1992-03-01), pages 371 - 378, XP000876800, ISSN: 0161-5890 *
See also references of WO9511702A1 *

Also Published As

Publication number Publication date
JPH09504432A (ja) 1997-05-06
EP0726777A1 (fr) 1996-08-21
KR100369286B1 (ko) 2003-07-23
WO1995011702A1 (fr) 1995-05-04
CA2175089A1 (fr) 1995-05-04
KR960705583A (ko) 1996-11-08

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